陈学思 - 中国科学院长春应用化学研究所 -

个人简介

1959年12月生于吉林长春。中国科学院长春应用化学研究所研究员，博士生导师。1982年8月毕业于吉林大学，获学士学位；1988年9月毕业于中科院长春应化所，获硕士学位；1997年3月，毕业于日本早稻田大学，获博士学位。1999年12月，回到中科院长春应化所工作，任课题组组长。主要从事生物降解医用高分子材料、组织工程和药物缓释、聚乳酸产业化等方向的研发工作。发表SCI学术论文800余篇，SCI他引2万余次，h-指数为87；授权专利260余项。任学术期刊《ACS Biomaterials Science and Engineering》副主编。中国科学院科技促进发展奖科技贡献奖，中国石油和化学工业联合会技术发明奖，吉林省科技进步奖一等奖2项。作为项目负责人承担国家科技部“十三五”重点研发计划项目，国家自然科学基金基础研究中心项目等。同浙江海正集团合作实现了1.5万吨聚乳酸产业化，技术水平达到了国际领先。组建了长春圣博玛生物材料有限公司，获得了可吸收骨折内固定钉和板CFDA两个注册证（III类），3个产品已提交注册申请或在临床评价（III类）。2004年获得国家自然科学杰出青年基金。2019年获评中国科学院院士。

研究领域

主要从事生物降解医用高分子材料、组织工程和药物缓释、聚乳酸产业化等方向的研发工作

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Antineoplastic Drug-Free Anticancer Strategy Enabled by Host-Defense-Peptides-Mimicking Synthetic Polypeptides; Advanced Materials; DOI: 10.1002/adma.202001108; Wei Shen, Yu Zhang, Pengqi Wan, Lin An, Peng Zhang, Chunsheng Xiao*, Xuesi Chen*, Rationally Designed Polymer Conjugate for Tumor-Specific Amplification of Oxidative Stress and Boosting Antitumor Immunity; Nano Letters; 20(4),2514-21(2020); Sheng Ma, Wantong Song*, Yudi Xu, Xinghui Si, Shixian Lv, Yu Zhang, zhaohui Tang, Xuesi Chen*. Neutralizing tumor-promoting inflammation with polypeptide-dexamethasone conjugate for microenvironment modulation and colorectal cancer therapy; Biomaterials; DOI: 10.1016/j.biomaterials. 2019.119676; Sheng Ma, Wantong Song, Yudi Xu, Xinghui Si, Dawei Zhang, Shixian Lv, Chenguang Yang, Lili Ma, Zhaohui Tang, Xuesi Chen*. Electroactive composite scaffold with locally expressed osteoinductive factor for synergistic bone repair upon electrical stimulation; Biomaterials; DOI: 10.1016/j.biomaterials.2019.119617; Liguo Cui, Jin Zhang, Jun Zou, Xianrui Yang, Huui Guo, Huayu Tian, Peibiao Zhang, Yu Wang, Ning Zhang, Xiuli Zhuang, Zhongming Li, Jingxun Ding*, Xuesi Chen*. Combretastatin A4 Nanodrug-Induced MMP9 Amplification Boosts Tumor-Selective Release of Doxorubicin Prodrug; Advanced Materials; 31(44); DOI: 10.1002/adma.201904278; Jian Jiang, Na Shen, Tianyuan Ci, Zhaohui Tang*, Zhen Gu*, Xuesi Chen*. Selectively Potentiating Hypoxia Levels by Combretastatin A4 Nanomedicine: Toward Highly Enhanced Hypoxia-Activated Prodrug Tirapazamine Therapy for Metastatic Tumors; Advanced Materials; 31(11); DOI: 10.1002/adma.201805955; Shengcai Yang, Zhaohui Tang*, Chenyang Hu, Dawei Zhang, Na Shen, Hiyang Yu, Xuesi Chen*. Breaking the paradox between catalytic activity and stereoselectivity: rac-Lactide polymerization by trinuclear Salen？Al complexes；Macromolecules；51（3）（2018）；Xuan Pang, Ranlong Duan, Xiang Li, Chenyang Hu, Xianhong Wang, Xuesi Chen*. Molecular strings significantly improved the gene transfection efficiency of polycations；Journal of the American Chemical Society； 140(38)（2018）；Huapan Fang, Zhaopei Guo, Lin Lin, Jie Chen, Pingjie Sun, Jiayan Wu, Caina Xu, Huayu Tian*, Xuesi Chen*. Sequentially responsive shell-stacked nanoparticles for deep penetration into solid tumors; Advanced Materials；29(32)（2017）; Jinjin Chen, Jianxun Ding*, Yucai Wang, Jianjun Cheng*, Shengxiang Ji, Xiuli Zhuang, Xuesi Chen*. Receptor and microenvironment dual-recognizable nanogel for targeted chemotherapy of highly metastatic malignancy；Nano Letters; 17(7)（2017）；Jinjin Chen, Jianxun Ding, Weiguo Xu, Tianmeng Sun, Haihua Xiao, Xiuli Zhuang, Xuesi Chen*.