黄诚 - 上海中医药大学

个人简介

黄诚研究员上海中医药大学，中药学院，研究员。目前从事抗肿瘤和治疗内分泌代谢性疾病的药物筛选和新靶点的鉴定，旨在从中药中发现具有减肥、降血糖、降血脂和抗肿瘤作用的新化合物或复方中药。共发表论文60余篇。受教育经历 1994/9-1997/7，上海中医药大学，博士 1987/9-1990/7，上海中医药大学，硕士 1979/10-1982/10，扬州大学医学院研究工作经历 2009/7-至今，上海中医药大学中药学院，研究员 2006/11-2007/5，美国肯塔基大学医学院，访问科学家 2005/7-2009/7，中国科学院营养科学研究所，副研究员 2002/11-2005/6，美国贝勒医学院分子与人类遗传系，ResearchAssociate 2001/6-2002/11，美国贝勒医学院儿科系，博士后 1999/9-2001/6，中国科学院上海生理研究所，副研究员 1997/9-1999/9，中国科学院上海生理研究所，博士后 1990/7-1997/9，上海市针灸经络研究所，助理研究员/副研究员所获荣誉、奖项 1.季光，王峥涛，黄诚，刘建文，王淼，吴涛，杨丽丽，张莉，宋海燕，柳涛，孙姗姗，范圣洁，魏华凤，郑培永，邢练军，安红梅，王磊，励冬斐，刘洋，潘洁露，舒祥兵，徐汉辰。基于病证结合中医药治疗非酒精性脂肪肝的转化医学研究，教育部，科技进步奖，二等奖，2014年1月。 2.季光，张莉，魏华凤，宋海燕，郑培永，刘建文，黄诚，杨丽丽，王淼，柳涛，杨莉，安红梅，吴涛，邢练军，王磊。基于病证结合中医药治疗非酒精性脂肪肝的转化医学实践，上海市，科学技术奖，一等奖，2013年12月12日。

研究领域

抗肿瘤和治疗内分泌代谢性疾病的药物筛选和新靶点的鉴定该实验室主要科研重点是有关代谢性疾病和肿瘤相关的药物研发和机制研究。通过建立3T3-L1脂肪细胞分化筛选平台、报告基因核受体筛选平台、肿瘤细胞筛选平台以及体内药效学筛选平台等，从中草药、复方、药食两用植物和天然产物中筛选具有明显减肥、降血糖、降血脂、防治动脉粥样硬化以及恶性肿瘤的前体药物，并对其进行相关靶点的机制研究。以期填补中药在阐明机制方面的不足。通过构建基因敲除、转基因等动物模型，开发新的药物靶点。为中医药防治代谢综合征和肿瘤提供科学理论依据及临床基础。

