刘文 - 中国科学院上海有机化学研究所 - 生命有机化学国家重点实验室

个人简介

工作经历 2003年8月至今：任中国科学院研究员，上海有机化学研究所，研究员 2001年9月至2003年7月：美国威斯康星大学麦迪逊分校药学院，研究助理 2000年9月至2001年8月：美国加州大学戴维斯分校化学系，博士后教育背景 1994年9月至2000年8月：中国协和医科大学（中国医学科学院）获硕士（1997年）、博士学位（2000年，美国加州大学戴维斯分校化学系联合培养），导师：李元教授、沈奔教授 1988年9月至1992年7月：四川大学生物工程系，获学士学位

研究领域

复杂天然产物的生物合成（遗传学、生物化学和化学）研究以产量提高和结构多样性为目的组合生物合成研究以基因组扫描为手段的新型天然产物发现研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Zhang, D.; Zhang, F.; Liu, W.*, A KAS-III Heterodimer in lipstatin biosynthesis nondecarboxylatively condenses C8 and C14 fatty acyl-CoA substrates by a variable mechanism during the establishment of a C22 aliphatic skeleton. Journal of the American Chemical Society 2019, 141, 3993−4001. Jia, L.; Tang, H.; Wang, W.; Yuan, T.; Wei, W.; Pang, B.; Gong, X.; Wang, S.; Li, Y.; Zhang, D.; Liu, W.*; Tang, W.*, A linear nonribosomal octapeptide from Fusarium graminearum facilitates cell-to-cell invasion of wheat. Nature Communications 2019, 10, 922. Qiu, Y.; Du, Y.; Wang, S.; Zhou, S.; Guo, Y.; Liu, W., Radical S‑adenosylmethionine protein NosN forms the side ring system of nosiheptide by functionalizing the polythiazolyl peptide S‑conjugated indolic moiety. Organic Letters 2019, 21, 1502−1505. Wang, J.; Lin, Z.; Bai, X.; Tao, J.; Liu, W., Optimal design of thiostrepton-derived thiopeptide antibiotics and their potential application against oral pathogens. Organic Chemistry Frontiers 2019, 6, 1194–1199. Liu, J.; Lin, Z.; Li, Y.; Zheng, Q.; Chen, D.; Liu, W., Insights into the thioamidation of thiopeptins to enhance the understanding of the biosynthetic logic of thioamide-containing thiopeptides. Organic & Biomolecular Chemistry 2019, 17, 3727–3731. Chen, D.; Zhao, Q.; Liu, W., Discovery of caerulomycin/collismycin-type 2,2′-bipyridine natural products in the genomic era. Journal of Industrial Microbiology & Biotechnology 2019, 46, 459-468. Liu, J.; Lin, Z.; Chen, H.; Guo, H.; Tao, J.; Liu, W., Biosynthesis of the central piperidine nitrogen heterocycle in series a thiopeptides. Chinese Journal of Chemistry 2019, 37, 35-41. Zhang, D.; Tang, Z.; Liu, W., Biosynthesis of lincosamide antibiotics: reactions associated with degradation and detoxification pathways play a constructive role. Accounts of Chemical Research 2018, 51(6), 1496-1506. Zhong, G.; Chen, H.; Liu, W., Reply to ‘C–C bond cleavage in biosynthesis of 4-alkyl-L-proline precursors of lincomycin and anthramycin cannot precede C-methylation’. Nature Communications 2018, doi: 10.1038/s41467-018-05500-1. Awakawa, T.; Fujioka, T.; Zhang, L.; Hoshino, S.; Hu, Z.; Hashimoto, J.; Kozone, I.; Ikeda, H.; Shin-Ya, K.; Liu, W.; Abe, I., Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution. Nature Communications 2018, 9, 3534. Zheng, Q.; Gong, Y.; Guo, Y.; Zhao, Z.; Wu, Z.; Zhou, Z.; Chen, D.; Pan, L.*; Liu, W.*, Structural insights into a flavin-dependent [4+2] cyclase that catalyzes trans-decalin formation in pyrroindomycin biosynthesis. Cell chemical biology 2018, 25, 718-727. Wang, M.; Chen, D.; Zhao, Q.; Liu, W., Isolation, structure elucidation, and biosynthesis of a cysteate-containing nonribosomal peptide in Streptomyces lincolnensis. Journal of Organic Chemistry 2018, 83(13), 7102-7108. Li, J.; Li, Y.; Niu, G.; Guo, H.; Qiu, Y.; Lin, Z.; Liu, W.*; Tan, H.*, NosP-Regulated Nosiheptide Production Responds to Both Peptidyl and Small-Molecule Ligands Derived from the Precursor Peptide. Cell chemical biology 2018, 25, 143-153. Zheng, Q.; Gong, Y.; Guo, Y.; Zhao, Z.; Wu, Z.; Zhou, Z.; Chen, D.; Pan, L.*; Liu, W.*, Structural insights into a flavin-dependent [4+2] cyclase that catalyzes trans-decalin formation in pyrroindomycin biosynthesis. Cell chemical biology 2018, doi: 10.1016/j.chembiol.2018.03.007. Wang, M.; Chen, D.; Zhao, Q.; Liu, W., Isolation, structure elucidation, and biosynthesis of a cysteate-containing nonribosomal peptide in Streptomyces lincolnensis. Journal of Organic Chemistry 2018, doi: 10.1021/acs.joc.8b00044. Li, J.; Li, Y.; Niu, G.; Guo, H.; Qiu, Y.; Lin, Z..; Liu, W.*; Tan, H.*, NosP-Regulated Nosiheptide Production Responds to Both Peptidyl and Small-Molecule Ligands Derived from the Precursor Peptide. Cell chemical biology 2018, 25, 143-153. Qiu, Y.; Du, Y.; Zhang, F.; Liao, R.; Zhou, S.; Peng, C.; Guo, Y.; Liu, W., Thiolation Protein-Based Transfer of Indolyl to a Ribosomally Synthesized Polythiazolyl Peptide Intermediate during the Biosynthesis of the Side Ring System of Nosiheptide. Journal of the American Chemical Society, 2017, 139, 18186-18189. Lin, Z.; Ji, J.; Zhou, S.; Zhang, F.; Wu, J.; Guo, Y.; Liu, W., Processing 2-Methyl-l-Tryptophan through Tandem Transamination and Selective Oxygenation Initiates Indole Ring Expansion in the Biosynthesis of Thiostrepton. Journal of the American Chemical Society 2017, 139, 12105-12108. Zhong, G.; Zhao, Q.; Zhang, Q.; Liu, W., 4-Alkyl-L-(dehydro)proline biosynthesis in Actinobacteria involves N-terminal nucleophile-hydrolase activity of -glutamyltranspeptidase homolog for C-C bond cleavage. Nature Communications, 2017, 8, 16109. Chen, M.; Liu, J.; Duan, P.; Li, M.; Liu, W., Biosynthesis and molecular engineering of templated natural products. National Science Review, 2017, doi: 10.1093/nsr/nww045.