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范瑞芳,女,河南省新乡人,博士,华南师范大学生命科学学院教授,博士研究生导师。 在国内外发表中英文论文50余篇,其中30篇被SCI及EI收录,“羧甲基聚合β-CD作为手性剂分离维拉帕米和布比卡因”一文获“第四届全国毛细管电泳及相关微分离分析技术学术报告会组委会”大会论文一等奖,曾获得华南师范大学科研工作优秀奖等荣誉,培养的多名研究生获得“广东省优秀学生”和“国家奖学金”等。 研究兴趣:(1)环境有机污染物生物监测与环境风险评价(2)环境污染物的毒理与健康效应。欢迎具有环境科学、生物技术、环境毒理学背景的学生报考研究生。 研究工作经历: 2014.12-今,华南师范大学生命科学学院,教授。 2010.09-2012.03,获国家留学基金委资助,赴美国加州公共卫生局(CaliforniaDepartmentofPublicHealth)访学一年半。 2006.12-2014.12,华南师范大学生命科学学院,副教授。 2001.12-2006.11,华南师范大学生命科学学院,助理研究员。 2000.03-2001.11,华南师范大学生命科学学院,实习研究员。 教育经历: 2004.03-2007.06,中科院广州地球化学研究所,博士。 1997.09-2000.02,北京理工大学,硕士。 1991.09-1995.06,河南师范大学,本科。 近5年主持/参与的国家、省部级基金项目有: [1]国家自然科学基金(21777048),2018.01-2021.12,64万元,主持,在研。 [2]国家自然科学基金重点项目(41731279),2018.01-2022.12,323万元,第一参与人/子课题负责人,在研。 [3]广州市科技计划项目(201510010107),20万,2015.06-2018.06,主持,结题。 [4]国家自然科学基金(21477041),87万元,2015.01-2018.12,主持,结题。 [5]广东省自然科学基金(S2013010013183),5万元,2013.10-2015.10,主持,结题。 [6]教育部留学回国人员科研启动基金(教外司留[2013]693号),3万元,2013.07-2015.07,主持,结题。 [7]教育部博士点基金(20124407120005),4万元,2012.12-2015.12,主持,结题。 [8]环境保护部全国重点地区环境与健康专项调查基金子课题(21111011101EHH(2011)-206),8万元,2011.07-2013.02,主持,结题。

