刘贻尧 - 电子科技大学 - 生命科学与技术学院

个人简介

1994/09－1998/07重庆大学材料科学与工程学院，材料工程，学士 1998/09－2001/07重庆大学生物工程学院，生物医学工程，硕士 2001/09－2004/09日本群马大学生物化学工程系，生物物理，博士 2004/09－2008/07电子科技大学生命科学与技术学院，副教授 2005/12－2007/09日本德岛大学医学部，博士后 2009/12－2017/12电子科技大学生命科学与技术学院，副院长 2014/07－2014/08德国卡尔斯鲁厄理工学院(KIT)，访问教授 2008/07－至今电子科技大学生命科学与技术学院，教授/博士生导师教学工作本科生：分子生物学（双语教学）研究生：生物力学与组织工程学

研究领域

1.肿瘤细胞力学与细胞信号转导 2.肿瘤微纳医学工程与分子成像

近期论文

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01.LiT,ShenX,XieX,ChenZ,LiS,QinX,YangH,WuC,LiuY*.(2018)Irinotecan/IR-820co-loadedhollowmesoporoussilicananoparticlesasaplatformforcombinationalchemotherapyandphotothermaltherapyoftumor.Nanomedicine.(accepted,inpress) 02.ZhangJ,LiL,PengY,ChenY,LiS,QinX,YangH,WuC,LiuY*.(2018)Surfacechemistryinducesmitochondria-mediatedapoptosisofbreastcancercellsviaPTEN/PI3K/AKTsignalingpathway.BiochimicaetBiophysicaActa(BBA)-MolecularCellResearch.1865:172-185. 03.YangH,ZhangC,LiT,ShenX,ChenZ,XieX,LiS,QinX,WuC,LiuY*.(2017)Rationaldesignofmultifunctionalpolymericmicelleswithstimuli-responsivepropertyforimaging-guidedcombinationcancertherapy.JournalofBiomedicalNanotechnology.13(10):1221-1234. 04.LiL,TangP,LiS,QinX,YangH,WuC,LiuY*.(2017)Notchsignalingpathwaynetworksincancermetastasis:anewtargetforcancertherapy.MedicalOncology.34:180.doi:10.1007/s12032-017-1039-6.(invitedreview). 05.LiS,LuJ,ChenY,XiongN,LiL,ZhangJ,YangH,WuC,ZengH,LiuY*.(2017)MCP-1-triggeredERK/GSK-3beta/Snailpathwayfacilitatesepithelial-mesenchymaltransitionandpromotescellmigrationofhumanbreastcarcinomaMCF-7cells.Cellular&MolecularImmunology.14:621-630. 06.ShenX,LiT,ChenZ,GengY,XieX,LiS,YangH,WuC,LiuY*.(2017)PLGA-basedluminescent/magnetichybridnanocomposites:aversatilenanocarriersystemfortargeteddrug/genedeliveryanddual-modalityimagingincancertheranostics.InternationalJournalofNanomedicine.12:4299-4322. 07.ZhangG,FanN,LvX,LiuY,GuoJ,YangL,PengB*,JiangH*.(2017)Investigationofthemechanicalpropertiesofhumanosteosarcomacellatdifferentcellcyclestages.Micromachines.8(3),89;DOI:10.3390/mi8030089. 08.YangH,ChenY,ChenZ,GengY,ShenX,LiT,LiS,WuC,LiuY*.(2017)Chemo-photodynamiccombinedgenetherapyanddual-modalcancerimagingachievedbypH-responsivealginate/chitosanmultilayers-modifiedmagneticmesoporoussilicananocomposites.BiomaterialsScience.5:1001-1013. 09.WuC,LiD,WangL,GuanX,TianY,YangH,LiS,LiuY*.(2017)Singlewavelengthlight-mediated,synergisticbimodalcancerphotoablationandamplifiedphotothermalperformancebygraphene/goldnanostar/photosensitizertheranostics.ActaBiomaterialia.53:631-642. 10.XiongN,LiS,TangK,BaiH,PengY,YangH,WuC,LiuY*.(2017).Involvementofcaveolin-1inlowshearstress-inducedbreastcancercellmotilityandadhesion:rolesofFAK/SrcandROCK/p-MLCpathways.BiochimicaetBiophysicaActa(BBA)-MolecularCellResearch.1864:12-22. 11.JiangY,SverdlovMS,TothPT,HuangL,DuG,LiuY,NatarajanV,MinshallRD*.