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个人简介

孙青原,男,1964年12月出生于山东省招远市。中国科学院动物研究所特聘研究员,中国科学院大学岗位教授,国家杰出青年基金获得者,“973”项目首席科学家,中国科学院“百人计划”和新世纪百千万人才工程国家级人选。1994年毕业于东北农业大学,获动物胚胎学理学博士学位。1996年-2001年在中国科学院动物研究所、以色列巴伊兰大学、美国密苏里大学、日本农林水产省畜产试验场、日本农业生物资源研究所等从事博士后或合作研究。1996年和1998年分别被晋升为副研究员、研究员。 目前兼任中国动物学会副理事长、生殖生物学分会理事长、中国解剖学会发育生物学分会副主任委员等。曾担任计划生育生殖生物学国家重点实验室主任、中国动物学会细胞与分子显微技术分会理事长、第六届国务院学位委员会生物学组成员等。长期从事卵子发育、成熟、受精、早期胚胎发育、动物克隆及生殖发育的表观遗传学研究,在Science、Cell、PNAS、NatComm、PLoSGenet、Development、EHP、JCellSci、JBC、MBC、HumReprod、FertilSteril、BiolReprod等杂志发表SCI论文332篇,受邀为领域知名期刊如MolAspectMed、HumReprodUpdate、Autophagy、SeminCellDevelopBiol、MolEndocinol、CellCycle、MolHumReprod、BiolReprod等撰写综述。2014、2015年入选爱思唯尔(Elsevier)中国高被引学者榜单(生化、遗传与分子生物学领域)。近5年来担任BiologyofReproduction、MolecularHumanReproduction、MolecularReproductionandDevelopment、ScientificReports、CellCycle、ReproductionFertilityandDevelopment、JournalofGeneticsandGenomics、JournalofReproductionandDevelopment等15个SCI期刊副主编或编委。曾获全国优秀博士后、中国科学院青年科学家奖、中国科学院杰出青年、国家留学回国人员成就奖、中国青年科技奖、“十一五”国家科技计划执行突出贡献奖等荣誉和国家自然科学二等奖1项、省部级一等奖3项、全国妇幼健康科技奖自然科学一等奖等。 学历及培训经历: 1999年10月-2001年8月UniversityofMissouri-Columbia,USA博士后(Researchassociate) 1996年10月-1998年4月Bar-IlanUniversity,Israel博士后 1994年8月-1996年8月中国科学院动物研究所生殖生物学国家重点实验室博士后 1991年8月-1994年6月东北农业大学生物工程系博士研究生 1985年7月-1988年6月东北农业大学生物工程系硕士研究生 1981年9月-1985年6月山东农业大学畜牧兽医系本科生 工作经历: 1996年9月-现在中国科学院动物研究所副研究员(1996)、研究员(1998),博士生导师(2000),生殖生物学中心主任(2002-2006),计划生育生殖生物学国家重点实验室常务副主任(2002-2006)、主任(2006-2011) 2009年4月-2005年7月UniversityofMissouri-Columbia,USA高级研究学者 2008年4月-2008年6月NationalInstituteofAgrobiologicalSciences,Japan,InvitedShort-TermJAPSFellow 2005年5月-2005年8月UniversityofMissouri-Columbia,USA高级研究学者 2003年3月-2003年4月NationalInstituteofAgrobiologicalSciences,Japan,InvitedShort-TermJAPSFellow 1996年1月-1996年4月NationalInstituteofAnimalIndustry,JapanSTAFellow 1988年7月-1991年7月山东农业大学畜牧兽医系助教 承担科研项目情况: 国家自然科学基金面上项目:urvivin在小鼠卵母细胞减数分裂成熟中的作用及机制研究(31272260),2013-2016 国家自然科学基金面上项目:利用小鼠模型研究PCOS对小鼠卵母细胞及后代生殖细胞DNA甲基化印迹影响(31472055),2015-2018 国家自然科学基金重点项目:蛋白磷酸酶2A类家族在小鼠卵子发生和成熟中的作用及机制研究(31530049),2016-2020 国家重大科学研究计划项目:雌性生殖细胞减数分裂的分子基础(2012CB944400),2012-2016

研究领域

研究领域: 卵母细胞减数分裂和受精的信号转导 卵母细胞减数分裂纺锤体组装、纺锤体检验点和染色体分离调节 卵子和早期胚胎发育(包括动物克隆)的表观遗传

近期论文

