刘国生 - 中国科学院上海有机化学研究所 - 金属有机化学国家重点实验室

个人简介

Experience 2003 - 2005 Research Associate, Department of Chemistry, Lehigh University, PA, USA (with Prof. Li Jia) 2005 - 2007 Research Associate, Department of Chemistry, University of Wisconsin at Madison, WI, USA (with Prof. Shannon S Stahl) 2007 - present Professor, Shanghai Institute of Organic Chemistry, CAS Education 1991-1995 B.S. Nanjing University of Science and Technology 1995-1999 M.S. Dalian Institute of Chemical Physics, CAS (Supervisor: Prof. Zhuo Zheng) 1999-2002 Ph.D. Shanghai Institute of Organic Chemistry, CAS (Supervisor: Prof. Xiyan Lu)

研究领域

TM-catalyzed fluorination and related transformations TM-Catalyzed oxidation of alkenes with green oxidants TM-catalyzed highly-selective radical reactions

近期论文

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Asymmetric 1,n-Remote Aminoacetoxylation of Unactivated Internal Alkenes Enabled by Palladium Catalysis Xintuo Yang, Pinhong Chen, Guosheng Liu* Angew. Chem. Int. Ed. 2024, 63, e202408305 Palladium-Catalyzed Remote Hydrosulfonamidation of Alkenes: Access to Primary N-Alkyl Sulfamides by the SuFEx Reaction Chuanqi Hou,# Zhenye Liu,# Lan Gan, Wenzheng Fan, Lin Huang, Pinhong Chen, Zheng Huang, Guosheng Liu* J. Am. Chem. Soc. 2024, 146, 13536–13545. Palladium(II)-Catalyzed Markovnikov Hydroalkynylation of Unactivated Terminal Alkenes.Chuanqi Hou, Pinhong Chen,* Guosheng Liu* Chin. J. Chem. 2024, 42, 29–34.2023 Site-selective sp2 C-H Cyanation of Allenes via Copper-catalyzed Radical Relay.Zhongming Cheng, Tilong Yang, Can Li, Yunshun Deng, Fangjia Zhang, Pinhong Chen, Zhenyang Lin,* Shengming Ma,* Guosheng Liu* J. Am. Chem. Soc. 2023, 145, 25995–26002. Cu/photoredox-catalyzed decarboxylative radical C(sp3)–C(sp3) cross-coupling reactions Chao Jiang, Pinhong Chen, Guosheng Liu* Sci. China Chem. 2023, 66, 2858–2862. Palladium-catalyzed Asymmetric Oxycarbonylation of Internal Z-Alkenes. Changyu Shao, Chuanqi Hou, Pinhong Chen, Haihui Peng,* Guosheng Liu* Asian J. Org. Chem. 2023, 12, e20230016. Copper-Catalyzed Asymmetric Functionalization of Vinyl Radicals for the Access to Vinylarene Atropisomers.Liang Fu,# Xin Chen,# Wenzheng Fan, Pinhong Chen, Guosheng Liu* J. Am. Chem. Soc. 2023,145,13476–13483. Regio- and enantioselective remote dioxygenation of internal alkenes.Xiaonan Li, Tilong Yang, Jiaoyuan Li, Xiang Li, Pinhong Chen, Zhenyang Lin*, Guosheng Liu* Nat. Chem. 2023, 15, 862–871. Asymmetric Palladium-Catalyzed Aminochlorination of Unactivated Alkenes.Zhigang Wang, Chuanqi Hou, Pinhong Chen* Org. Lett. 2023, 25, 2685–2690. Enantioselective Cyanation of Propargylic C-H Bonds via Cooperative Photoredox and Copper Catalysis.Yunshun Deng, # Ronghua Lu, # Pinhong Chen,* Guosheng Liu* Chem. Commun. 