陈以昀 - 中国科学院上海有机化学研究所 - 生命有机化学国家重点实验室

个人简介

陈以昀博士任中国科学院上海有机化学研究所生命有机化学国家重点实验室研究员,兼任上海科技大学物质学院教授。他本科期间在北京大学杨震教授指导下从事全合成研究并于2002年获得化学学士学位。在Joseph Z. Tsien教授实验室进行了短期的神经科学研究之后，他在普林斯顿大学Chulbom Lee教授实验室发展了过渡金属催化下的炔烃1，1位修饰方法学，并于2007年获得有机化学博士学位。在哈佛大学和霍华德休斯医学研究所David R. Liu教授实验室，他作为博士后研究人员进行了化学生物学相关的研究课题：利用DNA编码的新化学反应探索系统，他发现了生物相容的可见光引发的叠氮化合物还原反应。2011年秋，他加入上海有机化学研究所任课题组长，研究兴趣为生物相容光化学，具体包括有机光化学与光化学生物学。陈以昀获得的学术和研究荣誉包括药明康德生命化学研究奖（2021）、上海有机所拜耳研究奖（2021）、上海市优秀学术/技术带头人（2021）、上海市科技系统青年五四奖章（2018）、蒂姆化学期刊奖（2018）、中国光化学泊菲莱优秀青年科学家奖（2017）、国家自然科学基金委员会优秀青年科学基金（2016）、上海浦江人才计划（2012）、普林斯顿大学百时美施贵宝研究生合成化学奖（2005）、北京大学明德奖学金（1998-2002）、第30届国际化学奥林匹克竞赛银牌（1998）。陈以昀任Organic Chemistry Frontiers杂志顾问编委、欧盟研究委员会评审专家、中国化学会光化学专业委员会委员、中国感光学会光化学和光生物专业委员会委员、中国神经科学学会离子通道与受体专业委员会常委委员、ChemPhotoChem杂志创刊编委。

研究领域

主要发展生物相容性的光化学新方法用于分子科学及生命科学的研究，研究内容包括有机光化学及光化学生物学。研究目标为发展新的光引发的生物相容性反应（稳定的反应物及快速的反应动力学，多样化的成键断键反应类型，高时空分辨率的外源调控），从而实现小分子药物光释放、蛋白质光标记、及光调控自然细胞。

