个人简介

学习经历 2O13-2O14博士研究生美国堪萨斯州立大学病理生物学 2010-2013博士研究生美国南达科他州立大学生物科学 2007-2010硕士研究生中国农业科学院上海兽医研究所預防兽医学 2003-2007大学本科苏州大学生物科学 工作经历 2019.04-至今扬州大学兽医学院校特聘教授 2017.02-2019.03美国堪萨斯州立大学博士后研究员 2016.05-2017.01英国剑桥大学病理系病毒学研究所合作研究 2015.01-2016.04美国堪萨斯州立大学博士后研究员

研究领域

主要从事家畜病毒性疫病的致病机理，免疫应答机制及与宿主互作的机制研究，致力于开发和改进动物疫苗。在猪繁殖与呼吸综合征病毒（PRRSV）及新发猪病毒性传染病方面已经开展了独创性研究

1.扬州大学高层次人才科研启动项目，重大猪病毒性传染病与宿主相互作用的机制研究，2019-2023,在研。 2.NationalPorkBoard项目,DevelopmentofASFV-specificmonoclonalantibodiesandmAb-basedblockingELISA,2019,在研，参与。 3.SwineHealthInformationCenter项目,DevelopmentofaTaqManquantitativeRT-PCRtestforporcineparainfluenzavirus1,2016-2017,结题，主持。 发明专利 1.FangY,SnijderEJ,FirthAE,AtkinsJF,TreffersEE,TasA,LiY.Arterivirusprotein andexpressionmechanisms.PatentNo.:US9623103B2;JP2015533474A;KR20150100606A; CN104717978A;CA2879316A1;EP2874654A2;RU2015105173A;W02014015116A3. 2.袁世山，郑浩，高飞，郑海红,韦祖樟，龙进学,刘长龙，庄金山,于丹丹，孙志，王小敏，邓宇，李燕华,蔺涛，周艳，刘萍。重组杆状病毒及其构建方法和应用。专利号：CN101899421B。