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ZhangT,ZhouY,LiL,WangZB,ShenW,SchattenH,SunQY*.CenpHregulatesmeioticG2/MtransitionbymodulatingtheAPC/CCdh1-cyclinB1pathwayinoocytes.Development.2016Dec19.pii:dev.141135.[Epubaheadofprint] WangHH,CuiQ,ZhangT,GuoL,DongMZ,HouY,WangZB,ShenW,MaJY,SunQY*.Removalofmouseovaryfatpadaffectssexhormones,folliculogenesisandfertility.JEndocrinol.2017Feb;232(2):155-164. HuMW,MengTG,JiangZZ,DongMZ,SchattenH,XuX*,WangZB*,SunQY*.ProteinPhosphatase6ProtectsProphaseI-ArrestedOocytesbySafeguardingGenomicIntegrity.PLoSGenet.2016Dec8;12(12):e1006513.doi:10.1371/journal.pgen.1006513. LiuK,ZhaoQ,LiuP,CaoJ,GongJ,WangC,WangW,LiX,SunH,ZhangC,LiY,JiangM,ZhuS,SunQ,JiaoJ,HuB,ZhaoX,LiW,ChenQ,ZhouQ,ZhaoT.ATG3-dependentautophagymediatesmitochondrialhomeostasisinpluripotencyacquirementandmaintenance.Autophagy.2016Nov;12(11):2000-2008. QiST,MaJY,WangZB,GuoL,HouY,SunQY*.N6-methyladenosineseqencinghighlightstheinvolvementofmRNAmethylationinoocytemeioticmaturationandembryodevelopmentbyregulatingtranslationinXenopuslaevis.JBiolChem.2016Oct28;291(44):23020-23026. MaXS,LinF,WangZW,HuMW,HuangL,MengTG,JiangZZ,SchattenH,WangZB*,SunQY*.Geminindeletioninmouseoocytesresultsinimpairedembryodevelopmentandreducedfertility.MolBiolCell.2016,27(5):768-75. WangZB,MaXS,HuMW,JiangZZ,MengTG,DongMZ,FanLH,OuyangYC,SnapperSB,SchattenH,SunQY*.Oocyte-specificdeletionofN-WASPdoesnotaffectoocytepolarity,butcausesfailureofmeiosisIIcompletion.MolHumReprod.2016Sep;22(9):613-21. YuC,JiSY,ShaQQ,WangZW,SunQY,FanHY.BTG4isameioticcellcycle-coupledmaternal-zygotictansitionlicensingfactorinoocytes.NatureStructuralandMolecularBiology2016May;23(5):387-94. JiangZZ,HuMW,MaXS,SchattenH,FanHY,WangZB,SunQY*.LKB1actsasacriticalgatekeeperofovarianprimordialfolliclepool.Oncotarget.2016,7(5):5738-53. ZhangT,ZhouY,LiL,WangHH,MaXS,QianWP,ShenW,SchattenH,SunQY*.SIRT1,2,3protectmouseoocytesfrompostovulatoryaging.Aging(AlbanyNY).2016,8(4):685-96. MaXS,LinF,WangZW,HuMW,HuangL,MengTG,JiangZZ,SchattenH,WangZB,SunQY*.GemininDeletioninMouseOocytesResultsinImpairedEmbryoDevelopmentandReducedFertility.MolBiolCell.2016Jan13.pii:mbc.E15-06-0346.[Epubaheadofprint] YuC,JiSY,ShaQQ,SunQY,FanHY.CRL4-DCAF1ubiquitinE3ligasedirectsproteinphosphatase2Adegradationtocontroloocytemeioticmaturation.NatCommunications.2015Aug18;6:8017. HuMW,WangZB,TengY,JiangZZ,MaXS,HouN,ChengX,SchattenH,XuX*,YangX*,SunQY*.Lossofproteinphosphatase6inoocytescausesfailureofmeiosisIIexitandimpairedfemalefertility.JCellSci.2015Oct15;128(20):3769-80.(Commentedinthisissue,coverpaper) WeiY,YangCR,WeiYP,GeZJ,ZhaoZA,ZhangB,HouY,SchattenH,SunQY*.EnrichedEnvironment-InducedMaternalWeightLossReprogramsMetabolicGeneExpressioninMouseOffspring.JBiolChem.2015,20;290(8):4604-19. WeiYC,SchattenH,SunQY*.Environmentalepigeneticinheritancethroughgametesandimplicationsforhumanreproduction.HumReprodUpdate2015Mar-Apr;21(2):194-208 