研究领域
1)猪蓝耳病病毒和猪流行性腹泻病毒的基础和应用研究
(病毒遗传变异与进化,病毒免疫与致病机理,病毒疫苗的研制)
2)新发猪病毒性传染病病毒的基础和应用研究
(猪非典型瘟病毒和猪塞内卡谷病毒等新发病毒的遗传变异与进化,病毒与细胞相互作用的分子
基础,病毒疫苗及诊断试剂的研制)
3)副粘病毒科病毒等的应用基础研究
(副流感病毒5型和仙台病毒等疫苗载体的开发和应用;生物医学研究)
1)猪重要疫病的新型综合防控研究'江苏省“双创计划〃双创团队项目'2019-2021,核心成员;
2)猪塞尼卡谷病毒研究,2018-2021,国家自然科学基金面上项目,主持;
3)畜禽重要疫病病原学与流行病学研究,2017-2020,国家十三五重点研发计划项目,子课题主持;
4)猪病毒研究,2016-2020,扬州大学高层次人才科研启动费,主持;
5)MucosalProtectionAgainstHIVGeneratedbyPIV5PrimingandVLPBoosting,2014-2018
,美国NIH基金项目ROL参加;
6)ANovelApproachforMycobacteriumTuberculosisVaccineDevelopment,2013-2015,美国
NIH基金项目R21,参加;
7)DevelopingaParamyxovirus-basedH5N1Vaccine,2010~2014,美国NIH基金项目R0L参加;
8)TheroleofPRRSVnon-structuralproteins1and2inhostimmunity,2008~2011,美国农
近期论文
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1)PanS,YanY,ShiK,WangM,MouC,ChenZ#.Molecularcharacterizationoftwonovelatypicalporcinepestivirus(APPv)strainsfrompigletswithcongenitaltremorinChina.TransboundEmergDis,2018.(*correspondingauthor)
2)ZhangH,LiuQ,SuW,WangJ,SunY,Zhang],ShangK,ChenZ#,ChengS#,WuH*.Genome-wideanalysisofdifferentiallyexpressedgenesandthemodulationofPEDVinfectioninVeroE6cells.MicrobPathog,2018,117:247-254.(#correspondingauthors)
3)ChenZ.Parainfluenzavirus5-vectoredvaccinesagainsthumanandanimalinfectiousdiseases.RevMedVirol,2018,28(2):1965.
4)WeiH*,ChenZ*,ElsonA,Liz,AbrahamM,PhanS,KristhnamurthyS,McCrayJr.P,AndrewsS,SticeS,SakamotoK,JonesC,Tompkinss,HeB.Developingaplatformsystemforgenedelivery:amplifyingvirus-likeparticles(AVLP)asaninfluenzavaccine.npjVaccines,2017,2:32(*firstauthors
5)PhanSI,AdamCM,ChenZ,CitronM,LiangX,EspesethAS,WangD,HeB.ThegeneticstabilityofPIV5-vectoredRSvaccinecandidatesafterinvitroandinvivopassage.J.Virol,2017,91(19)
6)FuQ,HuangYe,WanC,FuG,QiB,ChengL,ShiS,ChenH,LiuR,ChenZ#GenomicandpathogenicAnalysisofaMuscovyDuckParvovirusStrainCausingShortBeakandDwarfismSyndromewithouttongueprotrusion.Res.Vet.Sci.,2017,115:393-400(#correspondingauthors)
7)ChenZ#,CollinE,PeddireddiL,ClementT,GaugerP,HauseBM#.GeneticdiversityinenvelopegenesofcontemporaryU.S.porcinereproductiveandrespiratorysyndromevirusstrainsinfluencesviralantigenicty.
