个人简介
09/2010–07/2014中国科学技术大学化学与材料科学学院,化学物理,学士
09/2014–12/2014新加坡南洋理工大学数理学院,研究助理
01/2015–06/2019新加坡南洋理工大学数理学院,生物物理,博士
08/2019–现在电子科技大学生命科学与技术学院,讲师
09/2019–现在新加坡南洋理工大学化学与生物医学工程学院,博士后
近期论文
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1.L.X.Yang,Z.S.Zhong,C.L.Tong,H.Jia,Y.R.Liu,G.Chen.(2018)Single-MoleculeMechanicalFoldingandUnfoldingofRNAHairpins:EffectsofSingleA-UtoA∙CPairSubstitutionsandSingleProtonBindingandImplicationsformRNAStructure-Induced−1RibosomalFrameshifting.JAmChemSoc,140,8172-8184.
2.J.Z.Tan,=L.X.Yang,=A.A.L.Ong,J.H.Shi,Z.S.Zhong,M.L.Lye,S.Y.Liu,J.Lisowiec-Wachnicka,R.Kierzek,X.Roca,G.Chen.(2019)ADisease-CausingIntronicPointMutationC19GAltersTauExon10SplicingviaRNASecondaryStructureRearrangement.Biochemistry,58,1565-1578.(=Theseauthorscontributedequallytothiswork).
3.J.Kesy,K.M.Patil,S.R.Kumar,Z.Shu,H.Y.Yong,L.Zimmermann,A.A.L.Ong,D.K.Toh,M.S.Krishna,L.X.Yang,J.L.Decout,D.Luo,M.Prabakaran,G.Chen,E.Kierzek.(2019)AShortChemicallyModifieddsRNA-BindingPNA(dbPNA)InhibitsInfluenzaViralReplicationbyTargetingViralRNAPanhandleStructure.BioconjugChem,30,931-943.
4.R.Y.Puah,=H.Jia,=M.Maraswami,=D.F.K.Toh,=R.Ero,=L.X.Yang,K.M.Patil,A.A.L.Ong,M.S.Krishna,R.M.Sun,C.L.Tong,M.Huang,X.Chen,T.P.Loh,Y.G.Gao,D.X.Liu,andG.Chen.(2018)SelectiveBindingtomRNADuplexRegionsbyChemicallyModifiedPeptideNucleicAcidsStimulatesRibosomalFrameshifting.Biochemistry,57,149-159.(=Theseauthorscontributedequallytothiswork).
5.Z.S.Zhong,L.X.Yang,H.P.Zhang,J.H.Shi,J.J.Vandana,D.T.Lam,R.C.L.Olsthoorn,L.Y.Lu,andG.Chen.(2016)MechanicalunfoldingkineticsoftheSRV-1gag-promRNApseudoknot:possibleimplicationsfor−1ribosomalframeshiftingstimulation.SciRep,6,39549.