近期论文

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【1】Effectsoflow-doseandperinatalexposuretobisphenolAonbraincellofoffspringmiceaswellasitsrelationshipswithalteredbehaviorofchildren,supportedbyNationalNaturalScienceFoundationofChina(grantNo.21777048),¥640,000,2017.01-2020.12. 【2】Effectsoflong-termandlow-doseexposuretobisphenolAonbraincellandbehaviorinseveralgenerationsofmiceduringperinatalperiod,supportedbytheGuangzhouKeyLaboratoryofEnvironmentalExposureandHealth(grantNo.GZKLEEH201607),¥50,000,2016.06-2018.06. 【3】RelationshipsbetweenpolycyclicaromatichydrocarbonexposurelevelsandDNAdamage,lungfunctionofchildren,supportedbyNationalNaturalScienceFoundationofChina(grantNo.21477041),¥870,000,2015.01-2018.12. 【4】EffectsofLong-termexposuretobisphenolAonbraincellandtheirrelationshipswiththechangeofchildrenbehavior,supportedbyScienceandTechnologyProgramofGuangzhou,China(grantNo.201510010107),¥200,000,2015.01-2017.12. 【5】RelationshipsbetweentheurinarybisphenolAexposureforkindergartenchildreninGuangzhou,theoxidativeDNAdamageandthedustconcentration,supportedbyNaturalScienceFoundationofGuangdong,China(grantNo.S2013010013183),¥50,000,2013.10-2015.10. 【6】PrimarystudyofaromaticcarcinogeniccompoundsinPM2.5airanditseffectsonchildreninGuangzhou,SupportedbyScientificResearchFoundationforReturnedScholars,MinistryofEducationofChina(grantNo.[2013]693),¥30,000,2013-2015. 【7】PrimarystudyofaromaticcarcinogeniccompoundsinPM2.5airanditseffectsonchildreninGuangzhou,supportedbyResearchFundfortheDoctoralProgramofHigherEducationofChina(grantNo.20124407120005),¥40,000,2013.0-2015.05. 【8】QA/QCsystemofthequantitationofhydroxylPAHinurine,supportedbyMinistryofEnvironmentalProtection,sub-fundingofenvironmentalhealthspecialsurveyofthekeyareaofChina(grantNo.21111011101EHH(2011)-206),¥80,000,2011.10-213.02. 【9】Children’sexposureleveltoPAHsinGuangzhouandtheirrelationshipswithDNAdamage,supportedbyOpenProjectofChinesestatekeylaboratoryoforganicchemistry(grantNoOGL-200706).¥20,000,2008.01-2009.12. 近年以通讯以及第一作者发表的代表性文章(Publicationsinthepastfiveyears): (1)HaibinZhang,ZhouyuWang,LingxueMeng,HongxuanKuang,JianLiu,XuejingLv,QihuaPang,RuifangFan*,MaternalexposuretoenvironmentalbisphenolAimpairstheneuronsinhippocampusacrossgenerations,Toxicology,2020,432:152393. (2)HongxuanKuang,YanyanDai,YonghongLi,CaihuiCha,WenhuiJiang,QihuaPang,HaibinZhang,RuifangFan*.TheassociationamongbloodBPDE-DNAadducts,seruminterleukin-8(IL-8)andoverallDNAdamageforchildrenwithpulmonarydisease.InternationalJournalofEnvironmentalHealthResearch,,2019,1-12.(SCI,IF=1.465) (3)HongxuanKuang,YonghongLi,WenhuiJiang,PeiqiongWu,JianhuaTan,HaibinZhang,QihuaPang,RuifangFan*.Simultaneousdeterminationofurinary31VOCmetabolites,8-hydroxy-2'-deoxyguanosineandtrans-3'-hydroxy-cotininebyUPLC-MS/MS:Theeffectofisotopedinternalstandardsoneliminationofmatrixeffect,AnalyticalandBioanalyticalChemistry,2019,411:7841-7855.(IF2018=3.286) (4)HaibingZhang,KuanghongXuan,YifanLuo,ShuhuaLiu,LingxueMeng,QihuaPang,RuifangFan*.Low-dosebisphenolAexposureimpairslearningandmemoryabilitywithalterationsofneuromorphologyandneurotransmittersinrats,ScienceoftheTotalEnvironment,2019,697:134036.(IF2018=5.589) (5)QihuaPang#,YanruLi#,LingxueMeng,GuanyongLi,ZhiweiLuo,RuifangFan*.NeurotoxicityofBPA,BPSandBPBforthehippocampalcellline(HT-22):animplicationforthereplaceofBPAinplastics,Chemosphere,2019,226:545-552.(SCI2018=5.108,2区) 6)邝洪轩,张海彬,谭建华,雒亦凡,刘舒华,庞启华,李楚华,范瑞芳*.维生素C抗氧化-同位素内标稀释-超高效液相色谱串联质谱法同时测定新生期大鼠海马体神经递质的含量,色谱,2019,37(4):404-411。 (7)LaiguoChen,GuochengHu,RuifangFan*,YanshanLv,YanyanDai,ZhenchengXu*.AssociationofPAHsandBTEXexposurewithlungfunctionandrespiratorysymptomsamongnon-occupationalpopulationnearthecoal-chemicalindustryinNorthernChina.EnvironmentInternational,2018,120:480-488.