何治 - 三峡大学

个人简介

何治，1978年7月生，湖北浠水人，医学博士，教授，博士/硕士研究生导师，湖北省高等学校优秀中青年科技创新团队负责人，三峡大学“151”学术带头人，湖北省新世纪高层次人才工程人选，湖北省青年博士“晨光计划”人选，国家自然科学基金同行评议专家，教育部学位中心学位论文评审专家，湖北省药理学会常务理事。现任三峡大学医学院院长，曾任三峡大学研究生院副院长、学科规划与建设办公室副主任。2008年获华中科技大学药理学专业博士学位，2012-2013年德国美因茨大学医学中心访问学者。目前主要从事脑卒中、药物成瘾等神经系统疾病发病机理及相关防治药物的研究，围绕HCN通道（超极化激活环核苷酸门控阳离子通道）与脑缺血及药物成瘾、ALPHA肾上腺素受体与脑缺血、天然药物的抗脑缺血作用及机制等研究领域开展工作。

研究领域

承担的主要科研项目： 1.国家自然科学基金(主持)：HCN通道功能抑制对脑缺血的保护作用及相关分子机制研究； 2.国家自然科学基金(主持)：从"聪明基因"NR2B途径探讨α2肾上腺素受体激动剂对血管性痴呆大鼠认知功能的调节作用 3.湖北省高等学校优秀中青年科技创新团队（负责人）：神经药理学

近期论文

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1.YanliLi,MinYu,BoZhao,YanWang,YunhongZha,ZichengLi,LinglingYu, linglingYan,ZhangaoChen,WenjuanZhang,XiaoliZeng,ZhiHe(通讯作者).Clonidinepreconditioningimprovedcerebralischemia-inducedlearningandmemorydeficitsinratsviaERK1/2-CREB/NF-κB-NR2Bpathway.EuropeanJournalofPharmacology(2018),818,167-173 2.LiYanli,ZhangXizhou,WangYan,ZhaoBo,ZhaYunhong,LiZicheng,YuLingling, Yanlingling,ChenZhangao,ZhengMin,HeZhi(通讯作者).Clonidinepreconditioningalleviatedfocalcerebralischemicinsultinratsviaup-regulatingp-NMDAR1anddown-regulatingNMDAR2A/p-NMDAR2B.EuropeanJournalofPharmacology (2016),793,89-94. 3.YunLu,Chang-junLi,ChengChen,PanLuo,MeiZhou,CaiLi,Xu-linXu,QingLu,ZhiHe(通讯作者),Lian-junGuo.ActivationofGABAB2subunitsalleviateschroniccerebral hypoperfusion-inducedanxiety-likebehaviours:AroleforBDNFsignallingandKir3channels.Neuropharmacology110(2016)308-321 4.PanLuo,ChengChen,YunLu,TianLiFu,QingLu,XulinXu,ChangjunLi,ZhiHe(通讯作者),LianjunGuo.Baclofenamelioratesspatialworkingmemoryimpairmentsinducedbychroniccerebralhypoperfusionviaup-regulationofHCN2expressioninthePFCinrats.BehaviouralBrainResearch,2016,308,6–13 5.YunLu,ChangjunLi,MeiZhou,PanLuo,PengchengHuang,JiahongTan,QingLu,XulinXu,ZhiHe(通讯作者),LianjunGuo.Clonidineamelioratescognitiveimpairmentinducedbychroniccerebralhypoperfusionviaup-regulationoftheGABABR1andGAD67inhippocampalCA1inrats.Pharmacology,BiochemistryandBehavior,2015,132,96-102 6.PanLuo,YunLu,ChangjunLi,MeiZhou,ChengChen,QingLu,XulinXu,ZhiHe(通讯作者),LianjunGuo.Long-lastingspatiallearningandmemoryimpairmentscausedbychroniccerebralhypoperfusionassociatewithadynamicchangeofHCN1/HCN2expressioninhippocampalCA1region.NeurobiologyofLearningandMemory,2015,123,72-83. 7.MeiZhou,PanLuo,YunLu,Chang-junLi,Dian-shiWang,QingLu,Xu-linXu,ZhiHe(通讯作者),Lian-junGuo.ImbalanceofHCN1andHCN2expressioninhippocampalCA1areaimpairsspatiallearningandmemoryinratswithchronicmorphineexposure.ProgressinNeuro-Psychopharmacology&BiologicalPsychiatry.2015,56,207–214 8.YouYan,YuMin,HuMin,ChenChao,QianYing,HeZhi(通讯作者).n-butanolsolublefractionofthewaterextractofChinesetoonfruitamelioratedfocalbrainischemicinsultinratsviainhibitionofoxidativestressandinflammation.JournalofEthnopharmacology，2014,151:176-782 9.HeZhi,HuMin,ZhaYun-hong,LiZi-cheng,ZhaoBo,YuLing-ling,YuMin,QianYing.Piracetamamelioratedoxygenandglucosedeprivation-inducedinjuryinratcorticalneuronsviainhibitionofoxidativestress,excitatoryaminoacidsreleaseandP53/Bax.CellMolNeurobiol2014，34:539–547 10.S.Li,Z.He（并列第一作者）,L.Guo，L.Huang,J.Wang,W.He.BehavioralalterationsassociatedwithadownregulationofHCN1mRNAinhippocampalcornusammon1regionandneocortexafterchronicincompleteglobalcerebralischemiainrats.Neuroscience,2010,165,654–661. 11.LinHuang,ZhiHe（并列第一作者）,LianjunGuo,HongxingWang.ImprovementofCognitiveDeficitandNeuronalDamageInRatswithChronicCerebralIschemiaviaRelativeLong-termInhibitionofRho-kinase.CellMolNeurobiol,2008.28(5):757-68. 12.ZhiHe,LinHuang,YanWu，JianzhiWang,HongxingWang,LianjunGuo.DDPH:Improvingcognitivedeficitsbeyonditsα1-adrenergicreceptorantagonisminchroniccerebralhypoperfusedrats.EurJofPharmacol.2008,588:178-188 13.ZhiHe,YunLiao,MinZheng,Fan-DianZeng,Lian-JunGuo.PiracetamImprovesCognitiveDeficitsCausedbyChronicCerebralHypoperfusioninRats.CellMolNeurobiol,2008,28:613-627. 14.ZhiHe,QingLu,XulinXu,LinHuang,JianguoChen,LianjunGuo.DDPHamelioratedoxygenandglucosedeprivation-inducedinjuryinrathippocampalneuronsviainterruptingCa2+overloadandglutamaterelease.EurJofPharmacol.2009，603:50-55