个人简介

1.学习简历 1987.09-1991.07安徽科技学院学士 1991.08-1996.07中国农业大学博士 2.工作简历 1996.08-1998.12中国农业大学讲师 1998-2000新西兰AgResearch分子胚胎实验室合作研究 1999.01-2003.09中国农业大学副教授，硕导 2011.10-2012.10美国西北大学医学院生殖医学中心博士后 2003.10-至今中国农业大学教授，博导 2015.05-至今扬州大学特聘教授，博导

研究领域

（1）从miRNA角度探索了猪生殖细胞的热应激抵御与损害机制。 （2）发现BimEL蛋白在调控哺乳动物卵泡闭锁中发挥关键作用。 （3）发现反刍动物妊娠信号IFN-τ自分泌调控牛、羊早期胚胎发育的分子机制。据此理论设计的新型胚胎培养液和移植液能明显提高牛胚胎体外发育率和移植后受胎率。 （4）提出哺乳动物卵子老化新机制。 （5）积极开展牛、绵羊、山羊、马和驴的胚胎移植和繁殖控制技术的推广工作

近年主持的科研项目： 1、国家“十一五”科技支撑计划（2006BAD14B08-05）“畜禽良种资源高效繁殖和生殖健康关键技术研究与产业化示范”子课题“羊高效排卵控制技术与推广示范”（2006－2008），经费18万。 2、国家“十一五”科技支撑计划（2008BAD2B09）“优质种用肉牛肉羊扩繁技术研究”子课题“高效肉羊胚胎生产技术的研究”（2008－2010），经费30万。 3、国家“十一五”863计划（2008AA101003）“家畜卵泡高效诱导发育技术研究与应用”子课题“猪高效胚胎体外生产体系的研究”（2008－2010），经费15万。 4、国家动物转基因专项(2008ZX08008-005)“转基因抗病羊的培育”子课题“抗布氏杆菌病转基因羊的培育”（2008－2010），经费20万。 5、教育部科学技术研究重点项目（109018）“MicroRNAs对猪卵泡闭锁的调控机制”(2009－2010)，经费10万。 6、高等学校博士学科点专项科研基金“Ca2+离子对猪体外成熟卵母细胞组蛋白乙酰化”（2010－2012）,经费6万 7、国家自然基金(31072031)“FSH抑制猪颗粒细胞中促凋亡蛋白Bim表达的分子机制”（2011－2013），经费33万。 8、国家自然基金(31172209)“IFN-τ调控牛囊胚发育的分子通路”（2012－2015）,经费60万。 9、国家转基因重大专项（2012ZX08011001-006)“转基因生物新品种培育”子课题“转bt基因稻米对猪生物学性状的安全评价”（2012－2015），经费98.9万。 10、“十二五”国家863计划（2012BAI32B05）“子宫内膜损伤机制和治疗方法研究”（2012-2016），可支配经费20万，. 11、高等学校博士学科点专项科研基金（优先发展领域20130008130001）“猪卵泡发育中bim基因新转录因子及其调控机制研究”（2014-2016），经费40万。 12、国家自然基金(31470077)“FSH通过BimEL调控猪卵泡自噬的分子机制”(2015-2018)，经费88万。 13、国家自然基金(31672419)“猪卵泡在闭锁过程中颗粒细胞内BimEL磷酸化修饰位点的变化规律及主要调控路径”(2017-2020)，经费64万。 14、东阿阿胶集团“东阿黑毛驴精液质量及输精技术提升项目方案”（2016-2018），经费195.2万。 15、国家重点研发计划专项（2017YFC1002003）“人类生育力下降机制和防护保存新策略研究”（2017-2020），可支配经费81.1万。 获得的科技奖励 1、“哺乳动物胚胎玻璃化冷冻保存技术的研究与应用”（北京市科技进步二等奖，2000，副主持）。 2、“牛羊胚胎生物技术研究与产业化”（中国高校科学技术二等奖，2004，副主持） 3、“应用胚胎生物技术加快纯（良）种肉牛繁殖技术（中国高校科学技术一等奖，2002， 第八完成人）。 获得发明专利 1、一种提高牛、羊胚胎移植妊娠率的方法。专利号：200710121136.8，2011年授权，发明。 2、正辛醇在延缓哺乳动物卵子体外老化中的应用。专利号：201210199708.5，2013年授权，发明。

