研究领域
1.病原的分子致病机理与免疫机制
2.疫苗和诊断试剂的研制与应用
科研情况
1、“鸡重要疫病免疫防控新技术研究〃，国家重点研发计划，2017-2020,主持
2、“H5亚型禽流感病毒幡白糠基化位点修饰诱导天然免疫差异性表达的机制研究〃，国家自然科
学基金，2019-2022,主持
3、“Sigma因子对沙门氏菌生物被膜形成和毒力基因的调控作用"，国家自然科学基金，2016-2019
,主持
4、“HA蛋白糠基化位点对H5N1亚型禽流感病毒致病性和抗原性的影响”，国家自然科学基金，
2014-2017,主持
5、“禽沙门氏菌和大肠杆菌病防控技术研究与示范”,公益性行业专项（农业）项目，2013-2017,
主持
6、禽流感病毒流行病学调查及防控新技术研究，江苏省农业科技自主创新资金，2015-2017,主持
7、“低致病力禽流感病毒病原谱流行规律研究〃，国家科技重大专项，2012-2015,主持
8、“水禽主要疫病快速诊断与疫苗研制”,公益性行业专项（农业）项目，2010-2014,主持
9、“H5亚型禽流感病毒N40NS基因部分缺失与致病作用”,江苏省自然科学基金重点项目
近期论文
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1.QinT,ZhuJ,MaR,YinY,ChenS,PengD,LiuX.Compatibilitybetweenhaemagglutininandneuraminidasedrivestherecentemergenceofnovelclade2.3.4.4H5NxavianinfluenzavirusesinChina.TransboundEnergDis.2018,doi:10.1111/tbed.12949.
2.SunZ,ShiB,MengF,MaR,HuQ,QinT,ChenS,PengD,LiuX.DevelopmentofaLoidalGold-BasedImmunochromatographicStripforRapidDetectionofH7N9InfluenzaViruses.FrontMicrobiol.2018.9:2069.
3.Wangx,ChenS,WangD,Zhax,ZhengS,QinT,MaW,PengD,Liux.SynergisticeffectofPB2283Mand526RcontributestoenhancedvirulenceofH5N8influenzavirusesinmice,VetRes.2017,48(1):67.
4.YinY,Zhangx,QiaoY,WangX,SuY,ChenS,QinT,PengD,Liux.Glycosylationat11AsnonhemagglutininofH5N1influenzaviruscontributestoitsbiologicalcharacteristics.VetRes.2017Nov21:48(1):81.
5.SunZ,QinT,MengF,ChenS,PengD,LiuX.Developmentofamultiplexprobecombination-basedone-stepreal-timereversetranscription-PCRforNAsubtypetypingofavianinfluenzavirus.SciRep.2017oct18:7(1):13455
6.ChenS,ZhuY,YangD,YangY,Shis,QinT,PengD,Liux.EfficacyofLiveAttenuatedHDN2InfluenzaVaccineCandidatesContainingNSITruncationsagainstH9N2AvianInfluenzaViruses.FrontMicrobiol.2017,8:1086.
7.E1HagM,FengZ,SuY,Wangx,YassinA,ChenS,PengD,Liux.ContributionofthecsgAandbcsagenestoSalmonellaentericaserovarPullorumbiofilmformationandvlence.AvianPathol.2017:1-7
8.ShiS,ChenS,HanW,WuB,ZhangX,TangY,Wangx,Zhuy,*PengD,Liux.CrosscladeprotectiveinmuneresponsesofNSl-truncatedliveattenuatedH5N1avianinfluenzacines.Vaccine.2016,34(3):350-357
9.WangX,MengF,WangD,LiuX,ChenS,QinT,*PengD,LiuX.Characteristicsoftwo
highlypathogenicavianinfluenzaH5N8viruseswithdifferentpathogenicityinmice.Arch
Vro1.2016,161(12):3365-3374.
10Zhangx,ChenS,YangD,WangX,ZhuJ,*PengD,LiuX.RoleofStemGlycansAttachedtoHaemagglutininontheBiologicalcharacteristicsofH5NlAvianInfluenzavirusJGenviro1,2015,96:1248m1257
11,Zhu,YangD,Ren@Yangy,Lux.xxLiuwChens,+pengD,Liux.IdentifitachedtoHaemagglutininontheBiologicalCharacteristicsofH5N1AvianInfluenzaVirus,2015,96:1248-1257
11,ZhuY,YangD,RenQ,YangY,LiuX,XuX,LiuV,ChenS,*PengD,LiuX.IdentificationandcharacterizationofanovelantigenicepitopeinthehemagglutininoftheescapemutantsofHN2avianinfluenzaviruses.VetMicrobiol.2015,178(1-2):144-149
12,ZhuY,YangY,LiuW,LiuX,YangD,SunZ,JuY,ChenS,*PengD,LiuX.ComparisonofbiologicalcharacteristicsofHON2avianinfluenzavirusesisolatedfromdifferenthosts.ArchViro1,2015,160:917-927.doi:10.1007/500705-015-2337-y
13,ZhangX,ChenS,JiangY,HuangK,HuangJ,YangD,ZhuJ,ZhuY,ShiS,*PengDLiux.HemagglutininglycosylationmodulatesthepathogenicityandantigenicityoftheH5N1avianinfluenzavirus.VetMicrobiol,2015,175(2-4):244-256
14,LiY,ChenS,Zhangx,FuQ,ZhangZ,ShiS,ZhuY,GuM,*PengD,LiuX.A20Amino-AcidDeletionintheNeuraminidaseStalkandaFive-AminoAcidDeletionintheNS1ProteinBothContributetothePathogenicityofH5N1AvianInfluenzaVirusesinMallardDucks.PLoSOne,2014,9(4):e95539
15,WuA,SuC,VangD,PengY,Liux,HuaS,LiT,GaoGr.Tangi,ChenJ.Liux,ShuY,*PengD,*kJiangT.SequentialReassortmentsUnderlieDiverseInfluenzaH7N9GenotypesinChina.CellHostMicrobe,2013,14(4):446-452
16,LiY,Zhangx,XuQ,FuQ,ZhuY,ChenS,*PengD,Liux.CharacterisationandhasagglutiningeneepitopemappingofavariantstrainofH5N1subtypeavianinfluenzavirus.Veterinarymicrobiology2013,162(2-4):614-622
17,QianC,ChenS,DingP,ChaiI,XuC,GanJ,*PengD,Liux.TheimmumeresponseofarecombinantfowlpoxviruscoexpressingtheHAgeneoftheH5N1highlypathogenicavianinfluenzavirusandchickeninterleukin6geneinducks.Vaccine,2012,30(44):6279-6286
18,LuY,ChenS,DongH,SunH,PengD,LiuX.IdentificationofGenesResponsibleforBiofilmForationorVirulenceinSalmoneA,aentericaSerovarPullorum.AvianDisases,2012,56(1):134-143
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