个人简介
2013 NSF CAREER Award
2002-03 Eli Lilly Predoctoral Fellowship
2002 Certificate of Distinction in Teaching, Harvard University
1999-00 Eli Lilly Predoctoral Fellowship
1998 Vojislav Stojanovic Award for Outstanding Academic Achievement, University of Belgrade, Serbia
1994-98 National Fellowship for Talented Students in Arts and Sciences, Serbia
研究领域
Organic and Organometallic Chemistry
The main focus of the Lalic group is the development of practical transition-metal catalyzed transformations that address problems encountered in the synthesis of complex organic molecules. Our approach to reaction development will involve the synthesis of new transition-metal complexes, the systematic study of their reactivity, and the detailed exploration of reaction mechanisms. Finally, the utility of the transformations pioneered in our group will be demonstrated by the expedient total synthesis of complex organic molecules.
Our focus on both practical and fundamental aspects of reaction development provides an opportunity for students in the group to get training and expertise in various aspects of organometallic, physical organic, and synthetic organic chemistry.
Enantioselective Fragment Coupling Reactions
The development of catalytic cross-coupling and enantioselective functionalization reactions in the last thirty years has revolutionized organic synthesis. One of the current challenges in organometallic chemistry and organic synthesis is the development of transformations that lead to both the increase in molecular complexity through fragment coupling and the concomitant enantioselective functionalization. Developing transformations of this type, such as carbohydroxylation of alkenes, is one of the main goals of our research.
Transition Metal-Catalyzed Transformations of Strained Heterocycles
Strained heterocycles, being readily available and thermodynamically unstable, are ideal yet underexploited substrates in metal-catalyzed transformations. Our goal is to explore the opportunities these molecules provide and discover new transformations that will be useful in synthesis of complex organic molecules.
Natural Product Synthesis
The synthesis of natural products is an important part of our group's research. Our choice of target molecules allows us to test the scope and utility of our methodologies, and provides inspiration for new ones.
近期论文
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Whittaker, A. M.; Rucker, R. P.; Lalic, G. "Catalytic SN2'-Selective Substitution of Allylic Chlorides With Arylboronic Esters." Org. Lett. 2010, 12, 3216.
Lalic G.; Corey E. J. "An Effective Enantioselective Route to the Platensimycin Core." Org. Lett. 2007, 9, 4921.
Fox R. J.; Lalic G.; Bergman R. G. "Regio- and Stereospecific Formation of Protected Allylic Alcohols via Zirconium-Mediated SN2' Substitution of Allylic Chlorides." J. Am. Chem. Soc. 2007, 129, 14144.
Lalic G.; Blum S. A.; Bergman R. G. "Zirconium-Mediated SN2' Substitution of Allylic Ethers: Regio- and Stereospecific Formation of Protected Allylic Amines." J. Am. Chem. Soc. 2005, 127, 16790.
Magdziak D.; Lalic G.; Myung Lee H.; Fortner K. C.; Aloise, A. D.; Shair M. D. "Catalytic Enantioselective Thioester Aldol Reactions That are Compatible With Protic Functional Groups." J. Am. Chem. Soc. 2005, 127, 7284.
Xu K.; Lalic G.; Sheehan S. M.; Shair M. D. "Dynamic Kinetic Resolution during a Cascade Reaction on Substrates with Chiral All-Carbon Quaternary Centers." Angew. Chem., Int. Ed. 2005, 44, 2259.