陈以昀 - 中国科学院上海有机化学研究所 - 生命有机化学国家重点实验室

个人简介

陈以昀博士任中国科学院上海有机化学研究所生命过程小分子调控全国重点实验室研究员,兼任上海科技大学物质学院教授与国科大杭州高等研究院化学与材料科学学院研究员。他本科期间在北京大学杨震教授指导下从事全合成研究并于2002年获得化学学士学位。在Joseph Z. Tsien教授实验室进行了短期的神经科学研究之后，他在普林斯顿大学Chulbom Lee教授实验室发展了过渡金属催化下的炔烃1，1位修饰方法学，并于2007年获得有机化学博士学位。在哈佛大学和霍华德休斯医学研究所David R. Liu教授实验室，他作为博士后研究人员进行了化学生物学相关的研究课题：利用DNA编码的新化学反应探索系统，他发现了生物相容的可见光引发的叠氮化合物还原反应。2011年秋，他加入上海有机化学研究所任课题组长，研究兴趣为生物相容光化学，具体包括有机光化学与光化学生物学。陈以昀获得的学术和研究荣誉包括国科大优秀授课教师（2022）、药明康德生命化学研究奖（2021）、上海有机所拜耳研究奖（2021）、上海市优秀学术/技术带头人（2021）、上海市科技系统青年五四奖章（2018）、蒂姆化学期刊奖（2018）、中国光化学泊菲莱优秀青年科学家奖（2017）、国家自然科学基金委员会优秀青年科学基金（2016）、上海浦江人才计划（2012）、普林斯顿大学百时美施贵宝研究生合成化学奖（2005）、北京大学明德奖学金（1998-2002）、第30届国际化学奥林匹克竞赛银牌（1998）。陈以昀任Organic Chemistry Frontiers杂志顾问编委、欧盟研究委员会外部评审专家、中国化学会光化学专业委员会委员、中国感光学会光化学和光生物专业委员会委员、中国神经科学学会离子通道与受体专业委员会常委委员、ChemPhotoChem杂志创刊编委。

研究领域

生物相容光化学——从有机光化学到光化学生物学陈以昀课题组致力于发展新型的生物相容性光化学反应，将有机光化学与光化学生物学相结合，为分子科学和生命科学研究提供新的工具。通过设计创新的可见光催化反应模式，我们系统地探索了生物相容性、新型化学反应性和生物应用。相比于传统的紫外光直接激发，我们的方法利用可见光或近红外光激发光催化剂或分子复合物，在温和条件下实现可控的化学反应。这一策略不仅拓展了光化学反应的底物范围，而且为细胞内生物分子的精准调控提供了新的途径。

