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王玉记1980年出生,博士,教授,首都医科大学化学生物学与药学院副院长。主要从事基于氨基酸的纳米抗肿瘤药物研究,特别是蛋白精氨酸脱亚胺酶4(PAD4)抑制剂的研究该文章他引用40次,并且被NIH和宾州州立大学等多家学术网站报道;并根据这样的设计技术,克服临床上阿司匹林药物的缺点,设计并制备了抗血栓小分子纳米药物,被美国化学会的ACSNano接受,并发表在2013,7:7664(IF=12.0)。基于以上研究,已承担包括863、国家自然科学基金项目、北京市高创计划等十余项项目,已发表SCI期刊论文55篇(IF=195.2),第一作者文章10篇(IF=39.2),作为封面文章1篇,单篇他引次数最高为70次。共申请中国发明专利187项,其中25项授权,包括1项美国专利;专利转化一项(金额100万)。近三年主持项目如下: 1.2015年科技部863项目,小分子抗肿瘤药物的纳米制备技术研究,117万; 2.2015年北京市科技转化项目,关于鸟氨酸试剂盒的开发研究,50万; 3.2015年北京市高创计划项目,小分子纳米抗肿瘤药物研究,50万; 4.2014年国家自然科学基金面上项目可对接PAD4活性口袋扰乱肿瘤细胞自噬的精氨酸衍生物的构效关系研究,61万; 5.2013年北京市科技新星项目,新型PAD4抑制剂的合成及抗肿瘤分子机理研究,35万, 教育经历 1998年8月至2002年6月北京大学药学院药学学士 2002年8月至2007年7月北京大学药学院药物化学博士 工作经历 2007年8月至2009年3月首都医科大学化学生物学院药学院,讲师 2009年3月至2009年8月美国宾州州立大学有机化学系,博士后 2009年8月至2010年3月美国宾州州立大学生化及分子生物学系,博士后 2010年3月至2011年12月首都医科大学化学生物学院药学院药化系副主任/讲师 2012年1月至2015年12月首都医科大学化学生物学院药学院药化系主任/副教授 2016年1月至今首都医科大学药学院副院长/教授 重要奖项 1.2015年北京市高创计划“青年拔尖人才” 2.2014年霍英东青年教师奖 3.2011年北京市教育先锋号(排名2)

研究领域

小分子的纳米抗肿瘤药物研究

近期论文

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1.YujiWang,JingchengTang,HaimeiZhu,XueyunJiang,JiawangLiu,WenyunXu,HaipingMa,QiqiFeng,JianhuiWu,MingZhao,ShiqiPeng.AqueousextractofRabdosiarubescensleaves:formingnanoparticles,targetingP-selectin,andinhibitingthrombosis.InternationalJournalofNanomedicine,2015,10:6905-6918. 2.GuifengKang,YujiWang(Co-firstauthor),JiawangLiu,JianhuiWu,MingZhao,GuochunLi,NingLi,LiPeng,XiaoyiZhang,LiLi,NathanMair,ShiqiPeng.Developmentofthree-componentconjugates:Togetnano-globeswithporoussurface,highinvivoanti-osteoporosisactivityandminimalsideeffects.JournalofMaterialsChemistry,2012,22:21740-21748.IF=6.63 3.YujiWang,JianhuiWu,GuifengKang,MingZhao,LinGui,NingLi,LiPeng,XiaoyiZhang,LiLi,ShiqiPeng.Novelnano-materials,RGD-tetrapeptide-modified17b-amino-11a-hydroxyandrost-1,4-diene-3-one:synthesis,self-assemblybasednano-imagesandinvivoanti-osteoporosisevaluation.JournalofMaterialsChemistry,2012,22:4652-4659.IF=6.63 4.YujiWang,PingxinLi,ShuWang,JingHu,XiangyunAmyChen,JianhuiWu,MeganFisher,KiraOshaben,NaZhao,YingGu,DongWang,GongChen,YanmingWang.AnticancerPADinhibitorsregulatetheautophagyfluxandthemammaliantargetofrapamycincomplexactivity.JournalofBiologicalChemistry,2012,287:25941-25953.IF=4.65 5.HuiliangZhang,YujiWang(Co-firstauthor),MingZhao,JianhuiWu,XiaoyiZhang,LinGui,MeiqingZheng,LiLi,JiawangLiu,ShiqiPeng.SynthesisandInVivoLeadDetoxificationEvaluationofPoly-α,β-DL-aspartyl-L-methionine.ChemicalResearchinToxicology,2012,25:471-477.IF=4.19 