张亚平 - 云南大学 - 生命科学学院

个人简介

个人简历博士，研究员，中国科学院院士，发展中国家科学院院士。现任中国科学院副院长、昆明动物研究所“遗传资源与进化”国家重点实验室学术委员会主任和分子进化与基因组多样性学科组负责人；通过推动中国科学院西南家猪分子育种基地的建设将畜禽进化基因组的研究成果应用于家猪分子育种实践并进行产业转化与推广。在建立具有国际影响的人群和动物DNA库的基础上，主要从分子水平研究生物多样性的演化及机制，澄清了灵长类、食肉类、两栖爬行类等动物类群系统与演化中的一些重要问题。揭示了东亚人群进化的一些规律和一些民族的演化历程。系统地研究了野生动物和家养动物的遗传多样性，发现遗传多样性贫乏与物种濒危之间没有必然的对应关系；确定了家犬的东亚起源，证明东亚是家养动物驯化的重要区域。对自然选择和人工选择作用下基因组进化的研究，揭示了一些重要的动物适应进化和畜禽经济性状形成的遗传机制。近5年来，在Science，Nature，PNAS，PLosGenetics等国际刊物发表SCI文章150余篇。先后获国家自然科学二等奖、长江学者成就一等奖、云南省科技突出贡献奖、何梁何利基金科学与技术进步奖等国家和省部级科技奖励20余项。由于在生物多样性研究领域的突出贡献，获国际重要奖项“生物多样性领导奖”，成为亚洲地区唯一的获奖人。

研究领域

近五年来，结合基因组学的发展，从基因组水平系统研究关键区域人群和重要家养动物和野生动物的自然选择和人工选择的遗传机制。 1、家养动物起源驯化与人工选择的基因组进化机制家养动物是人类社会发展到特定阶段的产物，阐明家养动物的起源驯化历史，在基因组水平上揭示人工驯化的遗传机制，不仅可为未来畜禽中新品种的培育奠定科学基础，而且对了解人类进化的历史也有重要意义。 2、动物适应性进化的遗传机制生物进化就是生物不断适应环境的过程，其遗传机制是生物学上的基本问题。我们主要围绕能量代谢、信息感受与传导等探讨动物适应其生态位的遗传机制。 3、人和动物高原适应的分子机制青藏高原是研究高原适应的天然实验室，我们采用比较基因组学研究策略，通过比较这一关键地区处于不同适应阶段的人群、家养动物和野生动物等不同类群高原适应机制的异同，以及同一类群在世界不同高原地区的适应机制，揭示高原适应的普遍规律。 4、基因组多样性与亚洲人群的了解自身的进化历程是人类不断探索的问题。我们在基因组水平研究现代人走出非洲之后的迁移历史及其对环境适应的遗传机制

