Badu-Tawiah, Abraham - The Ohio State University - Department of Chemistry & Biochemistry

个人简介

Education B.Sc./M.Sc. Kwame Nkrumah University of Science and Technology, Ghana 2005 M.S. Indiana University of Pennsylvania, Indiana PA, USA 2007 (advisor: John Ford) Ph.D. Purdue University, West Lafayette IN, USA 2012 (advisor: R. Graham Cooks) Professional Experience Postdoctoral Fellow, Department of Chemistry and Chemical Biology, Harvard University, Cambridge MA, USA 2012 – 2014 (advisor: George M. Whitesides) Assistant Professor, Department of Chemistry and Biochemistry, The Ohio State University, Columbus OH, USA 2014 – present Member, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH Honors/Awards 2021 Ohio State Early Career Innovator of the Year 2020 Sloan Fellowship Award 2019 NIH MIRA for New Investigators Award Eli Lilly Young Investigator Award in Analytical Chemistry 2017 Research Award, American Society for Mass Spectrometry 2017 Early Career Award, Department of Energy 2016 Lilly Innovative Fellowship Award, Purdue University 2012 Bilsland Dissertation Fellowship, Purdue University 2011 Andrews Fellowship, Purdue University 2007 – 2009 Academic Achievement Award, Indiana University of Pennsylvania 2006

研究领域

1. Diagnostic Mass Spectrometry The main motivation for this project is to develop a mass spectrometric method for use by MS non-experts. We are synthesizing novel chemical probes that will allow the use of ambient ionization techniques [e.g., desorption electrospray ionization (DESI), paper spray ionization, direct analysis in real time (DART), etc.] for the detection of disease biomarkers. The methodology is directly applicable in point-of-care diagnosis, tissue imaging, lipidomics, and other areas in biomedical research 2. Accelerated Droplet Reactions Accelerated reaction rates are observed for certain chemical reactions performed under charged micro-droplets environments. We are developing new MS techniques for containment, and the use of ionic species as ordinary reagents for organic reactions. The main advantage of conducting ionic reactions at atmospheric pressure is the fact that products are completely accessible during experiment, and thus can be collected for subsequent. 3. Therapeutic Aerosol Characterization We are developing ambient ion processing techniques for the characterization of therapeutic aerosols.

