个人简介

Editorial Advisory Board Member for Accounts of Chemical Research (2004-2009) and Organometallics (2008-2010) Editorial Advisory Board for Inorganic Chemistry (2002-2004) Closs Lecturer, University of Chicago (2001) Alternate Councilor of the Inorganic Division of the American Chemical Society (1999-2001) Alfred P. Sloan Research Fellow (1997-1999) Union Carbide Innovation Recognition Program Award (1995-1996) Henry Dreyfus Teacher-Scholar Award (1995) National Institutes of Health Postdoctoral Fellow (1988-1989) National Science Foundation Predoctoral Fellowship(1983-1986)

研究领域

Organometallic and Inorganic Chemistry

One of the most important applications of organometallic chemistry has been the use of organotransition metal catalysts in the commercial production of chemicals, pharmaceuticals and organic materials. The reaction steps in the catalytic cycles are typically general, or so called fundamental reactions in organometallic chemistry, such as oxidative addition, reductive elimination, migratory insertion and beta-hydride elimination. Understanding the mechanisms of these basic reaction steps is key to the improvement of current catalysts and to the design of new catalytic systems. The Goldberg group focuses on developing detailed mechanistic understanding of these fundamental reactions with the goal of creating catalysts for desirable and challenging transformations. As an example, in one particular project in the group, the reaction steps that could be involved in the selective oxidation of alkanes to alcohols are being studied. Shown below is an idealized catalytic cycle for converting methane to methanol – oxidative addition of the C-H bond forms a metal alkyl hydride, insertion of oxygen into the metal hydride bond forms a metal alkyl hydroxide species, and finally C-O reductive elimination forms the alcohol product and regenerates the catalyst. Understanding how each step proceeds, what type of MLn fragment (geometry and ligand set) is needed, and what type of solvent system will promote that reaction step provides insight and direction to efforts to rationally design catalysts that will carry out such transformations. Some other transformations for which we are trying to develop catalysts are anti-Markovnikov hydration and hydroamination of olefins, oxidation of olefins with molecular oxygen and the release of hydrogen from amine boranes and other viable hydrogen storage materials. Ph.D. students working on projects in the Goldberg group are trained in syntheses, characterization and mechanistic analysis using a variety of experimental, spectroscopic and analytical methods. These include the manipulation of air-sensitive compounds by Schlenk and vacuum line techniques, high field multinuclear NMR, IR and UV-visible spectrometry, mass spectrometry, and x-ray crystallography. Biography Karen Goldberg received her A.B. degree from Barnard College of Columbia University in New York City. As an undergraduate, she pursued research projects with Professor Roald Hoffmann at Cornell University, Professor Stephen Lippard at Columbia University, and Drs. Tom Graedel and Steven Bertz at AT&T Laboratories. She then went on to the University of California at Berkeley where she earned her Ph.D. in Chemistry working with Professor Robert Bergman. Following a postdoctoral year with Professor Bruce Bursten at The Ohio State University, she joined the faculty at Illinois State University, a primarily undergraduate institution in Normal, IL, in 1989. In 1995, she moved to the University of Washington as Assistant Professor of Chemistry. She was awarded tenure and promoted to Associate Professor in 2000, and in 2003 she was promoted to Professor. In 2007 she became the first Raymon E. and Rosellen M. Lawton Distinguished Scholar in Chemistry, and in 2010 she became the first Nicole A. Boand Endowed Professor of Chemistry. She currently serves as Director of the first National Science Foundation-funded Phase II Center for Chemical Innovation (CCI), the Center for Enabling New Technologies through Catalysis (CENTC), a collaborative effort between 17 principal investigators and their students at 13 institutions across North America. She is also on the Advisory Boards of the ACS journals Accounts of Chemical Research and Organometallics.

