汤文军 - 中国科学院上海有机化学研究所 - 生命有机化学国家重点实验室

个人简介

1995年毕业于华东理工大学精细化工系；1998年于中国科学院上海有机化学研究所获硕士学位；2003年于美国宾夕法尼亚州立大学获博士学位；2003-2005 年在美国Scripps 研究所从事博士后研究；2005-2009年在美国Boehringer Ingelheim药业公司药物工艺部门(Chemical Development) 任高级科学家(Senior Scientist), 在2009-2011年间任首席科学家 (Principal Scientist)；2011年7月起任中科院上海有机化学研究所研究员、课题组长；同时兼任上海科技大学物质学院教授、博导、杭州高等研究院首席教授及华东理工大学药学院博导，2015年获中国均相催化青年奖，2017年获国家杰出青年基金资助。2018年入选科技部中青年科技创新领军人才。2019年获药明康德生命化学研究奖学者奖。

研究领域

1.发展高效、实用、绿色的催化反应方法学过渡金属催化是当代有机合成化学中最活跃的领域之一。在过渡金属参与的催化反应中，过渡金属催化剂是整个反应过程的关键，而配体的特性包括电子效应，立体效应，和空间效应直接影响了催化剂的活性和选择性。手性膦配体的发展极大地推动了整个不对称催化领域。在过去的几年中，我们研究小组设计和发展了一系列有显著结构特征的P-手性膦配体在大位阻偶联、不对称偶联、不对称环化、以及不对称氢化中表现出优异的效率，为复杂天然产物和药物的高效合成提供了实用、绿色的催化反应方法学 2. 复杂天然产物全合成利用我们研究小组发展的合成方法学，开展对一些有重要生理活性天然产物的高效全合成或骨架合成，并进行相关药化研究。以下是我们研究小组已完成的一些天然产物 3. 药物绿色合成发展能工业化的、高效、经济的新反应或合成策略，实施对药物分子或农药的新工艺研究，非常愿意与有诚意的企业共同研发药物的绿色合成工艺

