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个人简介

学习经历 197.9-2001.7本科江西农业大学动物医学 2005.9-2010.7硕士/博士研究生扬州大学临床兽医学 进修情况 2017.9-2018.9韩国GyeongsangHationalUniversity访问学者 工作简历 2001.7-2005上海转基因研究中心 2010.6月至今扬州大学曾医学院讲师,副教授 2015年至2017年韩国KonkukUniversity博士后

研究领域

山羊、猫体细胞克隆与转基因克隆、动物转基因制药、人类动物疾病模型、功能纳米材料的制备及其在抗菌、抗肿瘤上的应用

科研情况 1.江苏省人兽共患病学重点实验室开放课题,基于乳铁蛋白修饰的纳米抗菌材料制备及其作用机制,R1807,2018.9-2020.12,主持,在研; 2.国家重点研发计划项目政府间国际科技创新合作重点专项,基于转基因动物平台的心脑血 管疾病转化医学研究,s2016G6252,2017/01-2019/12,90万,参加,在研. 3.扬州市科技合作资金-生物还原法合成纳米银材料及其抗菌和抗肿瘤作用机制的研究(SCK 2017020004),2017.7-2020.6,主持,在研; 4.扬州市-扬州大学科技合作资金一高活性重组人白细胞介素-2的制备及药理试验,sCx2017020004,2014-2016,主持; 5.中国博士后基金-山羊β乳球蛋白基因打靶及其对乳蛋白基因表达的影响,(2015M571827 ),2015.10-2017.6,主持; 6.江苏省博士后基金一山羊β-乳球蛋白基因打靶及其对乳蛋白表达的影响(1402001C),2015.10-2017.6,主持; 7.国家自然科学基金青年基金-锌指核酸酶定点突变转基因山羊外源GFP基因的研究 (31101871),主持,2012-2014年: 8.国家转基因生物品种培育重大专项一高品质转基因奶山羊新品系创制(2009ZX08008-009B)子课题负责人;2009-2012年; 9.国家转基因生物品种培育重大专项子课题-人乳铁蛋白转基因奶山羊新品种培育( 2008zx08008-004),主要负责人(2/9);2008-2010年; 10.国家转基因生物品种培育重大专项一人乳铁蛋白转基因奶山羊新品种培育( 2013ZX08008-004-005),主要参与人员(2/2);2011--2015年; 11.江苏省省支撑项目一新颖重组人纤溶酶原激活剂(rhPA)的分离、纯化及药理学试验,主要负责人(5/10);立项年度:2013-2016年, 发明专利申请: 1、袁玉国,一种纳米银的合成及其在耐药菌_上的应用,2017年,申请专利. 2、袁玉国,一种利用黑芥子硫苷酸钾合成纳米银的方法,2018年,申请专利.

