个人简介

学习、工作简历 1986年7月毕业于江苏农学院畜牧专业，获学士学位，同年留校。 2003年12月获扬州大学兽医专业硕士学位。 2006年12月获扬州大学动物遗传育种与繁殖学博士学位。 历任扬州大学动物科学与技术学院党委副书记、副院长、扬州大学科技处副处长、处长等职

研究领域

（1）猪疾病抗性和免疫应答的调控机制 （2）猪抗病育种和健康养殖

先后主持国家自然科学基金、国家转基因生物新品种培育科技重大专项、国家星火计划重点项目、江苏省科技支撑计划重点项目等科研项目20余项，其中国家级和部省级科研项目9项；获全国商业科技进步一等奖、全国农牧渔业丰收奖一等奖各1项。 主要科研项目： 1、“FUT1基因启动子区对断奶仔猪大肠杆菌抗性的调控机制分析”（国家自然科学基金，31472066） 2、“鞘糖脂生物合成通路及关键基因对猪F18大肠杆菌抗性的调控机理研究”（国家自然科学基金，31172183） 3、“太湖猪F18大肠杆菌抗性主效基因的筛选与功能研究”（国家自然科学基金，30972089） 4、“抗仔猪腹泻病转基因猪新品系培育”（转基因生物新品种培育科技重大专项，2014ZX08006-001B） 5、“抗仔猪腹泻病转基因猪育种新材料创制”（转基因生物新品种培育科技重大专项，2009ZX08006-004B） 6、“家畜规模化高效健康养殖技术示范及推广”（国家星火计划重点项目，2012GA690003） 7、“地方特色土种猪新品系及配套系选育”（江苏省科技支撑计划重点项目，BE2014357） 8、“中梅山猪专门化母系选育及其与巴克夏猪杂交配套研究”（江苏省科技支撑计划，BE2013345） 9、“苏太猪免疫应答评价体系建立及抗逆型配套系的培育”（江苏省科技支撑计划，BE2010371）