(2016)PhosphatidicacidproducedbyRalA-activatedPLD2stimulatescaveolae-mediatedendocytosisandtraffickinginendothelialcells.JournalofBiologicalChemistry.291:20729-20738. 12.GaoZ,LiT,XuX,LiuY,LuoH*,LiN*.(2016)Greenlight-emittingpolyepinephrine-basedfluorescentorganicdotsanditsapplicationinintracellularmetalionssensing.BiosensorsandBioelectronics.83:134-141. 13.LiT,ShenX,GengY,ChenZ,LiL,LiS,YangH,WuC,ZengH,LiuY*.(2016)Folate-functionalizedmagnetic-mesoporoussilicananoparticlesfordrug/geneco-deliverytopotentiatetheantitumorefficacy.ACSAppliedMaterials&Interfaces.8:13748-13758. 14.YangH,XuM,ShenX,LiT,YanJ,ZhangC,WuC,ZengH,LiuY*.(2016)Chitosanhybridnanoparticlesasatheranosticplatformfortargeteddoxorubicin/VEGFshRNAco-deliveryanddual-modalityfluorescenceimaging.RSCAdvances.6:29685-29696. 15.YangH,GuanL,LiS,JiangY,XiongN,LiL,WuC,ZengH,LiuY*.(2016)Mechanosensitivecaveolin-1activation-inducedPI3K/Akt/mTORsignalingpathwaypromotesbreastcancermotility,invadopodiaformationandmetastasisinvivo.Oncotarget.7(13):16227-16247. 16.LiL,ZhangJ,XiongN,LiS,ChenY,YangH,WuC,ZengH,LiuY*.(2016)Notch-1signalingactivatesNF-BinhumanbreastcarcinomaMDA-MB-231cellsviaPP2A-dependentPI3K/AKTpathway.MedicalOncology.33:33.DOI:10.1007/s12032-016-0747-7. 17.WuM,LiT,ChenL,PengS,LiaoW,BaiR,ZhaoX,YangH,WuC,ZengH,LiuY*.(2016)EssentialoilsfromInulajaponicaandAngelicaedahuricaeenhancesensitivityofMCF-7/ADRbreastcancercellstodoxorubicinviamultiplemechanisms.JournalofEthnopharmacology.180:18-27. 18.WuC,ZhuA,LiD,WangL,YangH,ZengH,LiuY*.(2016)Photosensitizer-assembledPEGylatedgraphene-coppersulfidenanohybridsasasynergisticnear-infraredphototherapeuticagent.ExpertOpiniononDrugDelivery.13:155-165. 19.YangH,DengL,LiT,ShenX,YanJ,ZuoL,WuC,LiuY*.(2015)MultifunctionalPLGAnanobubblesastheranosticagents:CombiningdoxorubicinandP-gpsiRNAco-deliveryintohumanbreastcancercellsandultrasoundcellularimaging.JournalofBiomedicalNanotechnology.11:2124-2136. 20.LiS,ZhangJ,YangH,WuC,DongX,LiuY*.(2015)CopperdepletioninhibitsCoCl2-inducedaggressivephenotypeofMCF-7cellsviadownregulationofHIF-1andinhibitionofSnail/Twist-mediatedepithelial-mesenchymaltransition.ScientificReports.5:12410;DOI:10.1038/srep12410. 21.ZengH,AgyapongD.A.Y,LiC,ZhaoR,YangH,WuC,JiangY,LiuY*.(2015)Acarcinoembryonicantigenoptoelectronicimmunosensorbasedonthiol-derivative-nanogoldlabeledanti-CEAantibodynanomaterialandgoldmodifiedITO.Sensors&ActuatorsB:Chemical.221:22-27. 22.LiT,ShenX,ChenY,ZhangC,YanJ,YangH,WuC,ZengH,LiuY*.(2015)Polyetherimide-graftedFe3O4@SiO2nanoparticlesastheranosticagentsforsimultaneousVEGFsiRNAdeliveryandMRimaging.InternationalJournalofNanomedicine.10:4279-4291. 23.WuC,HeQ,ZhuA,LiD,XuM,YangH,LiuY*.(2014)Synergisticanticanceractivityofphoto-andchemo-responsivenanoformulationbasedonpolylysine-functionalizedgraphene.ACSAppliedMaterials&Interfaces.6(23):21615-21623. 24.YangH(#),LiY(#),LiT,XuM,ChenY,WuC,LiuY*.(2014)Multifunctionalcore/shellNotch-1siRNAcarrierfortargetedkillingofbreastcancer.ScientificReports.4:7072;DOI:10.1038/srep07072. 