2023, 59, 4656-4659. Asymmetric Palladium-Catalyzed Aza-Wacker Reaction of Alkenes: Efficient Synthesis of Chiral 1,3-Oxazinan-2-ones.Xintuo Yang, Pinhong Chen, Guosheng Liu* Chin. J. Org. Chem. 2022, 42, 3382–3389. Palladium-Catalyzed Remote Hydrooxygenation of Internal Alkenes: An Efficient Access to Primary Alcohols.Xiang Li, Xintuo Yang, Pinhong Chen, Guosheng Liu* J. Am. Chem. Soc. 2022, 144, 22877–22883. Electrophotocatalytic Decoupled Radical Relay Enables Highly Efficient and Enantioselective Benzylic C–H Functionalization.Wenzheng Fan#, Xueyao Zhao#, Yunshun Deng, Pinhong Chen, Fei Wang,* Guosheng Liu* J. Am. Chem. Soc. 2022, 144, 21674–21682. Enantioselective Radical Trifluoromethylation of Benzylic C–H Bonds via Cooperative Photoredox and Copper Catalysis Pin Xu, Wenzheng Fan, Pinhong Chen, Guosheng Liu* J. Am. Chem. Soc. 2022, 10.1021/jacs.2c06432. Asymmetric Alkynylation of Tertiary Carbon-Centered Radical via Copper-Catalyzed Radical Relay Dunqi Wu, Lianqian Wu, Pinhong Chen, Guosheng Liu* Chin. J. Chem. 2022, 14, 1699-1704. Palladium(II)-Catalyzed Enantioselective Hydrooxygenation of Unactivated Terminal Alkenes Xintuo Yang, Xiang Li, Pinhong Chen*, Guosheng Liu* J. Am. Chem. Soc. 2022, 144, 7972–7977. Copper-Catalyzed Enantioselective Radical Chlorination of Alkenes Dunqi Wu, Wenzheng Fan, Lianqian Wu, Pinhong Chen, Guosheng Liu* ACS Catal. 2022, 12, 5284–5291. Palladium-Catalyzed Intermolecular Carbonylation-Based Difunctionalization of Alkenes Bing Tian, Pinhong Chen, Guosheng Liu* Synlett 2022, 33, 927-938. Palladium-catalyzed intermolecular alkynylcarbonylation of unactivated alkenes: an easy access to β-alkynylcarboxylic esters Xiang Li, Pinhong Chen,* Guosheng Liu* Chem. Commun. 2022, 58, 2544-2547. Copper-catalyzed radical relay in C(sp3)–H functionalization Zuxiao Zhang, Pinhong Chen, Guosheng Liu* Chem. Soc. Rev. 2022, 51, 1640-1658. Catalytic remote hydrohalogenation of internal alkenes Xiang Li,# Jianbo Jin,# Pinhong Chen, Guosheng Liu* Nat. Chem. 2022, 14, 425–432. Copper-catalysed asymmetric radical cyanation Fei Wang, Pinhong Chen, Guosheng Liu* Nat. Synth. 2022, 1, 107–116. Enantioselective Copper-Catalyzed Radical Cyanation of Propargylic C–H Bonds: Easy Access to Chiral Allenyl Nitriles Ronghua Lu#, Tilong Yang#, Xin Chen, Wenzheng Fan, Pinhong Chen, Zhenyang Lin,* Guosheng Liu* J. Am. Chem. Soc. 2021, 143, 14451–14457. Asymmetric Palladium-Catalyzed Oxycarbonylation of Terminal Alkenes: Efficient Access to β-Hydroxy Alkylcarboxylic Acids Bing Tian, Xiang Li, Pinhong Chen, Guosheng Liu*Angew. Chem. Int. Ed. 2021, 60, 14881–14886. Anionic Bisoxazoline Ligands Enable Copper-Catalyzed Asymmetric Radical Azidation of Acrylamides Lianqian Wu,# Zhihan Zhang,# Dunqi Wu,# Fei Wang, Pinhong Chen, Zhenyang Lin,* Guosheng Liu* Angew. Chem. Int. Ed. 2021, 60, 6997 –7001. (# These author contributed equally to this work) Palladium-Catalysed Enantioselective Diacetoxylation of Terminal Alkenes Bing Tian, Pinhong Chen , Xuebing Leng, Guosheng Liu* Nat. Catal. 