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本人自2003年攻读硕士研究生起,先后参与多项国家级及省部级课题。发表论文25篇,其中以一作或通讯作者发表SCI论文11篇,申请发明专利一项。攻读硕士及在中科院健康科学研究所期间,主要从事抗肿瘤药物的研发。对非小细胞肺癌中Notch信号通路及作用机理进行深入研究,此外还进行了非小细胞肺癌患者的分子遗传学研究。与此同时,本人通过噬菌体展示技术筛选靶向阻断Notch3的人源化单抗。该项课题为美国诺华(Novartis)公司资助课题。其后本人在四川省医学科学院?四川省人民医院任职期间主要从事胰岛再生、异种移植免疫等多个课题。先后参与胰管前体细胞在转录因子Pdx1诱导的小鼠胰岛再生中的作用(国家自然科学基金)、抗CD40/CD45RB单克隆抗体和带血管骨髓干细胞移植协同诱导猴肾脏移植免疫耐受机理的研究(国家自然科学基金)、老龄小鼠胰岛再生的研究(四川省卫生厅资助项目)、非人类灵长目藏酋猴胰岛再生的研究(四川省卫生厅资助项目)、sertoli细胞和胰岛细胞共移植诱导异种移植免疫耐受(四川省科技厅资助项目)、丹红注射液治疗糖尿病肾病的研究(步长集团资助项目)。本人以一作或通讯作者身份发表SCI文章和中文核心文章6篇,其中4篇为SCI文章。本人在美国俄亥俄州立大学/全美儿童医院新生儿系做博士后期间先后参与糖原合成激酶3β(GSK3β)降解乳腺癌抑制基因BRCA1及其对DNA损伤修复同源重组(HR)的关系,同时参与糖原合成激酶3β降解53BP1及其对脑瘤细胞DNA损伤修复非粘性末端连接(NHEJ)的关系。该项目为美国NIH基金资助课题(RO1)。同时主要研究MAPK信号通路在感染免疫中的作用,该项目为美国NIH基金资助课题(R21)。留学期间以一作身份发表SCI文章3篇。留学归国后现主要从事糖尿病、糖尿病肾病、免疫学和肿瘤学等方面的药物研究,以第一主研先后立项基金如下:芒果苷诱导老龄小鼠胰岛再生的研究(四川省医学科学院?四川省人民医院资助院基金项目);芒果苷诱导老龄小鼠胰岛再生促进胰岛素分泌的研究(四川省人事厅留学归国人员资助项目);芒果苷通过调节p16INK4a-Dcyclins-cdk4-Rb信号通路和PDX-1的表达诱导老龄小鼠胰岛再生促进胰岛素分泌的研究(四川省科技厅资助项目)。同时与广西中医药大学附属瑞康医院合作糖尿病肾病的研究,以一作或通讯作者身份发表SCI文章和中文核心文章6篇,其中4篇为SCI文章。 学术经历: 本人于2002年毕业于沈阳药科大学中药系,中药制药专业学士;2007年毕业于沈阳药科大学生命科学与生物制药学院,微生物与生化药学专业硕士;2012年毕业于四川大学生命科学学院,生物化学与分子生物学专业博士;自2012年至2014年在美国俄亥俄州立大学/全国儿童医院做博士后。先后在中科院健康科学研究所、睿智化学生物学部和四川省人民医院器官移植研究所工作。留学归国后到四川省人民医院药学部从事临床药学及新药研发工作。本人先后从事肿瘤分子遗传学、噬菌体展示技术筛选抗肿瘤单抗、DNA损伤修复机理研究、移植免疫分子生物学、胰岛细胞生物学、糖尿病及肿瘤新药筛选的研究,目前主要研究方向新药研发及临床前研究。 个人简介: 目前开展的主要研究课题包括芒果苷通过调节p16INK4a-Dcyclins-cdk4-Rb信号通路和PDX-1的表达诱导老龄小鼠胰岛再生促进胰岛素分泌的研究、芒果苷诱导老龄小鼠胰岛再生促进胰岛素分泌的研究和CDKL1在内质网应激介导的乳腺癌HCPT耐药中的分子机制研究,芒果苷通过调节p16INK4a-Dcyclins-cdk4-Rb信号通路和PDX-1的表达诱导老龄小鼠胰岛再生促进胰岛素分泌的研究,项目经费:20万元(含医院匹配5万),项目来源:四川省科技厅;芒果苷诱导老龄小鼠胰岛再生促进胰岛素分泌的研究,项目经费:6万元(含医院匹配3万),项目来源:四川省科技厅;CDKL1在内质网应激介导的乳腺癌HCPT耐药中的分子机制研究,芒果苷通过调节p16INK4a-Dcyclins-cdk4-Rb信号通路和PDX-1的表达诱导老龄小鼠胰岛再生促进胰岛素分泌的研究,项目经费:60万元,项目来源:四川省科技厅。

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Chunming Cheng, Si Zhang, Donglin Guan, Yi Wang, Nidhi Jyotsana. Editorial: Tumor metabolism: From molecular mechanisms to clinical application. Frontiers in Cell and Development Biology. 2023. (通讯作者) Hong Liang, Xia He, Yitong Tong, Niuniu Bai, Yushu Pu, Ke Han, Yi Wang. Ferroptosis open a new door for colorectal cancer treatment. Frontiers in Genetics. 2023 (通讯作者) Xueliang Yi, Xuemei Tang, Tianlong Li, Lin Chen, Hongli He, Xiaoxiao Wu, Chunlin Xiang, Min Cao, Zixiang Wang, Yi Wang, Yiping Wang, Xiaobo Huang. Therapeutic potential of the sphingosine kinase 1 inhibitor, PF-543. Biomedicine & Pharmacotherapy (通讯作者) Ling Xua, Yu’e Liu, Xi Chen, Hua Zhong, Yi Wang. Ferroptosis in life: To be or not to be. Biomedicine & Pharmacotherapy. 2023, 159,114241.(通讯作者) Yu’e Liu, Yihong Sun, Yadong Guo, Xiaoyun Shi, Xi Chen, Wenfeng Feng, Lei-Lei Wu, Jin Zhang, Shibo Yu, Yi Wang, Yufeng Shi. An Overview: The Diversified Role of Mitochondria in Cancer Metabolism. International Journal of Biological Science. 