6.YujiWang,KangGuifeng,LiuJiawang,ZhaoMing,WuJianhui,ZhangXiaoyi,LiYe,ZhongXiaobo,YangYifanandPengShiqi.NovelpotassiumN-[(2S,3R,4R,5R)-2,3,4,5,6-Pentahydroxylhex-1-yl]-L-aminoaciddichloro-platinates(II)withhighanti-tumoractivityandlowsidereaction.Metallomics,2012,4:441-447.IF=3.97 7.YujiWang,XueyunJiang,JiawangLiu,MingZhao,GuifengKang,JianhuiWu,LiPeng,ShiqiPeng.HPLC-MSaidedPC12cellsystems:toquantitativelymonitortheconversionofnitronylnitroxideinbiologicalsystemswithandwithoutNO.MolecularBioSystems,2011,7:1678-1683.IF=3.18 8.YujiWang,GuifengKang,MingZhao,JianhuiWu,XiaoyiZhang,YifanYang,JiawangLiu,ShiqiPeng.Anewplatinum-complexshowingeasypreparation,promisinganti-tumoractivity,andbetterefficacyanddistributionpropertiesthanoxaliplatin.MolecularBioSystems,2011,7:3245-3252.IF=3.18 9.YujiWang,LeiWei,MingZhao,ShenghuiMei,MeiqingZheng,YifanYang,HongWang,GongChen,ShiqiPeng.Developmentofhighlyeffectivethree-componentcytoprotectiveadjunctsforcisplatincancertreatment:synthesisandinvivoevaluationinS180-bearingmice.Metallomics,2011,3:1212-1217.IF=3.97 10.YujiWang,LanrongBi,BaoguangHou,YuChen,MingZhao,ChaoWang,WeiWang,JingfangJu,ShiqiPeng.Designandsynthesisofpentahydroxylhexylaminoacidsandtheireffectonleaddecorporation.ChemicalResearchinToxicology,2007,20:609-615.IF=4.19 11.TaipingGan,YujiWang,MingZhao,JianhuiWu,JianYang,ShiqiPeng.5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoicacid(BHIMHA):showingastrategyofdesigningdrugtoblocklungmetastasisoftumors.DrugDesign,DevelopmentandTherapy2016,10:711-721.IF=3.028 12.XiHu,MingZhao,YujiWang,YaonanWang,ShuruiZhao,JianhuiWu,XiangminLiandShiqiPeng.Tetrahydro-b-carboline-3-carboxyl-thymopentin:anano-conjugateforreleasingpharmacophorestotreattumorandcomplications.J.Mater.Chem.B,2016:4,1384-1397.IF=4.726 13.HaimeiZhu,YuanboSong,YujiWang,MingZhao,YiRen,YaonanWang,ShuruiZhao,JianhuiWuandShiqiPeng.Design,synthesisandevaluationofanovelπ–πstackingnano-intercalatorasananti-tumoragent.Med.Chem.Commun.,2016,7,247-257.IF=2.495 14.MinnaLi,YujiWang,YutongYang,YeqingGao,MingZhao,MeiqingZheng,ShiqiPeng。Oximatedrutheniumtris-bipyridylcomplex:synthesisandluminescentresponsespecificallyforClO−inwatercontainingmultipleions.DaltonTrans.,2015,44:14071-14076. 15.FengWang,ShanLi,YujiWang,HaimeiZhu,XiaoyiZhang,MingZhao,JianhuiWu,ShiqiPenga,Enantiomericdiketopiperazines:Gettinginsightoftheimpactoftheconfigurationtotheconformation,nanoimage,u-PAinhibitionandanti-metastaticactivity.MedChemComm2015,6,956-962. 