汤朝晖 - 中国科学院长春应用化学研究所 -

个人简介

1976年9月生于湖南衡阳。中国科学院长春应用化学研究所研究员，博士生导师。1999年7月毕业于湘潭大学，获学士学位;2005年3月毕业于中国科学院长春应用化学研究所，获博士学位。2005年3月至2006年9月在英国帝国理工学院做博士后;2007年1月至2008年12月在美国纽约州立大学石溪分校做博士后，2009年4月在中国科学院长春应用化学研究所工作。主要从事药物缓控释高分子材料领域的研究。作为课题负责人先后承担了国家自然科学基金6项（包括杰青、面上和青年）;参与国家重大新药创制等计划项目多项。近年来发表论文120多篇，授权专利40项。专业方向为“高分子化学与物理”。2020年获得国家自然科学杰出青年基金。

研究领域

主要从事药物缓控释高分子材料领域的研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wang, Y.; Yu, H.; Zhang, D.; Wang, G.; Song, W.; Liu, Y.; Ma, S.; Tang, Z.; Liu, Z.; Sakurai, K.; Chen, X., Co-administration of combretastatin A4 nanoparticles and sorafenib for systemic therapy of hepatocellular carcinoma. Acta Biomater. 2019, 92, 229-240. Qin, H.; Yu, H.; Sheng, J.; Zhang, D.; Shen, N.; Liu, L.; Tang, Z.; Chen, X., PI3Kgamma Inhibitor Attenuates Immunosuppressive Effect of Poly(l-Glutamic Acid)-Combretastatin A4 Conjugate in Metastatic Breast Cancer. Advanced Science 2019, 6 (12), 1900327. Yang, S.; Tang, Z.; Hu, C.; Zhang, D.; Shen, N.; Yu, H.; Chen, X., Selectively Potentiating Hypoxia Levels by Combretastatin A4 Nanomedicine: Toward Highly Enhanced Hypoxia-Activated Prodrug Tirapazamine Therapy for Metastatic Tumors. Adv. Mater. 2019, 31 (11), 1805955. Zhou, H.; Lv, S.; Zhang, D.; Deng, M.; Zhang, X.; Tang, Z.; Chen, X., A polypeptide based podophyllotoxin conjugate for the treatment of multi drug resistant breast cancer with enhanced efficiency and minimal toxicity. Acta Biomater. 2018, 73, 388-399. Zhou, H.; Sun, H.; Lv, S.; Zhang, D.; Zhang, X.; Tang, Z.; Chen, X., Legumain-cleavable 4-arm poly(ethylene glycol)-doxorubicin conjugate for tumor specific delivery and release. Acta Biomater. 2017, 54, 227-238. Liu, T.; Zhang, D.; Song, W.; Tang, Z.; Zhu, J.; Ma, Z.; Wang, X.; Chen, X.; Tong, T., A poly(l-glutamic acid)-combretastatin A4 conjugate for solid tumor therapy: Markedly improved therapeutic efficiency through its low tissue penetration in solid tumor. Acta Biomater. 2017, 53, 179-189. Wang, Y.; Lv, S.; Deng, M.; Tang, Z.; Chen, X., A charge-conversional intracellular-activated polymeric prodrug for tumor therapy. Polym. Chem. 2016, 7, 2253-2263. Tang, Z.; He, C.; Tian, H.; Ding, J.; Hsiao, B. S.; Chu, B.; Chen, X., Polymeric nanostructured materials for biomedical applications. Prog. Polym. Sci. 2016, 60, 86-128. Song, W.; Tang, Z.; Zhang, D.; Wen, X.; Lv, S.; Liu, Z.; Deng, M.; Chen, X., Solid Tumor Therapy Using a Cannon and Pawn Combination Strategy. Theranostics 2016, 6 (7), 1023-1030. Song, W.; Tang, Z.; Zhang, D.; Li, M.; Gu, J.; Chen, X., A cooperative polymeric platform for tumor-targeted drug delivery. Chemical Science 2016, 7 (1), 728-736. Song, W.; Tang, Z.; Shen, N.; Yu, H.; Jia, Y.; Zhang, D.; Jiang, J.; He, C.; Tian, H.; Chen, X., Combining disulfiram and poly(l-glutamic acid)-cisplatin conjugates for combating cisplatin resistance. J. Control. Release 2016, 231, 94-102. Song, W.; Tang, Z.; Lei, T.; Wen, X.; Wang, G.; Zhang, D.; Deng, M.; Tang, X.; Chen, X., Stable loading and delivery of disulfiram with mPEG-PLGA/PCL mixed nanoparticles for tumor therapy. Nanomed. Nanotechnol. Biol. Med. 2016, 12 (2), 377-86. Niu, Y.; Song, W.; Zhang, D.; Tang, Z.; Deng, M.; Chen, X., Functional computer-to-plate near-infrared absorbers as highly efficient photoacoustic dyes. Acta Biomater. 2016, 43, 262-8. Yu, H.; Tang, Z.; Zhang, D.; Song, W.; Zhang, Y.; Yang, Y.; Ahmad, Z.; Chen, X., Pharmacokinetics, biodistribution and in vivo efficacy of cisplatin loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) complex nanoparticles for tumor therapy. J. Control. Release 2015, 205, 89-97. Song, W.; Tang, Z.; Zhang, D.; Yu, H.; Chen, X., Coadministration of Vascular Disrupting Agents and Nanomedicines to Eradicate Tumors from Peripheral and Central Regions. Small 2015, 11 (31), 3755-3761. Shi, C.; Yu, H.; Sun, D.; Ma, L.; Tang, Z.; Xiao, Q.; Chen, X., Cisplatin-loaded polymeric nanoparticles: Characterization and potential exploitation for the treatment of non-small cell lung carcinoma. Acta Biomater. 2015, 18, 68–76. Song, W.; Tang, Z.; Zhang, D.; Zhang, Y.; Yu, H.; Li, M.; Lv, S.; Sun, H.; Deng, M.; Chen, X., Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin. Biomaterials 2014, 35 (9), 3005-3014. Song, W.; Tang, Z.; Li, M.; Lv, S.; Sun, H.; Deng, M.; Liu, H.; Chen, X., Polypeptide-based combination of paclitaxel and cisplatin for enhanced chemotherapy efficacy and reduced side-effects. Acta Biomater. 2014, 10 (3), 1392-1402.