近期论文

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近5年来带领课题组在ScientificReports、AnimalGenetics、PLosOne、Gene、Int.J.Mol.Sci、JournalofGenetics、中国农业科学、畜牧兽医学报、遗传、农业生物技术学报等国内外刊物上发表论文80余篇，其中SCI收录30篇，总影响因子超过60。 1.ZhengchangWu,YingLiu,WenhuaDong,Guo-qiangZhu,ShenglongWu&WenbinBao.CD14intheTLRssignalingpathwayisassociatedwiththeresistancetoE.coliF18inChinesedomesticweanedpiglets.ScientificReports,2016,6:24611. 2.SunL,WangJ,YinX,SunS,ZiC,ZhuG,WuS,BaoW.Identificationofa5-MethylcytosineSitethatmayRegulateC/EBPβBindingandDetermineTissue-SpecificExpressionoftheBPIGeneinPiglets.ScientificReports,2016,6:28506. 3.Y.Liu,L.N.Gan,W.Y.Qin,S.Y.Sun,G.Q.Zhu,S.L.Wu,W.B.Bao.DifferentialexpressionofToll-likereceptor4signalingpathwaygenesinEscherichiacoliF18-resistantand-sensitiveMeishanpiglets.PolishJournalofVeterinarySciences,2016,19(2):303-308. 4.DongWH,DaiCH,SunL,WangJ,SunSY,ZhuGQ,WuSL,BaoWB.Expressionofkeyglycosphingolipidbiosynthesis-globoseriespathwaygenesinEscherichiacoliF18-resistantandEscherichiacoliF18-sensitivepiglets.Animalgenetics,2016,47(4):428-435. 5.R.W.Xia,W.Y.Qin,L.N.Gan,J.Wang,S.L.Wu,W.B.Bao.DifferentialexpressionofFUT1andFUT2inLargeWhite,Meishan,andSutaiporcinebreeds.GenetMolRes.2016,15(1):15017613. 6.S.P.Zhu,X.M.Yin,L.Sun,S.Y.Sun,W.B.Bao,S.L.Wu.DifferentialexpressionofporcineTAP1geneindifferentpopulations.RussianJournalofGenetics.2015,51(3):308-312. 7.WenhuaDong,XuemeiYin,LiSun,JingWang,ShouyongSun,GuoqiangZhu,ShenglongWu,WenbinBao.Age-associatedmethylationchangeofTAP1promoterinpiglet.Gene.2015,573:70-74. 8.XueMeiYIN,YingLIU,WenHuaDONG,QiaoHuiZHAO,GuoQiangZHU,ShengLongWU,WenBinBAO.AssociationofMx1genepolymorphismwithsomeeconomictraitsinMeishanpigs.TurkishJournalofVeterinaryandAnimalSciences.2015,39:389-394. 9.YingLIU,XueMeiYIN,RiWeiXIA,YongJiuHUO,GuoQiangZHU,ShengLongWU,WenBinBAO.AssociationbetweentheMUC4g.243A>GpolymorphismandimmuneandproductiontraitsinLargeWhitepigs.TurkishJournalofVeterinaryandAnimalSciences.2015,39:1-6. 10.Z.C.Wu,Y.Liu,W.H.Dong,Y.J.Huo,S.L.Wu,W.B.Bao.IdentificationofBPIproteinproducedindifferentexpressionsystemanditsassociationwithEscherichiacoliF18susceptibility.GenetMolRes.2015,14(1):1111-1123. 11.Z.C.Wu,Y.Liu,Q.H.Zhao,Y.J.Huo,S.L.Wu,W.B.Bao.Associationofsinglenucleotidepolymorphismsofexon4andexon10oftheBPIgenewithimmuneindexesinSutaipigs.GenetMolRes.2015,14(2):6048-6058. 12.ZhengchangWu,RiweiXia,XuemeiYin,YongjiuHuo,GuoqiangZhu,ShenglongWuandWenbinBao.ProteomicanalysisofduodenaltissuefromEscherichiacoliF18-resistantand-susceptibleweanedpiglets.PLosOne.2015,10(6):e0127163. 13.QiaohuiZhao,YingLiu,WenhuaDong,ShipingZhu,YongjiuHuo,ShenglongWu,WenbinBao.GeneticVariationsofTAP1GeneExon3AffectsGeneExpressionandEscherichiacoliF18ResistanceinPiglets.Int.J.Mol.Sci.2014,15:11161-11171. 14.JingWang,XuemeiYin,LiSun,ShouyongSun,ChenZi,GuoqiangZhu,ShenglongWu,WenbinBao.CorrelationbetweenBPIGeneUpstreamCpGIslandMethylationandmRNAExpressioninPiglets.Int.J.Mol.Sci.2014,15:10989-10998. 15.J.Wang,Y.Liu,W.H.Dong,Y.J.Huo,X.G.Huang,S.L.WuandW.B.Bao.DynamicchangesinTAP1expressionlevelsinnewborntoweaningpiglets,anditsassociationwithEscherichiacoliF18resistance.GenetMolRes.2014,13(2):3686-3692. 