个人简介

NSF CAREER Award (2014) Cottrell Scholar Award (2014) Army Research Office Young Investigator Program Award (2011) National Institutes of Health (NCI) National Research Service Award (2008-2010) International Precious Metals Institute Student Award (2006) University of Texas Professional Development Award (2006) George Kozmetsky Award for Outstanding Graduate Research in Nanotechnology (finalist, 2006) University of Texas Graduate Fellowship (2005-2006)

研究领域

Organic/Organometallic/and Polymer Chemistry

Mechanochemical Transduction in Polymeric Systems: Investigations in the Boydston group focus on developing polymers and materials that undergo controlled, autonomic responses to environmental stimuli, particularly mechanical impetus. Our group seeks to understand how polymer architecture and composition influence mechanochemical reactivity, and how mechanochemical transduction can be used to design functional materials. Main focus areas include the development of new mechano-responsive functional groups, environmental influences on mechanochemical efficiency, and amplification of chemical reactions driven by the application of force. At the fundamental level, we are interested in how different force-guided structural changes (e.g., bending versus stretching versus torsion) translate into chemo-mechanical coupling efficiency and selectivity, how chemical catalysis can be combined with mechanical impetus, the use of mechanical energy to initiate spontaneous reaction cascades, and how branch points in macromolecular structures distribute forces resulting from stress and strain. We are motivated by potential for mechanochemical reactivity to impact important areas such as drug delivery, sensory materials, and self-reinforcing materials. Organocatalyzed Electro-organic Synthesis: Achieving improved and broadened synthetic capabilities is key to the development of advanced materials and efficient syntheses of target molecules. Redox reactions are some of the most important and fundamental processes to the synthetic chemist. Our group is targeting new reactions at the interface of electro-organic synthesis and organocatalysis to effect oxidations and reductions of organic substrates in a metal-free manner. By conducting experiments under a controlled cell potential, we are able to intercept reactive intermediates generated during organocatalyzed transformations and electrochemically change their oxidation states. Notably, electrochemical techniques can provide unique selectivity and reaction efficiency not achieved by stoichiometric oxidants and reductants.