近期论文

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1.LiY,BrierleyLFirthAE,SnijderEJ,CaiY,NapthineS,WangT,YanKuhnJ,FangY.Programmed-2/-1RibosomalFrameshiftinginSinarteriviruses:AnEvolutionarilyConservedMechanism.Journalofvirology.2019Jun5.pii：JVI.00370-19.doi：10.1128/JVI.00370-19.[Epubaheadofprint] 2.PetrovanV,YuanF,LiY,ShangP,MurgiaMV,MisraS’RowlandRRR,FangY.Developmentandcharacterizationofmonoclonalantibodiesagainstp30proteinofAfricanswinefevervirus.VirusRes.2019May23.pii：S0168T702(19)30202一3.doi：10.1016/j.virusres.2019.05.010.[Epubaheadofprint] 3.ZhangH,WangY,PorterE,LuN,LiY,YuanF,LohmanM,NollL,ZhengStoyC,LangY,HuberVC,MaPeddireddiL,FangY,ShiJ,AndersonG,LiuBaiJ.Developmentofamultiplexreal-timeRT-PCRassayforsimultaneousdetectionanddifferentiationofinfluenza&B,C,andDviruses.DiagnMicrobiolInfectDis.2019Apr29.pii：S0732-8893(18)30606-0.doi：10.1016/j.diagmicrobio.2019.04.Oil.[Epubaheadofprint] 4.LiY*,ShangP*,ShyuD,CarrilloC,Naraghi-AraniP,JaingCJ,RenukaradhyaGJ,FirthofporcinereproductiveandSchroeder%LechtenbergK,HenningsonJ,HauseB,BaiVirology.2016;497:111-124.PubMedrespiratorysyndromevirus(PRRSV)responses.Virology.201810.1016/j.virol.2017.12.017.[Epubaheadofprint](*：co-firstauthor) 5.LiYShyuDL*‘ShangP,BaiJ,OuyangK,DhakalS’hyaGJ,FangY.MutationsinaHighlyConservedMotifHiremathJ,BinjawadagiB,Renukarad"ofnsplpProteinAttenuatetheInnateImmuneSuppressionFunctionofPorcineReproductiveandRespiratorySyndromeVirus.Journalofvirology.2016;90(7):3584-99.PubMed[journal]PMID:26792733,PMCID:PMC4794661(*：co-firstauthor) 6.LiYTasA*,SunZ,SnijderEJ,FangY.Proteolyticprocessingoftheporcinereproductiveandrespiratorysyndromevirusreplicase.Virusresearch.2015;202:48一59・PubMed[journal]PMID:25557977(*：co-firstauthor) 7.LiY,TreffersEE,NapthineS,TasA,ZhuL,SunZ,BellS,MarkBL,vanVeelenPA,vanHemert，FirthAE,BrierleyI,SnijderEJ,FangY.Transactivationofprogrammedribosomalframeshiftingbyaviralprotein.ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica.2014;111(21)：E2172-81.PubMed[journal]PMID：24825891,PMCID:PMC4040542(IF:9.674) 8.GoYY*,LiYChenZ,HanM,YooD,FangY,BalasuriyaUB.Equinearteritisvirusdoesnotinduceinterferonproductioninequineendothelialcells：identificationofnonstructuralprotein1asamaininterferonantagonist.BioMedresearchinternational.2014;2014:420658.PubMed[journal]PMID：24967365,PMCID：PMC4055586(*：co-firstauthor) 9.LiY,ZhuL,LawsonS%FangY.Targetedmutationsinahighlyconservedmotifofthensplpproteinimpairtheinterferonantagonizingactivityofporcinereproductiveandre-spiratorysyndromevirus.TheJournalofgeneralvirology.2013;94(Pt9):1972-83.PubMed[journal]PMID:23761406 10.SunL*‘LiY*,Liu%Wang為GaoF,LinT,HuangT,YaoH,TongG,FanH,WeiZ,YuanS.Porcinereproductiveandrespiratorysyndromevirus0RF5aproteinisessentialforvirusviability.Virusresearch.2013;171(1)：178-85.PubMed[journal]PMID：23219923(*：co-firstauthor) 11.LiY,TasA,SnijderEJ,FangY.Identificationofporcinereproductiveandrespiratorysyndromevirus0RF1a"encodednon-structuralproteinsinvirus"infectedcells.TheJournalofgeneralvirology.2012;93(Pt4):829-39.PubMed[journal]PMID:22258855 12.FangY,TreffersEE*,LiY*,TasA,SunZ,vanderMeerY,deRuAH,vanVeelenPA,AtkinsJF,SnijderEJ,FirthAE.Efficient"2frameshiftingbymammalianribosomestosynthesizeanadditionalarterivirusprotein.ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica.2012;109(43):E2920-8.PubMed[journal]PMID:23043113,PMCID:PMC3491471(*：co-secondauthor) 13.LunneyJK,FangY,LadinigA,Chen虬LiY,RowlandB,RenukaradhyaGJ.PorcineReproductiveandRespiratorySyndromeVirus(PRRSV):PathogenesisandInteractionwiththeImmuneSystem.Annualreviewofanimalbiosciences.2016;4:129-54.PubMed[journal]PMID:26646630 14.SunL,ZhouY,LiuR,LiY,GaoF,Wang為FanH,YuanS’WeiZ,TongG.Cysteineresiduesoftheporcinereproductiveandrespiratorysyndromevirus0RF5aproteinarenotessentialforvirusviability.Virusresearch.2015;197:17-25.PubMed[journal]PMID：25499299

学术兼职

2015~,美国病毒学会(ASV)副会员 2017-,InternationaljournalofImmunologyandImmunobiology编委 Wology,ResearchinVeterinaryScience,Veterinarymicrobiology.JournalofVirologicalMethods杂志特邀审稿人