个人简介

Alfred P. Sloan Fellow, 2005. McKnight Technological Innovations in Neuroscience Award, 2004. Keck Distinguished Young Scholar in Biomedical Research, 2003. NIH Cutting-Edge Technology in Basic Research Award, 2002. National Science Foundation Career Award, 2002. Research Corporation’s Research Innovation Award, 2000. Dreyfus New Faculty Award, 2000.

研究领域

Analytical/Biological/Materials/and Physical Chemistry/Nanotechnology

How do biological systems, based on a complex series of coupled biochemical reactions, encode and process information, that is, compute? To approach this question experimentally, research in the Chiu group focuses on the development of new tools that combine ultrasensitive laser-based detection and manipulation methodologies with micro- and nano-fabrication techniques for interfacing with biological systems at the nanometer scale. Single-molecule methods. The Chiu group is developing and applying single-molecule methods for probing complex biological systems, specifically synaptic functioning and single-cell biology. The Chiu group is interested in studying both the biophysical properties of single proteins in the context of a cell, as well as using the sensitivities achieved in single-molecule detection for biotechnological applications, such as in high-throughput screening, in the separation and detection of trace biological molecules from single cells (e.g., signaling proteins), and in the development of ultrasensitive sensors. Integrated micro- and nano-fluidic systems on a biochip. Microfluidic systems, through miniaturization and integration, provide a platform for new types of rapid biological and chemical analyses. Successful demonstrations of this “lab-on-a-chip” concept include integrated devices for DNA and protein analyses and “gene chips” for monitoring the combinatorial expression of genes in cells. Applications of these devices range from fundamental studies in cell biology to clinical diagnosis and drug delivery. The main focus in the Chiu group is to study new phenomena unique to this micro- and nano-environment and to exploit these phenomena for addressing selected problems in biology. Biomaterials. Motivations for research at this biology/material science interface include the potential to integrate biological systems with electronic devices for monitoring and controlling biological responses, the study and development of biologically-inspired materials, and the possibility of creating complex microenvironment in vitro for fundamental studies in cellular networks and ecology. The main goals in the Chiu group are to pattern “real” neuronal networks on a chip, to study the dynamics of these networks, and to compare the behavior of these networks with that of artificial ones. An understanding of the behavior of these simple in vitro systems is a first step towards deciphering how complex biological systems encode and process information.

近期论文

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T. Schneider, G.S. Yen, A.M. Herrick, D.R. Burham, D.T. Chiu (2013) "Self-digitization of samples into a high-density bottom-well array" Anal. Chem. 85, 10417-10423. Q. Li, K. Sun, K. Chang, D.T. Chiu, C. Wu, W. Qin (2013) "Ratiometric luminescent detection of an anthrax biomarker with terbium chelated semiconducting polymer dots" Anal. Chem. 85, 9087-9091. M. Zhao, W.C. Nelson, B. Wei, P.G. Schiro, B.M. Hakimi, E.S. Johnson, R.K. Perdue, G. Gyurkey, L.M. White, S. Whiting, D.T. Chiu (2013) "New generation of ensemble-decision aliquot ranking based on simplified microfluidic components for large-capacity trapping of circulating tumor cells" Anal. Chem. 85, 9671-9677. W. Sun, J. Yu, F. Ye, Y. Rong, D.T. Chiu (2013) "Highly fluorescent semiconducting polymer dots for single-molecule imaging and sensing" Proc. SPIE-Int. Soc. Opt. Eng. (in press). W. Sun, J. Yu, R. Deng, Y. Rong, B. Fujimoto, H. Zhang, D.T. Chiu (2013) "Highly bright semiconducting polymer dots with ultra-narrow emission and long luminescence lifetime for time-gated cellular targeting" Angew. Chem. Int. Ed. 52, 11294-11297. D. Liu, B. Hakimi, M. Volny, J. Rolfs, X. Chen, F. Turecek, D.T. Chiu (2013) "Controlled generation of double emulsions in air" Anal. Chem. 85, 6190-6194. M. Zhao, B. Wei, D.T. Chiu (2013) "Imaging multiple biomarkers in eDAR captured rare cells with sequential immunostaining and photobleaching" Methods 64, 108-113. Y. Zhang, J. Yu, M.E. Gallina, W. Sun, Y. Rong, D.T. Chiu (2013) "Highly fluorescent fluorinated semiconducting polymer dots for cellular imaging and analysis" Chem. Comm. 49, 8256-8258. M.Zeigler, W. Sun, Y. Rong, D.T.Chiu (2013) "Hybrid semiconducting polymer nanoparticles as polarization-sensitive fluorescent probes" J. Amer. Chem. Soc. 135, 11453-11456. J.M. Schurr, B.S. Fujimoto, L. Huynh, D.T. Chiu (2013) "A theory of molecular chemotaxis" J. of Phys. Chem. B 117, 7626-7652. W. Sun, F. Ye, M.E. Gallina, C. Wu, D.T. Chiu (2013) "Lyophilization of semiconducting polymer dot bioconjugates" Anal. Chem. 85, 4316-4320. F. Ye, P.B. Smith, C. Wu, D.T. Chiu (2013) "Ultrasensitive detection of proteins on Western blots with semiconducting polymer dots" Macromol. Rapid Commun. 34, 785-790. T. Schneider, J. Kreutz, D.T. Chiu (2013) "The potential impact of droplet microfluidics in biology" Anal. Chem. 85, 3476-3482. B. Neupane, F. Chen, W. Sun, D.T. Chiu, G. Wang (2013) "Tuning Donut Profile for Spatial Resolution in Stimulated Emission Depletion Microscopy" Rev. Sci. Instr. 84, 043701. X. Zhang, J. Yu, Y. Rong, F. Ye, D.T. Chiu, K. Uvdal (2013) "High-intensity Near-IR Fluorescence in Semiconducting Polymer Dots Achieved by Cascade Energy Transfer" Chem. Sci. 4, 2143-2151. M. Zhao, P.G. Schiro, J.S. Kuo, K.M. Koehler, D.E. Sabath, V. Popov, Q. Feng, D.T. Chiu (2013) "An Automated High-Throughput Counting Method for Screening Circulating Tumor Cells in Peripheral Blood" Anal. Chem. 85, 2465-2471. Y. Rong, C. Wu, J. Yu, X. Zhang, F. Ye, M. Zeigler, M. Gallina, I. Wu, Y. Zhang, Y.H. Chan, W. Sun, K. Uvdal, D.T. Chiu (2013) "Multicolor fluorescent semiconducting polymer dots with narrow band emissions" ACS Nano 7, 376-384. M.B. Zeigler, D.T. Chiu (2013) "Single-cell nanosurgery" Methods Mol.Bio. 991,139-148. A.E. Sgro, S.M. Bajjalieh, D.T. Chiu (2013) "Single-organelle analysis of axonal transport vesicles reveals new protein-motor associations" ACS Chem. Neurosci. 4, 277-284. C. Wu and D.T. Chiu (2013) "Semiconducting polymer dots: A new family of fluorescent nanoparticles for biological applications Angew. Chem. Int. Ed. 52, 3086-3109. J.C. Gadd, B.S. Fujimoto, S.M. Bajjalieh, D.T. Chiu (2012) "Single-molecule fluorescence quantification with a photobleached internal standard" Anal. Chem. 84, 10522-10525.