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个人简介

教育经历 2002年09月—2006年07月 北京大学生命科学学院,生物科学专业,获学士学位; 2006年11月—2011年11月 香港大学化学系,化学生物学专业, 获博士学位。 工作经历 2011年9月—2014年10月 哈佛大学医学院/波士顿儿童医院,博士后; 2014年11月—2022年4月 中山大学化学学院,副教授; 2022年04月—至今 中山大学化学学院,教授 讲授课程 化学生物学导论,大学化学(三),化学生物学(研究生),配位化学(研究生)

研究领域

1.金属蛋白:采用分子生物学、生物化学、结构生物学等方法,研究在感染、免疫等生理过程中关键金属蛋白的结构调控与功能机制; 2.功能金属配合物:设计合成具有靶向、催化等功能的金属配合物,研究其抗菌抗肿瘤、免疫调节等生物学活性及作用分子机制

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

“In Situ Prodrug Activation by an Affibody-Ruthenium Catalyst Hybrid for HER2-Targeted Chemotherapy” Z Zhao, X Tao, Y Xie, Q Lai, W Lin, K Lu, J Wang, W Xia*, Z-W Mao*, Angew. Chem. Int. Ed., 2022, e202202855. “Identification of an Au(I) N-heterocyclic carbene compound as a bactericidal agent against Pseudomonas aeruginosa” J Wang, X Sun, Y Xie, Y Long, H Chen, X He*, T Zou*, ZW Mao*, Wei Xia*, Frontiers in Chemistry, 2022, 10, 895159. “Inhibition of Quorum-Sensing Regulator from Pseudomonas aeruginosa Using a Flavone Derivative” Y Xie, J Chen, B Wang, AY Peng, ZW Mao*, W Xia*, Molecules, 2022, 27, 2439. “Inhibition of SARS-CoV-2 replication by zinc gluconate in combination with hinokitiol” X Tao#, L Zhang#, L Du, K Lu, Z Zhao, Y Xie, X Li, S Huang, PH Wang, JA Pan, W Xia*, J Dai, ZW Mao*, J. Inorg. Biochem., 2022, 231, 111777. (#: Co-first authors) “Regulation of DNA binding activity of the Staphylococcus aureus catabolite control protein A by copper (II)-mediated oxidation” X Liao#, H Li#, Y Guo#, F Yang, Y Chen, X He, H Li, W Xia*, ZW Mao*, H Sun*, J. Biol. Chem., 2022, 298, 101587. (#: Co-first authors) “Allosteric inhibition of SARS-CoV-2 3CL protease by colloidal bismuth subcitrate” X Tao, L Zhang, L Du, R Liao, H Cai, K Lu, Z Zhao, Y Xie, PH Wang, JA Pan, Y Zhang*, G Li*, J Dai*, ZW Mao*, W Xia*, Chem. Sci., 2021, 12, 14098-14102 “Light-triggered Nitric Oxide Release Photosensitizer to Combat Bacterial Biofilm Infections” Z Zhao, H Li, X Tao, Y Xie, L Yang, ZW Mao, W Xia*, Chem. Eur. J., 2021, 27, 5453-5460 (selected as inside cover) “Structural Insight into the Substrate Gating Mechanism by Staphylococcus aureus Aldehyde Dehydrogenase.” X Tao#, Z Zhang#, X Zhang, H Li, H Sun*, Z-W Mao, W Xia*, CCS Chem. 2020, 6, 946-954 “Identification of a Novel Inhibitor of Catabolite Control Protein A from Staphylococcus aureus.” Q Huang#, Z Zhang#, H Li#, Y Guo, X Liao, H Li, H Zhou, Wei Xia*, ACS Infect. Dis., 2020, 6, 347-354 “Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa.” Y Guo, W Li, H Li, W Xia*, ACS Infect. Dis., 2019, 10, 1693-1697 “Inactivation of NikR from Helicobacter pylori by a bismuth drug.” Y Guo, C Guan, H Wan, Z Zhang, H Li, H Sun*, W Xia*, J. Inorg. Biochem., 2019, 196, 110685-110690. “The unique trimeric assembly of the virulence factor HtrA from Helicobacter pylori occurs via N-terminal domain swapping.” Z Zhang#, Q Huang#, X Tao, G Song, P Zheng, H Li, H Sun, W Xia*, J. Biol. Chem., 2019, 294, 7990-8000. (#: Co-first authors) “Bismuth-induced Inactivation of Ferric Uptake Regulator from Helicobacter pylori.” X He, X Liao, H Li, W Xia*, H Sun*, Inorg. Chem., 2017, 56, 15041-15048 “Targeting the Thioredoxin Reductase-Thioredoxin System from Staphylococcus aureus by Silver Ions.” X Liao, F Yang, H Li, PK So, Z Yao, YT, W Xia*, H Sun*, Inorg. Chem., 2017, 56, 14823-14830 “Identification of Catabolite Control Protein A from Staphylococcus aureus as a Target of Silver Ions.” X Liao, F Yang, R Wang, X He, H Li, YT Richard, W Xia*, H Sun*, Chem. Sci., 2017, 8, 8061-8066

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