2021, 4, 172-179. Enantioselective Intermolecular Aminoalkynylation of Styrenes via Copper-Catalyzed Radical Relay Zhoumi Hu, Liang Fu, Pinhong Chen, Weiguo Cao,* Guosheng Liu* Org. Lett. 2020, 23, 129-134. Enantioselective Arylcyanation of Styrenes via Copper-Catalyzed Radical Relay. Weiwen Zhuang, Pinhong Chen, Guosheng Liu* Chin. J. Chem. 2021, 39, 50-54. Ligand-Controlled Regioselective Pd-Catalyzed Diamination of Alkenes Xiaojian Liu, Chuanqi Hou, Yiyuan Peng,* Pinhong Chen,* Guosheng Liu* Org. Lett. 2020, 22, 9371-9375. Copper-Catalyzed Benzylic C–H Bond Thiocyanation: Enabling Late-Stage Diversifications Chao Jiang, Pinhong Chen, Guosheng Liu* CCS Chemistry, 2020, 2, 1884–1893. Enantioselective Copper-Catalyzed Trifluoromethylation of Benzylic Radicals via Ring Opening of Cyclopropanols Chao Jiang, Lei Wang, Honggang Zhang, Pinhong Chen, Yin-Long Guo, Guosheng Liu* Chem 2020, 6, 2407-2419. Asymmetric Coupling of Carbon-Centered Radical Adjacent to Nitrogen: Copper-Catalyzed Cyanation and Etherification of Enamides Guoyu Zhang, Song Zhou, Liang Fu, Pinhong Chen, Yibiao Li,* Jianping Zou,* Guosheng Liu* Angew. Chem. Int. Ed. 2020, 59, 20439-20444. Palladium(II)-Catalyzed Enantioselective Azidation of Unactivated AlkenesXiaonan Li, Xiaoxu Qi, Chuanqi Hou, Pinhong Chen,* Guosheng Liu* Angew. Chem. Int. Ed. 2020, 59, 17239-17244. Copper-Catalyzed Asymmetric Cyanation of Alkenes via Carbonyl-Assisted Coupling of Alkyl-Substituted Carbon-Centered Radicals Song Zhou, Guoyu Zhang, Liang Fu, Pinhong Chen, Yibiao Li,* Guosheng Liu* Org. Lett. 2020, 22, 6299–6303. Enantioselective Copper-Catalyzed Alkynylation of Benzylic C-H Bonds via Radical Relay Liang Fu, Zhihan Zhang, Pinhong Chen, Zhenyang Lin*, Guosheng Liu* J. Am. Chem. Soc. 2020, 142, 28, 12493-12500. Palladium(II)-Catalyzed Aminotrifluoromethoxylation of Alkenes: Mechanistic Insight into the Effect of N-Protecting Groups. Chaohuang Chen, Chuanqi Hou, Pinhong Chen, Guosheng Liu* Chin. J. Chem. 2020, 38, 346-350. Enantioselective Copper-Catalyzed Radical Ring-Opening Cyanation of Cyclopropanols and Cyclopropanone Acetals. Lianqian Wu, Lei Wang, Pinhong Chen, Yin-Long Guo,* GuoshengLiu* Adv. Synth. Catal. 2020, 362, 2189-2194. Enantioselective Palladium(II)-Catalyzed Oxidative Aminofluorination of Unactivated Alkenes with Et4NF·3HF as a Fluoride Source. Chuanqi Hou, Pinhong Chen, Guosheng Liu* Angew. Chem. Int. Ed. 2020, 59, 2735-2739. Recent Advances and Perspectives in Transition Metal-Catalyzed 1,4-Functionalizations of Unactivated 1,3-Enynes for the Synthesis of Allenes. Liang Fu, Steffen Greßies, Pinhong Chen, Guosheng Liu* Chin. J. Chem. 2020, 38, 91-100. Site-specific Allylic C-H Bond Functionalization with a Copper-Bound N-Centred Radical Jiayuan Li, Zhihan Zhang, Lianqian Wu, Wen Zhang, Pinhong Chen, Zhenyang Lin,* Guosheng Liu* Nature, 2019, 574, 516-521. Iodine(III) reagent (ABX—N3)-induced intermolecular anti-Markovnikov hydroazidation of unactivated alkenes Xiaonan Li, Pinhong Chen, Guosheng Liu* Sci. China Chem. 2019, 62, 1537-1541. Enantioselective Cyanation of Remote C-H Bonds via Cooperative Photoredox Catalysis and Copper Catalysis (cover paper) Zhongming Cheng; Pinhong Chen; Guosheng Liu* Acta Chim. Sinica 2019, 77, 856-860. Proton-Coupled Electron Transfer Enables Tandem Radical Relay for