WeiY,YangCR,WeiYP,ZhaoZA,HouY,SchattenH,SunQY*.Paternallyinducedtransgenerationalinheritanceofsusceptibilitytodiabetesinmammals.ProcNatlAcadSciUSA(PNAS)111(5):1873-1878,2014 YuXJ,YiZ,GaoZ,QinDD,ZhaiY,ChenX,Ou-YangYC,WangZB,ZhengP,ZhuMS,WangH,SunQYDeanJ,LiL.ThesubcorticalmaternalcomplexcontrolssymmetricdivisionofmousezygotesbyregulatingF-actindynamics.NatureCommunications2014Sep11;5:4887. GeZJ,LuoSM,LinF,LiangQX,HuangL,WeiYC,HouY,HanZM,SchattenH,SunQY*.DNAmethylationinoocytesandliveroffemalemiceandtheiroffspring:Effectsofhigh-fat-diet-inducedobesity.EnvironmentalHealthPerspectives122(2):159-164,2014. JiangZZ,HuMW,WangZB,HuangL,LinF,QiST,OuyangYC,FanHY,SchattenH,MakTW,SunQY*.Survivinisessentialforfertileeggproductionandfemalefertilityinmice.CellDeathDis.2014Mar27;5:e1154.doi:10.1038/cddis.2014.126. GeZJ,ZhangCL,SchattenH,SunQY*.Maternaldiabetesmellitusandtheoriginofnon-communicablediseasesinoffspring:theroleofepigenetics.BiolReprod.2014May14.pii:biolreprod.114.118141.[Epubaheadofprint] LinF,MaXS,WangZB,WangZW,LuoYB,HuangL,JiangZZ,HuMW,SchattenH,SunQY*.DifferentfatesofoocyteswithDNAdouble-strandbreaksinvitroandinvivo.CellCycle2014,13(17):inpress. HuMW,WangZB,JiangZZ,QiST,HuangL,LiangQX,SchattenH,SunQY*.ScaffoldSubunitAalphaofPP2AIsEssentialforFemaleMeiosisandFertility.BiolReprod.2014Jun4.pii:biolreprod.114.120220.[Epubaheadofprint] QiaoJ,WangZB,FengHL,MiaoYL,WangQ,YuY,WeiYC,YanJ,WangWH,ShenW,SunSC,SchattenH,SunQY*.Therootofreducedfertilityinagedwomenandpossibletherapenticoptions:Currentstatusandfutureperspects.MolecularAspectsofMedicine2013Jun21.doi:pii:S0098-2997(13)00041-1.10.1016/j.mam.2013.06.001.[Epubaheadofprint],2014 YuC,ZhangYL,PanWW,LiXM,WangZW,GeZJ,ZhouJJ,CangY,TongC,SunQY*,FanHY*.CRL4complexregulatesmammalianoocytesurvivalandreprogrammingbyactivationofTETproteins.Science342:1518-21,2013.(HighlightedbyBiolReprod,2014) WangZB,JiangZZ,ZhangQH,HuMW,HuangL,OuXH,GuoL,OuyangYC,HouY,BrakebuschC,SchattenH,SunQY*.SpecificdeletionofCdc42doesnotaffectmeioticspindleorganization/migrationandhomologouschromosomesegregation,butdisruptspolarityestablishmentandcytokinesisinmouseoocyte.MolecularBiologyoftheCell24:3832-3841,2013. LuoSM,GeZJ,WangZW,JiangZZ,WangZB,OuyangYC,HouY,Schattenh,SunQY*.Uniqueinsightsintomaternalmitochondrialinheritanceinmice.ProcNatlAcadSciUSA(PNAS)110(32):13038-13043,2013. WangZW,MaXS,MaJY,LuoYB,LinF,WangZB,SchattenH,FanHy,SunQY*.LaserMicrobeam-InducedDNADamageInhibitsCellDivisioninFertilizedEggsandEarlyEmbryos.CellCycle12(20):3336-3344,2013. LuoSM,SunQY*.AutophagyIsNotInvolvedintheDegradationofSpermMitochondriaafterFertilizationinMice.Autophagy9(12):2156-2157,2013. XiaP,WangS,DuY,ZhaoZ,ShiL,SunL,HuangG,YeB,LiC,DaiZ,HouN,ChengX,SunQY,LiL,YangX,FanZWASHinhibitsautophagythroughsuppressionofBeclin1ubiquitination.EMBOJournal.32(20):2685-2696,2013. MaJY,LiM,LuoYB,SongS,TianD,YangJ,ZhangB,HouY,SchattenH,LiuZ,SunQY*.Maternalfactorsrequiredforoocytedevelopmentalcompetenceinmice:Transcriptomeanalysisofnon-surroundednculeolus(NSN)andsurroundednucleolus(SN)oocytes.CellCycle.12:1928-1938,2013. QiST,WangZB,OuyangYC,ZhangQH,HuMW,HuangX,GeZJ,GuoL,WangYP,HouY,SchattenH,SunQY*OverexpressionofSETβ,aproteinlocalizingtocentromeres,causesprecociousseparationofchromatidsduringthefirstmeiosisofmouseoocyte.JournalofCellScience126,1595-1603,2013. LuoYB,MaJY,ZhangQH,LinF,WangZW,HuangL,SchattenH,SunQY*.MBTD1isassociatedwithPr-Set7tostabilizeH4K20me1inmouseoocytemeioticmaturation.CellCycle.12(7):1142-1150,2013. MaJY,OuyangYC,LuoYB,WangZB,HouY,HanZM,LiuZH,SchattenH,SunQY*CyclinOregulatesgerminalvesiclebreakdowninmouseoocytes.BiologyofReproduction,88(5):110,1-9,2013. GeZJ,LiangXW,GuoL,LiangQX,LuoSM,WangYP,WeiYC,HanZM,SchattenH,SunQY*MaternaldiabetescausesalterationsofDNAimprintinginmurineoocytes.BiologyofReproduction,88(5):117,1-9,2013. (ReportedbyScienceDaily,ScienceNews,MedicalNewsToday,MedicalExpress,MedSci) MaJY,OuyangYC,WangZW,WangZB,JiangZZ,LuoSM,HouY,LiuZH,SunQY*TheeffectsofDNAdouble-strandbreaksonmouseoocytemeioticmaturation.CellCycle12(8):1928-1938,2013. YangSW,GaoC,ChenL,SongYL,ZhuJL,QiST,JiangZZ,WangZW,LinF,HuangH,XingFQ,SunQY*Nek9regulatesspindleorganizationandcellcycleprogressionduringmouseoocytemeiosisanditslocationinearlyembryomitosis.CellCycle16;11(23):4366-77,2012. MaJY,LiangXW,SchattenH,SunQY*ActiveDNAdemethylationinmammalianpreimplantationembryos:newinsightsandnewperspectives.MolecularHumanReproduction.18(7):333-40,2012.(Coverpaper) OuXH,LiS,WangZB,LiM,QuanS,XingF,ChaoSB,ChenZJ,LiangXW,HouY,SchattenH,SunQY*.Maternalinsulinresistancecausesoxidativestressandmitochondrialdysfunctioninmouseoocytes.HumanReproduction27(7):2130-45,2012. LiS,OuXH,WeiL,WangZB,ZhangQH,OuyangYC,HouY,SchattenH,SunQY*.Septin7isrequiredfororderlymeiosisinmouseoocytes.CellCycle.11(17):3211-8,2012. ChenL,ChaoSB,WangZB,QiST,ZhuXL,YangSW,YangCR,ZhangQH,OuyangYC,HouY,SchattenH,SunQY*Checkpointkinase1isessentialformeioticcellcycleregulationinmouseoocytes.CellCycle15;11(10):1948-55,2012. ChaoSB,Guol,OuXH,LuoSM,WangZB,SchatetnH,Gaol,SunQY*Heatedspermatozoa:effectsonembryonicdevelopmentandepigenetics.HumanReproduction27(4):1016-24,2012. ZhangQH,QiST,WangZB,YangCR,WeiYC,ChenL,OuYangYC