iRes.Vet.Sci.,2017,115:432-441(*correspondingauthors)
8)ChenZ,YuanF,LiY,ShangP,SchroederR,LechtenbergK,HenningsonJ,HauseB,BaiJ,RowlandRR,ClavijoA,FangY.Constructionandcharacterizationofafull-lengthcDNAinfectiouscloneofemergingporcineSenecavirusAVirology,2016,497:111-124
9)PalinskiRM,ChenZ,HenningsonJN,LangY,RowlandRR,FangY,PrickettJ,GaugerPC,HauseBM.WidespreaddetectionandcharacterizationofporeparainfluenzainpigsintheUnitedStates.J.Gen.Virol,2016,97(2):281-6
10)ChenZ,GuptaT,XuP,PhanS,PickarA,YauW,KarlsRK,QuinnFD,SakamotoK,HeB.Efficacyofparainfluenzavirus5(PIV5)-basedtuberculosisvaccinesinmiceVaccine,2015,33(51):7217-24
11)HauseB,CollinEA,PeddireddiL,YuanF,ChenZ,HesseRA,GaugerPC,ClementT,FangY,AndersonG.DiscoveryofanovelputativeatypicalporcinepestivirusinpigsintheUnitedStates.J.Gen.Virol.,2015,96(10):2994~8.
12)HuangY,ChenZ,HuangJ,FuZF,HeB.Parainfluenzavirus5expressingtheGproteinofrabiesvirusprotectedmiceafterrabiesvirusinfection.J.Virol.,2015,89(6):3427-3429.
13)PhanSI,ChenZ,XuP,LiZ,GaoX,FosterSL,TengMN,TrippRA,SakamotoK,HeB.Arespiratorysyncytialvirus(RSV)vaccinebasedonparainfluenzavirus5(PIV5).Vaccine,2014,32(25):3050-3057.
14)XuP,ChenZ,PhanS,PickaxA,HeB.Immunogenicityofnovelmumpsvaccinecandidatesgeneratedusingareversegeneticssystem.J.Virol.,2014,88(5):2600~2610.
15)LiZ,XuJ,ChenZ,XGao,WangLF,BaslerC,SakamotoK,HeB.TheLGeneofJParamyxovirusPlaysaCriticalRoleinViralPathogenesis.J.Virol.,2013,87(23),12990-12998.
16)ChenZ,ZhouM,Gaox,ZhangG,RenG,FuZF,HeB.Anovelrabiesvaccinebasedonarecombinantparainfluenzavirus5expressingrabiesvirusglycoprotein.J.Viro1.,2013,87(6):2986-2993.
17)ChenZ,XuP,SalyardsG,HarveyS,RadaB,FuZF,HeB.EvaluatingaPIv5basedvaccineinahostwithpre-existingimmunityagainstPIV5.PLoSOne,2012,7(11),e50144.
18)SunZ,ChenZ,LawsonSR,FangY.Thecysteineproteasedomainofporcinere-productiveandrespiratorysyndromevirusnonstructuralprotein2possessesdeubiquitinatingandinterferonantagonismfunctions.J.Virol,2010,84(15):7832-46.
19)ChenZ,LawsonS,SunZ,ZhouX,GuanX,Christopher-HenningsJ,NelsonEA,FangY.Identificationoftwoauto-cleavageproductsofnonstructuralprotein1nsp1)inporcinereproductiveandrespiratorysyndromevirusinfectedcells:nsplfunctionasinterferonantagonist.Virology,2010,398(1):87-97
20)ChenZ,ZhouX,SunZ,LunneyJ,LawsonS,NelsonEA,Christopher-HenningsJ,FangY.Immunodominantepitopesinnsp2ofporcinereproductiveandrespiratorysym-dromevirusaredispensableforreplicationbutplayanimportantroleinviralpathogenesis.J.Gen.Virol,2010,91(4):1047-57
21)ChenZ,GuoX,GeX,JiaH,YangH.ProtectiveimmuneresponseinmicevaccinatedwitharecombinantadenoviruscontainingcapsidprecursorpolypeptidePl,non-structuralprotein2Aand3Cproteasegenes(P12A3C)ofencephalomyocarditisvirusVaccine,2008,26(4):573-80
22)ChenZ,GuoX,GeX,ChenY,YangH.PreparationofmonoclonalantibodiesagainstpseudorabiesvirusglycoproteingcbyadenovirusimmunizationaloneorasaboostfollowingDNApriming.Hybridoma,2008,27(1):36-42