近期论文

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“Charge Inversion Under Plasma-Nanodroplet Reaction Conditions Excludes Fisher Esterification for Unsaturated Fatty Acids: A Chemical Approach for Type II Isobaric Overlap” Dmytro S. Kluyk, Glib V. Baryshnikov, Purva S. Damale, Simon Maher, and Abraham K. Badu-Tawiah* Chemical Science 2024 “The Growing Influence of Mass Spectrometry in Measurement Science” Abraham K. Badu-Tawiah* ACS Meas. Sci. Au 2023 “Dual Tunability for Uncatalyzed N−Alkylation of Primary Amines Enabled by Plasma−Microdroplet Fusion“ Alexander Grooms, Anna Nordmann, and Abraham K. Badu-Tawiah* Angewandte Chemie 2023 “Two-Dimensional Isomer Differentiation Using Liquid Chromatography-Tandem Mass Spectrometry with In-Source, Droplet-Based Derivatization“ Derik Heiss, Enoch Amoah, and Abraham K. Badu-Tawiah* Analyst 2023, 148, 5270 – 5278 “High-Throughput Nanoliter Sampling and Direct Analysis of Biological Fluids using Droplet Imbibition Mass Spectrometry“ Taghi Sahraeian, Enoch Amoah, Dmytro Kulyk, and Abraham Badu-Tawiah* Analytical Chemistry 2023, 95 (18), 7093 -7099 “Mass Spectrometry Approach for Differentiation of Positional Isomers of Saccharides: Toward Direct Analysis of Rare Sugars“ Enoch Amoah, Dmytro Kulyk, Christopher Callam, Christopher Hadad, and Abraham Badu-Tawiah* Analytical Chemistry 2023, 95, 13, 5635–5642 “Plasma-Droplet Reaction Systems: A Direct Mass Spectrometry Approach for Enhanced Characterization of Lipids at Multiple Isomers Levels“ Alexander Grooms, Anna Nordmann, and Abraham K. Badu-Tawiah* ACS Measurement Science Au 2023, 3, 32–4 “Mass Spectrometry for Metabolomics Analysis: Applications in Neonatal and Cancer Screening“ Alexander Grooms, Benjamin Burris, and Abraham Badu-Tawiah* Mass Spectrometry Reviews 2022, e21826. “Online Cross-Linking of Peptides and Proteins During Contained-Electrospray Ionization Mass Spectrometry“ Benjamin Burris, Leah Walsh, and Abraham Badu-Tawiah* Analytical Chemistry 2022, 95, 2, 1085–1094 “Capturing Fleeting Intermediate in Claisen Rearrangement Using Non-Equilibrium Droplet Imbibition Reaction Conditions” Taghi Sahraeian, Dmytro Kulyk, Joseph Fernandez, Christopher Hadad and Abraham Badu-Tawiah* Analytical Chemistry 2022, 94, 43,15093-15099 “Malaria Diagnosis using Paper-Based Immunoassay for Clinical Blood Sampling and Analysis by Miniature Mass Spectrometer” Suji Lee, Dmytro Kulyk, Stephen Opoku Afriyie, Kingsley Badu, and Abraham K. Badu-Tawiah* Analytical Chemistry 2022, 94, 41, 14377-14384 “Liquid Chromatography-Tandem Mass Spectrometry with Online, In-Source Droplet-Based Phenylboronic Acid Derivatization for Sensitive Analysis of Saccharides” Derik Heiss and Abraham K. Badu-Tawiah* Analytical Chemistry 2022, 94, 40, 14071-14078 “Assessment of Creatinine Concentration in Whole Blood Spheroids using Paper Spray Ionization – Tandem Mass Spectrometry“ Tung-Ting Sham, Abraham K. Badu-Tawiah, Stephen J McWilliam, and Simon Maher Scientific Reports 2022, 12, 14308 “Resolving Graphite-Electrolyte Interphase in Li-Ion Batteries Using Air-Tight Ambient Mass Spectrometry“ Taghi Sahraeian, Jingfeng Zheng, Remy Lalisse, Christopher Hadad, Yiying Wu, and Abraham K. Badu-Tawiah Batteries & Supercaps 2022, e202200280 “The Effect of the Physical Morphology of Dried Biofluids on the Chemical Stability of Analytes Stored in Paper and Direct Analysis by Mass Spectrometry” Benjamin S. Frey, Deidre E. Damon, and Abraham K. Badu-Tawiah* Analytical Chemistry, 2022, 94, 27, 9618-9626 “Dehydration of gas-phase benzyl amine alcohols studied at atmospheric pressure“ Dmytro Kulyk, Qiongqiong Wan, Taghi Sahraeian, Abraham K. Badu-Tawiah* International Journal of Mass Spectrometry 2022, 476, 116836 “Automated Immunoassay Performed on 3D Microfluidic Paper-Based Device for Malaria Detection by Ambient Mass Spectrometry” Sierra Jackson, Suji Lee, Abraham K. Badu-Tawiah Analytical Chemistry, 2022, 94, 12, 5132–5139 “Utility of machine learning in developing a predictive model for early-age-onset colorectal neoplasia using electronic health records” Hisham Hussan, Jing Zhao, Abraham K. Badu-Tawiah, Peter Stanich, Fred Tabung, Darrell Gray, Qin Ma, Matthew Kalady, Steven K. Clinton PLoS ONE 2022, 17(3): e0265209 “Embossed Paper Platform for Whole Blood Collection, Room Temperature Storage, and Direct Analysis by Pinhole Paper Spray Mass Spectrometry“ Benjamin S. Frey, Derik R. Heiss, Abraham K. Badu-Tawiah* Analytical Chemistry 2022, 94, 10, 4417–4425 “Reactive Thread Spray Mass Spectrometry for Localization of C=C Bonds in Free Fatty Acids: Applications for Obesity Diagnosis” Devin J. Swiner, Dmytro S. Kulyk, Hannah Osae, George R. Durisek, Abraham K. Badu-Tawiah* Analytical Chemistry 2022, 94, 5, 2358–2365 “Ambient ion focusing for paper spray ionization“ Smith, B.L.; Boisdon, C.; Romero-Perez, D.; Sham, T.