16.ShipingZhu,YingLiu,WenhuaDong,XianruiZheng,GuoqiangZhu,ShenglongWu,WenbinBao.PolymorphismofFUT1GeneM307anditsRelationshipwithPartialImmuneIndexesandEconomicTraitsinYorkshirePigs.AsianJournalofAnimal&VeterinaryAdvances.2014,9(4):253-261. 17.ChenZi,ZhengchangWu,JingWang,YongjiuHuo,GuoqiangZhu,ShenglongWuandWenbinBao.TranscriptionalActivityoftheFUT1GenePromoterRegioninPigs.Int.J.Mol.Sci.2013,14:24126-24134. 18.WangJ,PanZY,ZhengXR,WuZC,SuXM,ZhuGQ,HuangXG,WuSL,BaoWB.TLR4geneexpressioninpigpopulationsanditsassociationwithresistancetoEscherichiacoliF18.GenetMolRes.2013,12(3):2625-2632. 19.LuLiu,JingWang,QiaohuiZhao,ChenZi,ZhengchangWu,XianminSua,YongjiuHuo,GuoqiangZhu,ShenglongWu,WenbinBao.Geneticvariationinexon10oftheBPIgeneisassociatedwithEscherichiacoliF18susceptibilityinSutaipiglets.Gene.2013,523(1):70-75. 20.J.Zhu,C.Zi,Z.C.Wu,L.Liu,X.R.Zheng,X.M.Su,G.Q.Zhu,X.G.Huang,S.L.WuandW.B.Bao.Age-dependentexpressionoftheBPIgeneinSutaipiglets.GenetMolRes.2013,12(2):2120-2126. 21.L.Ye,C.Zi,Z.Y.Pan,J.Zhu,Z.D.Du,G.Q.Zhu,X.G.Huang,W.B.Bao,S.L.Wu.InvestigationoftherelationshipbetweenSLA-1andSLA-3geneexpressionandsusceptibilitytoEscherichiacoliF18inpost-weaningpigs.ComparativeImmunology,MicrobiologyandInfectiousDiseases.2012(35):23–30. 22.LanYe,XianminSu,ZhengchangWu,XianruiZheng,JinWang,ChenZi,GuoqiangZhu,ShenglongWu,WenbinBao.AnalysisofDifferentialmiRNAExpressionintheDuodenumofEscherichiacoliF18-Sensitiveand-ResistantWeanedPiglets.PLoSONE.2012,7(8):e43741. 23.Wen-binBao,LanYe,ChenZi,LuLiu,ChenZi,JingZhu,Zhang-yuanPan,Guo-qiangZhu,Xue-genHuang,Sheng-longWu.RelationshipbetweentheexpressionlevelofSLA-DQAandEscherichiacoliF18infectioninpiglets.Gene.2012(494):140–144. 24.Wen-BinBao,LanYe,ChenZi,Xian-MinSu,Zhang-YuanPan,JinZhu,Guo-QiangZhu,Xiao-GuoHuang,Sheng-LongWu.Studyontheage-dependenttissueexpressionofFUT1geneinporcineanditsrelationshiptoE.coliF18receptor,Gene.2012(497):336–339. 25.Wen-binBao,LanYe,Zhang-yuanPan,JingZhu,Zi-DongDu,Guo-qiangZhu,Xue-genHuang,Sheng-longWu.TheeffectofmutationatM307inFUT1geneonsusceptibilityofEscherichiacoliF18andgenenSutaipiglets.MolecularBiologyReports.2012,39(3):3131–3136. 26.Wen-binBao,LanYe,JingZhu,Zhang-yuanPan,Guo-qiangZhu,Xue-genHuang,Sheng-longWu.EvaluationofM307ofFUT1geneasageneticmarkerfordiseaseresistancebreedingofSutaipigs.MolecularBiologyReports.2012,39(4):4223–4228. 27.W.B.Bao,L.Ye,Z.Y.Pan,J.Zhu,Z.D.Du,G.Q.Zhu,X.G.HuangandS.L.Wu.MicroarrayanalysisofdifferentialgeneexpressioninsensitiveandresistantpigtoEscherichiacoliF18.AnimalGenetics.2012,43(5):525-534. 28.W.B.BAO,L.YE,Z.Y.PAN,J.ZhU,G.Q.ZhU,X.G.HUANG,S.L.WU.AnalysisofpolymorphismintheporcineTLR4geneanditsexpressionrelatedtoEscherichiacoliF18infection.CzechJournalofAnimalScience.2011,56(11):475–482. 29.W.B.Bao,L.Ye,J.Zhu,Z.Y.Pan,G.Q.Zhu,X.G.Huang&S.L.Wu.BeneficialgenotypeofswineFUT1genegoverningresistancetoE.coliF18isassociatedwithimportanteconomictraits.JournalofGenetics.2011,90(2):315–318. 30.WEN-BinBao,LanYe,ZHANG-YuanPan,JinZhu,GUO-QiangZhu,XUE-GenHuangandSHENG-LongWu.PolymorphismofM307oftheFUT1geneanditsrelationshipwithsomeimmuneindexesinSutaipigs(Duroc×Meishan).BiochemicalGenetics.2011,49:665–673.

学术兼职

江苏省规模猪场高效健康养殖公共技术服务中心主任 江苏省生猪产业技术创新联盟副理事长 江苏省太湖猪基因库及保种项目首席专家 江苏省农业科技创新团队（东串猪选育）首席专家