个人简介

David and Lucille Packard Fellowship in Science and Engineering 2008 Camille and Henry Dreyfus Foundation New Faculty Award 2007 Miller Research Fellowship 2004 Lester Wolfe Graduate Fellowship 2002 Outstanding Teaching Assistant Award 1999 McGregory Fellowship for graduate study in chemistry 1998 Phi Beta Kappa 1997

研究领域

Physical Chemistry

The Khalil group aims to understand the ultrafast structural dynamics of light-driven chemical and biological processes in solution. We study how transient molecular configurations on relevant electronic surfaces and their interactions with the surrounding solvent dictate the course of chemical reactions. Our goal is to design experiments that are sensitive to the details of the electronic and atomic structural rearrangements as the reaction of interest evolves over decades in time. Current problems of interest include: (i) mapping intra and inter-molecular vibrational phase and energy relaxation on excited electronic states during charge transfer processes and photolysis in solution; (ii) deciphering the electronic and structural basis for light-induced molecular changes in coordination compounds in the condensed phase; and (iii) unraveling the complex interactions between natural chromophores and their protein hosts that leads to optical signals being converted to large scale atomic motions. These problems are important both from a basic science perspective and for designing new materials and molecular devices. To study these problems, we use and develop multidimensional vibrational and electronic spectroscopies along with ultrafast x-ray absorption spectroscopy. Multidimensional spectroscopy probes time-dependent vibrational and electronic couplings and relative orientations between interacting chemical moieties. These observables quantify physical parameters of the chemical system, such as conformational heterogeneity, phase and energy relaxation dynamics and solute-solvent interactions. Ultrafast x-ray absorption spectroscopy is an ideal tool for understanding local time-dependent phenomena accompanying chemical processes in solution as it provides element-specific information about electronic and structural rearrangements with sub-angstrom resolution. The x-ray experiments are performed at the Advanced Light Source located at Lawrence Berkeley National Laboratory.

近期论文

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H. S. Chung, M. Khalil, A. W. Smith, and A. Tokmakoff. "A transient 2D IR spectrometer for probing nanosecond temperature-jump kinetics." Review of Scientific Instruments 78: 063101 (2007). Loh, Z. H., M. Khalil, R. E. Correa, R. Santra, C. Buth, and S. R. Leone. "Quantum State-Resolved Probing of Strong-Field-Ionized Xenon Atoms Using Femtosecond High-Order Harmonic Transient Absorption Spectroscopy." Physical Review Letters 98: 1436011-14 (2007). M. Khalil, M. A. Marcus, A. L. Smeigh, J. K. McCusker, H. H. W. Chong, and R. W. Schoenlein. "Picosecond X-Ray Absorption Spectroscopy of Photochemical Transient Species in Solution." Springer Series in Chemical Physics 88: 722 (2007). A. Cavalleri, S. Wall, M. Rini, C. Simpson, N. Dean, M. Khalil, E. Statz, D. Ward, K. A. Nelson, and R. W. Schoenlein. "Lattice Motions from Thz Phonon-Polaritons Measured with Femtosecond X-Ray Diffraction." Springer Series in Chemical Physics 88: 716 (2007). M. Khalil, M. A. Marcus, A. L. Smeigh, J. K. McCusker, H. H. W. Chong, and R. W. Schoenlein. "Picosecond X-Ray Absorption Spectroscopy of a Photoinduced Iron(II) Spin Crossover Reaction in Solution." Journal of Physical Chemistry A 110: 38-44 (2006). H. S. Chung, M. Khalil, A. W. Smith, Z. Ganim, and A. Tokmakoff. "Conformational Changes During the Nanosecond-to-Millisecond Unfolding of Ubiquitin." Proceedings Of The National Academy Of Sciences Of The United States Of America 102: 612-17 (2005). H. S. Chung, M. Khalil, A. W. Smith, Z. Ganim, and A. Tokmakoff. "Thermal Denaturing of Proteins: Equilibrium and Transient Studies Using Nonlinear Infrared Probes." Springer Series in Chemical Physics 79: 551-53 (2005). H. S. Chung, M. Khalil, and A. Tokmakoff. "Nonlinear Infrared Spectroscopy of Protein Conformational Change During Thermal Unfolding." Journal Of Physical Chemistry B 108: 15332-42 (2004). N. Demirdöven, C. M. Cheatum, H. S. Chung, M. Khalil, J. Knoester, and A. Tokmakoff. "Two-Dimensional Infrared Spectroscopy of Antiparallel Beta-Sheet Secondary Structure." Journal Of The American Chemical Society 126: 7981-90 (2004). M. Khalil, N. Demirdöven, and A. Tokmakoff. "Vibrational Coherence Transfer Characterized with Fourier-Transform 2D IR Spectroscopy." Journal Of Chemical Physics 121: 362-73 (2004). Demirdöven, N., M. Khalil, and A. Tokmakoff. "Correlated Vibrational Dynamics in Solution Studied by Two-Dimensional Fourier Transform Infrared Spectroscopy." Springer Series in Chemical Physics 71: 589-91 (2003). M. Khalil, N. Demirdöven, and A. Tokmakoff. "Coherent Two-Dimensional Fourier Transform Infrared Spectroscopy." Springer Series in Chemical Physics 71: 583-85 (2003). M. Khalil, N. Demirdöven, and A. Tokmakoff. "Coherent 2D IR Spectroscopy: Molecular Structure and Dynamics in Solution." Journal Of Physical Chemistry A 107: 5258-79 (2003). M. Khalil, N. Demirdöven, and A. Tokmakoff. "Obtaining Absorptive Line Shapes in Two-Dimensional Infrared Vibrational Correlation Spectra." Physical Review Letters 90: 474011-14 (2003). N. Demirdöven, M. Khalil, O. Golonzka, and A. Tokmakoff. "Dispersion Compensation with Optical Materials for Compression of Intense Sub-100-Fs Mid-Infrared Pulses." Optics Letters 27: 433-35 (2002). N. Demirdöven, M. Khalil, and A. Tokmakoff. "Correlated Vibrational Dynamics Revealed by Two-Dimensional Infrared Spectroscopy." Physical Review Letters 89: 2374011-14 (2002). Golonzka, O., M. Khalil, N. Demirdöven, and A. Tokmakoff. "Third-Order Nonlinear Spectroscopy of Coupled Vibrations." ACS Symposium Series 820: 169-81 (2002). N. Demirdöven, M. Khalil, O. Golonzka, and A. Tokmakoff. "Correlation Effects in the Two-Dimensional Vibrational Spectroscopy of Coupled Vibrations." Journal Of Physical Chemistry A 105: 8025-30 (2001) . Golonzka, O., M. Khalil, N. Demirdöven, and A. Tokmakoff. "Coupling and Orientation between Anharmonic Vibrations Characterized with Two-Dimensional Infrared Vibrational Echo Spectroscopy." Journal Of Chemical Physics 115: 10814-28 (2001). Golonzka, O., M. Khalil, N. Demirdöven, and A. Tokmakoff. "Vibrational Anharmonicities Revealed by Coherent Two-Dimensional Infrared Spectroscopy." Physical Review Letters 86: 2154-57 (2001).