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.LiuYH,WangL,XuT,GuoXM,LiY,YinTT,YangHC,HuY,AdeolaAC,SankeOJ,OteckoNO,WangM,MaYP,CharlesOS,SindingMHS,GopalakrishnanS,SamaniegoJA,HansenAJ,FernandesC,GaubertP,BuddJ,DawudaPM,RuenessEK,JiangLB,ZhaiWW,GilbertMTP,PengMS,XiaopengQiXP*,WangGD*,ZhangYP*.Whole-genomesequencingofAfricandogsprovidesinsightsintoadaptationsagainsttropicalparasites.MolecularBiologyandEvolution,2018,35:287-298. 2.WangMS,OteckoNO,WangS,WuDD,YangMM,XuY,MurphyRW,PengMS*,ZhangYP*.Anevolutionarygenomicperspectiveonthebreedingofdwarfchickens.MolecularBiologyandEvolution,2017,34:3081-3088. 3.WangMS,ZengY,WangX,NieWH,WangJH,SuWT,OteckoNO,XiongZJ,WangS,QuKX,YanSQ,YangMM,WangW,DongY*,WuDD*,ZhangYP*.Draftgenomeofthegayal,Bosfrontalis.Gigascience,2017,6(11):1-7. 4.ZengL,MingC,LiY,SuLY,SuYH,OteckoNO,LiuHQ,WangMS,YaoYG,LiHP,WuDD*,ZhangYP*.Rapidevolutionofgenesinvolvedinlearningandenergymetabolismfordomesticationofthelaboratoryrat.MolecularBiologyandEvolution,2017,34:3148-3153. 5.ZengL,MingC,LiY,SuLY,SuYH,OteckoNO,DaleckyA,DonnellanS,AplinK,LiuXH,SongY,ZhangZB,EsmailizadehA,SohrabiSS,NanaeiHA,LiuHQ,WangMS,AtteynineSA,RocamoraG,BresciaF,MorandS,IrwinDM,PengMS,YaoYG,LiHP*,WuDD*,ZhangYP*.OutofsouthernEastAsiaofthebrownratrevealedbylargescalegenomesequencing.MolecularBiologyandEvolution,2017,doi:10.1093/molbev/msx276. 6.LiY,WangMS,OteckoNO,WangW,ShiP,WuDD*,ZhangYP*.HypoxiapotentiallypromotesTibetanlongevity.CellResearch,2017,27(2):302-305. 7.YuL*,WangGD,RuanJ,ChenYB,YangCP,CaoX,WuH,LiuYH,DuZL,WangXP,YangJ,ChengSC,ZhongL,WangL,WangX,HuJY,FangL,BaiB,WangKL,YuanN,WuSF,LiBG,ZhangJG,YangYQ,ZhangCL,LongYC,LiHS,YangJY,IrwinDM,RyderOA,LiY,WuCI*,ZhangYP*.Genomicanalysisofsnub-nosedmonkeys(Rhinopithecus)identifiesgenesandprocessesrelatedtohigh-altitudeadaptation.NatureGenetics.2016,48:947. 8.LiHP,Xiang-YuJG,DaiGY,GuZL,MingC,YangZF,RyderOA,LiWH*,FuYX*,ZhangYP*.Largenumbersofvertebratesbeganrapidpopulationdeclineinthelate19thcentury.PNAS.2016,113:14079-14084. 9.ShenQK,SulaimanX,YaoYG,PengMS*,ZhangYP*.WasADH1BunderSelectioninEuropeanPopulations?AmJHumGenet.2016,99:1217-1219. 10.WangGD,ZhaiWW,YangHC,WangL,ZhongL,LiuYH,FanRX,YinTT,ZhuCL,PoyarkovAD,IrwinDM,HytonenMK,LohiH,WuCI,SavolainenP,andZhangYP*.OutofsouthernEastAsia:thenaturalhistoryofdomesticdogsacrosstheworld.CellResearch.2016,26:21-33. 11.WangGD,PengMS,YangHC,SavolainenP,ZhangYP*.QuestioningtheevidenceforaCentralAsiandomesticationoriginofdogs.PNAS.2016,113:E2554-E2555. 12.WangMS,ZhangRW,SuLY,LiY,PengMS,LiuHQ,ZengL,IrwinDM,DuJL,YaoYG,WuDD*,ZhangYP*.Positiveselectionratherthanrelaxationoffunctionalconstraintdrivestheevolutionofvisionduringchickendomestication.CellResearch.2016,26:556-573. 13.WangMS,HuoYX,LiY,OteckoNO,SuLY,XuHB,WuSF,PengMS,LiuHQ,ZengL,IrwinDM,YaoYG,WuDD*,ZhangYP*.Comparativepopulationgenomicsrevealsgeneticbasisunderlyingbodysizeofdomesticchickens.JMolCellBiol.2016,8(6):542-552. 14.WangGD,ZhaiWW,YangHC,WangL,ZhongL,LiuYH,FanRX,YinTT,ZhuCL,PoyarkovAD,IrwinDM,HytönenMK,HannesLohiH,WuCI,SavolainenP*,ZhangYP*.OutofsouthernEastAsia:thenaturalhistoryofdomesticdogsacrosstheworld.CellResearch,2016,26:21-33. 15.WangMS,LiY,PengMS,ZhongL,WangZJ,LiQY,TuXL,DongY,ZhuCL,WangL,YangMM,WuSF,MiaoYW,LiuJP,IrwinDM,WangW,WuDD*,ZhangYP*.GenomicanalysesrevealpotentialindependentadaptationtohighaltitudeinTibetanchickens.MolecularBiologyandEvolution,2015,32:1880-1889. 16.PengMS,ShiNN,YaoYG,ZhangYP*.CaveatsaboutinterpretationofancientchickenmtDNAsfromnorthernChina.PNAS,2015,112:E1970-E1971. 17.PengMS,FanL,ShiNN,NingT,YaoYG,MurphyRW,WangWZ*,ZhangYP*.DomeTree:acanonicaltoolkitformitochondrialDNAanalysesindomesticatedanimals.MolecularEcologyResources,2015,15:1238-1242. 