个人简介

American Association for the Advancement of Sciences (AAAS) Fellow Arthur C. Cope Scholar Award Fellow of the Alfred P. Sloan Foundation Searle Scholar National Science Foundation Predoctoral Fellow

研究领域

Organic and Bioorganic Chemistry

Bioorganic chemistry is the chemistry of life. The Hopkins’ group brings the experimental techniques and theories of modern organic chemistry to bear on problems of structure and reactivity involving Nature’s molecules. Current projects probe the secrets of Nature’s most magnificent molecules, the proteins and nucleic acids. The small molecules that have predominated in the history of organic chemistry as a discipline invariably play pivotal roles in the projects. Students in Hopkins’ group are exposed to a variety of experimental and theoretical techniques, and learn to think about problems from a variety of perspectives. Electron paramagnetic resonance, gel electrophoresis, and automated solid phase synthesis are as likely to be used as the thin layer chromatography plate or infrared spectrometer of classical organic chemistry. It is no coincidence that so many organic chemists are exploring biological problems: it is a field of great excitement!

近期论文

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"Monitoring DNA Dynamics Using Spin-Labels With Different Independent Mobilities.", E. J. Hustedt, J. J. Kirchner, A. Spaltenstein, P. B. Hopkins and B. H. Robinson, Biochemistry, 34 4369 (1995). "FR66979 Requires Reductive Activation to Cross-Link DNA Efficiently.", H. Huang, S. R. Rajski, R. M. Williams, and P. B. Hopkins, Tetrahedron Lett., 35 9669 (1995). "DNA-DNA Interstrand Cross-Linking by cis-Diamminedichloroplatinum(II): N7(dG)-to-N7(dG) Cross-Linking at 5'-d(GC) in Synthetic Oligonucleotides.", H. Huang, J. Woo, S. C. Alley and P. B. Hopkins, Bioorg. Med. Chem., 3 659 (1995). (invited contribution) "A Probe for Sequence-Dependent Nucleic Acid Dynamics.", T. R. Miller, S. C. Alley, A. Reese, M. S. Solomon, W. McCallister, C. Mailer, B. H. Robinson, and P. B. Hopkins, J. Am. Chem. Soc., 117 9377 (1995). "Direct Evidence for DNA-DNA Intrastrand Cross-Linking at 5'-d(GG) by Mechlorethamine.", S. M. Rink and P. B. Hopkins, Bioorg. Med. Chem. Lett., 5 2845 (1995). "An NMR Study of [d(CGCGAATTCGCG)]Containing an Interstrand Cross-Link Derived from a Distamycin-Pyrrole Conjugate.", P. A. Fagan, H. P. Spielmann, S. Th. Sigurdsson, S. M. Rink, P. B. Hopkins, and D. E. Wemmer, Nucleic Acids Res., 24 1566 (1996). "Solution Structure of a Cisplatin-Induced DNA Interstrand Cross-Link.", H. Huang, L. Zhu, B. R. Reid, G. P. Drobny and P. B. Hopkins, Science, 270 1842 (1995). "Bending of DNA by the Mitomycin C-Induced, GpG Intrastrand Cross-Link.", S. M. Rink, R. Lipman, S. C. Alley, P. B. Hopkins, and M. Tomasz, Chem. Res. Toxicol., 9 382 (1996). "DNA-DNA Interstrand Cross-Linking by FR66979 and FR900482: Requirement of Metal Ions During Reductive Activation.", M. M. Paz and P. B. Hopkins, Tetrahedron Lett. 38 343 (1997). "DNA-DNA Interstrand Cross-Linking by FR66979: Intermediates in the Activation Cascade.", M. M. Paz and P. B. Hopkins, J. Am. Chem. Soc., 119 5999 (1997). "Synthesis of Duplex DNA Containing a Rigidly Spin-Labeled Analogue of 2'-Deoxycytidine.", P. L. Fischhaber, A. W. Reese, T. Nguyen, J. J. Kirchner, E. J. Hustedt, B. H. Robinson, and P. B. Hopkins, Nucleosides and Nucleotides, 16 365 (1997). "Effect of Nucleosome Structure on DNA Interstrand Cross-Linking Reactions.", J. T. Millard, R. J. Spencer, and P. B. Hopkins, Biochemistry, 37 5211 (1998). "Chemical Synthesis and Preliminary Structural Characterization of a Nitrous Acid Interstrand Cross-Linked Duplex DNA.", E. A. Harwood, S. Th. Sigurdsson, N. B. F. Edfeldt, B. R. Reid, and P. B. Hopkins, J. Am. Chem. Soc., 121 5081 (1999). "Quantification of Formaldehyde-Mediated Covalent Adducts of Adriamycin with DNA.", R. A. Luce, S. Th. Sigurdsson, and P. B. Hopkins, Biochemistry, 38 8682 (1999). "Direct Demonstration in Synthetic Oligonucleotides that BCNU Cross-Links N1 of Deoxyguanosine to N3 of Deoxycytidine on Opposite Strands of Duplex DNA.", P. L. Fischhaber, A. S. Gall, J. A. Duncan, and P. B. Hopkins, Cancer Research, 59 4363 (1999). "Monoalkylation of DNA by Reductively Activated FR66979.", M. M. Paz, S. Th. Sigurdsson, and P. B. Hopkins, Bioorg. Med. Chem., 8 173 (2000). "Flexibility of Duplex DNA on the Submicrosecond Timescale.", T.M. Okonogi, A. W. Reese, S. C. Alley, P. B. Hopkins, B. H. Robinson, Biophys. J., 77 3256 (1999). "Sequence-Dependent Dynamics in Duplex DNA.", T.M. Okonogi, S. C. Alley, A. W. Reese, P. B. Hopkins, B. H. Robinson, Biophys. J., 78 2560 (2000). "Chemical Synthesis of Cross-Link Lesions Found in Nitrous Acid Treated DNA: A General Method for the Preparation of N2-Substituted 2'-Deoxyguanosines.", E. A. Harwood, P. B. Hopkins, S. Th. Sigurdsson, J. Org. Chem., 65 2959 (2000). "Chemical Cross-Linking of Drugs to DNA.", R. A. Luce and P. B. Hopkins, Methods Enzymol., 340 396 (2001).