2023, 19, 897-915.(通讯作者) Bo Gong, Yi Liang, Qian Zhang, Huan Li, Jialing Xiao, Liang Wang, Han Chen, Wenjie Yang, Xiaoqing Wang, Yi Wang, Zongze He. Epigenetic and transcriptional activation of the secretory kinase FAM20C as an oncogene in glioma. Journal of Genetics and Genomics. 2023 Jan 25;S1673-8527(23)00023-1. (通讯作者) Qiao Zhou, Li Long, Xixi Chen, Xiaobo Huang, Shaoping Deng, Yi Wang. Identification of methylated differentially expressed hub genes in systemic lupus erythematosus patients by WGCNA based epigenome-wide and transcriptome-wide analysis. Genes & Diseases. (通讯作者) Fei Xiong, Qiao Zhou, Xiaobo Huang, Peng Cao, Yi Wang. Ferroptosis plays a novel role in nonalcoholic steatohepatitis pathogenesis. Frontiers in Pharmacology. 2022, December 2, 13, 1055739 (通讯作者) Tiantian Lei, Lin Chen, Kejing Wang, Suya Du, Carmen Gonelle-Gispert, Yi Wang, Leo H. Buhler. Genetic engineering of pigs for xenotransplantation to overcome immune rejection and physiological incompatibilities: The first clinical steps. Frontiers in Immunology.2022, December 6, 10, 1031185 (通讯作者) Zhen Geng, Qi Zhang, Ting Li, Ting Huang, Hailian Wang, Qiao Zhou, Shaoping Deng, Yanshuang Zhao, Yanjiao Li, Chunming Cheng, Carmen Gonelle-Gispert, Leo H. Buhler and Yi Wang. Advantages of the retroperitoneal retrocolic space as the transplant site for encapsulated xenogeneic islets. Xenotransplantation. 2022 Dec 1;e12787. (通讯作者) Meng Zhang, Qian Lei, Xiaobo Huang, Yi Wang. Molecular mechanisms of ferroptosis and the potential therapeutic targets of ferroptosis signaling pathways for glioblastoma. Front. Pharmacol. 2022;13:1071897 (通讯作者) Xia He, Ning Wang, Yu Zhang, Xiaobo Huang, Yi Wang. The therapeutic potential of natural products for treating pancreatic cancer. Front. Pharmacol, 2022;13:1051952 (通讯作者) Fan Zeng, Yunping Lan, Ning Wang, Lijing Yang, Xiaobo Huang, Qiao Zhou, Yi Wang. Ferroptosis, a new therapeutic target for bladder cancer. Front. Pharmacol. 2022;13:1043283 (通讯作者) Qiao Zhou, Ting Li, Qin Qin, Ning Wang, Xiaobo Huang and Yi Wang. The Relationship between ferroptosis and lymphoma: emerging mechanisms and a novel therapeutic approach. Front. Genetics. 2022;13: 1039951 (通讯作者) Qiao Zhou, Ting Li, Kaiwen Wang, Qi Zhang, Zhuowen Geng, Shaoping Deng, Chunming Cheng and Yi Wang. Current Status of Xenotransplantation Research and the Strategies for Preventing Xenograft Rejection. Front. Immunol. 2022;13:928173. (通讯作者) Li Long, Hongmei Guo, Xixi Chen, Yan Liu, Ruyi Wang, Xiaomei Zheng, Xiaobo Huang, Qiao Zhou, Yi Wang. Advancement in understanding the role of ferroptosis in Rheumatoid arthritis. Front. Physiol., 04 October 2022;13:1036515. (通讯作者) Lu Yu, Minghan Sun, Qi Zhang, Qiao Zhou, Yi Wang. Harnessing the immune system by targeting immune checkpoints: providing new hope for oncotherapy. Front. Immunol. 