近期论文

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Lv, Y.; Liao, H.; Tang, W.* “Synthesis of a Sitagliptin Intermediate via Ruthenium-Catalyzed Asymmetric Hydrogenation of Enamine Ester”.Chin. J. Org. Chem. 2024, . Lin, Y.; Xu, G.;* Tang, W.* “Chiral Polymeric Diamine Ligands for Iridium-Catalyzed Asymmetric Transfer Hydrogenation”.J. Am Chem. Soc. 2024, . Cao, Z.; He, D.; Tang, W.* “Catalysis and Synthesis Enabled by P-Chiral Dihydrobenzooxaphosphole Ligands”.Org. Process Res. Dev. 2024, . Bai, H. (1st co-author); Gu, W.(1st co-author); Zhao, D.; Xu, G.;* Tang, W.* “Synthesis of dydrogesterone by aromatization-dearomatization strategy”.Green Synthesis and Catalysis. 2023, . Peng, H.(1st co-author); Zhao, D.(1st co-author); Tang, W.;* Peng, A.* “Dienediamine: A Safe Herbicide as Paraquat Surrogate”.Mol. Plant. 2023, 16, 1962-1975. Liu, Z.; Gao, B.; Chernichenko, K.; Yang, H.;* Lemaire, S.;* Tang, W.* “Enantioselective C-H Arylation for Axially Chiral Heterobiaryls”.Org. Lett. 2023, 25, 7004-7008. Yang, H.(1st co-author); Yu, H.(1st co-author); Stolarzewicz. I. A.;* Tang, W.* “Enantioselective transformations in the synthesis of therapeutic agents”.Chem. Rev. 2023, . Sun, J.; Chen, Y.; Ragab. S. S.; Gu, W.; Tang, Z.; Tang, Y.; Tang, W.* “Total Syntheses of Polyhydroxylated Steroids by an Unsaturation-Functionalization Strategy”Angew. Chem., Int. Ed. 2023, 62, e202303639. Zhou, M.(1st co-author); Lin, Y.(1st co-author); Chen, X.-X.(1st co-author); Xu, G.;* Chung, L. W.;* Tang, W.* "Asymmetric Synthesis of Vicinal Tetrasubstituted Diamines via Reductive Coupling of Ketimines Templated by Chiral Diborons".Angew. Chem., Int. Ed. 2023, 62, e202300334. Zhu, Y.; Dong, W.; Tang, W.* "Palladium-Catalyzed Cross-Couplings in the Synthesis of Agrochemicals".Advanced Agrochem 2022, 1, 125-138. Li, B.; Luo, B.; Yang, H.;* Tang, W.* "Heck Reaction of N-Heteroaryl Halides for Concise Synthesis of Chiral α-Heteroaryl-substituted Heterocycles".Angew. Chem., Int. Ed. 2022, 61, e202209087. Yang, H.; Tang, W.* “Enantioselective Construction of ortho-Sulfur- or Nitrogen-Substituted Axially Chiral Biaryls and Asymmetric Synthesis of Isoplagiochin D”.Nat. Commun. 2022, 13, 4577. Kang, X.; Qian, C.; Yang, H.; Shi, J.;* Claverie, J.;* Tang, W.* “Protecting-group-free enantioselective tandem allylic substitution of o-phenylenediamines and o-aminophenols”.Green Synthesis and Catalysis. 2022, 3, 185-189. Li, Z.; Xu, R.; Guo, H.; Yang, H.; Xu, G.; Shi, E.* Xiao, J.* Tang, W.* “Enantioselective Rhodium-Catalyzed Hydrogenation of (Z)‑N‑Sulfonyl-α-Dehydroamido Boronic Esters”.Org. Lett. 2022, 24, 714-719. Li, B.; Luo, B.; Blakemore, C. A.;* Smith, A. C.; Widlicka, D. W.; Berritt, S.; Tang, W.* “Synthesis of α-Heteroaryl Propionic Esters by Palladium-Catalyzed α-Heteroarylation of Silyl Ketene Acetals”.Org. Lett. 2021, 23, 6439-6443. Tian, W.; Li, B.; Tian, D.; Tang, W.* “Regioselective 2-alkylation of indoles with α-bromo esters catalyzed by Pd/P,P=O system”.Chin. Chem. Lett. 2022, 33, 197-200. Sun, J.; Gu, W.; Yang, H.;* Tang, W.* “Enantioselective total synthesis of parnafungin A1 and 10a-epi-hirtusneanine”.Chem. Sci. 2021, 12, 10313-10320. Wan, F.; Wang, N.; Zhu, Y.; Tang, C.; Claverie, J. P.;* Tang, W.* “Enantioselective Hydrogenation of Cyclic Tetrasubstituted-Olefinic Dehydroamino Acid Derivatives”.Chem. Commun. 2021, 57, 5546-5549. Peng, H.; Li, T.; Tian, D.; Yang, H.; Xu, G.; Tang, W.* “Metal-Free Reduction of Unsaturated Carbonyls, Quinones, and Pyridinium Salts with Tetrahydroxydiboron/Water”.Org. Biomol. Chem. 2021, 19, 4327-4337. Xu, R.; Gao, Z.,; Yu, Y.; Tang, Y.; Tian, D.; Chen, T.; Chen, Y. ; Xu G. Shi, E.; Tang, W.* "A Facile and Practical Preparation of P-Chiral Phosphine Oxides".Chem. Commun. 