近期论文

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1.LiuG,ZhangY,LiuC,XuD,ZhangR,ChengY,PanY,HuangC,ChenY.Luteolinalleviatesalcoholicliverdiseaseinducedbychronicandbingeethanolfeedinginmice.JNutr.144(7):doi:10.3945/jn.114.193128.(2014). 2.HuangC*.NaturalmodulatorsofliverXreceptors.JIntegrMed.7(2):76-85,(2014). 3.FanS,ZhangY,SunQ,ZhengB,WuX,YangB,LiY,HuangC*.Extractofokralowersbloodglucoseandserumlipidsinhigh-fatdietinducedobeseC57BL/6mice.JNutrBiochem.25:(2014). 4.TanS,LiM,DingX,FanS,GuoL,GuM,ZhangY,FengL,JiangD,LiY,XiW,HuangC*,ZhouZ*.EffectsofFortunellamargaritafruitextractonmetabolicdisorderinhigh-fatdiet-inducedobeseC57BL/6mice.PLoSOne.9(4):e93510,(2014). 5.LiJ,ZhangL,HuangC,GuoF,LiY.FivenewcyotoxicsteroidalglycosidesfromthefruitsofSolanumtorvum.Fitoterapia.93:209-215,(2014). 6.LuY,XiW,DingX,FanS,ZhangY,JiangD,LiY,HuangC*,ZhouZ*.Citrangefruitextractsalleviateobesity-associatedmetabolicdisorderinhigh-fatdietinducedC57BL/6mouse.IntJMolSci.14:23736-23750,(2013). 7.FengL,LiuX,ZhuW,GuoF,WuY,WangR,ChenK,HuangC*,LiY*.Inhibitionofhumanneutrophilelastasebypentacyclictriterpenes.PLoSOne.8(12):e82794,(2013). 8.GuM,ZhangY,FanS,DingX,JiG*,HuangC*.ExtractsofRhizomaPolygonatiOdoratipreventhigh-fatdiet-inducedmetabolicdisordersinC57BL/6mice.PLoSOne.8(11):e81724,(2013). 9.DingX,GuoL,ZhangY,FanS,GuM,LuY,JiangD,LiY*,HuangC*,ZhouZ*.Extractsofpomelopeelspreventhigh-fatdiet-inducedmetabolicdisordersinC57BL/6micethroughactivatingthePPARαandGLUT4pathway.PLoSOne.8(10):e77915,(2013). 10.FanS,GuoL,ZhangY,SunQ,YangB,HuangC*.Okrapolysaccharideimprovesmetabolicdisordersinhigh-fatdiet-inducedobeseC57BL/6mice.MolNutrFoodRes.57:2075-2078,(2013). 11.JingL,ZhangY,FanS,GuM,GuanY,LuX,HuangC*,ZhouZ*.Preventiveandamelioratingeffectsofcitrusd-limoneneondyslipidemiaandhyperglycemiainmicewithhigh-fatdiet-inducedobesity.EurJPharmacol.715:46-55,(2013). 12.GuoF,FengL,HuangC,DingH,ZhangX,WangZ,LiY.PrenylflavonederivativesfromBroussonetiapapyrifera,inhibitthegrowthofbreastcancercellsinvitroandinvivo.PhytoLett.6:331-336,(2013). 13.HuN,YuanL,LiH-J,HuangC,MaoQ-M,ZhangY-Y,LinM,SunY-Q,ZhongX-Y,TangP,LuX.Anti-diabeticactivitiesofJiaotaiwanindb/dbmicebyaugmentationofAMPKproteinactivityandup-regulationofGLUT4expression.Evid-BasedComplAltMed.180721,(2013). 14.顾明,黄诚*.减肥药研发:窘境背后的希望.中国新药杂志.22(5):535-541,(2013). 15.FengQ,GouXJ,MengSX,HuangC,ZhangYQ,TangYJ,WangWJ,XuL,PengJH,HuYY.QushiHuayuDecoctionInhibitsHepaticLipidAccumulationbyActivatingAMP-ActivatedProteinKinaseInVivoandInVitro.Evid-BasedComplAltMed.184358,(2013). 16.GuM,FanS,LiuG,GuoL,DingX,LuY,ZhangY,JiG,HuangC*.Extractofwaxgourdpeelpreventshigh-fatdiet-inducedhyperlipidemiainC57BL/6miceviatheinhibitionofthePPARγpathway.Evid-BasedComplAltMed.342561,(2013). 17.FanS,ZhangY,HuN,SunQ,DingX,LiG,ZhengB,GuM,HuangF,SunY-Q,ZhouZ,LuX,HuangC*,JiG*.Extractofkudingteapreventshigh-fatdiet-inducedmetabolicdisordersinC57BL/6micevialiverXreceptor(LXR)βantagonism.PLoSOne.7(12):e51007,(2012). 18.DingX,FanS,LuY,ZhangY,GuM,ZhangL,LiuG,GuoL,LiY,LuX,ZhouZ*,HuangC*.Citrusichangensispeelextractexhibitsanti-obesityeffectsbytheinhibitionofPPARγandLXRsignalinginhigh-fatdiet-inducedC57BL/6mouse.Evid-BasedComplAltMed.678592,(2012). 19.ZhangL,FanS,LiuH,HuangC*.TargetingSMARCAL1asanovelstrategyforcancertherapy.BiochemBiophysResCommun.427:232-235,(2012). 20.ZhangY,FanS,HuN,GuM,ChuC,LiY,LuX,HuangC*.Rheinreducesfatweightindb/dbmouseandpreventsdiet-inducedobesityinC57BL/6mousethroughtheinhibitionofPPARγsignaling.PPARRes.374936,(2012). 21.LiY,HuangW,HuangS,DuJ*,HuangC*.Screeningofanti-canceragentusingzebrafish:ComparisonwiththeMTTassay.BiochemBiophysResCommun.422:85-90,(2012). 22.ZhangY,HuangC*.Targetingadipocyteapoptosis:Anovelstrategyforobesitytherapy.BiochemBiophysResCommun.417:1-4,(2012) 23.WangP,GuoF,TanJ,HuangC,WangG,LiY.AnovelC29sterolfromClerodendrumcyrtophyllum.ChemNatComp.48:594-596,(2012). 24.FengL,ZhuW,HuangC,LiY.DirectinteractionofONO-5046withhumanneutrophilelastasethrough1HNMRandmoleculardocking.IntJBiolMacromo.51:196-200,(2012). 25.GaoN,ChengS,BudhrajaA,GaoZ,ChenJ,LiuE-H,HuangC,ChenD,YangZ,LiuQ,LiP,ShiX,ZhangZ.Ursolicacidinducesapoptosisinhumanleukaemiacellsandexhibitsanti-leukaemicactivityinnudemicethroughthePKBpathway.BrJPharmacol.165:1813-1826,(2012). 26.WangY,FengL,ZhangB,WangX,HuangC,LiY,DuW.PalladiumcomplexesaffecttheaggregationofhumanprionproteinPrP106-126.InorgChem.50:4340-4348,(2011). 27.GaoN,BudhrajaA,ChengS,LiuE-H,HuangC,ChenJ,YangZ,ChenD,ZhangZ,ShiX.InterruptionoftheMEK/ERKsignalingcascadepromotesdihydroartemisinin-inducedapoptosisinvitroandinvivo.Apoptosis.16:511-523,(2011). 28.李乙根，黄文瑾，黄诚*.斑马鱼在新药发现中的应用。生命科学，23:273-278,(2011). 29.ChenC,ZhangY,HuangC*.BerberineinhibitsPTP1Bactivityandmimicsinsulinaction.BiochemBiophysResCommun.397:543-547,(2010). 30.HuangC*,GuS,YuP,YuF,FengC,GaoN,DuJ.Deficiencyofsmarcal1causescellcyclearrestanddevelopmentalabnormalitiesinzebrafish.DevBiol.339:89-100,(2010).