近期论文

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1.GaoFang-Fang,WuZhong-YiandZengShen-Ming.Bovineinterferon-tauexpressioninEscherichiacoliandidentificationofitsbiologicalactivities.ChineseJournalofAgriculturalBiotechnology5(3);189–195;2008. 2.ShuaishuaiWU,HengCHEN,YingzhengWANG,HuiGAO,ShenmingZENG.EffectofcalciumonporcineICSIembryosexpressingEGFPisrelatedtoactivationofooplasmicDNaseI.Front.Agr.Sci.Eng.2015,2(1):84–89. 3.Y.Yuan,Z.D.Hao,J.Liu,Y.Wu,L.Yang,G.S.Liu,J.H.Tian,S.E.Zhu,S.M.Zeng.Heatshockatthegerminalvesiclebreakdownstageinducesapoptosisinsurroundingcumuluscellsandreducesmaturationratesofporcineoocytesinvitro.Theriogenology.2008.70:168–178. 4.CuiMao-sheng,Yi-pengFan,Jin-haoLiu,YiWu,Ze-dongHao,Peng-chengWan,LinYang,Fang-fangGao,ShenLiu,HenChen,Shen-mingZeng.Porcinecumuluscellinfluencesooplasmicmitochondria–lipiddistributions,GSH–ATPcontentsandcalciumreleasepatternafterelectro-activation.Theriogenology71(2009)412–421. 5.YaoNing,Peng-chengWan,Ze-dongHao,Fang-fangGao,LingYang,Mao-shengCui,YiWu,Jing-haoLiu,ShenLiu,HengChen,Guo-shiLiu,Jian-huiTian,Shi-enZhuandShen-mingZeng.Expressionofinterferon-taumRNAinbovineembryosderivedfromdifferentprocedures.Reprod.Dom.Anim.44,132–139(2009). 6.YiWu,Cheng-JunLiu，Peng-ChengWan,Ze-DongHao,Shen-MingZeng.FactorsaffectingtheefficiencyofproducingporcineembryosexpressingenhancedgreenfluorescenceproteinbyICSI-mediatedgenetransfermethod.Anim.Reprod.Sci.113：156–166(2009). 7.Ze-DongHao,LiuS,WuY,WanPC,CuiMS,ChenH,Shen-MingZeng.Thechangesinmitochondria,lipiddroplets,ATPandglutathionecontentsinporcineoocyteduringageinginvitroassociatewithdecreasingCa2+releaseandpoordevelopmentalcompetenceafterelectro-activation.ReproductionFertilityandDevelopment21:323-332,2009. 8.Peng-chengWan,Ze-dongHao,PingZhou,YiWu,LingYang,Mao-shengCui,Shou-renLiu,Shen-mingZeng.EffectsofSOFandCR1mediaondevelopmentalcompetenceandcellapoptosisofovineinvitrofertilizationembryos.Anim.Reprod.Sci.114:279–288,2009. 9.YangL.,X.L.Wang,P.C.Wan,L.Y.Zhang,Y.Wu,D.W.Tang,andS.M.Zeng.Up-regulationofexpressionofinterferon-stimulatedgene15inthebovinecorpusluteumduringearlypregnancy.J.DairySci.93:1000-1011;2010. 10.Mao-ShengCui,Xian-LongWang,Da-WeiTang,JingZhang,YanLiu,Shen-MingZeng.AcetylationofH4K12inporcineoocytesduringinvitroaging:potentialroleofooplasmicreactiveoxygenspecies.Theriogenology.2011.75:638–646. 11.TangD.W.andS.M.Zeng.RelationshipsofCa2+oscillationsandERclusterdistributiontoporcineoocytefragmentation.Asianjournalofanimalandveterinaryadvances.2011.6(4):322-332. 12.Peng-chengWan,Zhong-jianBao,YiWu,LingYang,Ze-dongHao,Yong-linYang,Guo-qingShi,YanLiuandShen-mingZeng.αvβ3integrinmayparticipateinconceptusattachmentbyregulatingmorphologicchangesoftheendometriumduringperiimplantationinovine.Reprod.Dom.Anim.2011.46(5):757-942. 13.AhmedS.Abdoon,OmaimaM.Kandil,ShenM.ZengandCuiMS.Mitochondrialdistribution,ATP-GSHcontents,calcium[Ca2+]oscillationduringinvitromaturationofdromedarycameloocytes.Theriogenology76(2011)1207–1214. 14.WuYi,Cheng-JunLiu，Peng-ChengWan,Ze-DongHao,Shen-MingZeng.BIMEL-mediatedapoptosisincumuluscellscontributestodegenerativechangesinagedporcineoocytesviaaparacrineaction.Theriogenology2011,76:1487-1495. 