近期论文

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Church, D. C.; Peterson, G. I.; Boydston, A. J. "Comparison of Mechanochemical Chain Scission Rates for Linear versus Three-Arm Star Polymers in Strong Acoustic Fields." ACS Macro Lett. 2014, 3, 648-651. Diesendruck, C. E.; Peterson, G. I.; Kulik, H. J.; Kaitz, J. A.; Mar, B. D.; May, P. A.; White, S. R.; Martínez, T. J.; Boydston, A. J.; Moore, J. S. "Mechanically-Triggered Heterolytic Unzipping of a Low Ceiling Temperature Polymer." Nat. Chem. 2014, 6, 623-628. Ogawa, K. A.; Boydston, A. J. "Electrochemical Characterization of Azolium Salts." Chem. Lett. 2014, 43, 907-909. Ogawa, K. A.; Boydston, A. J. "Anodic Oxidation of Aldehydes to Thioesters." Org. Lett. 2014, 16, 1928-1931. Larsen, M. B.; Boydston, A. J. "Successive Mechanochemical Activation and Small Molecule Release in an Elastomeric Material." J. Am. Chem. Soc. 2014, 136, 1276-1279. Larsen, M. B.; Boydston, A. J. "Flex-Activated Mechanophores: Using Polymer Mechanochemistry to Direct Bond Bending Activation." J. Am. Chem. Soc. 2013, 135, 8189-8192. Peterson, G. I.; Larsen, M. B.; Boydston, A. J. "Controlled Depolymerization: Stimuli-Responsive Self-Immolative Polymers." Macromolecules 2012, 45, 7317-7328. Finney, E, E.; Ogawa, K. A.; Boydston, A. J. "Organocatalyzed Anodic Oxidation of Aldehydes." J. Am. Chem. Soc. 2012, 134, 12374-12377. Momčilović, N.; Clark, P. G.; Boydston, A. J.; Grubbs, R. H. "One-Pot Synthesis of Polyrotaxanes via Acyclic Diene Metathesis Polymerization of Supramolecular Monomers." J. Am. Chem. Soc. 2011, 133, 19087-19089. Xia, Y.; Boydston, A. J.; Grubbs, R. H. "Synthesis and Direct Imaging of Ultrahigh Molecular Weight Cyclic Brush Polymers." Angew. Chem. Int. Ed. 2011, 50, 5882-5885. Boydston, A. J.; Holcombe, T. W.; Unruh, D. A.; Fréchet, J. M. J.; Grubbs, R. H. "A Direct Route to Cyclic Organic Nanostructures via Ring-Expansion Metathesis Polymerization of a Dendronized Macromonomer." J. Am. Chem. Soc. 2009, 131, 5388-5389. (Highlighted: C&E News 2009, April 14, 32; Nature Chemistry 2009, 1, 178-179) Xia, Y.; Boydston, A. J.; Yao, Y.; Kornfield, J. A.; Gorodetskaya, I. A.; Spiess, H. W.; Grubbs, R. H. "Ring-Expansion Metathesis Polymerization: Catalyst Dependent Polymerization Profiles." J. Am. Chem. Soc. 2009, 131, 2670-2677. Boydston, A. J.; Xia, Y.; Kornfield, J. A.; Gorodetskaya, I. A.; Grubbs, R. H. "Cyclic Ruthenium-Alkylidene Catalysts for Ring-Expansion Metathesis Polymerization." J. Am. Chem. Soc. 2008, 130, 12775-12782. Boydston, A. J.; Vu, P. D.; Dykhno, O. L.; Chang, V.; Wyatt, A. R., II; Stockett, A. S.; Ritschdorff, E. T.; Shear, J. B.; Bielawski, C. W. "Modular Fluorescent Benzobis(imidazolium) Salts: Syntheses, Photophysical Analyses, and Applications." J. Am. Chem. Soc. 2008, 130, 3143-3156. Boydston, A. J.; Pecinovsky, C. S.; Chao, S. T.; Bielawski, C. W. "Phase-Tunable Fluorophores Based Upon Benzobis(imidazolium) Salts." J. Am. Chem. Soc. 2007, 129, 14550-14551. Khramov, D. M.; Boydston, A. J.; Bielawski, C. W. "Synthesis and Study of Janus Bis(carbene)s and Their Transition Metal Complexes." Angew. Chem., Int. Ed. 2006, 45, 6186-6189. Boydston, A. J.; Williams, K. A.; Bielawski, C. W. "A Modular Approach to Main-Chain Organometallic Polymers." J. Am. Chem. Soc. 2005, 127, 12496-12497. (Highlighted by C&E News 2005, Sept. 5, 32.) Sartin, M. M.; Boydston, A. J.; Pagenkopf, B. L.; Bard, A. J. "Electrochemistry, Spectroscopy, and Electrogenerated Chemiluminescence of Silole-Based Chromophores." J. Am. Chem. Soc. 2006, 128, 10163-10170. (Highlighted by the ACS: Chemical Innovation Heart Cut: August 28, 2006.) Boydston, A. J.; Pagenkopf, B. L. "Improving Quantum Efficiencies of Siloles and Silole-derived Butadiene Chromophores through Structural Tuning." Angew. Chem., Int. Ed. 2004, 43, 6336-6338. (Highlighted by the ACS: Chemical Innovation Heart Cut: December 13, 2004.) Boydston, A. J.; Yin, Y.; Pagenkopf, B. L. "A Controlled, Iterative Synthesis of Oligo[(p-phenyleneethynylene)-alt-(2,5-siloleneethynylene)]s." J. Am. Chem. Soc. 2004, 126, 10350-10354. Boydston, A. J.; Yin, Y.; Pagenkopf, B. L. "Synthesis and Electronic Properties of Donor-Acceptor p-Conjugated Siloles." J. Am. Chem. Soc. 2004, 126, 3724-3725. (Highlighted by the ACS: Chemical Innovation Heart Cut: April 19, 2004.) Boydston, A. J.; Bondarenko, L.; Dix, I.; Weakley, T. J. R.; Hopf, H.; Haley, M. M. "[2.2]Paracyclophane/Dehydrobenzoannulene Hybrids: Transannular Delocalization in Open-Circuited Conjugated Macrocycles." Angew. Chem., Int. Ed. 2001, 40, 2986-2989.