Thompson, David H. - Purdue University - Department of Chemistry

个人简介

B.S., Chemistry & B.A., Biology, 1978, University of Missouri-Columbia; Ph.D., Organic Chemistry, 1984, Colorado State University; Postdoctoral Associate, Membrane Chemistry, 1984-1987, Oregon Graduate Institute.

研究领域

Development of transiently-‐stable carrier systems for intracellular drug & gene delivery; supported membrane applications; materials for accelerated protein structure elucidation

近期论文

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Kulkarni, A.;DeFrees, K.;Schuldt, R. A.;Hyun, S. H.;Wright, K. J.;Yerneni, C. K.;VerHeul, R.;Thompson, D. H. Cationic alpha-Cyclodextrin:Poly(ethylene glycol) Polyrotaxanes for siRNA Delivery Molecular Pharmaceutics 2013 85 14 6820-6825 Kulkarni, A.;DeFrees, K.;Schuldt, R. A.;Vlahu, A.;VerHeul, R.;Hyun, S. H.;Deng, W.;Thompson, D. H. Multi-armed cationic cyclodextrin:poly(ethylene glycol) polyrotaxanes as efficient gene silencing vectors Integrative Biology 2013 117 29 6244-6249 Kulkarni, A.;VerHeul, R.;DeFrees, K.;Collins, C. J.;Schuldt, R. A.;Vlahu, A.;Thompson, D. H. Microfluidic assembly of cationic-beta-cyclodextrin: hyaluronic acid-adamantane host: guest pDNA nanoparticles Biomaterials Science 2013 7 1 725-731 Mondjinou, Y. A.;McCauiff, L. A.;Kulkarni, A.;Paul, L.;Hyun, S. H.;Zhang, Z. R.;Wu, Z.;Wirth, M.;Storch, J.;Thompson, D. H. Synthesis of 2-Hydroxypropyl-beta-cyclodextrin/Pluronic-Based Polyrotaxanes via Heterogeneous Reaction as Potential Niemann-Pick Type C Therapeutics Biomacromolecules 2013 42 9 691-708 Morimoto, N.;Hirano, S.;Takahashi, H.;Loethen, S.;Thompson, D. H.;Akiyoshi, K. Self-Assembled pH-Sensitive Cholesteryl Pullulan Nanogel As a Protein Delivery Vehicle Biomacromolecules 2013 42 9 691-708 Harle, M.;Towns, M. H. Students' Understanding of Primary and Secondary Protein Structure: Drawing Secondary Protein Structure Reveals Student Understanding Better Than Simple Recognition of Structures Biochemistry and Molecular Biology Education 2013 10 5 1918-1927 Deng, W.;Chen, J.;Kulkarni, A.;Thompson, D. H. Poly(ethylene glycol)-poly(vinyl alcohol)-adamantanate: synthesis and stimuli-responsive micelle properties Soft Matter 2012 8 - 5843-5846 Kim, H. K.;Van den Bossche, J.;Hyun, S. H.;Thompson, D. H. Acid-Triggered Release via dePEGylation of Fusogenic Liposomes Mediated by Heterobifunctional Phenyl-Substituted Vinyl Ethers with Tunable pH-Sensitivity Bioconjugate Chemistry 2012 23 - 2071-2077 Kim, H. K.;Wei, H. L.;Kulkarni, A.;Pogranichniy, R. M.;Thompson, D. H. Effective Targeted Gene Delivery to Dendritic Cells via Synergetic Interaction of Mannosylated Lipid with DOPE and BCAT Biomacromolecules 2012 13 - 636-644 Kulkarni, A.;DeFrees, K.;Hyun, S. H.;Thompson, D. H. Pendant Polymer:Amino-beta-Cyclodextrin:siRNA Guest:Host Nanoparticles as Efficient Vectors for Gene Silencing Journal of the American Chemical Society 2012 134 - 7596-7599 Kulkarni, A.;Deng, W.;Hyun, S. H.;Thompson, D. H. Development of a Low Toxicity, Effective pDNA Vector Based on Noncovalent Assembly of Bioresponsive Amino-beta-cyclodextrin:Adamantane-Poly(vinyl alcohol)-Poly(ethylene glycol) Transfection Complexes Bioconjugate Chemistry 2012 23 - 933-940 Deng, W.;Thompson, D. H. pH and cation-responsive supramolecular gels formed by cyclodextrin amines in DMSO Soft Matter 2010 6 9 1884-1887 Grey, J. L.;Thompson, D. H. Challenges and opportunities for new protein crystallization strategies in structure-based drug design Expert Opinion on Drug Discovery 2010 5 11 1039-1045 Hyun, S. H.;Kim, H. K.;Kim, J. M.;Thompson, D. H. Oriented Insertion of phi29 N-Hexahistidine-tagged gp10 Connector Protein Assemblies into C(20)BAS Bolalipid Membrane Vesicles Journal of the American Chemical Society 2010 132 48 17053-17055 Mulligan, K.;Brownholland, D.;Carnini, A.;Thompson, D. H.;Johnston, L. J. AFM Investigations of Phase Separation in Supported Membranes of Binary Mixtures of POPC and an Eicosanyl-Based Bisphosphocholine Bolalipid Langmuir 2010 26 11 8525-8533 Boomer J. A.;Qualls, M. M.;Inerowicz, H. D.;Haynes, R. H.;Patri, V. S.;Kim, J. M.;Thompson, D. H. Cytoplasmic Delivery of Liposomal Contents Mediated by an Acid-Labile Cholesterol-Vinyl Ether-PEG Conjugate Bioconjugate Chemistry 2009 20 - 47-59 Acharya G.;Chang, C. L.;Holland, D. P.;Thompson, D. H.;Savran, C. A. Rapid detection of S-adenosyl homocysteine using self-assembled optical diffraction gratings Angewandte Chemie-International Edition 2008 47 - 1051-1053 Holland D. P.;Struts, A. V.;Brown, M. F.;Thompson, D. H. Bolalipid membrane structure revealed by solid-state H-2 NMR spectroscopy Journal of the American Chemical Society 2008 130 - 4584-+ Thompson D. H. Adenovirus in a synthetic membrane wrapper: An example of hybrid vigor? Acs Nano 2008 2 - 821-826 Longo G. S.;Thompson, D. H.;Szleifer, I. Stability and phase separation in mixed monopolar lipid/bolalipid layers Biophysical Journal 2007 93 - 2609-2621