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个人简介

教育和工作经历 2020/03- 至今, 复旦大学材料科学系,教授、博士生导师 2017/09-2020/02,上海市绿色化学与化工过程绿色化重点实验室,常务副主任 2016/03-2020/02,华东师范大学化学与分子工程学院,教授、博士生导师 2011/10-2016/02,高性能陶瓷和超微结构国家重点实验室,副主任 2010/02-2010/08,The University of Queensland,高级研究学者 2008/09-2016/02,中国科学院上海硅酸盐研究所,研究员、博士生导师 2002/08-2008/08,中国科学院上海硅酸盐研究所,博士后、助研、副研究员 1997/09-2002/06,南京工业大学,材料学,博士学位 1993/09-1997/07,齐鲁工业大学,材料学,学士学位 主要荣誉和奖励 课题组PI步文博教授,曾获得国家杰出青年科学基金(结题评价:优秀A)、科技部中青年科技创新领军人才、上海市优秀学术带头人等人才计划。 2022年,荣获上海市自然科学奖一等奖(第一完成人:步文博) 2022年,入选 Clarivate Analytics(科睿唯安)全球高被引科学家 2021年,入选 Clarivate Analytics(科睿唯安)全球高被引科学家 2020年,入选 Clarivate Analytics(科睿唯安)全球高被引科学家 2019年,入选 Clarivate Analytics(科睿唯安)全球高被引科学家 2017年,入选“国家自然科学基金委杰出青年科学基金” 2017年,入选科技部“中青年科技创新领军人才计划” 2016年,入选“上海市优秀学术带头人计划”2012年,入选“上海市青年科技启明星跟踪计划” 2012年,入选“上海市人才发展资金计划” 2012年,获“中国科学院上海分院第三届杰出青年科技创新人才提名奖” 2008年,获“第五届柳大纲优秀青年科技奖” 2007年,入选“上海市青年科技启明星计划(A类)” 2004年,获“国防科学技术二等奖”(排名第三)

研究领域

材料生物学(材料物理与化学,材料学): 1. 新型光/电/磁功能材料的合成方法学研究 2. 稀土功能材料的光磁学、分子影像学与肿瘤诊疗研究 3. 新型功能材料用于脑科学研究(神经显像与神经调控) 课题组的研究方向为无机生物化学与医用功能材料,是材料学、化学、物理学、生物学、基础医学等多学科综合交叉领域的前沿研究。

近期论文

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Yang Chen, Chaochao Wang, Yelin Wu, Ya Wang, Yun Meng, Fan Wu, Huilin Zhang, Yuen Yee Cheng, Xingwu Jiang, Jieyun Shi, Huiyan Li, Peiran Zhao, Jinfeng Wu*, Bin Zheng, Dayong Jin*, Wenbo Bu* Nutrient-Delivery and Metabolism Reactivation Therapy for Melanoma Nature Nanotechnology, 2024, DOI: 10.1038/s41565-024-01690-6. Jian Chen, Yanyan Liu, Feixiang Chen, Mengnan Guo, Jiajia Zhou, Pengfei Fu, Xin Zhang, Xueli Wang, He Wang, Wei Hua, Jinquan Chen, Jin Hu, Ying Mao*, Dayong Jin*, and Wenbo Bu*. Non-Faradaic Optoelectrodes for Safe Electrical Neuromodulation Nature Communications, 2024, 15, 405. Zhigao Yi, Xujuan Qin, Li Zhang, Huan Chen, Tianlin Song, Zichao Luo, Tao Wang, Junwei Lau, Yelin Wu, Tan Boon Toh, Chun-Sing Lee*, Wenbo Bu*, Xiaogang Liu*. Near-infrared voltage nanosensors enable real-time imaging of neuronal activities in mice and zebrafish. Journal of the American Chemical Society, 2024, 146, 9413-9421. Peiran Zhao, Huiyan Li, Bingxia Sun, Chaochao Wang, Guanglei Lv, Chao Chen, Leilei Ying, Xinhong He*, Dayong Jin*, and Wenbo Bu*. Carbon Free Radical (R∙) Inactivates NF‐κB for Radical Capping Therapy. Angewandte Chemie-International Edition, 2024, DOI: 10.1002/anie.202405913. Jiyue Wu, Yun Meng, Fan Wu, Jieyun Shi, Qingwen Sun, Xingwu Jiang, Yanyan Liu, Peiran Zhao, Qiao Wang, Lehang Guo, Yelin Wu*, Xiangpeng Zheng*, Wenbo Bu*. Ultrasound-driven Non-metallic Fenton-active Center Construction for Extensive Chemodynamic Therapy. Advanced Materials, 2024, 36(2), 2307980. Tao Wang, Chaochao Wang, Ya Wang, Xuelian Zhang, Xuechao Cai, Zhongqiu Guo, Xianfu Meng, Xingwu Jiang, Yelin Wu, Yi Cao*, Changjing Zuo*, Wenbo Bu*. Radioiodine‐Mediated Transition Metal Valence Conversion for Enhanced Chemodynamic Therapy. Advanced Functional Materials 2024, DOI: 10.1002/adfm.2024007911. Peiran Zhao, Huiyan