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个人简介

2003.03-2006.01天津大学,应用物理专业,,学士 2000.09-2003.01天津大学,生物物理专业,硕士 2003.03-2006.01天津大学,生物物理专业,博士 2006.01-2008.07电子科技大学生命科学与技术学院,讲师; 2008.08-2010.11电子科技大学生命科学与技术学院,副教授,硕士生导师; 2010.12-2014.07电子科技大学生命科学与技术学院,副教授,博士生导师; 2012.01-2013.08香港大学微生物系,香江学者; 2014.08-至今电子科技大学生命科学与技术学院,教授,博士生导师l 教学工作 本科生:进化生物学、大数据与精准医学 研究生:基因组信息学

研究领域

1.计算、比较、进化与功能基因组学 2.基因组信息学

近期论文

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01.XiongN,WeiW,GaoF,DuMZ,HuaHL,WangJ,GuoFB*(2016)ZislandExplorer:detectgenomicislandsbycombininghomogeneityandheterogeneityproperties.BriefingsinBioinformatics,doi:10.1093/bib/bbw019. 02.YeYN,MaBG,DongC,ZhangH,ChenLL,GuoFB*(2016)Anovelproposalofasimplifiedbacterialgenesetandtheneo-constructionofageneralminimizedmetabolicnetwork.SciRep,6:35082. 03.WeiW,JinYT,DuMZ,WangJ,RaoN,GuoFB*(2016)Genomiccomplexityplaceslessrestrictionsontheevolutionofyoungcoexpressionnetworksthanprotein-proteininteractions.GenomeBiolEvol,8(8):2624-31. 04.HaoGF,JiangW,YeYN,WuFX,ZhuXL,GuoFB*,YangGF*(2016)ACFIS:awebserverforfragment-baseddrugdiscovery.NucleicAcidsRes,44(W1):W550-6. 05.HuaZG,LinY,YuanYZ,YangDC,WeiW,GuoFB*(2015)ZCURVE3.0:identifybacterialgeneswithhigheraccuracyaswellasautomaticallyandaccuratelyselectessentialgenes.NucleicAcidsRes,43(W1):W85-90.(IF>9) 06.GuoFB*,YeYN,NingLW,WeiW(2015)Threecomputationaltoolsforpredictingbacterialessentialgenes.MethodsinMolecularBiology,1279:205-217. 07.WeiW,NingLW,YeYN,LiSJ,ZhouHQ,HuangJ,GuoFB*(2014)SMAL:Aresourceofspontaneousmutationaccumulationlines.MolBiolEvol,31(5):1302-1308. 08.WeiW,YeYN,LuoS,DengYY,LinD,GuoFB*(2014)IFIM:adatabaseofintegratedfitnessinformationformicrobialgenes.Database,2014:bau052. 09.YeYN,HuaZG,HuangJ,RaoN,GuoFB*(2013)CEG:adatabaseofessentialgeneclusters.BMCGenomics,14:769. 10.WeiW,ZhangT,LinD,YangZJ,GuoFB*(2013)Transcriptionalabundanceisnotthesingleforcedrivingtheevolutionofbacterialproteins.BMCEvolBiol,13:162. 11.LinD,YinX,WangXL,ZhouPandGuoFB*(2013)Re-annotationofprotein-codinggenesinthegenomeofSaccharomycescerevisiaebasedonSupportVectorMachines.PLoSOne,8(7):e64477. 12.GuoFB,XiongL,TengJL,YuenKY,LauSK,WooPC*.(2013)Re-annotationofprotein-codinggenesin10completegenomesofneisseriaceaefamilybycombiningsimilarity-basedandcomposition-basedmethods.DNARes,20(3):273-86. 13.GuoFB*,YeYN,ZhaoHL,LinD,WeiW.(2012)Universalpatternanddiversestrengthsofsuccessivesynonymouscodonbiasinthreedomainsoflife,particularlyamongprokaryoticgenomes.DNARes,19(6):477-85 14.GuoFB*(2012)Editorial[HotTopic:Replicatingstrandasymmetryinbacterialandeukaryoticgenomes].CurrGenomics,13(1),2-3. 15.GuoFB*,NingLW,HuangJ,LinH,ZhangHX.(2010)ChromosometranslocationanditsconsequenceinthegenomeofBurkholderiacenocepaciaAU-1054.BiochemBiophysResCommun,403(3-4):375-9. 16.GuoFB*,LinH,HuangJ.(2009)AplotofG+Ccontentagainstsequencelengthof640bacterialchromosomesshowsthepointsarewidelyscatteredintheuppertriangulararea.ChromosomeRes,17(3):359-64. 17.GuoFB*,YuanJB(2009).Codonusagesofgenesonchromosome,andsurprisingly,genesinplasmidareprimarilyaffectedbystrand-specificmutationalbiasesinLawsoniaintracellularis.DNARes,16(2):91-104. 18.GuoFB*,YuXJ.(2007)SeparatebaseusagesofgeneslocatedontheleadingandlaggingstrandsinChlamydiamuridarumrevealedbytheZcurvemethod.BMCGenomics,8:366.

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