Asymmetric Copper-Catalyzed Phosphinoylcyanation of Styrenes Guoyu Zhang, Liang Fu, Pinhong Chen, Jianping Zou*, Guosheng Liu* Org. Lett. 2019, 21, 5015-5020. Enantioselective Arylation of Benzylic C-H bonds via CopperCatalyzed Radical Relay Wen Zhang, Lianqian Wu, Pinhong Chen, Guosheng Liu* Angew. Chem. Int. Ed. 2019, 58, 6425–6429. Palladium(II)-Catalyzed Enantioselective Aminotrifluoromethoxylation of Unactivated Alkenes using CsOCF3 as a Trifluoromethoxide Source Chaohuang Chen, Philipp Miro Pflüger, Pinhong Chen, Guosheng Liu* Angew. Chem. Int. Ed. 2019, 58, 2392 –2396. Enantioselective Construction of Quaternary All-Carbon Centers via Copper-Catalyzed Arylation of Tertiary Carbon-Centered Radicals Lianqian Wu, Fei Wang, Pinhong Chen, Guosheng Liu* J. Am. Chem. Soc. 2019, 141, 1887−1892. Palladium-Catalyzed Intramolecular Fluoroarylation of Alkenes Wencheng Yang, Xiaoxu Qi, Pinhong Chen,* Guosheng Liu* Chin. J. Org. Chem. 2019, 39, 122-128. Pd-Catalyzed Intermolecular Arylcarbonylation of Unactivated Alkenes: Incorporation of Bulky Aryls at Room Temperature Xiang Li, Pinhong Chen*, Guosheng Liu* Angew. Chem. Int. Ed. 2018, 57, 15871–15876. Copper-Catalyzed Radical Relay for Asymmetric Radical Transformations Fei Wang, Pinhong Chen, Guosheng Liu* Acc. Chem. Res. 2018, 51, 2036–2046. Enantioselective Trifluoromethylalkynylation of Alkenes via Copper-Catalyzed Radical Relay Liang Fu, Song Zhou, Xiaolong Wan, Pinhong Chen, Guosheng Liu* J. Am. Chem. Soc., 2018, 140, 10965–10969. Copper-mediated intramolecular aminofluorination of 1,3-dienes by using nucleophilic fluorine reagents. Zuxiao Zhang, Pinhong Chen,* Guosheng Liu* Chem. Commun. 2018, 54, 8709-8712. Enantioselective Pd(II)-Catalyzed Intramolecular Oxidative 6-endo Aminoacetoxylation of Unactivated Alkenes. Xiaoxu Qi, Chaohuang Chen, Chuanqi Hou, Liang Fu, Pinhong Chen, Guosheng Liu* J. Am. Chem. Soc. 2018, 140, 7415−7419. Decarboxylative Fluorination of Arylcarboxylic Acids Promoted by ortho-Hydroxy and Amino Groups. Dinghai Wang, Zheliang Yuan, Qilun Liu, Pinhong Chen, Guosheng Liu* Chin. J. Chem. 2018, 36, 507－514. Recent advances in hypervalent iodine(III)-catalyzed functionalization of alkenes. Xiang Li, Pinhong Chen,* Guosheng Liu*Beilstein J. Org. Chem. 2018, 14, 1813–1825. Divergent Synthesis of CF3-Substituted Allenyl Nitriles by Ligand-Controlled Radical 1,2- and 1,4-Addition to 1,3-Enynes. Fei Wang, Dinghai Wang, Yu Zhou, Ling Liang, Ronghua Lu, Pinhong Chen, Zhenyang Lin,* Guosheng Liu* Angew. Chem. Int. Ed. 2018, 57, 7140 –7145. Regioselective Palladium-Catalyzed C-H Bond Trifluoroethylation of Indoles: Exploration and Mechanistic Insight Hao Zhang, Hao-Yang Wang,* Yixin Luo, Chaohuang Chen, Yimiao Cao, Pinhong Chen, Yin-Long Guo, Yu Lan,* Guosheng Liu* ACS Catal. 2018, 8, 2173−2180 Palladium-Catalyzed Intermolecular Ditrifluoromethoxylation of Unactivated Alkenes: CF3O‑Palladation Initiated by Pd(IV) Chaohuang Chen, Yixin Luo, Liang Fu, Pinhong Chen, Yu Lan,* Guosheng Liu* J. Am. Chem. Soc, 2018，140，1207-1210