Li*, Wenbo Bu*. A Forward Vision for Chemodynamic Therapy: Issues and Opportunities. Angewandte Chemie-International Edition, 2023, 62, e202210415. Huilin Zhang, Yang Chen, Wei Hua, Wenjun Gu, Hongjun Zhuang, Huiyan Li, Xingwu Jiang, Ying Mao,* Yanyan Liu,* Dayong Jin and Wenbo Bu*. Heterostructures with Built-in Electric Fields for Long-lasting Chemodynamic Therapy. Angewandte Chemie-International Edition, 2023, DOI: 10.1002/anie. 202300356. Huiyan Li, Huilin Zhang, Xiaofang He, Peiran Zhao, Tong Wu, Jinxuan Xiahou, Yelin Wu, Yanyan Liu, Yang Chen, Xingwu Jiang, Guanglei Lv, Zhenwei Yao*, Jian Wu*, Wenbo Bu*. Blocking Spatiotemporal Crosstalk between Subcellular Organelles for Enhancing Anticancer Therapy with Nanointercepter Advanced Materials, 2023, DOI:10.1002/adma.202108653. Hongjun Zhuang, Xiaofang He, Huiyan Li, Yang Chen, Tong Wu, Xingwu Jiang, Huilin Zhang, Peiran Zhao, Ya Wang, Jian Chen, Jian Zhang, Yanyan Liu*, Wenbo Bu*. MnS Nanocapsule Mediates Mitochondrial Membrane Permeability Transition for Tumor Ion-Interference Therapy. ACS Nano, 2023, 17(14), 13872-13884. Xianfu Meng, Jiahao Gao, Yanhong Sun, Fei Duan, Bixue Chen, Guanglei Lv, Huiyan Li, Xingwu Jiang, Yelin Wu, Jiawen Zhang, Xiangming Fang*, Zhenwei Yao, Changjing Zuo*, Wenbo Bu* Fusing Positive and Negative CT Contrast Nanoagent for the Sensitive Detection of Hepatoma. Advanced Science, 2023, 10(34), 2304668. Lijie Chen, Xingwu Jiang, Meng Lv, Xueli Wang, Peiran Zhao, Meng Zhang, Guanglei Lv, Jiyue Wu, Yanyan Liu, Yang Yang*, Jinquan Chen*, and Wenbo Bu*. Reductive-damage-induced intracellular maladaptation for cancer electronic interference therapy. Chem, 2022, 8, 866-879. Yun Meng, Lijie Chen, Yang Chen, Jieyun Shi, Zheng Zhang, Yiwen Wang, Fan Wu, Xingwu Jiang, Wei Yang, Li Zhang, Chaochao Wang, Xianfu Meng, YelinWu*, Wenbo Bu*. Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing. Nature communications, 2022, 13, 7353. Fan Wu, Yanli Li, Yun Meng, Xuechao Cai, Jieyun Shi, Jinjin Li, Yang Chen, Li Zhang, Xianfu Meng, Huiyan Li, Xingwu Jiang, Zhenxiao Fu, Yelin Wu*, Wenbo Bu*. An Ion-Enhanced Oncolytic Virus-Like Nanoparticle for Tumor Immunotherapy. Angewandte Chemie-International Edition, 2022, 61, e202210487. Xu Chu, Hongjun Zhuang, Yanyan Liu*, Jinjin Li, Ya Wang, Yaqin Jiang, Huilin Zhang, Peiran Zhao, Yang Chen, Xingwu Jiang, Yelin Wu, Wenbo Bu*. Blocking Cancer–Nerve Crosstalk for Treatment of Metastatic Bone Cancer Pain. Advanced Materials, 2022, 34, 2108653. Ya Wang, Huilin Zhang, Yanyan Liu, Muhsin H. Younis, Weibo Cai*, Wenbo Bu*. Catalytic radiosensitization: Insights from materials physicochemistry. Materials Today, 2022, 57, 262-278. (Invited Review) Kun Wang, Jinjin Lia, Yan Yi, Bin Lv, Yelin Wu*, Chaochao Wang, Huiyan Li, Yanli Li, Yang Liu, Xuechao Cai, Xianfu Meng, Xingwu Jiang, Xiangpeng Zheng*, Zhaocai Zhou, Wenbo Bu*. Polyamine-activated carbonyl stress strategy for oxidative damage therapy. Nano Today, 2022, 42, 101355. Xianfu