,HouY,SchatetnH,SunQY*LocalizationandfunctionoftheSkacomplexduringmouseoocytemeioticmaturation.CellCycle11(5):909-16,2012. ZhuXL,QiST,LiuJ,ChenL,ZhangC,YangSW,OuYangYC,HouY,SchattenH,SunQY*Synaptotagmin1isrequiredforspindlestabilityandmetaphase-anaphasetransitioninmouseoocytes.CellCycle11(4):818-26,2012. WangZB,SchattenH,SunQY*Whyischromosomesegregationrrrorinoocytesincreasedwithmaternalaging?Physiology26:314-325,2011.(coverpaper) SunQY*Ndc80complex:Newevidencefortheexistenceofspindleassemblycheckpointinmammalianoocytemeiosis.CellCycle15;10(6):877-8,2011. LiangXW,GeZJ,GuoL,LuoSM,HanZM,SchattenH,SunQY*EffectofpostovulatoryoocyteagingonDNAmethylationimprintingacquisitioninoffspringoocytes.FertilityandSterility.96:1479-1484,2011. ZhangCH,WangZB,QuanS,HuangX,TongJS,MaJY,GuoL,WeiYC,OuyangYC,HouY,XingFQ,SunQY*GM130,acis-Golgiprotein,regulatesmeioticspindleassemblyandasymmetricdivisioninmouseoocyte.CellCycle10(11):2230-2236,2011. (CommentedbySunSCinCellCycle,2011;LiuXJinCellCycle,2011) LiangXW,GeZJ,WeiL,GuoL,HanZM,SchattenH,SunQY*Theeffectsofpostovulatoryagingofmouseoocytesonmethylationandexpressionofimprintedgenesatmid-termgestation.MolecularHumanReproduction17:562-567,2011. SchattenH*,SunQY*Theroleofcentrosomesinfertilization,celldivisionandestablishmentofasymmetryduringembryodevelopment.SeminarsinCell&DevelopmentalBiology.21:174-184,2010. GuL,WangQ*,SunQY*Histonemodificationsduringmammalianoocytematuration:dynamics,regulation,andfunctions.CellCycle23;9(10):1942-1950,2010. OuXH,LiS,XuBZ,WangZB,QuanS,LiM,ZhangQH,OuyangYC,SchattenH,XingFQ*,SunQY*p38αMAPKIsaMTOC-AssociatedProteinRegulatingSpindleAssembly,SpindleLengthandAccurateChromosomeSegregationduringMouseOocyteMeioticMaturation.CellCycle9:4130-4143,2010.(Facultyof1000) WangZB,OuXH,TongJS,LiS,Weil,OuyangYC,HouY,SchattenH,SunQY*TheSUMOpathwayfunctionsinmouseoocytematuration.CellCycle9(13):2640-2046,2010. QiaoJ,ChenY,YanLY,YanJ,LiuP,SunQY.ChangesinhistonemethylationduringhumanoocytematurationandIVF-orICSI-derivedembryodevelopment.FertilSteril.93(5):1628-36,2010 ZhangQH,WeiL,TongJS,QiST,LiS,OuXH,OuyangYC,HouY,AnLG,SchattenH,SunQY*LocalizationandfunctionofmSpindlyduringmouseoocytemeioticmaturation.CellCycle9(11):2230-2236,2010. ZhuJL,LinSL,Lim,OuyangYC,HouY,SchattenH,SunQY*Septin2ismodifiedbySUMOylationandrequiredforchromosomecongressioninmouseoocytes.CellCycle9(8)1607-1616,2010. ShaW,XuBZ,LiM,LiuD,FengHL,SunQY*Impactofgonadotrophinsonoocytematurationinvitro:Ananimalmodel.FertilityandSterility93(5):1650-1661,2010. WeiL,LiangXW,ZhangQH,LiM,YuanJ,LiS,SunSC,OuyangYC,SchattenH,SunQY*BubR1isaspindleassemblycheckpointproteinregulatingmeioticcellcycleprogressionofmouseoocyte.CellCycle9(6)1112-1121,2010. (Coverpaper,commentedbyFanHY.CellCycle.2010Apr15;9(8);JonesKT,HoltJE.CellCycle.2010Mar15;9(6)) MaCH,YanLY,QiaoJ,ShaW,LiL,ChenY,SunQYEffectsoftumornecrosisfactor-alphaonporcineoocytemeiosisprogression,spindleorganization,andchromosomealignment.FertilSteril.93:920-926,2010. SunQY*,MiaoYL,SchattenH*Towardsanewunderstandingontheregulationofmammalianoocytemeiosisresumption.CellCycle8(17):2741-7,2009. MiaoYL,KikuchiK,SunQY*,SchattenH*Oocyteaging:implicationsfordevelopmentalpotential,andpracticalsignificanceforassistedreproductiontechnologies.HumanReproductionUpdate15:573-585,2009.(coverpaper) YuanJ,SunQY*.Astrinregulatesmeioticspindleorganization,spindlepoletetheringandcellcycleprogressioninmouseoocytes.CellCycle8(20)3384-3395,2009. YanLY,QiaoJ,ChenY,HuangJ,LiuP,SunQYApplicationof3D-fluorescenceinsituhybridizationtohumanpreimplantationgeneticdiagnosis.FertilityandSterility92(4):1492-5,2009. SunSC,WeiL,LiM,LinSL,XuBZ,LiangXW,KimNH,SchattenH,LuSS,SunQY*Perturbationofsurvivinexpressionaffectschromosomealignmentandspindlecheckpointinmouseoocytemeioticmaturation.CellCycle8(20)3365-3372,2009. SchattenH,SunQY*TheroleofcentrosomesinmammalianfertilizationanditssignificanceforICSI.MolecularHumanReproduction15:531-538,2009. LiM,SchattenH,SunQY*Androgenreceptor’sdestinyinmammalianoocytes:anewhypothesis.MolecularHumanReproduction15:149-154,2009. SunY,KucejM,FanHY,YuH,SunQY,ZouHSeparaseisrecruitedtomitoticchromosomestodissolvesisterchromatidcohesioninapolynucleotide-dependentmanner.Cell137:123-132,2009.

学术兼职

杂志编委: 《BiologyofReproduction》(SCI)编委会委员(综述委员会)(2007-2009);编委会委员(审稿编辑委员会)(2009—现在) 《CellCycle》(SCI)编委员会委员(2007-现在) 《MolecularReproductionandDevelopment》(SCI)副主编(2007-2008)(2014—现在) 《Reproduction,FertilityandDevelopment》(SCI)执行副主编(2009-2016) 《JournalofReproductionandDevelopment》(SCI)编委员会委员(2004-现在) 《AsianJournalofAndrology》(SCI)编委员会委员(2004—2015) 《ProgressinNaturalScience》(SCI)编委员会委员(2004--2009) 《ProgBiophysBiochem》(SCI)编委员会委员(2010—现在) 《CurrentZoology》副主编(SCI)(2009—现在) 《TheScientificWorldJournal》编委员会委员(2010—现在) 《PLoSONE》Editor(2012-现在) 《JournalofGeneticsandGenomics》编委会委员(2014—2016)、副主编(2017-2019) 《PeerJ》编委会委员 《动物学报》编委员会委员(1999--2008) 《动物学杂志》编委员会委员(1999—现在) 《生殖医学杂志》编委员会委员(2002—现在) 《细胞生物学杂志》编委员会委员(2007—2009) 《中国细胞生物学报》编委员会委员(2010-现在) 《遗传》副主编(2010—2013) 《生殖与避孕》副主编(2012-现在) 《ScientificReprots》(SCI)编委员会委员(2015—现在) 《MolecularHumanReproduction》副主编(2017—)

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