近期论文

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Zhang, Y.1; Tan, J.1; Chen, Y.* Visible-Light-Induced Proteins Labeling in Live Cells with Aryl Azides. Chem. Commun. 2023, doi: 10.1039/D2CC06987C. Invited Feature Article in Themed Collection “2023 Pioneering Investigators” and “Photofunctional Materials and Transformations”. Liu, D.1; Yang, K.1; Fang, D.1; Li, S.; Lan, Y.*; Chen, Y.* Formyl Radical Generation from α-Chloro N-Methoxyphthalimides Enables Selective Aldehyde Synthesis. Angew. Chem., Int. Ed. 2023, 62, e202213686. Highlighted by Chinese Academy of Sciences, X-MOL, CBG. Zhang, Y.1; Han, L.1; Tian, X.; Peng, C.; Chen, Y.* Ligand-Directed Caging Enables the Control of Endogenous DNA Alkyltransferase Activity with Light inside Live Cells. Angew. Chem., Int. Ed. 2022, 61, e202115472. Highlighted by Wiley Chem, Chinese Academy of Sciences, X-MOL, CBG. Liu, Z.; Wu, S.; Chen, Y.* Selective C(sp3)-C(sp3) Cleavage/Alkynylation of Cycloalkylamides Enables Aminoalkyne Synthesis with Hypervalent Iodine Reagents. ACS Catal. 2021, 11, 16, 10565-10573. Wang, H.1; Zhang, Y.1; Zeng, K.1; Qiang, J.1; Cao, Y.; Li, Y.; Fang, Y.; Zhang, Y.*; Chen, Y.* Selective Mitochondrial Protein Labeling Enabled by Biocompatible Photocatalytic Reactions inside Live Cells. JACS Au2021, 1, 7, 1066-1075. Highlighted by NSFC Chemistry, and Chinese Academy of Sciences. Zhang, J.1; Liu, D.1.; Liu, S.; Ge, Y.; Lan, Y.*; Chen, Y.* Visible-Light-Induced Alkoxyl Radicals Enable α-C(sp3)-H Bond Allylation. iScience. 2020, 23, 100755. Xie, S.; Li, D.; Huang, H.; Zhang, F.; Chen, Y.* Intermolecular Radical Addition to Ketoacids Enabled by Boron Activation. J. Am. Chem. Soc. 2019, 141, 11, 16237-16242. Highlighted by Chinese Academy of Sciences. Wang, H; Li, W.; Zeng, K.; Wu, Y.; Zhang, Y.; Xu, T.*; Chen, Y.* Photocatalysis Enables Visible Light Uncaging of Bioactive Molecules in Live Cells. Angew. Chem., Int. Ed. 2019, 58, 561-565. Highlighted by Wiley China, Advanced Science News, and Chinese Academy of Sciences. Chen, Y.*; Lu, L. Q.*; Yu, D. G.*; Zhu, C. J.*; Xiao, W. J.* Visible Light-Driven Organic Photochemical Synthesis in China. Sci. China Chem. 2019, 62, 24-57. Invited Review. Jia, K.; Chen, Y.* Visible-Light-Induced Alkoxyl Radical Generation for Inert Chemical Bond Cleavage/Functionalizations. Chem. Commun. 2018, 54, 6105-6112. Invited Feature Article. Zhang, J.; Li, Y.; Xu, R.; Chen, Y.* Donor-Acceptor Complex Enables Alkoxyl Radical Generation for Metal-Free C(sp3)-C(sp3) Cleavage and Allylation/Alkenylation. Angew. Chem., Int. Ed. 2017, 56, 12619-12623. Highlighted by Science Foundation in China, China Science Daily, Chin. J. Org. Chem. and Chinese Academy of Sciences. Jia, K.; Pan, Y.; Chen, Y.* Selective Carbonyl-C(sp3) Bond Cleavage to Construct Ynamides, Ynoates, and Ynones by Photoredox Catalysis. Angew. Chem., Int. Ed. 2017, 56, 2478–2481. Highlighted by Chin. J. Org. Chem. and Chinese Academy of Sciences. Qi, L.; Chen, Y.* Polarity-Reversed Allylations of Aldehydes, Ketones, and Imines Enabled by Hantzsch Ester in Photoredox Catalysis. Angew. Chem., Int. Ed. 2016, 55, 13312-13315. Huang, H.1; Jia, K.1; Chen, Y.* Radical Decarboxylative Functionalizations Enabled by Dual Photoredox Catalysis.ACS Catal. 2016, 6, 4983-4988. Invited Perspective. Jia, K.; Zhang, F.; Huang, H.; Chen, Y.* Visible-Light-Induced Alkoxyl Radical Generation Enables Selective C(sp3)-C(sp3) Bond Cleavage and Functionalizations. J. Am. Chem. Soc. 2016, 128, 1514-1517. Highlighted by Organic Chemistry Portal. and Chinese Academy of Sciences. Zhang, J.; Li, Y.; Zhang, F.; Hu, C.; Chen, Y.* Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp3)-H Functionalization under Mild Reaction Conditions. Angew. Chem., Int. Ed. 2016, 55, 1872-1875. Highlighted by Angew. Chem., Int. Ed. Huang, H.1; Zhang, G.1; Chen, Y.* Dual Hypervalent Iodine (III) Reagents and Photoredox Catalysis Enable Decarboxylative Ynonylation under Mild Conditions. Angew. Chem., Int. Ed. 2015, 54, 7872-7876. Highlighted by Chin. J. Org. Chem. and Chinese Academy of Sciences. Huang, H.; Jia, K.; Chen, Y.* Hypervalent Iodine Reagents Enable Chemoselective Deboronative/Decarboxylative Alkenylation by Photoredox Catalysis. Angew. Chem., Int. Ed. 2015, 54, 1881-1884. Highlighted by Synfacts. Yang, J.; Zhang, J.; Qi, L.; Hu, C.; Chen, Y.* Visible-Light-Induced Chemoselective Reductive Decarboxylative Alkynylation under Biomolecule-Compatible Conditions. Chem. Commun. 2015, 51, 5275-5278. Invited Themed Collection “2015 Emerging Investigators”. Huang, H.; Zhang, G.; Gong, L.; Zhang, S.; Chen, Y.*, Visible-Light-Induced Chemoselective Deboronative Alkynylation under Biomolecule-Compatible Conditions. J. Am. Chem. Soc. 2014, 136, 2280-2283. Highlighted by Chin. J. Org. Chem., Organic Chemistry Portal, and Synfacts. Dumelin, C.; Chen, Y.; Leconte, A. M.; Chen, Y. G.; Liu, D. R.*, Discovery and Biological Characterization of Geranylated RNA in Bacteria. Nat. Chem. Bio. 2012, 8, 913-919. Chen, Y.; Kamlet, A. S.; Steinman, J. B.; Liu, D. R.*, A Biomolecule-Compatible Visible-Light-Induced Azide Reduction from a DNA-Encoded Reaction-Discovery System. Nat. Chem. 2011, 3, 146-153. Chen, Y.; Ho, D. M.; Lee, C.*, Ruthenium-Catalyzed Hydrative Cyclization of 1,5-Enynes. J. Am. Chem. Soc. 2005, 127, 12184-12185.