25.LiL,ZhaoF,LuJ,LiT,YangH,WuC,LiuY*.(2014)Notch-1signalingpromotesthemalignantfeaturesofhumanbreastcancerthroughNF-kBactivation.PLoSONE.9(4):e95912. 26.ZhaoF,LiL,GuanL,YangH,WuC,LiuY*.(2014)RolesofGPIIb/IIIaandαvβ3integrinsinMDA-MB-231cellinvasionandshearflow-inducedcancercellmechanotransduction.CancerLetters.344:62-73. 27.DengL,LiL,YangH,LiL,ZhaoF,WuC,LiuY*.(2014)DevelopmentandoptimizationofdoxorubicinloadedPLGAnanobubblesfordrugdeliveryintoHeLacells.JournalofNanoscienceandNanotechnology.14:2947-2954. 28.WuC*,HeQ,ZhuA,YangH,LiuY*.(2014)Probingtheproteinconformationandadsorptionbehaviorsinnanographeneoxide-proteincomplexes.JournalofNanoscienceandNanotechnology.14:2591-2598. 29.YangH,ShiM,XuM,LiY,WuC,LiuY*.(2013)Multifunctionalsilicananoparticlesastheranosticagents:combiningVEGFgenedeliveryanddual-modalitycellularimaging.JournalofControlledRelease.172(1):e120-e121. 30.YangH,ZhaoF,LiY,XuM,LiL,WuC,MiyoshiH,LiuY*.(2013)VCAM-1-targetedcore/shellnanoparticlesforselectiveadhesionanddeliverytoendothelialcellswithlipopolysaccharide-inducedinflammationundershearflowandcellularmagneticresonanceimaginginvitro.InternationalJournalofNanomedicine.8:1897-1906. 31.LiuY*,ShiM,XuM,YangH,WuC.(2012)MultifunctionalnanoparticlesofFe3O4@SiO2(FITC)/PAHconjugatedtherecombinantplasmidofpIRSE2-EGFP/VEGF165withdualfunctionsforgenedeliveryandcellularimaging.ExpertOpiniononDrugDelivery.9(10):1197-1207. 32.YangH,ZhangL,XiongX,LiuY*.(2011)SpecificadhesionandaccumulationofVCAM-1-targetedultrasoundmicrobubblestoinflammatoryendothelialcellsunderhemodynamicshearflowsimulation.JournalofControlledRelease.152(s1):e227-e229. 33.ShiM,LiuY*,XuM,YangH,WuC,MiyoshiH.(2011)Core/shellFe3O4@SiO2nanoparticlesmodifiedwithPAHasavectorforEGFPplasmidDNAdeliveryintoHeLacells.MacromolecularBioscience.11:1563-1569. 34.YangH(#),LouC(#),XuM,WuC,MiyoshiH,LiuY*.(2011)Investigationoffolateconjugatedfluorescentsilicananoparticlesfortargetingdeliverytofolatereceptor-positivetumorsandtheirinternalizationmechanism.InternationalJournalofNanomedicine.6:2023-2032. 35.YangH,XiongX,ZhangL,WuC,LiuY*.(2011)Adhesionofbio-functionalizedultrasoundmicrobubblestoendothelialcellsbytargetingtovascularcelladhesionmolecule-1undershearflow.InternationalJournalofNanomedicine.6:2043-2051. 36.LiuY*,LouC,YangH,ShiM,MiyoshiH.(2011)Silicananoparticlesaspotentialdrug/genedeliverycarriersandfluorescentnano-probes:recentadvances.CurrentCancerDrugTargets.11:156-163. 37.XiongX,ZhaoF,ShiM,YangH,LiuY*.(2011)Polymericmicrobubblesforultrasonicmolecularimagingandtargetedtherapeutics.JournalofBiomaterialsScience-PolymerEdition.22:417-428. 38.MengG,LiuY*,LouC,YangH.(2010)Emodinsuppresseslipopolysaccharide-inducedpro-inflammatoryresponsesandNF-kBactivationbydisruptinglipidraftsinCD14-negativeendothelialcells.BritishJournalofPharmacology.161:1628-1644. 