近期论文

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Photochemical 1,3-Boronate Rearrangement Enables Three-Component N-Alkylation for α-Tertiary Hydroxybenzylamine Synthesis.Zou, P.1; Fu, D.1; Wang, H.1; Sun, R.; Lan, Y.*; Chen, Y.* Nat. Commun. 2024, 15, 10234. Photocatalytic Aldehyde Allylation for Site-Specific DNA Functionalization.Zhang, Y.1; Huang, Y.1; Che, Q.1; Chen, Y.* Chin. J. Chem. 2025, 43, 97−103. Highlighted by Chin. J. Chem, CBG. Chemoselective Synthesis of α-Tertiary Hydroxy Oximes via Photochemical 1,3-Boronate Rearrangement.Cai, R.; Zou, P.; Zhang, Y.; Chen, Y.* Org. Lett. 2024, 26, 7795−7799. Radical 6-Endo Addition Enables Pyridine Synthesis under Metal-Free Conditions.Dong, X.1; Shao, Y.1; Liu, Z.; Huang, X.; Xue, X.*; Chen, Y.* Angew. Chem., Int. Ed. 2024, 63, e202410297. Highlighted by Synfacts, Chinese Academy of Sciences, Wiley Chem China, and X-MOL. Photocatalytic Oxyalkynylation of Unactivated Alkenes Enabled by Hypervalent Iodine (III) Reagents.Qin, H.1; Liu, Z.1; Zhang, Y.1; Chen, Y.* ACS Catal. 2024, 14, 13202−13208. Featured as the Front Cover of the September Issue in 2024, ACS Catal. Highlighted by ACS China, CBG. Site-Specific DNA Post-Synthetic Modification via Fast Photocatalytic Allylation.Huang, Y.1; Zhang, Y.1; Hu, C.; Chen, Y.* Org. Chem. Front. 2024, 11, 4408-4415. Highlighted by Org. Chem. Front. Genetically Encoded Photocatalysis Enables Spatially Restricted Optochemical Modulation of Neurons in Live Mice.Zeng, K.1; Jiao, Z.1; Jiang, Q.; He, R.; Zhang, Y.; Li, W.*; Xu, T.*; Chen, Y.* ACS Cent. Sci. 2024, 10, 1, 163–175. Featured as the Front Cover of the January Issue in 2024, ACS Cent. Sci. Highlighted by ACS China, X-MOL. Metal-Free 1,3-Boronate Rearrangement to Ketones Driven by Visible Light.Hao, K.1; Li, D.1; Fu, D.; Zou, P.; Xie, S.; Lan, Y.*; Chen, Y.* Angew. Chem., Int. Ed. 2024, 63, e202316481.Highlighted by Chinese Academy of Sciences, X-MOL, CBG. 2-(Chloromethoxy)-1H-isoindole-1,3(2H)-dione.Liu, D.; Chen, Y.* e-EROS Encyclopedia of Reagents for Organic Synthesis; Paquette, L. A., Ed.; John Wiley & Sons, 2024. Photo-Modulation of Gene-Editing Enzymes CRISPR/Cas9 with Bifunctional Small-Molecule Ligands.Zhang, Y.1; Zhang, Y.1; Han, L.1; Che, Q.; Tan, J.; Zou, P.; Chen, Y.* Chin. J. Chem. 2023, 41, 3639−3644. Highlighted by Chin. J. Chem. Dedicated to the memory of Professor Xiyan Lu. Selective C–H Acyloxylation of Sulfides/Disulfides Enabled by Hypervalent Iodine Reagents.Wu, S.; Chen, Y.* Adv. Syn. Catal. 2023, 365, 2690−2696. Very Important Publication. Invited Special Thematic Issue: Iodine in Catalysis and Organic Synthesis. Distal Amidoketone Synthesis Enabled by Dimethyl Benziodoxoles via Dual Copper/Photoredox Catalysis.Ge, Y.; Shao, Y.; Wu, S.; Liu, P.; Li, J.; Qin, H.; Zhang, Y.; Xue, X.*; Chen, Y.* ACS Catal. 2023, 13, 3749−3756. Highlighted by Org. Chem. Highlights, CBG. Visible-Light-Induced Proteins Labeling in Live Cells with Aryl Azides.Zhang, Y.1; Tan, J.1; Chen, Y.* Chem. Commun. 2023, 59, 2413−2420. Invited Feature Article in Themed Collection “2023 Pioneering Investigators” and “Photofunctional Materials and Transformations”. Formyl Radical Generation from α-Chloro N-Methoxyphthalimides Enables Selective Aldehyde Synthesis.Liu, D.1; Yang, K.1; Fang, D.1; Li, S.; Lan, Y.*; Chen, Y.* Angew. Chem., Int. Ed. 2023, 62, e202213686. Highlighted by Chinese Academy of Sciences, X-MOL, CBG. Hypervalent Iodine Reagents Enable C(sp2)–H Amidation of (Hetero)arenes with Iminophenylacetic Acids.Pan, Y.1; Liu, Z.1; Zou, P.; Chen, Y.; Chen, Y.* Org. Lett. 2022, 24, 6681−6685. Highlighted by CBG. Hypervalent Iodine Reagents Enable C−H Alkynylation with Iminophenylacetic Acids via Alkoxyl Radicals.Liu, Z.1; Pan, Y.1; Zou, P.; Huang, H.; Chen, Y.; Chen, Y.* Org. Lett. 2022, 24, 5951−5956. Endogenous Proteins Modulation in Live Cells with Small Molecules and Light.Zeng, K.; Han, L.; Chen, Y.* Chembiochem 2022, 23, e202200244. Invited Concept.38. Radical C(sp3)-H Heck-type Reaction of N-Alkoxybenzimidoyl Chlorides with Styrenes to Construct Alkenols.Fang, D.; Zhang, Y.; Chen, Y.