个人简介
姜启晓，男，1983年11月生，山东青岛人。2007年本科毕业于青岛大学医学院，临床医学学士学位。2013年博士毕业于EastCarolinaUniversity,BrodySchoolofMedicine，获Ph.D.inPharmacology&Toxicology学位，现为青岛大学公共卫生学院副教授。
主要从事毒理学的科研与教学工作，现为SocietyofToxicology正式会员，主持国家自然科学基金一项，参与一项。以通讯及第一作者共发表SCI论文15篇。
学术专著
ToxicologicalEffectsofPerfluoroalkylandPolyfluoroalkylSubstances-Chapter7，2015年由Springer旗下Humana出版社出版，ISBN：978-3-319-15517-3
三、主要科研项目
1.国家自然科学基金面上项目，81872591，基于mtDNA甲基化的大气颗粒物致心脏毒性机制及早期效应标志物探索，2019/01-2023/12，57万元，在研，参与
3.国家自然科学基金青年项目，81502835,全氟辛酸（PFOA）诱导发育心脏毒性机制研究，2016/01-2018/12，18万元，结题，主持
四、获奖及荣誉称号
第四届全国大学生基础医学创新论坛暨实验设计大赛二等奖（指导教师）
首届全国MBBS项目青年教师英文讲课大赛优秀奖
青岛大学医学部第五届中青年教师英文授课大赛一等奖
近期论文
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发表论文
1:LvN,ZhaoM,HanY,CuiL,ZhongW,WangC,JiangQ*.Therolesofbonemorphogeneticprotein2inperfluorooctanoicacidinduceddevelopmentalcardiotoxicityandl-carnitinemediatedprotection.ToxicolApplPharmacol.2018Aug1;352:68-76.doi:10.1016/j.taap.2018.05.028.Epub2018May23.PubMedPMID:29800642.
2:ZhaoM,JiangQ*,GengM,ZhuL,XiaY,KhanalA,WangC.TheroleofPPARalphainperfluorooctanoicacidinduceddevelopmentalcardiotoxicityandl-carnitinemediatedprotection-Resultsofinovogenesilencing.EnvironToxicolPharmacol.2017Dec;56:136-144.doi:10.1016/j.etap.2017.09.006.Epub2017Sep14.PubMedPMID:28934691.
3:ZhaoM,JiangQ*,WangW,GengM,WangM,HanY,WangC.TheRolesofReactiveOxygenSpeciesandNitricOxideinPerfluorooctanoicAcid-InducedDevelopmentalCardiotoxicityandl-CarnitineMediatedProtection.IntJMolSci.2017Jun8;18(6).pii:E1229.doi:10.3390/ijms18061229.PubMedPMID:28594376;PubMedCentralPMCID:PMC5486052.
4:JiangQ*,WangC,XueC,XueL,WangM,LiC,DengZ,WangQ.Changesinthelevelsofl-carnitine,acetyl-l-carnitineandpropionyl-l-carnitineareinvolvedinperfluorooctanoicacidinduceddevelopmentalcardiotoxicityinchickenembryo.EnvironToxicolPharmacol.2016Dec;48:116-124.doi:10.1016/j.etap.2016.10.017.Epub2016Oct19.PubMedPMID:27771504.
5:JiangQ*,MaW,WuJ,WingardCJ,DeWittJC.Perfluorooctanoicacid-inducedtoxicityinprimaryculturesofchickenembryocardiomyocytes.EnvironToxicol.2016Nov;31(11):1580-1590.doi:10.1002/tox.22162.Epub2015Jun22.PubMedPMID:26098785.
6:JiangQ,LustRM,DeWittJC.Perfluorooctanoicacidinduced-developmentalcardiotoxicity:areperoxisomeproliferatoractivatedreceptorα(PPARα)andbonemorphorgenicprotein2(BMP2)pathwaysinvolved?JToxicolEnvironHealthA.2013;76(11):635-50.doi:10.1080/15287394.2013.789415.PubMedPMID:23941634.
7:JiangQ,LustRM,StrynarMJ,DagninoS,DeWittJC.Perflurooctanoicacidinducesdevelopmentalcardiotoxicityinchickenembryosandhatchlings.Toxicology.2012Mar11;293(1-3):97-106.doi:10.1016/j.tox.2012.01.005.Epub2012Jan18.PubMedPMID:22273728.
8:JiangQ,HaoR,WangW,GaoH,WangC.SIRT1/Atg5/autophagyareinvolvedintheantiatherosclerosiseffectsofursolicacid.MolCellBiochem.2016Sep;420(1-2):171-84.doi:10.1007/s11010-016-2787-x.Epub2016Aug11.PubMedPMID:27514536.
9:JiangQ,HanY,GaoH,TianR,LiP,WangC.Ursolicacidinducedanti-proliferationeffectsinratprimaryvascularsmoothmusclecellsisassociatedwithinhibitionofmicroRNA-21andsubsequentPTEN/PI3K.EurJPharmacol.2016Jun15;781:69-75.doi:10.1016/j.ejphar.2016.04.001.Epub2016Apr13.PubMedPMID:27085898.
10:JiangQ,WangD,HanY,HanZ,ZhongW,WangC.Modulationofoxidized-LDLreceptor-1(LOX1)contributestotheantiatherosclerosiseffectofoleanolicacid.IntJBiochemCellBiol.2015Dec;69:142-52.doi:10.1016/j.biocel.2015.10.023.Epub2015Oct25.PubMedPMID:26510581.