近期论文

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1.Yu-GuoYuan*,Yun-JungChoi,AbuMusaMdTalimurReza.NicotinamidearrestedmouseembryoatSphaseof2--cellwithconstitutiveacetylationofH3K56.2019,Submit 2.YuanYG*,XuL,Zhangs,MesalamA,LeeKL,LiuH,JooMD,IdreesM,KongIK*. PolydatinandI-CBP112protectsearlybovineembryoagainstnicotinamide-induced mitochondrialdysfunction.Theriogenology.2019Aug:134:1-10.2区,IF2.29 3.Yu-GuoYuan*,ShiminZhang,Ji-oonHwang,Il--KeunKong*.SilverNanoparticles PotentiatesCytotoxicityandApoptoticPotentialofCamptothecininHumanCervical CancerCells.0xidMedCellLongev,2018.2区,IF4.9 4.Yu-GuoYuan*,Yan-HongWang,SGurunathan*.Quercetinmediatedsynthesisographeneoxide-silvernanoparticlesnanocomposites:Asuitablealternativenanotherapyforneuroblastomacancer.IntJNanomedicine.2017,12:5819-5839.2区,IF4.32.. 5.Yu-GuoYuan*,Qiu-LinPeng,SGurunathan*.Silvernanoparticlesenhancestheapoptoticpotentialofgemcitabineinhumanovariancancercells:Combinationtherapyforeffectivecancertreatment.IntJNanomedicine,2017,12:6487-6502.2区,IF4.32. 7.Yu-GuoYuan*,SGurunathan*.Combinationofgrapheneoxide--silvernanoparticles nanocompositesandcisplatinenhancesapoptosisandautophagyinhumancervical cancercells.IntJNanomedicine,2017,12:6537-6558.2区,IF4.32. 8.Yu-GuoYuan*,Qiu-LinPeng,sGurunathan*.EffectsofsilvernanoparticlesonmultipledrugresistantstrainsofStaphylococcusaureusandPseudomonasaeruginosafrommastitis--infectedgoats:Analternativeapproachforantimicrobialtherapy.INTJmMOL,2017,18(3):E569.2区,IF3.2. 10.Yu-GuoYuan,SongSao--Zheng,ZhuMeng-Ming,Zheng-YiHe,YongCheng*.Humanlactoferrinefficientlytargetedintocaprinebeta-lactoglobulinlocuswithTALENs. Asian-AustralasJAnimSci.2017,30(8):1175-1182.2区,IF0.8 11.Yu-GuoYuan,YongCheng,Jin-YuWlang,Qiu-LinPeng*.Targetedmutagenesisof beta-1actog1obulingeneincaprinefetalfibroblastsbycontext-dependentassembly zincfingernucleases,0penAccessLibraryJournal,2016,3(1):e2813.. 12.Yu-GuoYuan,LiYouAn,BaoLiYu,YongCheng*.ExpressionofRecombinantHuman Alpha-LactalbuminintheMilkofTransgenicGoatsUsingaHybridPromoterEnhancer. JournalofAnalyticalMethodsinChemistry,2014,(2):1~7.SCI,IF0.9 13.LiYouAn#,Yu-GuoYuan#,BaoLiYu,YongCheng*.Generationofhumanlactoferrin transgenicclonedgoatsusingdonorcellswithdualmarkersandamodifiedselection procedure.Theriogenology,2012,78:1303-1311.(#共同第一-作者). 14.YongCheng#*,LiYouAn#,Yu-GuoYuan#,etal.Hybridexpressioncassettesconsistingofamilkproteinpromoterandacytomegalovirusenhancersignificantlyincreasemanmary--specificexpressionofhumanlactoferrinintransgenicmice.MolReprodDev,2012,79:573-585.(#共同第--作者).IF2.8 16.Yu-GuoYuan,LiYouAn,BaoLiYu,YongCheng*.EffectofFol1icle-Stimulating HormoneDosage,SeasonsandTreatmentFrequencyonSuper-0vulationinGoats.Animal husbandyandfoodscience,2011,20(11):21-43.. 17.袁玉国,安礼友,成勇*.以经过转染的乳腺上皮细胞生产克隆羊.生物工程学报,2009, 8:13-19. 18.LuR,YuanT,WangY,ZhangT,YuanY,WuuD,ZhouM,HeZ,Lu了,ChenY,FanJ,LiangJ,ChengY.Spontaneousseverehypercholesterolemiaandatherosclerosislesionsinrabbitswithdeficiencyoflow-densitylipoproteinreceptor(LDLR)onexon7.EBioMedicine.2018,36:29-38.2区,IF6.68 19.Songs,QiZ,ShaoB,ZhuM,MiF,ChengY*.EfficientTALEN-mediatedmyostatingeneeditingingoats.BMCDevBiol.2016,16(1):26.SCI,IF2.09 20.XingHShaoB,GuYY,Yu-GuoYuan,ZhangT,ZangJ,ChengY*.Analysisof polymorphismsinmilkproteinsfromclonedandsexullyreproducedgoats.GenetMol Res.2015,14(4):16196-203.sCI,IF0.76 21.Songs,Gex,ChengY,LuR,ZhangT,YuB,Jix,QiZ,RongY,Yu-GuoYuan,ChengY*.High-levelexpressionofanovelrecombinanthumanplasminogenactivator(rhPA)inthemilkoftransgenicrabbitsanditsthrombolyticbioactivityinvitro.MolBiol Rep.2016,43(8):775-83.scI,IF1.69(*通讯作者)

学术兼职

SMBoneMarrowResearch杂志编委;ACSAppliedMaterials&Interfaces,Biologyof Reproduction,Plos0ne,InternationalJournalofAnimalScience和农业生物技术学报特约中国畜牧兽医外科协会会员。

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