16.FeiGao,HaiqingLiu,LiLi,JianpengGuo,YujiWang,MingZhao,ShiqiPeng.Design,synthesis,andtestingofanisoquinoline-3-carboxylic-basednovelanti-tumorleadBioorganic&MedicinalChemistryLetters,2015,25:4434-4436. 17.HualongYu,ShenghuiMei,LiZhao,MingZhao,YujiWang,HaimeiZhu,YaonanWang,JianhuiWu,ChunyingCui,WenyunXu,ShiqiPeng,RGD-peptidesmodifyingdexamethasone:Toenhancetheefficacyofanti-inflammationandlimittheriskofosteoporosis.MedChemComm2015,6,1345-1351. 18.ShanLi,YujiWang,FengWang,YaonanWang,XiaoyiZhang,MingZhao,QiqiFeng,JianhuiWu,ShuruiZhao,WeiWu,ShiqiPeng,SmallmoleculePZL318:Formingfluorescentnanoparticlescapableoftracingtheirinteractionswithcancercellsandactivatedplatelets,slowingtumorgrowthandinhibitingthrombosis.IntJNanomed,2015,10:5273-5292. 19.ShanLi,YujiWang,MingZhao,JianhuiWu,ShiqiPeng.BPIC:Anovelanti-tumorleadcapableofinhibitinginflammationandscavengingfreeradicals.BioorgMedChemLett.2015,25(5):1146-50 20.WenhuaZhao,YujiWang,WeijiaHao,HYang,SongX,MingZhao,ShiqiPeng.Preparativeisolationandpurificationofurolithinsfromtheintestinalmetabolitesofpomegranateellagitanninsbyhigh-speedcounter-currentchromatography.JChromatogrBAnalytTechnolBiomedLifeSci.2015,990:111-7. 21.JianhuiWu,YujiWang,YaonanWang,MingZhao,XiaoyiZhang,LinGui,ShuruiZhao,HaimeiZhu,JinghuaZhao,ShiqiPeng.Cu2+-RGDFRGDS:exploringthemechanismandhighefficacyofthenanoparticleinantithrombotictherapy.InternationalJournalofNanomedicine2015,10:2925–2938. 22.XueyunJiang,YujiWang,HaimeiZhu,YaonanWang,MingZhao,ShuruiZhao,JianhuiWu,ShanLi,ShiqiPeng.Modifyingtetramethyl–nitrophenyl–imidazolinewithaminoacids:design,synthesis,and3D-QSARforimprovinginflammatorypaintherapy.DrugDesign,DevelopmentandTherapy2015,9:2329–2342. 23.ShuanglingChen,YujiWang,ShanLi,YaonanWang,MingZhao,HaimeiZhu,JianhuiWu,ShiqiPeng.Poly-α,β-aspartyl-Arg-Gly-Asp-Phe:anovelpolymericnanomedicine.Med.Chem.Commun.,2015,6:182-186. 24.WenhuaZhao,YujiWang,WeijiaHao,MingZhao,ShiqiPeng.Invitroinhibitionoffattyacidsynthaseby1,2,3,4,6-penta-O-galloyl-β-D-glucoseplaysavitalroleinanti-tumouractivity.BiochemBiophysResCommun.2014,445:346-51. 25.FengxiangDu,XiaoyiZhang,ShanLi,YaonanWang,MeiqingZheng,YujiWang,ShuruiZhao,JianhuiWu,LinGui,MingZhaoandShiqiPeng.Mechanismofformingtrimer,self-assemblingnano-particleandinhibitingtumorgrowthofsmallmoleculeCIPPCT.Med.Chem.Commun.,2014,5:1634-1643. 26.HaimeiZhu,YujiWang,YaonanWang,ShuruiZhao,MingZhao,LinGui,WenyunXu,XiangyunAmyChen,YanmingWang,ShiqiPeng.FoldedConformation,CyclicPentamer,Nano-StructureandPAD4BindingModeofYW3-56.TheJournalofPhysicalChemistryC,2013,117:10070-10078. 