15.CuiMao-sheng,LIUZhen-xing,Xian-longWang,JingZhang,YiWu,Guo-caiHan,Shen-mingZeng.RelationshipbetweenDifferentialExpressionofBaxandBcl-2GenesandDevelopmentalDifferencesofPorcineParthenotesCulturedinPZM-3andNCSU-23.AgriculturalSciencesinChina,2011,10(11):1772-1780. 16.Xian-LongWang,YiWu,Lu-BinTan,ZhenTian,Jing-HaoLiu,De-ShengZhu,andShen-MingZeng.Follicle-stimulatinghormoneregulatesPro-apoptoticproteinBcl-2-interactingmediatorofcelldeath-extralong(BimEL)inducedporcinegranulosacellapoptosis.TheJournalofBiologicalChemistry,2012,287(13):10166–10177. 17.LingYang,Le-YingZhang,Cheng-MingWang,BinWang,Xue-MinWangandShen-MingZeng.DifferentialexpressionpatternofISG15indifferenttissueexplantsandcellsinducedbyvariousinterferons.MicrobiologyandImmunology,2012;56:163–170. 18.Xian-LongWang,KunWang,Guo-CaiHan,Shen-MingZeng.Apotentialautocrineroleforinterferontauinovinetrophectoderm.Reprod.Dom.Anim.2013;48:819–825. 19.Xian-LongWang,KunWang,Shen-MingZeng.Oocyte-secretedgrowthdifferentiationfactor9inhibitsBCL-2-interactingmediatorofcelldeath-extralongexpressioninporcinecumuluscell.BiologyofReproduction.2013,89:56-64. 20.Da-WeiTang,YuanFang,Zhen-XingLiu,YiWu,Xian-LongWang,ShuanZhao,Guo-CaiHanandShen-MingZeng.TheDisturbancesofEndoplasmicReticulumCalciumHomeostasisCausedbyIncreasedIntracellularReactiveOxygenSpeciesContributestoFragmentationinAgedPorcineOocytes.BiologyofReproduction.2013,89:124-131. 21.LiuZ,ZhaoS,WuS,ZhangJ,NieZ,ZengS.Anovelroleoftransientreceptorpotentialmucolipin1(TRPML1)inprotectingagainstimidazole-inducedcytotoxicity.BiochemCellBiol.2014,92(4):279-86. 22.Zhong-JianBao,ShuanZhao,IhteshamUlHaqandShen-MingZeng.Recombinantbovineinterferon-τenhancesinvitrodevelopmentofbovineembryosbyupregulatingexpressionofconnexin43andE-cadherin.J.DairySci.2014;97(11):6917-25. 23.YuGuangmin,IhteshamulHaq,SherHayatKhanandZengMingsheng.ActinFilamentsareNecessaryforFSH-InducedCYP19A1TranscriptioninBovineGranulosaCellsinvitro.PakistanVeterinaryJournal,2015,35(1):53-57. 24.ZhenxingLiu,YingzhengWang,ShuanZhao,JingyouZhang,YiWuandShenmingZeng.ImidazoleinhibitsautophagyfluxbyblockingautophagicdegradationandtriggersapoptosisviaincreasingFoxO3a-Bimexpression.InternationalJournalOncology.2015,46(2):721-31. 25.ZhaoS,LiuZ-X,BaoZ-J,WuY,WangK,YuG-M,WangC-M,ZengS-M.Age-associatedpotencydeclineinbovineoocytesisdelayedbyblockingextracellularCa2+influx.Theriogenology.2015,83(9):1493–1501. 26.ShuanZhao,Zhen-XingLiu,HuiGao,YiWu,YuanFang,Shuai-ShuaiWu,Ming-JieLiJia-HuaBai,YanLiu,AlexanderEvans,Shen-MingZeng.Athree-dimensionalculturesystemusingalginatehydrogelprolongshatchedcattleembryodevelopmentinvitro.Theriogenology2015,84(2):184-192. 27.YFang,WShang,DLWei,SMZeng.Cited2proteinlevelincumuluscellsisabiomarkerforhumanembryoqualityandpregnancyoutcomeinoneinvitrofertilizationcycle.FertilityandSterility.Availableonline23January2016. 28.HuiGao,LuLin,IhteshamUlHaq,Shen-mingZeng.InhibitionofNF-κBpromotesautophagyviaJNKsignalingpathwayinporcinegranulosacells.BiochemicalandBiophysicalResearchCommunications.2016,473:311–316. 