Meng, Yan Yi, Yun Meng, Guanglei Lv, Xingwu Jiang, Yelin Wu, Wei Yang, Yefeng Yao, Huixiong Xu*, Wenbo Bu*. Self-Enhanced Acoustic Impedance Difference Strategy for Detecting the Acidic Tumor Microenvironment. ACS Nano, 2022, 16, 4217−4227. Zhongmin Tang, Shiman Wu, Peiran Zhao, Han Wang, Dalong Ni, Huiyan Li, Xingwu Jiang, Yelin Wu*, Yun Meng, Zhenwei Yao*, Weibo Cai, and Wenbo Bu*. Chemical Factory-Guaranteed Enhanced Chemodynamic Therapy for Orthotopic Liver Cancer. Advanced Science, 2022, 9, 2201232. Yelin Wu, Yanli Li, Guanglei Lv, Wenbo Bu*. Redox dyshomeostasis strategy for tumor therapy based on nanomaterials chemistry. Chemical Science, 2022, 13, 2202-2217. (Invited Review) Zhongmin Tang, Peiran Zhao, Han Wang, Yanyan Liu*, Wenbo Bu*. Biomedicine meets Fenton chemistry. Chemical Reviews, 2021, 121 (4), 1981-2019. (Invited Review) Xiaoyan Chen, Yang Chen, Chaochao Wang, Yaqin Jiang, Xu Chu, Fan Wu, Yelin Wu, Xuechao Cai, Yi Cao,* Yanyan Liu,* and Wenbo Bu*. NIR-triggered intracellular H+ transients for lamellipodia-collapsed antimetastasis and enhanced chemodynamic therapy. Angewandte Chemie-International Edition, 2021,60, 21905-21910. Yanli Li, Teng Gong,* Hongbao Gao, Yang Chen, Huiyan Li, Peiran Zhao, Yaqin Jiang, Kun Wang, Yelin Wu, Xiangpeng Zheng,* and Wenbo Bu* ZIF-Based Nanoparticles Combine X-Ray-Induced Nitrosative Stress with Autophagy Management for Hypoxic Prostate Cancer Therapy. Angewandte Chemie-International Edition, 2021, 60, 15472-15481. Peiran Zhao, Yaqin Jiang, Zhongmin Tang, Yanli Li, Bingxia Sun, Yelin Wu, Jiyue Wu, Yanyan Liu,* Wenbo Bu* Constructing Electron lever in Perovskite Nanocrystal to Regulate Local Electron Density for Intensive Chemodynamic Therapy. Angewandte Chemie-International Edition, 2021, 60, 8905–8912. Huilin Zhang, Jinjin Li, Yang Chen, Jiyue Wu, Kun Wang, Lije Chen, Ya Wang, Xingwu Jiang, Yanyan Liu, Yelin Wu, Dayong Jin, Wenbo Bu* Magneto-electrically enhanced intracellular catalysis of FePt-FeC heterostructures for cancer chemodynamic therapy. Advanced Materials, 2021, 33 (17), 2100472. Han Wang, Hongbo Gao, Xingwu Jiang, Peiran Zhao, Dalong Ni, Zhongmin Tang, Yanyan Liu,* Xiangpeng Zheng,b,* Wenbo Bu*. Regulating Water States by Vacancies for Cancer Therapy Nano Today, 2021, 37, 101099. Geyong Guo, Teng Gong, Hao Shen, Qiaojie Wang, Feng Jiang, Jin Tang, Xingwu Jiang, Jiaxing Wang,* Xianlong Zhang,* and Wenbo Bu* Self-Amplification Immunomodulatory Strategy for Tissue Regeneration in Diabetes Based on Cytokine-ZIFs System. Advanced Functional Materials 2021, 31, 2100795. Xu Chu, Xingwu Jiang, Yanyan Liu*, Shaojie Zhai, Yaqin Jiang, Yang Chen, Jun Wu, Ya Wang, Yelin Wu, Xiaofeng Tao, Xinhong He*, and Wenbo Bu* Nitric Oxide Modulating Calcium Store for Ca2+-initiated Cancer Therapy. Advanced Functional Materials 2021, 31, 2008507. Yang Liu, Shaojie Zhai, Xingwu Jiang*, Yanyan Liu, Kun Wang, Chaochao Wang, Meng Zhang, Xuanyong Liu*, and Wenbo Bu* Intracellularmutual promotion