近期论文

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Denney, Melanie C.; Smythe, Nicole A.; Cetto, Kara L.; Kemp, Richard A.; Goldberg, Karen I.; "Insertion of Molecular Oxygen into a Palladium(II)-Hydride Bond" J. Am. Chem. Soc. 2006, 126, 2508-2509. Kloek, Susan M.; Heinekey, D. Michael; Goldberg, Karen I. "Stereoselective Decarbonylation of Methanol to Form a Stable Iridium(III) Trans-Dihydride Complex", Organometallics 2006, 25, 3007-3011. Keith, J.M.; Muller, R.P.; Kemp, R.A.; Goldberg, K.I.; Goddard, W.A., III; Oxgaard, Jonas, "Mechanism of Direct Molecular Oxygen Insertion in a Palladium (II) – Hydride Bond", Inorg.Chem. 2006, 45, 9631-9633. Arthur, Kathryn L; Wang, Qi. L.; Bregel, Dawn M.; Smythe, Nicole A.; O’Neill, Bridget A.; Goldberg, Karen I.; Moloy, Kenneth. G., "The Gem-Dialkyl Effect as a Test for Preliminary Diphosphine Chelate Opening in a Reductive Elimination Reaction" Organometallics, 2005, 24, 4624-4628. Procelewska, Joanna; Zahl, Achim; Liehr, Günter; van Eldik, Rudi; Smythe, Nicole A.; Williams, B. Scott; Goldberg, Karen I. "Mechanistic Information on the Reductive Elimination from Cationic Trimethylplatinum(IV) Complexes to Form Carbon-Carbon Bonds" Inorg. Chem. 2005, 44, 7732-7742. Goldman, Alan S.; Goldberg, Karen I. "C-H Bond Activation by Transition Metals: An Introduction" In Activation and Functionalization of C-H Bonds; Goldberg, K. I; Goldman, A. S. Eds.; ACS Symposium Series 885; American Chemical Society: Washington, DC, 2004, 1-45. Look, Jennifer L.; Fekl, Ulrich; Goldberg, Karen I. "Mechanisms of Reactions Related to Selective Alkane Oxidation by Pt Complexes" In Activation and Functionalization of C-H Bonds; Goldberg, K. I.; Goldman, A. S. Eds.; ACS Symposium Series 885; American Chemical Society: Washington, DC, 2004, 283-302. Fekl, Ulrich; Kaminsky, Werner; Goldberg, Karen I. "b-Diiminate Platinum Complexes for Alkane Dehydrogenation" J. Am. Chem. Soc. 2003, 125, 15286-15287. Crumpton-Bregel, D. M.; Goldberg, Karen I. "Mechanisms of C C and C H Alkane Reductive Eliminations from Octahedral Pt(IV): Reaction via Five-Coordinate Intermediates or Direct Elimination?" J. Am. Chem. Soc. 2003, 125, 9442-9456. Jensen, Michael P.; Wick, Douglas, D.; Reinartz, Stephan.; White, Peter S.; Templeton, Joseph L.; Goldberg, Karen I. "Reductive Elimination/Oxidative Addition of Carbon-Hydrogen Bonds at Pt(IV)/Pt(II) Centers: Mechanistic Studies of the Solution Thermolyses of TpMe2Pt(CH3)2H" J. Am. Chem. Soc. 2003, 125, 8614-8624. Fekl, Ulrich; Goldberg, Karen I. "Five-Coordinate Platinum(IV) as a Precursor to a Novel Pt(II) Olefin Hydride Complex for Alkane Activation" J. Am. Chem. Soc. 2002, 124, 6804-6805. Fekl, Ulrich; Goldberg, Karen I. " A Stable Five-Coordinate Platinum(IV) Complex" J. Am. Chem. Soc. 2001,123, 6423-6424. Bartlett, Kevin L.; Goldberg, Karen I.; Borden, Weston Thatcher "A Computational Study of Reductive Elimination Reactions to Form C-H Bonds from Pt(II) and Pt(IV) Centers with Strongly Coordinating Trimethylphosphine Ligands" Organometallics, 2001, 20, 2669-2678. Getty, April D.; Goldberg, Karen I. "Reaction of a Palladium(II) Complex Chelated by a Tridentate PNC Ligand with Water to Produce a [(PN)Pd(m-oH)]22+ Dimer: A Rare Observation of a Well-Defined Hydrolysis of a Pd(II)-Aryl Compound" Organometallics, 2001, 20, 2545-2551. Williams, B. Scott; Goldberg, Karen I. "Studies of Reductive Elimination Reactions to Form Carbon-Oxygen Bonds from Pt(IV) Complexes" J. Am. Chem. Soc. 2001, 123, 2576-2587. Fekl, Ulrich; van Eldik, Rudi; Lovell, Scott; Goldberg, Karen I. "Effects of Trifluormethyl Substituents in a Tris(pyrazolyl)borate Ligand: A Structural and Spectroscopic Study of Analogous Pt(IV) Trimethyl Complexes" Organometallics, 2000, 19, 3535-3542. Bartlett, Kevin L.; Goldberg, Karen I.; Borden, Weston Thatcher "A Computational Study of Reductive Elimination Reactions to Form C-H Bonds from Pt(II) and Pt(IV) Centers. Why Does Ligand Loss Precede Reductive Elimination from Six-Coordinate But Not Four-Coordinate Platinum?" J. Am. Chem. Soc. 2000, 122, 1456-1465. Crumpton, Dawn M.; Goldberg, Karen I. "Five-Coordinate Intermediates in Carbon-Carbon Reductive Elimination Reactions from Pt(IV)" J. Am. Chem. Soc. 2000, 122, 962-963. Wick, Douglas D.; Goldberg, Karen I. "Insertion of Dioxygen into a Platinum-Hydride Bond to Form a Novel Dialkylhydroperoxo Pt(IV) Complex," J. Am. Chem. Soc. 1999, 121, 11900-11901. Williams, B. Scott; Holland, Andrew W.; Goldberg, Karen I. "Direct Observation of C-O Reductive Elimination from Pt(IV)" J. Am. Chem. Soc. 1999, 121, 252-253.