-T.; Bastani, B.; Zhou, Y.; McWilliam, S.; Badu-Tawiah, A.K.; Maher, S. International Journal of Mass Spectrometry 2022, 471, 116737 – 116737 “Enzyme-Catalyzed Hydrolysis of Lipids in Charged Microdroplets Studied by Contained-Electrospray Ionization” Benjamin J. Burris and Abraham Badu-Tawiah* Analytical Chemistry, 2021, 93, 13001–13007 “Microsampling with Solid Phase Extraction Cartridge: Storage and Online Mass Spectrometry Analysis” Dmytro S. Kulyk, Taghi Sahraeian, Suji Lee, and Abraham K. Badu-Tawiah* Analytical Chemistry, 2021, 93, 13632 –13640 “In-source Microdroplet Derivatization using Coaxial Contained-Electrospray Mass Spectrometry for Enhanced Sensitivity in Saccharides Analysis” Derik R. Heiss and Abraham K. Badu-Tawiah* Analytical Chemistry, 2021, 93, 50, 16779–16786 “Protective Mechanism of Dried Blood Spheroids: Stabilization of Labile Analytes in Whole Blood, Plasma and Serum” Benji S. Frey, Deidre Damon, Danyelle M. Allen, Jill Baker, Samuel Asamoah, and Abraham K. Badu-Tawiah* Analyst, 2021, 146, 6780 – 6787 “Enhanced Thread Spray Mass Spectrometry: A General Method for Direct Pesticide Analysis in Various Complex Matrices” Sierra Jackson and Abraham K. Badu-Tawiah* Analyst, 2021, 146, 5592 – 5600 “Clinical Chemistry for Developing Countries: Mass Spectrometry” Suji Lee, Kavyasree Chintalapudi, and Abraham K. Badu-Tawiah* Annu. Rev. Anal. Chem. 2021, 14, 437-465 “Uncatalyzed N-Alkylation of Amines in Ionic Wind from Ambient Corona Discharge“ Suji Lee, Dmytro S. Kulyk, Nicholas Marano, and Abraham K. Badu-Tawiah* Analytical Chemistry 2021, 93, 4, 2440 “Monoacylation of Symmetrical Diamines in Charge Microdroplets“ Emelia Ansu-Gyeabourh, Enoch Amoah, Chandrashekar Ganesa, and Abraham K. Badu-Tawiah* J. Am. Soc. Mass Spectrom. 2021, 32, 2, 531–536 “Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray“ Norfatirah Muhamad Sarih, David Romero-Perez, Behnam Bastani, Monrawat Rauytanapanit, Cedric Boisdon, Thanit Praneenararat, Hairul Anuar Tajuddin, Zanariah Abdullah, Abraham K. Badu-Tawiah*, and Simon Maher* Scientific Reports 2020, 10, 21504 “High-Throughput Mass Spectrometry Screening Platform for Discovering New Chemical Reactions under Uncatalyzed, Solvent-Free Experimental Conditions“ Dmytro S. Kulyk, Enoch Amoah, and Abraham K. Badu-Tawiah* Analytical Chemistry 2020, 92, 15025–15033 “An Integrated Electrocatalytic nESI-MS Platform for Quantification of Fatty Acid Isomers Directly from Untreated Biofluids“ Kavyasree Chintalapudi and Abraham K. Badu-Tawiah* Chemical Science, 2020, 11, 9891 “Direct Differentiation of Whole Blood for Forensic Serology Analysis by Thread Spray Mass Spectrometry“ Sierra Jackson, Benjamin S. Frey, Maia N. Bates, Devin J. Swiner, and Abraham K. Badu-Tawiah* Analyst, 2020 145, 5615-5623 “Analysis of non‑conjugated steroids in water using paper spray mass spectrometry“ Fred. P. M. Jjunju, Deidre E. Damon, David Romero‑Perez, Iain S. Young, Ryan J. Ward, Alan Marshall, Simon Maher* and Abraham K. Badu‑Tawiah* Scientific Reports 2020, 10, 10698 “Spray Mechanism of Contained-Electrospray Ionization” Colbert Miller, Benjamin Burris, and Abraham K. Badu-Tawiah* J. Am. Soc. Mass Spectrom. 2020, 31, 1499–1508 “Direct Analysis of Doping Agents in Raw Urine Using Hydrophobic Paper Spray Mass Spectrometry” Eduardo Luiz Rossini, Dmytro S. Kulyk, Emelia Ansu-Gyeabourh, Taghi Sahraeian, Helena Redigolo Pezza, and Abraham K. Badu-Tawiah* J. Am. Soc. Mass Spectrom. 2020, 31, 1212–1222 “A proof-of-concept, two-tiered approach for ricin detection using ambient mass spectrometry“ Devin J. Swiner, George R. Durisek III, Hannah Osae and Abraham K. Badu-Tawiah* RSC Advances, 2020, 10, 17045-17049 “Applications of Mass Spectrometry for Clinical Diagnostics: The Influence of Turnaround Time“ Devin Swiner, Sierra Jackson, Ben Burris, Abraham K. Badu-Tawiah* Analytical Chemistry, 2020, 92, 1, 183–202 “Novel Manufacturing Method for Producing Apohemoglobin and its Biophysical Properties“ Ivan S. Pires, Donald A. Belcher, Colbert Miller, Abraham K. Badu-Tawiah, Jin Baek, Paul Buehler Andre Palmer* Biotechnology and Bioengineering, 2020, 117, 125-145