39.YangH,LiuZ,LiuY*,LouC,RenZ,MiyoshiH.(2010)Vasculargenetransferanddrugdeliveryinvitrousinglowfrequencyultrasoundandmicrobubbles.ActaPharmacologicaSinica.31:515-522. 40.YangH,MiyoshiH,LouC,RenZ,LiuY*.(2010)Preparation,characterizationandreleaseofmethylviologenfromanovelnanoparticledeliverysystemwithdoubleshellsofsilicaandPLGA.ChineseScienceBulletin.55:263-267. 41.LiuY*,ZhaoF,GuW,YangHS,MengQ,ZhangY,YangH,DuanQ.(2009)TheRolesofPlateletGPIIb/IIIaandαvβ3integrinsduringHeLacellsadhesion,migration,andinvasiontomonolayerendotheliumunderstaticanddynamicshearflow.JournalofBiomedicineandBiotechnology.DOI:10.1155/2009/829243. 42.MiyoshiH,*MatsuoY,LiuY*,SakataT,MoriH.(2009)Behaviorsofthefluorescentmoleculesboundtotheinteriorofthesilicananocapsulesinvarioussolvents.JournalofColloidandInterfaceScience.331:507-513. 43.YangH,LiK,LiuY*,LiuZ,MiyoshiH.(2009)Poly(D,L-lactide-co-glycolide)nanoparticlesencapsulatedfluorescentisothiocyanateandpaclitaxol:preparation,releasekineticsandanticancereffect.JournalofNanoscienceandNanotechnology.9:282-287. 44.LiuY*,MiyoshiH.(2008)Preparationandcharacterizationofnoveldrugdeliverysystemoflight-sensitivesilicananocapsuleswiththinshells.JournalofBiomedicalNanotechnology.4:25-32. 45.GuoZ,CaiSX,FangR,ChenH,DuJ,TanY,MaW,HuH,CaiSH,LiuY*.(2007)ThesynergisticeffectsofCXCR4andEGFRonpromotingEGF-mediatedmetastasisinovariancancercells.ColloidsandSurfacesB:Biointerfaces.60:1-6. 46.LiuY*,MiyoshiH,NakamuraM.(2007)Nanomedicinefordrugdeliveryandimaging:apromisingavenueforcancertherapyanddiagnosisbytargetedfunctionalnanoparticles.InternationalJournalofCancer.120:2527-2537. 47.LiuY*,MiyoshiH,NakamuraM.(2007)Noveldrugdeliverysystemofhollowmesoporoussilicananocapsuleswiththinshells:Preparationandfluoresceinisothiocyanate(FITC)releasekinetics.ColloidsandSurfacesB:Biointerfaces.58:180-187. 48.LiuY*,MiyoshiH,NakamuraM.(2006)Encapsulatedultrasoundmicrobubbles:therapeuticapplicationindrug/genedelivery.JournalofControlledRelease.114:89-99. 49.LiuY*YangH,SuQ,SakanishiA.(2006)InfluenceofparenteralfatemulsionIntraliposandcitricacidonbloodviscosityanderythrocytemorphologyinvitro.ColloidsandSurfacesB:Biointerfaces.53:51-54. 50.LiuY*,YangH,TakatsukiH,SakanishiA.(2006)EffectofultrasonicexposureonCa2+-ATPaseactivityinplasmamembranefromAloearborescenscalluscells.UltrasonicsSonochemistry.13:232-236. 51.LiuY*,YangH,SakanishiA.(2006)Ultrasound:mechanicalgenetransferintoplantcellsbysonoporation.BiotechnologyAdvances.24:1-16. 52.LiuY,UnoH,TakatsukiH,HiranoM,SakanishiA.(2005)InterrelationbetweenHeLa-S3celltransfectionandhemolysisinredbloodcellsuspensionusingpulsedultrasoundofvariousdutycycles.EuropeanBiophysicsJournalwithBiophysicsLetters.34:163-169. 53.LiuY*,YangH,OtakaK,TakatsukiH,SakanishiA.(2005)Effectsofvascularendothelialgrowthfactor(VEGF)andchondroitinsulfateonhumanmonocyticTHP-1cellmigration.ColloidsandSurfacesB:Biointerfaces.43:216-220.