(SCI2018=7.943,1区) (8)YanruLi,HaibinZhang,HongxuanKuang,RuifangFan*,CaihuiCha*,GuanyongLi,ZhiweiLuo,QihuaPang.RelationshipbetweenBisphenolAexposureandAttention-deficit/hyperactivitydisorder:Acase-controlstudyforprimaryschoolchildreninGuangzhou,China.EnvironmentalPollution,2018,235:141-149.(SCI2018=5.714,2区) (9)YuanxiuZhou,ZhouyuWang,MinghanXia,SiyiZhuang,XiaobingGong*,JianwenPan,ChuhuaLi,RuifangFan*,QihuangPang,ShaoyouLu.NeurotoxicityoflowbisphenolA(BPA)exposureforyoungmalemice:AnimplicationforchildrenexposedtoenvironmentallevelofBPA,EnvironmentalPollution,2017,229:40-48.(SCI2017=4.358,2区) (10)YanshanLv#,ShaoyouLu#,YanyanDai,CaiyanRui,YongjunWang,YanruLi,YuanxiuZhou,QihuaPang,RuifangFan*.HigherdermalexposureofcashierstoBPAanditsassociationwithDNAoxidativedamage,EnvironmentInternational,2017,98:69-74.SCI2017=7.297,1区). (11)YanshanLv,CaiyanRui,YanyanDai,QihuaPang,YanruLi,RuifangFan*,ShaoyouLu*.ChildrenexposuretoBPAthroughdustandtheassociationofurinaryBPA,triclosanwithoxidativestressinGuangzhou,China.EnvironmentalScience:processes&impact,2016,18:1492-1499.(SCI,IF2016=2.592) (12)ShaoyouLu,LuRen,JianzhangFang,JiajiaJi,GuihuaLiu,JianqingZhang,HuiminZhang,RuorongLuo,KaiLin,RuifangFan*.Traceelementscanincreaseurinary8-hydroxy-2’-deoxyguanosinelevel:acasestudyofcollegestudentsinGuangzhou,China.EnvironmentalScienceandPollutionResearch,2016,23:8484–8491.(SCI,IF2016=2.741) (13)周苑秀,李敏杰,钟伟红,范瑞芳*.彗星电泳法测定双酚A对雄性小鼠脑细胞的DNA损伤.生态毒理学报,2016,11(2):666-671。 (14)JunnanLi#,ShaoyouLu#,GuihuaLiu,YuanxiuZhou,YanShanLv,JianwenShe,RuifangFan*.Co-exposuretopolycyclicaromatichydrocarbons,benzeneandtolueneandtheirdose-effectsonoxidativestressdamageinkindergarten-agedchildreninGuangzhou,China.ScienceoftheTotalEnvironment,2015,524-525:74-80.(SCI,IF2015=4.099,2区). (15)RuifangFan*,BiyanZeng,XiaosuLiu,ChaoChen,QinweiZhuang,YongjunWang,MingliHu,YanshanLv,JunnanLi,YuanxiuZhou,ZhiYuan(William)Lin.Levelsofbisphenol-AindifferentpaperproductsinGuangzhou,Chinaandassessmentofhumanexposureviadermalcontact.EnvironmentalScience:Processes&Impacts,2015,17:667-673.(SCI,IF2015=2.401) (16)RuifangFan*,DongliWang,JianwenShe.Methoddevelopmentforthesimultaneousanalysisoftrans,trans-muconicacid,1,2-dihydroxybenzene,S-phenylmercapturicacidandS-benzylmercapturicacidinhumanurinebyliquidchromatography/tandemmassspectrometery.AnalyticalMethods,2015,7:573-580.(SCI,IF2015=1.821) (17)JunnanLi,RuifangFan*,ShaoyouLu*,DongruZhang,YuanxiuZhou,YanshanLv.ExposuretoPolycyclicAromaticHydrocarboncouldcausetheiroxidativeDNADamage:ACaseStudyforCollegeStudentsinGuangzhou,China.EnvironmentalScienceandPollutionResearch,2015,22:1770-1777.(SCI,IF2015=2.828) (18)RuifangFan,JunnanLi,LaiguoChen*,ZhenchengXu*,DechunHe,YuanxiuZhou,YuanyuanZhu,FushengWei,JihuaLi.Biomassfuelsandcokeplantsareimportantsourcesofhumanexposuretopolycyclicaromatichydrocarbons,benzeneandtoluene.EnvironmentalResearch,2014,135:1–8.(SCI,IF2014=4.373) (19)RuifangFan*,DongliWang,ChuanweiMao,ShangkangOu,ZhixiaLian,ShaolingHuang,QiongshanLin,RunhaoDing,JianwenShe.Preliminarystudyofchildren’sexposuretoPAHsanditsassociationwith8-hydroxy-2’-deoxyguanasineinGuangzhou,China.EnvironmentInternational,2012,42:53-58.(SCI,IF2012=6.248) (20)RuifangFan,RobertRamage,DongliWang,JunqiangZhou,JianwenShe*.Determinationoftenmonohydroxylatedpolycyclicaromatichydrocarbonsbyliquid-liquidextractionandliquidchromatography/tandemmassspectrometry.Talanta,2012,93:383-395.(SCI,IF2012=3.498) (21)RuifangFan,DongliWang,RobertRamage,JianwenShe*.Fastandsimultaneousdeterminationofurinary8-hydroxy-2'-deoxyguanosineandtenmonohydroxylatedpolycyclicaromatichydrocarbonsbyliquidchromatography/tandemmassspectrometery.ChemicalResearchinToxicology,2012,25(2)491-499.(SCI,IF2012=3.667.)

学术兼职

任广东省环境诱变剂协会理事,长期担任EnvironmentInternational,EnvironmentalScience&Technology,ScienceofTotalEnvironment,EnvironmentalResearch,ScientificReports,Chemosphere等杂志的审稿人。

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