29.ShuanZhao,YiWu,HuiGao,AlexanderEvansandShen-MingZeng.Rolesofinterferon-stimulatedgene15proteininbovineembryodevelopment.Reproduction,FertilityandDevelopment.http://dx.doi.org/10.1071/RD15209,2016. 30.JieyunLi,HuiGao,ZhenTian,YiWu,YingzhengWang,YuanFang,LuLin,YingHan,ShuaishuaiWu,IhteshamUlHaqandShenmingZeng.Effectsofchronicheatstressongranulosacellapoptosisandfollicularatresiainmouseovary.JournalofAnimalScienceandBiotechnology.2016,7:57-67. 31.Guang-MinYu,Jia-HuaBai,YanLiu,TeruoMaeda,Shen-MingZeng。AweeklypostpartumPGF2aprotocolenhancesuterinehealthindairycows.ReproductiveBiology.2016,16(4):295–299. 32.IhteshamUlHaq,YingHan,TariqAli,YingzhengWang,HuiGao,LuLin,YiWu,ShuaishuaiWu,ShenmingZeng.Expressionofinterferon-stimulatedgeneISG15andubiquitinationenzymesisupregulatedinperipheralbloodmonocyteduringearlypregnancyindairycattle.ReproductiveBiology.2016,16(4):255–260. 33.DanYi,ShenmingZeng,YumingGuo.DecreasedSpermQualityinMiceFedaDietwithFishOil.J.Ani.Sci.andBiotech.2011,2(3):164-172. 34.D.Yi,S.Zeng,Y.GuoAdietrichinn-3polyunsaturatedfattyacidsreducedprostaglandinbiosynthesis,ovulationrate,andlittersizeinmice.doi:10.1016/j.theriogenology.2012.01.013 35.GouK.M.,X.R.An,H.Guan,X.Y.Yang,J.Hou,S.E.Zhu,S.M.Zeng,J.H.TianandY.F.Chen.Transgenictwinlambsclonendbygranulosecells.CloningandStemCells.5(1):71-77,2003. 36.QuanGB,TYWu,SMZeng,ZCZhang,SEZhu.Astudyofthecryopreservationofmousezygotesbyopenpulledstrawmethod.Cryobiology2005,50:224. 37.TianXZ,WenQ,ShiJM,Liang-Wang,ZengSM,TianJH,ZhouGB,ZhuSE,LiuGS.Effectsofmelatoninoninvitrodevelopmentofmousetwo-cellembryosculturedinHTFmedium.EndocrRes.2010;35(1):17-23. 38.ShiJM,TianXZ,ZhouGB,WangL,GaoC,ZhuSE,ZengSM,TianJH,LiuGS.Melatoninexistsinporcinefollicularfluidandimprovesinvitromaturationandparthenogeneticdevelopmentofporcineoocytes.J.PinealRes.2009,47(4):318-323. 39.ZhouGB,MaCB,LiuGS,ZhuSE,ZhangHH,JiaLL,SuoL,ShiJM,WangYB,TianJH,ZengSM.VitrificationoffarmedbluefoxoocytesinethyleneglycolandD"TEXT-INDENT:0cm;MARGIN-LEFT:-0.1pt;"class=MsoNormal>40.SuoL,WangF,ZhouGB,ShiJM,WangYB,ZengSM,TianJH,ZhuSE,LiuGS.Optimalconcentrationofcalciumandelectricfieldlevelsimprovetetraploidembryoproductionbyelectrofusioninmice.JReprodDev.2009,55(4):383-385. 41.LiuGS,ZhouGB,ZhangHH,MaCB,ShiWQ,ZhuSE,YangZQ,KangJ,JiaLL,ZengSM,TianJH,WangF.Surgicalembryotransferresultedinbirthofliveoffspringinfarmedbluefox.AnimReprodSci.2008,105(3-4):424-429. 42.TianJH,WuZH,LiuL,CaiY,ZengSM,ZhuSE,LiuGS,LiY,WuCX.Effectsofoocyteactivationandspermpreparationonthedevelopmentofporcineembryosderivedfrominvitro-maturedoocytesandintracytoplasmicsperminjection.Theriogenology.2006,66(2):439-448. 43.LiangDeng,,HongyunDuan,XiangZhang,ShenmingZeng,ChangxinWu,GuocaiHan,AdvancesintheResearchandApplicationofArtificialInseminationtoEquidsinChina:1935–2012.JournalofEquineVeterinaryScience.publishedonline21October2013. 44.JinlongZhu,XiangfangZeng,QianPeng,ShenmingZeng,HaiyiZhao,HexiaoShenandShiyanQiao.MaternalN-CarbamylglutamateSupplementationduringEarlyPregnancyEnhancesEmbryonicSurvivalandDevelopmentthroughModulationoftheEndometrialProteomeinGilts.JournalofNutrition.2015,145:2212-2220.

学术兼职

中国畜牧兽医学会动物繁殖学分会、马学分会常务理事、中国奶业协会理事、中国畜牧兽医学会高级会员；AmericanSocietyforBiochemistryandMolecularBiology(ASBMB)会员。