任充华 - 华南师范大学 - 生命科学学院

个人简介

教育经历 2014.11-2016.09 美国加州大学戴维斯分校（UC Davis），博士联合培养 2011.09-2016.12 西北农林科技大学，硕博连读，获博士学位 2007.09-2011.06 西北农林科技大学，本科，获学士学位工作经历 2017.03-2019.02 华南师范大学师资博士后 2019.03-2020.12 华南师范大学副教授 2021.01-至今华南师范大学研究员

研究领域

动物肢体发育与再生动物肢体再生的分子机理研究组织器官的再生一直是生物学研究中最令人着迷的现象之一，也被国际顶级期刊Science列入全世界最前沿的125个科学问题之一，研究动物肢体发育及再生的分子机制可为再生生物学及再生医学的发展提供借鉴与参考。肢体发育和再生过程涉及诸多基因表达和细胞命运决定等生物学过程，本实验室主要聚焦转录调控、表观遗传（组蛋白以及DNA修饰）和蛋白修饰等如何调控基因表达进而控制动物肢体的发育和再生过程。

近期论文

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Zheng Zhao#, Liang Li#, Ruichen Zeng, Liangguan Lin, Dongwei Yuan, Yejie Wen, Na Li, Yingying Cui, Shiming Zhu, Zhi-Min Zhang, Sheng Li*, and Chonghua Ren*. 5mC modification orchestrates choriogenesis and fertilization by preventing prolonged ftz-f1 Expression. Nature Communications. 2023 Dec 12;14(1):8234 (IF=16.6) Chonghua Ren# *, Yejie Wen#, Shaojuan Zheng#, Zheng Zhao#, Ethan Yihao Li, Chenjing Zhao, Mingtao Liao, Liang Li, Xiaoshuai Zhang, Suning Liu, Dongwei Yuan, Wei Wang, Jifeng Fei, Sheng Li*. Two transcriptional cascades orchestrate cockroach leg regeneration. Cell Reports. 2024.43(3) 113889. DOI: 10.1016/j.celrep.2024.113889 Xiaoshuai Zhang# *, Lin Wei#, Wei Zhang, Feixue Zhang, Lin Li, Liang Li, Yejie Wen, Jiahui Zhang, Suning Liu, Dongwei Yuan, Yanmei Liu, Chonghua Ren*, Sheng Li*. ERK-activated CK-2 triggers blastema formation during appendage regeneration. Science Advances. 2024 10:adk8331 Henriette O’Geen#, Chonghua Ren#, Charles M. Nicolet, Andrew A. Perez, Julian Halmai, Victoria M. Le, Joel P. Mackay, Peggy J. Farnham and David J. Segal*. dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression. Nucleic Acids Research. 2017. DOI: 10.1093/nar/gkx578 (共同第一作者) (IF=19.16) Xingmei Mai#, Mingtao Liao#, Fangming Zhao#, Ethan Yihao Li, Fangzheng Liu, Renaguli Aisa, Sichen Wu, Nan Chen, Sheng Li*, Chonghua Ren*. Hox-determined appendage regeneration restores cockroach courtship rituals. SCIENCE CHINA-Life Sciences. 2024 In press Chonghua Ren#, Nan Chen#, Sheng Li*. Harnessing “Little Mighty” cockroaches：Pest management and beneficial utilization. The Innovation. 2023. 4(6).100531. (IF=33.1) Jiru Zhong#, Andi Jing#, Shaojuan Zheng, Sheng Li, Xiaoshuai Zhang* and Chonghua Ren*. Physiological and molecular mechanisms of insect appendage regeneration. Cell Regeneration. 2023 12:9 Liang Li#, Kai Cheng#, Jiru Zhong#, Shaojuan Zheng#, Chenjing Zhao, Yejie Wen, Sheng Li, and Chonghua Ren*. Protocol for high-resolution 3D visualization of insect regenerating legs through micro-computed tomography. STAR Protocols. 2024.5(4) 103342 Chonghua Ren#, Kun Xu#, David Jay Segal*, Zhiying Zhang*. Strategies for the enrichment and selection of genetically modified cells. Trends in Biotechnology. 37(1) 2019 pp. 56-71 (IF=21.942) Sheng Li#*, Shiming Zhu#, Qiangqiang Jia#, Dongwei Yuan#, Chonghua Ren#, Kang Li, Suning Liu, Yingying Cui, Haigang Zhao, Yanghui Cao, Gangqi Fang, Daqi Li, Xiaoming Zhao, Jianzhen Zhang, Qiaoyun Yue, Yongliang Fan, Xiao-Qiang Yu, Qili Feng, and Shuai Zhan*. The genomic and functional landscapes of developmental plasticity in the American cockroach. Nature Communications. 2018. DOI: 10.1038/s41467-018-03281-1 (共同第一作者) (IF=16.6) Chonghua Ren#, Kun Xu#, Zhongtian Liu, Juncen Shen, Furong Han, Zhilong Chen, Zhiying Zhang*. Dual-reporter surrogate systems for efficient enrichment of genetically modified cells. Cellular and Molecular Life Sciences. 2015. 72(14), p. 2773-4 (IF= 9.234) Kun Xu#, Chonghua Ren#, Zhongtian Liu, Tao Zhang, Tingting Zhang, Duo Li, Ling Wang, Qiang Yan, Lijun Guo, Juncen Shen, Zhiying Zhang*. Efficient genome engineering in eukaryotes using Cas9 from Streptococcus thermophilus. Cellular and Molecular Life Sciences. 72 (2) (2014), pp. 383-399 (共同第一作者) Liang Li#, Andi Jing#, Minxin Xie, Sheng Li, Chonghua Ren*. Applications of RNA interference in American cockroach. Journal of Visualized Experiments. 2021 Dec 17;(178). Zheng Zhao#, Liang Li#, Min Cheng#, Andi Jing, Suning Liu, Shiming Zhu, Erxia Du, Sheng Li, Yunxia Luan*, Chonghua Ren*. Grainy head signaling regulates epithelium development and ecdysis in Blattella germanica. Insect Science. 2021 Apr;28(2):485-494 Na Li#, Mei Zeng#, Huilu Xiao, Shuren Lin, Shuting Yang, Haixin Huang, Shiming Zhu, Zheng Zhao, Chonghua Ren*, Sheng Li*. Alteration of insulin and nutrition signal gene Expression or depletion of Met reduce both lifespan and reproduction in the German cockroach. Journal of Insect Physiology 2019 Oct;118:103934