2022;13:982026. (通讯作者) Guanghui Du, Qi Zhang, Xiaobo Huang,Yi Wang, Molecular mechanisms of ferroptosis and its role in the occurrence and treatment of diabetes. Frontiers in Genetics, 2022;13:1018829. (通讯作者) Qiao Zhou, Lijing Yang, Ting Li, Kaiwen Wang, Xiaobo Huang, Jingfen Shi and Yi Wang. Mechanisms and inhibitors of ferroptosis in psoriasis. Frontiers in Molecular Biosciences.2022;9:1019447. (通讯作者) Yi Wang, Yuya Wang, Yifei Ren, Qi Zhang, Ping Yi, Chunming Cheng. Metabolic modulation of immune checkpoints and novel therapeutic strategies in cancer. Semin Cancer Biol. 2022 Feb 10; S1044-579X(22)00031-1. (第一作者) Qiao Zhou, Qi Zhang, Kevin Wang, Ting Huang, Shaoping Deng, Yi Wang, Chunming Cheng. Anti-rheumatic drug-induced hepatitis B virus reactivation and preventive strategies for hepatocellular carcinoma. Pharmacol Res. 2022 Mar 15;178:106181. (通讯作者) Qi Zhang, Yanjiao Li, Zhen Geng, Sandrine Gerber, Yi Wang, Leo H. Bühler. Islet encapsulation: new developments for the treatment of type 1 diabetes. Front. Immunol. 2022;13:869984. (通讯作者) Suya Du, Yanjiao Li, Zhen Geng, Qi Zhang, Leo H. Buhler, Carmen Gonelle-Gispert and Yi Wang. Engineering Islets from Stem Cells: the optimal solution for the treatment of diabetes? Front. Immunol. 2022;13:869514. (通讯作者) Mi Zhou, Da Xu, Wenjun Zhang, Yi Wang, Mingliang Zuo, Siming Wang, Ting Liu, Junqing Zhang, Lixue Yin, Zhiyu Guo, Jun Liu, Jing Tan. The hepato-cardiac disorders in Tibetan residents with hepatic echinococcosis: A case–control echocardiography study. Journal of Clinical Ultrasound. 2022;50(9):1251-1259. Yi Wang, Xie Q, Tan H, Liao M, Zhu S, Zheng LL, Huang H, Liu B. Targeting cancer epigenetic pathways with small-molecule compounds: Therapeutic efficacy and combination therapies. Pharmacol Res. 2021;173:105702.(第一作者) Ji-Chao Tang, Wang-Jie Suolang, Chong Yang, Yi Wang, Ming-Wu Tian, Yu Zhang. Monosegmental ALPPS combined with ante-situm liver resection: A novel strategy for end-stage hepatic alveolar echinococcosis. Hepatobiliary Pancreat Dis Int. 2021;21(2):186-189. Zhang Yu, Xie Ping, Yang Chong,Wang Yi, Liu Xingchao, Yang Hongji, Liu Jun, Zhou Guo, Deng Shaoping. The Value of Hepatic vein Stent Placement as a Bridge Therapy on Treating Hepatic Alveolar Echinococcosis Presenting with Budd-Chiari Syndrome. Annals of surgery. 2021;273(4):e154-e156. Suping Li, Jing Fu, Yi Wang, Chunmei Hu, Fei Xu. LncRNA MIAT enhances cerebral ischaemia/reperfusion injury in rat model via interacting with EGLN2 and reduces its ubiquitin-mediated degradation. Journal of cellular and molecular medicine. 