18.BaiB,ZhaoWM,TangBX,WangYQ,WangL,ZhangZ,YangHC,LiuYH,ZhuJW,IrwinDM,WangGD*,ZhangYP*.DoGSD:thedogandwolfgenomeSNPdatabase.NucleicAcidsResearch,2015,43:D777-D783. 19.LiuHQ,WeiJK,LiB,WangMS,WuRQ,RizakJD,ZhongL,WangL,XuFQ,ShenYY*,HuXT*,ZhangYP*.Divergenceofdim-lightvisionamongbats(order:Chiroptera)asestimatedbymolecularandelectrophysiologicalmethods.ScientificReports,2015,5. 20.ShaoY,LiJX,GeRL,ZhongL,IrwinDM,MurphyRW,ZhangYP*.Geneticadaptationsoftheplateauzokorinhigh-elevationburrows.ScientificReports,2015,5. 21.ZhouZY,LiAM,WangLG,IrwinDM,LiuYH,XuD,HanXM,WangL,WuSF,WangLX*,XieHB*,ZhangYP*.DNAmethylationsignaturesoflongintergenicnoncodingRNAsinporcineadiposeandmuscletissues.ScientificReports,2015,5. 22.LiY,WangGD,WangMS,IrwinDM,WuDD*,ZhangYP*.DomesticationoftheDogfromtheWolfWasPromotedbyEnhancedExcitatorySynapticPlasticity:AHypothesis.GenomeBiologyandEvolution,2014,6:3115-3121. 23.ShiNN,FanL,YaoYG,PengMS*,ZhangYP*.Mitochondrialgenomesofdomesticanimalsneedscrutiny.MolecularEcology,2014,23:5393-5397. 24.LiY,WuDD,BoykoAR,WangGD,WuSF,IrwinDM,ZhangYP*.PopulationVariationRevealedHigh-AltitudeAdaptationofTibetanMastiffs.MolecularBiologyandEvolution2014,31(5):1200–1205. 25.HeL,WuWJ,YangJK,ChengH,ZuoXB,LaiW,GaoTW,MaCL,LuoN,HuangJQ,LuFY,LiuYQ,HuangYJ,LuQJ,ZhangHL,WangL,WangWZ,WangMM,XiaoSX,SunQ,LiCY,BaiYP,LiH,ZhouZC,ZhouFS,ChenG,LiangB,QiJ,YangXY,YangT,ZhengX,SunLD,ZhangXJ,andZhangYP*.Twonewsusceptibilityloci1q24.2and11p11.2conferrisktosevereacne.NatureCommunications2014,5. 26.LiuJ,WangXP,ChoS,LimBK,IrwinDM,RyderOA,ZhangYP*,YuL*.EvolutionaryandFunctionalNoveltyofPancreaticRibonuclease:aStudyofMusteloidea(orderCarnivora).ScientificReports,2014,4. 27.LuoJ,GaoY,MaW,BiXY,WangSY,WangJ,WangYQ,ChaiJ,DuR,WuSF,MeyerA,ZanRG,XiaoH,MurphyRW,ZhangYP*.TempoandmodeofrecurrentpolyploidizationintheCarassiusauratusspeciescomplex(Cypriniformes,Cyprinidae).Heredity,2014,112:415-427. 28.28.WangGD,XieHB,PengMS,IrwinD,andZhangYP*.DomesticationGenomics:EvidencefromAnimals.AnnualReviewofAnimalBiosciences,2014,2:65-84. 29.ZhouZY,LiAM,AdeolaAC,LiuYH,IrwinDM,XieHB*,ZhangYP*.Genome-WideIdentificationofLongIntergenicNoncodingRNAGenesandTheirPotentialAssociationwithDomesticationinPigs.GenomeBiologyandEvolution,2014,6:1387-1392. 30.LiY,vonHoldtBM,ReynoldsA,BoykoAR,WayneRK,WuDD*,ZhangYP*.Artificialselectiononbrain-expressedgenesduringthedomesticationofdog.MolecularBiologyandEvolution2013,30(8):1867-76. 31.WangGD,ZhaiWW,YangHC,FanRX,CaoX,ZhongL,WangL,LiuF,GaoY,LvXM,IrwinDM,SavolainenP,WuCI*,ZhangYP*.Thegenomicsofselectionindogsandtheparallelevolutionbetweendogsandhumans.NatureCommunications,2013,4:1860. 32.LiJT,LiY,KlausS,RaoDQ,HillisDM,ZhangYP*:DiversificationofrhacophoridfrogsprovidesevidenceforacceleratedfaunalexchangebetweenIndiaandEurasiaduringtheOligocene.PNAS,2013,110(9):3441-3446. 33.GeRL,CaiQL,ShenYY,MurphyRW,WangJ,ZhangYP*,WangJ*.DraftgenomesequenceoftheTibetanantelope.NatureCommunications,2013,4. 34.MurphyRW,CrawfordAJ,BauerAM,CheJ,DonnellanSC,FritzU,HaddadCFB,NagyZT,PoyarkovNA,VencesM,WangWZ,ZhangYP*:Coldcode:theglobalinitiativetoDNAbarcodeamphibiansandnonavianreptiles.MolecularEcologyResources2013,13(2):161-167. 35.YanF,ZhouWW,ZhaoHT,YuanZY,WangYY,JiangK,JinJQ,MurphyRW,CheJ*,ZhangYP*.GeologicaleventsplayalargerrolethanPleistoceneclimaticfluctuationsinthegeneticstructureofthemontanestream-dwellingfrogQuasipaaboulengeri(Anura:Dicroglossidae)insouthernChina.MolecularEcology2013,22:1120–1133.

学术兼职

中国遗传学会理事长、中国动物学会副理事长，国际重要刊物GenomeBiolEvol副主编、AnimGenet、SciRep、JHered编委。