王东辉 - 中国科学院上海有机化学研究所 - 有机功能分子合成与组装化学重点实验室

个人简介

Professor Dong-Hui Wang was born in Heilong Jiang province, China. He was awarded the national "Thousand Talents" youth program in 2013. Educational Background: 2000 BA, Lanzhou University (Supervisor: Prof. Zhongli Liu ) 2007 MsA, Brandeis University (Supervisor: Prof. Jin-Quan Yu) 2010 Ph.D., The Scripps Research Institute (Supervisor: Prof. Jin-Quan Yu) Working Experience: 2000-2004 Research Technician, Shanghai Institute of Organic Chemistry (Supervisor: Prof. Zhaoguo Zhang) 2010-2012 Postdoctoral Associate, Massachusetts Institute of Technology (Supervisor: Prof. Stephen L. Buchwald) 2012-2014 Medicinal Scientist, Abide Therapeutics Inc. 2014-present Professor, Shanghai Institute of Organic Chemistry, CAS

研究领域

Research interest: 1, Transition-metal Nano-particles catalyzed Cross-Coupling reactions; 2, Free radical chemistry; and 3, C-H activations. So far, Prof. Wang has published more than 20 research reports on prestigious journals, such as Science, J. Am. Chem. Soc., Angew. Chem., Int. Ed., and Org. Lett. He has 3 issued world patents. The total citation is more than 5000.

近期论文

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Jin-Ling Dai, Nan-Qi Shao, Jin Zhang, Run-Ping Jia, Dong-Hui Wang J. Am. Chem. Soc. 2017, ASAP. DOI: 10.1021/jacs.7b06785 DeAngelis, A.; Wang, D.-H.; Buchwald, S. L. Mild and rapid Pd-catalyzed cross-coupling with hydrazine in continuous flow: application to the synthesis of functionalized heterocycles Angew. Chem., Int. Ed. 2013, 52, 3434. Wang, D.-H.; Yu, J.-Q. “Highly Convergent Total Synthesis of (+)-Lithospermic Acid via a Late-Stage Intermolecular C–H Olefination” J. Am. Chem. Soc. 2011, 133, 5767. Wang, D.-H.; Engle, K. M.; Shi, B.-F.; Yu, J.-Q. “Ligand-Enabled Reactivity and Selectivity in a Synthetically Versatile Aryl C–H Olefination.”Science 2010, 327, 315. Engle, K. M.; Wang, D.-H.; Yu, J.-Q. “Ligand-Accelerated C–H Olefination Reactions: Evidence for a Switch of Mechanism.” J. Am. Chem. Soc. 2010, 132, 14137. Engle, K. M.; Wang, D.-H.; Yu, J.-Q. “Constructing Multiply Substituted Arenes Using Sequential Pd(II)-Catalyzed C–H Olefination.” Angew. Chem. Int. Ed. 2010, 49, 6169. Mei, T.-S.; Wang, D.-H.; Yu, J.-Q. “Expedient Drug Synthesis and Diversification via ortho-C–H Iodination Using Recyclable PdI2 as the Precatalyst.” Org. Lett. 2010, 12, 3140. Lu, Y.; Wang, D.-H.; Engle, K. M.; Yu, J.-Q. “Pd(II)-Catalyzed Hydroxyl-Directed C–H Olefination Enabled by Monoprotected Amino Acid Ligands.” J. Am. Chem. Soc. 2010, 132, 5916. Shi, B.-F.; Zhang, Y.-H.; Lam, J. K.; Wang, D.-H.; Yu, J-.Q. “Pd(II)-Catalyzed Enantioselective C–H Olefination of Diphenylacetic Acids.” J. Am. Chem. Soc. 2010, 132, 460. Chen, X.; Engle, K. M.; Wang, D.-H.; Yu, J.-Q. “Palladium(II)-Catalyzed C–H Activation/C–C Cross-Coupling Reactions: Versatility and Practicality.” Angew. Chem. Int. Ed. 2009, 48, 5094. Wang, D.-H.; Mei, T.-S.; Yu, J.-Q. “Versatile Pd(II)-Catalyzed C–H Activation/Aryl–Aryl Coupling of Benzoic and Phenyl Acetic Acids.” J. Am. Chem. Soc. 2008, 130, 17676. Wang, D.-H.; Wasa, M.; Giri, R.; Yu, J.-Q. “Pd(II)-Catalyzed Cross-Coupling of sp3 C–H Bonds with sp2 and sp3 Boronic Acid Using Air as the Oxidant.” J. Am. Chem. Soc. 2008, 130, 7190. Giri, R.; Maugel, N.; Li, J.-J.; Wang, D.-H.; Breazzano, S. P.; Saunders, L. B.; Yu, J.-Q. “Palladium-Catalyzed Methylation and Arylation of sp2 and sp3 C–H Bonds in Simple Carboxylic Acid.” J. Am. Chem. Soc. 2007, 129, 3510. Wang, D.-H.; Hao, X.-S.; Wu, D.-F.; Yu, J.-Q. “Palladium-Catalyzed Oxidation of Boc-Protected N-Methylamines with IOAc as the Oxidant: A Boc-Directed sp3 C–H Bond Activation.” Org. Lett. 2006, 8, 3387. Giri, R.; Liang, J.; Lei, J.-G.; Li, J.-J.; Wang, D.-H.; Chen, X.; Naggar, I. C.; Guo, C.-Y.; Foxman, B. M.; Yu, J.-Q. “Pd-Catalyzed Stereoselective Oxidation of Methyl Groups by Inexpensive Oxidants under Mild Condition: A dual Role for Carboxylic Anhydrides in Catalytic C–H Bond Oxidation.” Angew. Chem. Int. Ed. 2005, 44, 7420. Sun, Y.; Wan, X.; Guo, M.; Wang, D.; Dong, X.; Pan, Y.; Zhang, Z. “Chiral biphosphine ligands for the Ru-catalyzed enantioselective hydrogenation of β-ketoesters.” Tetrahedron: Asymmetry 2004, 15, 2185. Wang, D.-H.; Zhang, Z.-G. Activation and reaction of carboxylic anhydride catalyzed by palladium Youji Huaxue 2004, 24, 258. Wang, D.; Zhang, Z. “Palladium-Catalyzed Cross-Coupling Reactions of Carboxylic Anhydrides with Organozinc Reagents.” Org. Lett. 2003, 5, 4645.