2021;25:(21):10140-10151 Chunmei Hu, Linhan Yang, Yi Wang, Shijie Zhou, Jing Luo, Yi Gu. Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop. Journal of ginseng research. 2021,45:(6):734-743 Yi Wang, Hongji Yang, Huirong Liu, Leo H. Buhler, Shaoping Deng. Strategies to halt 2019 novel coronavirus (SARS-CoV-2) spread for organ transplantation programs at the Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, China. American Journal of Transplantation. 2020;20(7): 1837-1839.(第一作者) Yuping Liu, Lixia Qin, Rongsheng Tong, Ting Liu, Chen Ling, Tiantian Lei, Dingding Zhang, Yi Wang, Shaoping Deng. Regulatory changes in China on xenotransplantation and related products. Xenotransplantation.2020;27(3):e12601. (通讯作者). Yong Yang, Hailian Wang, Kang Chen, Jun Zhou, Shaoping Deng, Yi Wang. Shelter hospital mode: how to prevent novel coronavirus infection 2019 (COVID-19) hospital-acquired infection? Infection Control & Hospital Epidemiology. 2020;41(7):872-873.(通讯作者). Yuping Liu, Ting Liu, Tiantian Lei, Dingding Zhang, Suya Du, Lea Girani, Dandan Qi, Chen Lin, Rongsheng Tong and Yi Wang, RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy. International Journal of Molecular Medicine.2019;44(3):771-781. (通讯作者). Wenjing He, Yaodong You, Suya Du, Tiantian Lei, Hailian Wang, Xiang Li, Xia He, Rongsheng Tong and Yi Wang, Anti-neoplastic effect of mangiferin on human ovarian adenocarcinoma OVCAR8 cells via the regulation of YAP. Oncology Letters.2019;17(1):1008-1018. (通讯作者). Yi Wang, Tiantian Lei, Liang Wei, Suya Du, Lea Girani and Shaoping Deng. Xenotransplantation in China: Present status. Xenotransplantation. 2019;26(1):e12490. (通讯作者). Hanrui Zheng, Ting Liu, Tiantian Lei, Lea Girani, Yi Wang and Shaoping Deng. Promising Potentials of Tibetan Macaques in Xenotransplantation. Xenotransplantation. 2019;26(1):e12489. (通讯作者). Lea Girani, Xiaofang Xie, Tiantian Lei, Liang Wei, Yi Wang and Shaoping Deng. Xenotransplantation in Asia. Xenotransplantation. 2019;26(1):e12493. (通讯作者). Suya Du, Huirong Liu, Tiantian Lei, Xiaofang Xie,Hailian Wang, Xia He, Rongsheng Tong and Yi Wang, Mangiferin: An effective therapeutic agent against several disorders. Molecular Medicine Reports. 2018;18(6):4775-4786. (通讯作者). Faguang Mu, Ting Liu, HanRui Zheng, Xiaofang Xie, Tiantian Lei, Xia He, Suya Du, Rongsheng Tong and Yi Wang, Mangiferin induces radiosensitization in glioblastoma cells by inhibiting nonhomologous end joining. Oncology Reports. 