of redox homeostasis regulation and iron metabolism disruption for enduring chemodynamic therapy. Advanced Functional Materials, 2021, 31, 2010390. Shiman Wu, Xianfu Meng, Xingwu Jiang, Yelin Wu, Shaojie Zhai, Xiaoshuang Wang, Yanyan Liu, Jiawen Zhang, Xinxin Zhao, Yan Zhou*, Wenbo Bu*, Zhenwei Yao*. Harnessing X-ray Energy Dependent Attenuation of Bismuth-Based Nanoprobes for Accurate Diagnosis of Liver Fibrosis. Advanced Science, 2021, 8, 2002548. Xianfu Meng, Yelin Wu*, Wenbo Bu* Functional CT Contrast Nanoagents for the Tumor Microenvironment Advanced Healthcare Materials, 2021, 10 (5), 2000912. Yaqin Jiang, Pengfei Fu, Yanyan Liu*, Chaochao Wang, Peiran Zhao, Xu Chu, Xingwu Jiang, Wei Yang, Yelin Wu, Ya Wang, Guohua Xu*, Jin Hu, Wenbo Bu* Near-infrared Light-Triggered NO Release for Spinal Cord Injury Repair. Science Advances, 2020, 6 (39), eabc3513. Jianan Liu, Limin Pan, Chunfeng Shang, Bin Lu, Rongjie Wu, Yun Feng, Weiyu Chen, Rongwei Zhang, Jiwen Bu, Zhiqi Xiong, Wenbo Bu*, Jiulin Du,* and Jianlin Shi* A highly sensitive and selective nanosensor for near-infrared potassium imaging Science Advances, 2020, 6 (16), eaax9757. Jianan Liu, Rongwei Zhang, Chunfeng Shang, Yu Zhang, Yun Feng, Limin Pan, Bing Xu, Taeghwan Hyeon, Wenbo Bu*, Jianlin Shi* and Jiulin Du* Near-infrared voltage nanosensors enable real-time imaging of neuronal activities in mice and zebrafish. Journal of the American Chemical Society, 2020, 142, 7858-7867. Ruixue Song, Han Wang, Meng Zhang, Yanyan Liu, Xianfu Meng, Shaojie Zhai, Chaochao Wang, Teng Gong, Yelin Wu, Xingwu Jiang, Mingyuan He, Wenbo Bu* Near-infrared Light-triggered Chlorine Radicals (•Cl) Stress for Cancer Therapy Angewandte Chemie-International Edition, 2020, 59, 21032–21040. Yanli Li, Peiran Zhao, Teng Gong*, Meng Zhang, Hui Cheng, Yanyan Liu, Yelin Wu*, Wenbo Bu*. Redox Dyshomeostasis Strategy for Hypoxia Tumor Therapy. Angewandte Chemie-International Edition, 2020, 59, 22537–22543. Zhongmin Tang, Yanyan Liu, Dalong Ni, Jiajia Zhou, Meng Zhang, Peiran Zhao, Bin Lv, Han Wang, Dayong Jin, Wenbo Bu* Biodegradable Nanoprodrugs: Delivering ROS To Cancer Cells For Molecular Dynamics Therapy. Advanced Materials, 2020, 32, 1904011. Xiaoyan Chen, Huilin Zhang, Meng Zhang, Peiran Zhao, Ruixue Song, Teng Gong, Yanyan Liu*, Xinhong He*, Kuaile Zhao, and Wenbo Bu* Amorphous Fe–based Nanoagents for Self–enhanced Chemodynamic Therapy by Re-establishing Tumor Acidosis. Advanced Functional Materials 2020, 30 (6), 1908365. Bin Lv, Huilin Zhang, Xiangpeng Zheng,* Han Wang, Weiqiang Ge,Yanping Ren, Zi Tan, Meng Zhang, Zhongmin Tang, Yanyan Liu, Libo Zhang, Yelin Wu, Xingwu Jiang, Wenbo Bu*. Structure-oriented catalytic radiosensitization for cancer radiotherapy. Nano Today, 2020, 35, 100988. Weiwei Su, Han Wang, Tao Wang, Xiao Li, Zhongmin Tang, Shuai Zhao, Meng Zhang, Danni Li, Xingwu Jiang, Teng Gong, Wei Yang, Changjing, Zuo*, Yelin Wu*, Wenbo Bu*. Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy. Advanced Science, 2020, 7 (10), 1903585. Teng Gong, Yanli Li, Bin Lv, Han Wang, Yanyan Liu*, Yelin Wu, Xingwu Jiang, Hongbo Gao, Xiangpeng Zheng*, Wenbo Bu*. Full-Process Radiosensitization Based on Nanoscale Metal-Organic Frameworks. ACS Nano, 2020, 14(3), 3032-3040. Geyong Guo, Huilin Zhang, Hao Shen, Chongzun Zhu, Renke He, Jin Tang, Ya Wang, Xingwu Jiang, Jiaxing Wang,* Wenbo Bu*, Xianlong Zhang*. Space-Selective Chemodynamic Therapy of CuFe5O8 Nanocubes for Implant-Related Infections. ACS Nano, 2020, 14 (10), 13391-13405. Chaochao Wang, Peiran Zhao, Guoliang Yang, Xiaoyan Chen, Yaqin Jiang, Meng Zhang, Xingwu Jiang, Yelin Wu, Yanyan Liu, Weian Zhang,* Wenbo Bu*. Reconstructing the Intracellular pH Microenvironment for Enhancing Photodynamic Therapy. Materials Horizons, 2020, 7, 1180-1185. Weiwei Su, Chen Chen, Tao Wang, Xiao Li, Yanyan Liu, Han Wang, Danni Li, Shuai Zhao, Changjing Zuo,* Gaofeng Sun,* Wenbo Bu*. Radionuclide Labeled Gold Nanoparticles for Nuclei-Targeting Internal Radio-Immunity Therapy. Materials Horizons, 2020, 7, 1115 - 1125. Xianfu Meng, Boyu Zhang, Yan Yi, Hui Cheng, Baoming Wang, Yanyan Liu, Teng Gong, Wei Yang, Yefeng Yao, He Wang*, and Wenbo Bu*. Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT. Nano Letters. 2020, 20 (4), 2522-2529. Yang Liu, Shiman Wu, Yanyan Liu*, Hua Zhang, Meng Zhang, Zhongmin Tang, Yan Wang, Teng Gong, Zhenwei Yao, Xiangming Fang*, Wenbo Bu*. Cathodic Protected Mn2+ by NaxWO3 Nanorods for Stable Magnetic Resonance Imaging-Guided Tumor Photothermal Therapy. Biomaterials, 2020, 234, 119762. Kun Wang, Huilin Zhang, Aijun Shen, Peiran Zhao, Xianfu Meng, Xiaoyan Chen, Yang Liu, Yanyan Liu, Teng Gong, Wanlu Wu, Xiangming Fang*, Peijun Wang, Wenbo Bu* Magnetic Resonance Energy Transfer for in vivo Glutathione Susceptibility Weighted Imaging. Biomaterials, 2020, 232, 119703. Chaolin Song, Xianfu Meng, Yanyan Liu*, Aijun Sheng, Chulun Shao, Kun Wang, Hui Cheng, Xiangming Fang*, Peijun Wang, Wenbo Bu* Susceptibility-weighted Imaging for Metabolic Pathway Mapping of Low-dosage Nanoparticles in Organisms. Biomaterials, 2020, 230, 119631. Xuan Mei, Tingting Hu, Hui Wang, Ruizheng Liang*, Wenbo Bu*, Min Wei* Highly dispersed nano-enzyme triggered intracellular catalytic reaction toward cancer specific therapy Biomaterials, 2020, 258, 120257. Yanyan Liu, Meng Zhang, Wenbo Bu* Bioactive nanomaterials for ion‐interference therapy. View 2020, 1 (2), e33. (Invited Review) Chaochao Wang, Peiran Zhao, Dawei Jiang, Guoliang Yang, Yudong Xue, Zhongmin Tang, Meng Zhang, Han Wang, Xingwu Jiang, Yelin Wu, Yanyan Liu, Weian Zhang,* Wenbo Bu* In Situ Catalytic Reaction for Solving the Aggregation of Hydrophobic Photosensitizers in Tumor ACS Applied Materials & Interfaces 2020, 12 (5), 5624-5632 Chemodynamic therapy: integration of Fenton chemistry and biomedicine Xiaoyan Chen, Yanyan Liu, Wenbo Bu* Scientia Sinica Chimica 2020, 50 (2), 159-172.

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