2021, 57, 3335-3338. Wu, T.; Zhou, Q.; Tang, W.* “Enantioselective α‐Carbonylative Arylation for Facile Construction of Chiral Spirocyclic β,β'‐Diketones".Angew. Chem., Int. Ed. 2021, 60, 9978-9983. Sun, J.; Yang, H.;* Tang, W.* "Recent advances in total syntheses of complex dimeric natural products".Chem. Soc. Rev. 2021, 50, 2320-2336. Tian, D,; Xu, R,; Zhu, J.; Huang, J.; Dong, W.; Claverie, J.; Tang, W.* "Asymmetric Hydroesterification of Diarylmethyl Carbinols".Angew. Chem., Int. Ed. 2021, 60, 6305-6309. Tang, W.* "Author Profile".Angew. Chem., Int. Ed. 2020, 59, 7988. Wan, F.; Tang, W.* "Phosphorus Ligands from the Zhang Lab: Design, Asymmetric Hydrogenation, and Industrial Applications".Chin. J. Chem. 2021, 39, 954-968. Aliyu, M.; Li, B.; Yang, H.; Tang, W.* "Palladium-catalyzed reductive cross-coupling between α-bromo carboxamides and terminal alkynes".Org. Chem. Front. 2020, 7, 3505-3508. i, K.; Nie, M.; Tang, W.* "Synthesis of α-tertiary allylsilanes by palladium-catalyzed hydrosilylation of 1,1-disubstituted allenes".Green Synthesis and Catalysis. 2020, 1, 171-174. u, H.; Yang, H.;* Shi, E.;* Tang, W.* “Development and Clinical Application of Phosphorus-Containing Drugs".Med. Drug Discov. 2020, 8, 100063. u, T.; Tang, W.* “Construction of Bridged Polycyclic Skeletons via Transition‐Metal Catalyzed Carbon‐Carbon Bond‐Forming Reaction".Chem. Eur. J. 2021, 27, 3944-3956. i, B.; Aliyu, M.; Gao, Z.; Li, T.; Dong, W.; Shi, E.* Tang, W.* “General Synthesis of Chiral α,α-Diaryl Carboxamides by Enantioselective Palladium-Catalyzed Cross-Coupling".Org. Lett. 2020, 13, 4974-4978. u, T.; Kang, X.; Bai, H.; Xiong, W.; Xu, G.; Tang, W.* “Enantioselective Construction of Spiro Quaternary Carbon Stereocenters via Pd-Catalyzed Intramolecular α-Arylation".Org. Lett. 2020, 22, 4602-4607. Qian, C.; Tang, W.* "A Versatile Synthesis of Vinyl-Substituted Heterocycles via Regio- and Enantioselective Pd-Catalyzed Tandem Allylic Substitution".Org. Lett. 2020, 22, 4483-4488. Zhou, M.; Li, K.; Chen, D.; Xu, R.; Xu, G.* Tang, W.* "Enantioselective Reductive Coupling of Imines Templated by Chiral Diboron".J. Am. Chem. Soc. 2020, 142, 10337-10342. Xu, R.H.; Yang, H.; Tang, W.*“Efficient Synthesis of Chiral Drugs Facilitated by P-Chiral Phosphorus Ligands”.Chin. J. Org. Chem. 2020, 14, 581. Liu, Z.; Li, T.; Zhao, J.; Tang, W.* “A substituted tricyclohexylphosphane with ‘conformational lock’”.Tetrahedron. 2020, 76, 131216. Yang, H.; Sun, J.; Gu, W.; Tang, W.* "Enantioselective Cross-Coupling for Axially Chiral Tetra-ortho-Substituted Biaryls and Asymmetric Synthesis of Gossypol".J. Am. Chem. Soc. 2020, 142, 8036–8043. Mu, X.; Yu, H.; Peng, H.; Xiong, W.; Wu, T.; Tang, W.* "Expedite Construction of Various Bridged Polycyclic Skeletons by Palladium-Catalyzed Dearomatization".Angew. Chem., Int. Ed. 2020, 59, 8143-8147. Wu, T; Xu, G; Tang, W.* “P-Chiral Phosphorus Ligands for Cross-Coupling and Asymmetric Hydrogenation Reactions”.Aldrichimica Acta 2020, 53, 27-35. Li, C.; Ragab. S.S.; Liu, G.;* Tang, W.* "Enantioselective Formation of Quaternary Carbon Stereocenters in Natural Product Synthesis: A Recent Update".Nat. Prod. Rep. 2020, 37, 276. Zhu, J.; Huang, L.; Dong, W.; Li, N.; Yu, X.; Deng, W.*; Tang,W.* "Enantioselective Rhodium-Catalyzed Addition of Arylboroxines to N-Unprotected Ketimines: Efficient Synthesis of Cipargamin".Angew. Chem., Int. Ed. 2019, 58, 16119-16123. Li, C.(1st co-author); Wan, F.(1st co-author); Chen, Y.; Peng, H.; Tang, W.*; Yu, S.*; McWilliams, J. C.*, Mustakis, J.; Samp, L.; Maguire, R. J. "Stereoelectronic Effects in Ligand Design: Enantioselective RhodiumCatalyzed Hydrogenation of Aliphatic Cyclic Tetrasubstituted Enamides and Concise Synthesis of (R)-Tofacitinib".Angew. Chem., Int. Ed. 2019, 58, 13573-13583.