2018;40(6): 3663-3673. (通讯作者). Hailian Wang, Xia He, Tiantian Lei, Yilong Liu, Guoli Huai, Minghan Sun and Shaoping Deng, Hongji Yang, Rongsheng Tong and Yi Wang, Mangiferin induces islet regeneration in aged mice through regulating p16INK4a. International Journal of Molecular Medicine.2018;41(6):3231-3242. (通讯作者). Huirong Liu, Suya Du, Tiantian Lei, Hailian Wang, Xia He, Rongsheng Tong and Yi Wang. Multifaceted regulation and functions of YAP/TAZ in tumors (Review).Oncology Reports.2018;40(1): 16-28. (通讯作者). Yong Yang, Tiantian Lei, Suya Du, Rongsheng Tong, Hailian Wang, Jiao Yang, Juan Huang, Minghan Sun, Zhi Dong and YiWang, Nuclear GSK3β induces DNA double-strand break repair by phosphorylating 53BP1 in glioblastoma. International Journal of Oncology. 2018;52(3):709-720. (通讯作者). Jie Peng, Hailian Wang, Xin Wang, Minghan Sun, Shaoping Deng and Yi Wang. YAP and TAZ mediate steroid-induced alterations in the trabecular meshwork cytoskeleton in human trabecular meshwork cells. International Journal of Molecular Medicine. 2017;41(1):164-172. (通讯作者). Xin Wang, Guoli Huai, Hailian Wang, Yuande Liu, Ping Qi, Wei Shi, Jie Peng, Hongji Yang, Shaoping Deng and Yi Wang. Mutual regulation of the Hippo/Wnt/LPA/TGF-β signaling pathways and their roles in glaucoma. International Journal of Molecular Medicine. 2018;41(3):1201-1212. (通讯作者). Xiang Li, Yi Wang, Shaoping Deng, Meeting report: The first international conference on xenotransplantation in Chengdu, China, Xenotransplantation, 2017; 24(6): 12376-12378. (共同一作). Xia He, Suya Du, Tiantian Lei, Xiang Li, Yilong Liu, Hailian Wang, Rongsheng Tong and Yi Wang, PKM2 in carcinogenesis and oncotherapy, Oncotarget, 2017; 8(66): 110656-110670. (通讯作者). Wenchun Jiang, Xin Li, Tongyu Li, Hailian Wang, Wei Shi, Ping Qi, Chunyang Li, Jie Chen, Jinku Bao, Guodong Huang and Yi Wang. Repositioning of amprenavir as a novel extracellular signal-regulated kinase-2 inhibitor and apoptosis inducer in MCF-7 human breast cancer. International Journal of Oncology. 2017;50(3):823-834. (通讯作者). Jianzhen Lv, Wen Xiong, Tiantian Lei, Hailian Wang, Minghan Sun, Erwei Hao, Zhiping Wang, Xiaoqi Huang, Shaoping Deng, Jiagang Deng and Yi Wang, Amygdalin ameliorates the progression of atherosclerosis in LDL receptor-deficient mice. Molecular Medicine Reports. 2017; 16(6): 8171-8179. (通讯作者). Bingyu Zou, Hailian Wang, Yilong Liu, Ping Qi, Tiantian Lei, Minghan Sun and Yi Wang, Mangiferin induces apoptosis in human ovarian adenocarcinoma OVCAR3 cells via the regulation of Notch3. Oncology Reports. 2017:38(3): 1431-1441. (通讯作者). Guodong Huang, Bingyu Zou, Jianzhen Lv, Tongyu Li, Guoli Huai, Shaowei Xiang, Shilong Lu, Huan Luo, Yaping Zhang, Yi Jin and Yi Wang. Notoginsenoside R1 attenuates glucose-induced podocyte injury via the inhibition of apoptosis and the activation of autophagy through the PI3K/Akt/mTOR signaling pathway. International Journal of Molecular Medicine. 2017;39(3):559-568. (通讯作者).

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