11:HanY,ZhaoH,JiangQ,GaoH,WangC.ChemopreventivemechanismofpolypeptidesfromChlamyFarreri(PCF)againstUVB-inducedmalignanttransformationofHaCaTcells.Mutagenesis.2015Mar;30(2):287-96.doi:10.1093/mutage/geu071.Epub2014Nov12.PubMedPMID:25392149.
12:HanY,JiangQ,GaoH,FanJ,WangZ,ZhongF,ZhengY,GongZ,WangC.Theanti-apoptoticeffectofpolypeptidefromChlamysfarreri(PCF)inUVB-exposedHaCaTcellsinvolvesinhibitionofiNOSandTGF-β1.CellBiochemBiophys.2015Mar;71(2):1105-15.doi:10.1007/s12013-014-0315-8.PubMedPMID:25331675.
13:GaoH,JiangQ,HanY,PengJ,WangC.shRNA-mediatedEMMPRINsilencinginhibitshumanleukemicmonocytelymphomaU937cellproliferationandincreaseschemosensitivitytoadriamycin.CellBiochemBiophys.2015Mar;71(2):827-35.doi:10.1007/s12013-014-0270-4.PubMedPMID:25260396.
14:GaoH,JiangQ,HanY,PengJ,WangC.Hispidulinpotentiatestheantitumoreffectofsunitinibagainsthumanrenalcellcarcinomainlaboratorymodels.CellBiochemBiophys.2015Mar;71(2):757-64.doi:10.1007/s12013-014-0260-6.PubMedPMID:25260394.
15:WangX,JiangQ,WangW,SuL,HanY,WangC.MolecularmechanismofpolypeptidesfromChlamysfarreri(PCF)'santi-apoptoticeffectinUVA-exposedHaCaTcellsinvolvesHSF1/HSP70,JNK,XO,iNOSandNO/ROS.JPhotochemPhotobiolB.2014Jan5;130:47-56.doi:10.1016/j.jphotobiol.2013.11.005.Epub2013Nov14.PubMedPMID:24296267.
16:LiuS,PiaoJ,LiuY,TangJ,LiuP,YangD,ZhangL,GeN,JinZ,JiangQ,CuiL.Radiosensitizingeffectsofdifferentsizebovineserumalbumin-templatedgoldnanoparticlesonH22hepatoma-bearingmice.Nanomedicine(Lond).2018Jun;13(11):1371-1383.doi:10.2217/nnm-2018-0059.Epub2018May11.PubMedPMID:29749804.
17:HanY,JiangQ,WangY,LiW,GengM,HanZ,ChenX.Theanti-prolifertiveeffectsofoleanolicacidonA7r5cells-RoleofUCP2anddownstreamFGF-2/p53/TSP-1.CellBiolInt.2017Dec;41(12):1296-1306.doi:10.1002/cbin.10838.Epub2017Aug31.PubMedPMID:28792088.
18:ZhangL,ZhangJ,JiangQ,ZhangL,SongW.Zincbindinggroupsforhistonedeacetylaseinhibitors.JEnzymeInhibMedChem.2018Dec;33(1):714-721.doi:10.1080/14756366.2017.1417274.Review.PubMedPMID:29616828;PubMedCentralPMCID:PMC6009916.
19:KongD,HanY,WangC,ChenX,JiangQ,WangQ,HanZ.CytoprotectiveEffectsofOleanolicAcidinHumanUmbilicalVascularEndothelialCellsisMediatedViaUCP2/ROS/CytochromeC/AIFPathway.JCardiovascPharmacol.2016Apr;67(4):344-50.doi:10.1097/FJC.0000000000000360.PubMedPMID:26771154.
20:WangZ,LiP,WangC,JiangQ,ZhangL,CaoY,ZhongW,WangC.ProtectiveeffectsofArctiumlappaL.rootextracts(AREs)onhighfatdietinducedquailatherosclerosis.BMCComplementAlternMed.2016Jan8;16:6.doi:10.1186/s12906-016-0987-2.PubMedPMID:26746431;PubMedCentralPMCID:PMC4706685.
21:ZhangL,HanY,JiangQ,WangC,ChenX,LiX,XuF,JiangY,WangQ,XuW.Trendofhistonedeacetylaseinhibitorsincancertherapy:isoformselectivityormultitargetedstrategy.MedResRev.2015Jan;35(1):63-84.doi:10.1002/med.21320.Epub2014Apr29.Review.PubMedPMID:24782318.
22:XieJ,GaoH,PengJ,HanY,ChenX,JiangQ,WangC.Hispidulinpreventshypoxia-inducedepithelial-mesenchymaltransitioninhumancoloncarcinomacells.AmJCancerRes.2015Feb15;5(3):1047-61.eCollection2015.PubMedPMID:26045985;PubMedCentralPMCID:PMC4449434.
23:GaoH,XieJ,PengJ,HanY,JiangQ,HanM,WangC.HispidulininhibitsproliferationandenhanceschemosensitivityofgallbladdercancercellsbytargetingHIF-1α.ExpCellRes.2015Mar15;332(2):236-46.doi:10.1016/j.yexcr.2014.11.021.Epub2014Dec8.PubMedPMID:25499970.
24:ZhangL,ChenY,JiangQ,SongW,ZhangL.Therapeuticpotentialofselectivehistonedeacetylase3inhibition.EurJMedChem.2019Jan15;162:534-542.doi:10.1016/j.ejmech.2018.10.072.Epub2018Nov17.Review.PubMedPMID:30472601.
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