27.HaimeiZhu,YujiWang,MingZhao,JianhuiWu,XiaoyiZhang,GuodongYang,ShiqiPeng.EnergyminimizedcrystalstructuresofP-selectinsbasedonmoleculardynamicssimulation:leadingtotwoaveragestructurescapableofdesigninganti-thromboticagents.Med.Chem.Commun.,2013,4:1066-1072. 28.JiawangLiu,YujiWang,YifanYang,XueyunJiang,MingZhao,WenjingWang,GuofengWu,JianhuiWu,MeiqingZheng,ShiqiPeng.Pyrolo[1,2:4,5]-1,4-dioxopyrazino[1,2:1,6]pyrido[3,4-b]indoles:AGroupofUrokinaseInhibitors,theirSynthesis,andStereochemistry-DependentActivity.ChemMedChem,2011,6:2312-2322. 29.YanxiaXu,YujiWang,LingWang,MingZhao,XiaoyiZhang,XiaominHu,BaoguangHou,LiPeng,MeiqingZheng,JianhuiWu,ShiqiPeng.LeadDetoxificationActivitiesofaClassofNovelDMSA-AminoAcidConjugates.ChemicalResearchinToxicology,2011,24:979-984. 30.YanxiaXu,YujiWang,MingZhao,BaoguangHou,LiPeng,MeiqingZheng,JianhuiWu,ShiqiPeng.LeaddetoxificationactivitiesandADMEThepatotoxicitiesofaclassofnovel5-(1-carbonyl-L-amino-acid)-2,2-dimethyl-[1,3]dithiolane-4-carboxylicacids.BioorganicMedicinalChemistryLetters,2011,21:1754-1757. 31.YiqingFeng,YujiWang,BradleyLandgraf,ShiLiu,GongChen.FacileBenzo-RingConstructionviaPalladium-CatalyzedFunctionalizationofUnactivatedsp(3)C-HBondsunderMildReactionConditions.OrganicLetter,2010,12:3414-3417. 32.MingZhao,YujiWang,CaixiaHuo,JiawangLiu,ChunyuLi,XiaoyiZhang,LiPeng,ShiqiPeng.LeadDetoxificationActivityandADMETHepatotoxicityofN-(alpha-l-Arabino-furanos-1-yl)-l-cysteine.ChemicalResearchinToxicology,2010,23:1282-1285. 33.MingZhao,YujiWang,CaixiaHuo,ChunyuLi,XiaoyiZhang,LiPeng,ShiqiPeng.StereoselectivesynthesisofnovelN-(a-L-arabinofuranos-1-yl)-L-aminoacids.Tetrahedron:Asymmetry,2009,20:20247-20258. 34.LinGui,MingZhao,YujiWang,YinyeWang,YangQin,LiLi,ShiqiPeng.Synthesis,nano-features,exvivoanti-plateletaggregationandinvivoantithromboticactivitiesofpoly-α,β-DL-aspartyl-L-arginine.MedicinalChemistryCommunication,2012,3:102-108. 35.JingchengTang,MingZhao,YujiWang,GuifengKang,JianhuiWu,MeiqingZheng,ShiqiPeng.OnesingleHPLC-PDA/(-)ESI-MS/MSanalysistosimultaneouslydetermine30componentsoftheaqueousextractofRabdosiarubescens.JournalofChromatographyB,2011,879:2783-2793. 36.WenjingWang,MingZhao,YujiWang,JiawangLiu,JianhuiWu,GuifengKang,ShiqiPeng.{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}aceticacidmethylester(MIAM):itsanti-cancerefficacyandintercalationmechanismidentifiedviamulti-modelsystems.MolecularBioSystems,2011,7:766-772. 