* Org. Lett. 2022, 24, 2050−2054. Ligand-Directed Caging Enables the Control of Endogenous DNA Alkyltransferase Activity with Light inside Live Cells.Zhang, Y.1; Han, L.1; Tian, X.; Peng, C.; Chen, Y.* Angew. Chem., Int. Ed. 2022, 61, e202115472. Featured as the Inside Cover of the Issue 17 in 2022, Angew. Chem., Int. Ed. Highlighted by Wiley Chem, Chinese Academy of Sciences, X-MOL, CBG. Terminal Trifluoromethylation of Ketones via Selective C-C Cleavage of Cycloalkanols Enabled by Hypervalent Iodine Reagents.Wu, S.; Li, J.; He, R.; Jia, K.; Chen, Y.* Org. Lett. 2021, 23, 9204−9209. Highlighted by Organic Chemistry Portal. Oxygen-Centered Radicals.Zhang, J.; Liu, D.; Chen, Y.* Science of Synthesis: Free Radicals: Fundamentals and Applications in Organic Synthesis. Fensterbank, L.; Ollivier, D., Ed.; Thieme: Stuttgart, 2021.Vol. 1, 323−380. Selective C(sp3)-C(sp3) Cleavage/Alkynylation of Cycloalkylamides Enables Aminoalkyne Synthesis with Hypervalent Iodine Reagents.Liu, Z.; Wu, S.; Chen, Y.* ACS Catal. 2021, 11, 10565−10573. Selective Mitochondrial Protein Labeling Enabled by Biocompatible Photocatalytic Reactions inside Live Cells.Wang, H.1; Zhang, Y.1; Zeng, K.1; Qiang, J.1; Cao, Y.; Li, Y.; Fang, Y.; Zhang, Y.*; Chen, Y.* JACS Au. 2021, 1, 1066−1075. Featured as the Supplementary Cover of the July Issue in 2021, JACS Au. Highlighted by NSFC, Chinese Academy of Sciences. Investigations on 1,2-Hydrogen Atom Transfer Reactivity of Alkoxyl Radicals under Visible-Light-Induced Reaction Conditions.Liu, D.; Zhang, J.; Chen, Y.* Synlett. 2021, 32, 356−361. Invited Account. Special Cluster for Radicals – by Young Chinese Organic Chemists. Illuminating Biology with Visible-Light-Induced Biocompatible Reactions.Chen, Y.* Chemphotochem. 2020, 4, 319−320. Meet the board. Visible-Light-Induced Alkoxyl Radicals Enable α-C(sp3)-H Bond Allylation.Zhang, J.1; Liu, D.1.; Liu, S.; Ge, Y.; Lan, Y.*; Chen, Y.* iScience. 2020, 23, 100755. DNA-Encoded Library Chemistry: Amplification of Chemical Reaction Diversity for the Exploration of Chemical Space.Huang, Y.; Savych, O.; Moroz, Y.; Chen, Y.*; Goodnow, R. A.* Aldrichimica Acta. 2019, 52, 75−87. Invited Review. Intermolecular Radical Addition to Ketoacids Enabled by Boron Activation.Xie, S.; Li, D.; Huang, H.; Zhang, F.; Chen, Y.* J. Am. Chem. Soc. 2019, 141, 16237−16242. Highlighted by Chinese Academy of Sciences, CBG. Acyl Radical Smiles Rearrangement to Construct Hydroxybenzophenones by Photoredox Catalysis.Li, J.; Liu, Z.; Wu, S.; Chen, Y.* Org. Lett. 2019, 21, 2077−2088. Photocatalysis Enables Visible-Light Uncaging of Bioactive Molecules in Live Cells.Wang, H; Li, W.; Zeng, K.; Wu, Y.; Zhang, Y.; Xu, T.*; Chen, Y.* Angew. Chem., Int. Ed. 2019, 58, 561−565. Highlighted by NSFC, Wiley China, and Chinese Academy of Sciences, X-MOL, CBG. Visible Light-Driven Organic Photochemical Synthesis in China.Chen, Y.*; Lu, L. Q.*; Yu, D. G.*; Zhu, C. J.*; Xiao, W. J.* Sci. China Chem. 2019, 62, 24–57. Invited Review. Cyclic Iodine Reagents Enable Allylic Alcohols for Alkyl Boronate Addition/Rearrangement by Photoredox Catalysis.Liu, M; Huang, H.; Chen, Y.* Chin. J. Chem. 2018, 36, 1209−1212. Special Issue for Prof. Xiyan Lu’s 90th Birthday. Photochemistry of Hypervalent Iodine Compounds.Jia, K.; Chen, Y.* Patai’s Chemistry of Functional Groups. Marek, I, Olofsson, B., Rappoport, Z., Ed.; John Wiley & Sons, 2018. Metal-Free C(sp3)-H Allylation via Aryl Carboxyl Radicals Enabled by Donor-Acceptor Complex.Li, Y.1; Zhang, J.1; Li, D.; Chen, Y.* Org. Lett. 2018, 20, 3296−3299. Visible-Light-Induced Alkoxyl Radical Generation for Inert Chemical Bond Cleavage/Functionalizations.Jia, K.; Chen, Y.* Chem. Commun. 2018, 54, 6105−6112. Invited Feature Article. Investigations of Alkynyl Benziodoxole Derivatives for Radical Alkynylations in Photoredox Catalysis.Pan, Y.; Jia, K.; Chen, Y.*; Chen, Y.* Beilstein J. Org. Chem. 2018, 14, 1215−1221. Invited Thematic Series “Hypervalent Iodine Chemistry in Organic Synthesis”. Selective P-C(sp3) Bond Cleavage and Radical Alkynylation of α-Phosphorus Alcohols by Photoredox Catalysis.Jia, K.; Li, J.; Chen, Y.* Chem. Eur. J. 2018, 24, 3174–3177.