37.ShaomingJin,YaonanWang,HaimeiZhu,YujiWang,ShuruiZhao,MingZhao,JiawangLiu,JianhuiWu,WenGao,ShiqiPeng.NanosizedAspirin-Arg-Gly-Asp-Val:DeliveryofAspirintoThrombusbytheTargetCarrierArg-Gly-Asp-ValTetrapeptide.ACSNano,2013,7:7664-7673. 38.LiLi,MingZhao,WenhaoLi,YujiWang,ChunnaLiu,ZhugeZhang,SongchunSu,ShiqiPeng.pH-Dependentnanostructurebasedonisoquinoline-cyclodextrinconjugateforthrombosistherapy.Nanomedicine:NBM,2012,DOI:10.1016/j.nano.2011.12.008 39.LiLi,MingZhao,WenhaoLi,YujiWang,ZhugeZhang,RanAn,ShiqiPeng.Self-complexationandcomplexation-controlledtargetcancertherapy.MedicinalChemistryCommunication,2012,3:1059-1061. 40.LiLi,JianhuiWu,MingZhao,YujiWang,HuiliangZhang,XiaoyiZhang,LinGui,JiawangLiu,NathanMair,ShiqiPeng.Poly-α,β-dl-Aspartyl-l-Cysteine:ANovelNanomaterialHavingaPorousStructure,SpecialComplexationCapabilityforPb(II),andSelectivityofRemovingPb(II).ChemicalResearchinToxicology,2012,25:1948-1954 41.ChunyuLi,XiaoyiZhang,MingZhao,YujiWang,JianhuiWu,JiawangLiu,MeiqingZheng,ShiqiPeng.AclassofnovelN-(1-methyl-b-carboline-3-carbonyl)-N’-(aminoacid-acyl)-hydrazines:Aromatizationleadeddesign,synthesis,invitroanti-plateletaggregation/invivoanti-thromboticevaluationand3DQSARanalysis.EuropeanBioorganicMedicinalChemistry,2011,46:5598-5608. 42.JianhuiWu,LeiWei,MingZhao,YujiWang,GuifengKang,ShiqiPeng.N-[2(3-Carboxyl-9-benzyl-carboline-1-yl)ethyl-1-yl]-aminoacids:correlationofspectralpropertywithinvivoanti-tumoractivity.MedicinalChemistryResearch,2010,DOI:10.1007/s00044-010-9504-1 43.LiLi,GuohuiCui,MingZhao,YujiWang,HongWang,WeiLi,ShiqiPeng.Assemblyofbeta-cyclodextrinwith3S-tetrahydro-beta-carboline-3-carboxylicacidandself-assemblyof6-(3'S-carboline-3'-carboxylaminoethylamino)-6-deoxy-β-cyclodextrin.JournalofPhysicalChemistryB,2008,112:12139-12147. 44.KunYao,MingZhao,XiaoyiZhang,YujiWang,LiLi,MeiqingZheng,ShiqiPeng.AclassoforalN-[(1S,3S)-1-methyl-1,2,3,4-tetrahydro-b-carboline-3-carbonyl]-N-(amino-acid-acyl)hydrazine:Discovery,synthesis,invitroanti-plateletaggregation/invivoanti-thromboticevaluationand3DQSARanalysis.EuropeanJournalofMedicinalChemistry,2011,46:3237-3249. 45.GuodongYang,HaimeiZhu,MingZhao,JianhuiWu,YujiWang,YanjuWang,MeiqingZheng,MinChen,JiawangLiu,ShiqiPeng.Theapplicationoftetrahydroisoquinoline-3-carbonyl-TARGD(F)Fasananti-thromboticagenthavingdualmechanismsofaction.MolecularBioSystems,2012,8:2672-2679. 46.ShenghuiMei,JiawangLiu,MingZhao,WenjingWang,YujiWang,GuofengWu,MeiqingZheng,ShiqiPeng.FromCerius2basedstereoviewtomouseandenzyme:themodelsystemsfordiscoveryofnovelurokinaseinhibitors.MolecularBioSystems,2011,7:2664-2669. 47.JianhuiWu,ChunyuLi,MingZhao,WenjingWang,YujiWang,ShiqiPeng.Aclassofnovelcarbolineintercalators:Theirsynthesis,invitroanti-proliferation,invivoanti-tumoraction,and3DQSARanalysis.Bioorganic&MedicinalChemistry,2010,18:6220-6229. 48.HongWang,LePeng,MingZhao,JiawangLiu,XiaoyiZhang,YujiWang,JianhuiWu,LiLi,ShiqiPeng.2-Substituted(S)-2-(3,3-dimethyl-1-oxo-10,10a-dihydroimidazo[1,5-b]isoquinolin-2(1H,3H,5H)-yl)aceticacids:Conformationalprediction,synthesis,anti-thromboticandvasodilativeevaluation.Bioorganic&MedicinalChemistry,2011,19:871-882. 49.XiaoyiZhang,YifanYang,MingZhao,LiuLiu,MeiqingZheng,YujiWang,JianhuiWu,ShiqiPeng.AclassofTrp-Trp-AA-OBzl:Synthesis,invitroanti-proliferation/invivoanti-tumorevaluation,intercalation-mechanisminvestigationand3DQSARanalysis,EuropeanBioorganicMedicinalChemistry,2011,46:3410-3419. 50.MeiqingZheng,XiaoyiZhang,MingZhao,HengWeiChang,WeiWang,YujiWang,ShiqiPeng.(3S)-N-(L-Aminoacyl)-1,2,3,4-tetrahydroisoquinolines,aclassofnovelantithromboticagents:synthesis,bioassay,3DQSAR,andADMEanalysis.BioorganicMedicinalChemistry,2008,16:9574-9587. 51.JiawangLiu,ShannonTaylor,PatrickDupart,CoreyArnold,JayalakshmiSridhar,QuanJiang,YujiWang,ElenaSkripnikova,MingZhao,MaryamForoozesh.Pyranoflavones:AGroupofSmall-moleculeProbesforExploringtheActiveSiteCavitiesofCytochromeP450Enzymes1A1,1A2,and1B1.JournalofMedicinalChemistry,2013,56(10):4082-4092. 52.LiuLiu,LeiWei,YifanYang,MingZhao,XiaoyiZhang,MeiqingZheng,YujiWang,ShiqiPeng.AclassofnovelAA-Trp-Trp-OBzl:synthesis,invitroanti-proliferation,invivoanti-tumoraction,andintercalationmechanism.MedicinalChemistryCommunication,2011,2:126-131. 53.MeiqingZheng,YifanYang,XiaoyiZhang,MingZhao,JianhuiWu,GongChen,LiPeng,YujiWang,PengShiqi.AclassofnovelN-isoquinoline-3-carbonyl-l-aminoacidbenzylesters:Synthesis,anti-tumorevaluationand3DQSARanalysis.EuropeanBioorganicMedicinalChemistry,2011,46:1672-1681. 54.AdharshP.Ponnapakam,JiawangLiu,KaustubhN.Bhinge,BarbaraA.Drew,TonyL.Wang,JamesW.Antoon,ThongT.Nguyen,PatrickS.Dupart,YujiWang,MingZhao,Yong-YuLiu,MaryamForoozesh,BarbaraS.Beckmana.3-Ketone-4,6-dieneceramideanalogsexclusivelyinduceapoptosisinchemo-resistantcancercells.Bioorganic&MedicinalChemistry,2014,22:1412-1420. 55.LiuJ,PhamPT,SkripnikovaEV,ZhengS,LovingsLJ,YujiWang,GoyalN,BellowSM,MensahLM,ChattersAJ,BrattonMR,WieseTE,ZhaoM,WangG,ForoozeshM.ALigand-BasedDrugDesign,Discoveryof4-Trifluoromethyl-7,8-PyranocoumarinasaSelectiveInhibitorofHumanCytochromeP4501A2.JMedChem.2015,58(16):6481-6493

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