谭彩萍 - 中山大学

个人简介

教育经历 1998.09—2002.06 华南师范大学化学与环境学院，学士 2002.09—2008.06 中山大学化学与化学工程学院，博士工作经历 2008.03—2011.03 中山大学生命科学学院，博士后； 2011.04—2016.01 中山大学化学与化学工程学院，讲师 2016.02—2017-02 美国芝加哥大学，访问学者 2016.01—至今中山大学化学与化学工程学院，副教授

研究领域

从事的学科领域为生物无机化学。研究兴趣包括靶向性金属抗肿瘤药物的设计、抗肿瘤活性及机制研究。近两年，以与肿瘤发生、发展的关键的蛋白分子为靶点，设计了系列的金属配合物作为新颖的抑制剂，并研究了它们的抗肿瘤作用机制。主要研究的靶点包括组蛋白去乙酰化酶（Histone deacetylases, HDACs）和细胞周期素依赖性激酶（Cyclin-dependent kinases, CDKs）等。

近期论文

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Cao, J. J., Tan, C. P.*, Chen, M. H., Wu, N., Yao, D. Y., Liu, X. G., Ji, L.-N., Mao, Z. W.* Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium (III) complexes. Chemical Science 2017, 8, 631-640. IF: 8.668 Chen, M. H., Wang, F. X., Cao, J. J., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Light-Up Mitophagy in Live Cells with Dual-Functional Theranostic Phosphorescent Iridium(III) Complexes. ACS Applied Materials & Interfaces, 2017, 9 (15), 13304-13314. IF: 7.504 Zhang, D. Y., Zheng, Y., Tan, C. P.*, Sun, J. H., Zhang, W., Ji, L. N. and Mao, Z. W.* Graphene Oxide Decorated with Ru(II)–Polyethylene Glycol Complex for Lysosome-Targeted Imaging and Photodynamic/Photothermal Therapy. ACS Applied Materials & Interfaces2017, 9 (8), 6761-6771. IF: 7.504 Wang, F. X., Chen, M. H., Lin, Y. N., Zhang, H., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Dual Functions of Cyclometalated Iridium(III) Complexes: Anti-Metastasis and Lysosome-Damaged Photodynamic Therapy. ACS Applied Materials & Interfaces, 2017, 9 (49), 42471–42481. IF: 7.504 Zhang, D. Y., Zheng, Y., Zhang, H., He, L., Tan, C. P.*, Sun, J. H., Zhang, W., Peng, X. Y., Ji, L. N. and Mao, Z. W.* Ruthenium complex-modified carbon nanodots for lysosome-targeted one- and two-photon imaging and photodynamic therapy. Nanoscale, 2017, 9, 18966-18976.IF: 7.367 Xue, S. S., Tan, C. P.*, Chen, M. H., Cao, J. J., Zhang, D. Y., Ye, R. R., Ji, L. N. and Mao, Z. W.* Tumor-targeted supramolecular nanoparticles self-assembled from a ruthenium-beta-cyclodextrin complex and an adamantane-functionalized peptide. Chemical Communications 2017, 53 (5), 842-845. IF: 6.319 (Front Cover) Wu, N., Cao, J. J., Wu, X. W., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Iridium(III) Complexes with Five-Membered Heterocyclic Ligands for Combined Photodynamic Therapy and Photoactivated Chemotherapy. Dalton Transactions 2017, 46, 13482-13491. IF: 4.029 Zheng, Y., He, L., Zhang, D. Y., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Mixed-ligand iridium(III) complexes as photodynamic anticancer agents. Dalton Transactions 2017, 46, 11395-11407. IF: 4.029 Ye, R. R.，Cao, J. J.， Tan, C. P.，Ji, L. N.，Mao, Z. W.*， Valproic Acid-Functionalized Cyclometalated Iridium(III)Complexes as Mitochondria-Targeting Anticancer Agents. Chemistry-A European Journal 2017, 23(60), 15166-15176. IF: 5.317 Wang, F. X., Chen, M. H., Hu, X. Y., Ye, R. R., Tan, C. P.*, Ji, L. N. and Mao, Z. W. Ester-Modified Cyclometalated Iridium(III) Complexes as Mitochondria-Targeting Anticancer Agents. Scientific Reports 2016, 6, 38954. IF: 4.259 Ye, R. R., Tan, C. P.*, Ji, L. N. and Mao, Z. W.* Coumarin-appended phosphorescent cyclometalated iridium(III) complexes as mitochondria-targeted theranostic anticancer agents. Dalton Transactions 2016, 45(33), 13042-13051. IF: 4.029 (Front Cover) Ye, R. R., Tan, C. P.*, Chen, M. H., Hao, L., Ji, L. N. and Mao, Z. W.* Mono- and dinuclear phosphorescent rhenium(I) complexes: impact of subcellular localization on anticancer mechanisms. Chemistry-A European Journal 2016, 22(23), 7800-7809. IF: 5.317 Zhang, W., Shen, J., Su, H., Mu, G., Sun, J. H., Tan, C. P., Liang, X. J., Ji, L. N., Mao, Z. W.* Co-delivery of cisplatin prodrug and chlorin e6 by mesoporous silica nanoparticles for chemo-photodynamic combination therapy to combat drug resistance. ACS Applied Materials & Interfaces 2016, 8(21), 13332-13340. IF: 7.504 He, L., Li, Y., Tan, C. P.*, Ye, R. R., Chen, M. H., Cao, J. J., Ji, L. N. and Mao, Z. W.* Cyclometalated iridium(III) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents. Chemical Science 2015, 6, 5409-5418. IF: 8.668 (Back Cover) Ye, R. R., Tan, C. P.*, Lin, Y. N., Ji, L. N., Mao, Z. W.* A phosphorescent rhenium(I) histone deacetylase inhibitor: mitochondrial targeting and paraptosis induction. Chemical Communications 2015, 51(39),8353-8356. IF: 6.319 Li, Y., Tan, C. P. (Co-first author), He, L., Ji, L. N., Mao, Z. W.* Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents. Biomaterials2015, 39, 95-104. IF: 8.402 Zhang, W., Li, Y., Sun, J. H., Tan, C. P., Ji, L. N., Mao, Z. W.* Supramolecular self-assembled nanoparticles for chemo-photodynamic dual therapy against cisplatin resistant cancer cells. Chemical Communications 2015, 51(10), 1807-1810. IF: 6.319 Li, J. M., Zhang, W., Su, H., Wang, Y. Y., Tan, C. P., Ji, L. N., Mao, Z. W.* Reversal of multidrug resistance in MCF-7/ADR cells by codelivery of doxorubicin and BCL2 siRNA using a folic acid-conjugated polyethylenimine hydroxypropyl-beta-cyclodextrin nanocarrier.International Journal of Nanomedicine 2015, 10, 3147-3162. IF: 4.300 He, L., Tan, C. P.*, Ye, R. R., Zhao, Y. Z., Liu, Y. H., Zhao, Q., Ji, L. N., Mao, Z. W.* Theranostic iridium(III) complexes as one- and two-photon phosphorescent trackers to monitor autophagic lysosomes. Angewandte Chemie International Edition 2014, 53(45), 12137-12141.IF: 11.994 Ye, R. R., Tan, C. P.*, He, L., Chen, M. H., Ji, L. N., Mao, Z. W.* Cyclometalated Ir(III) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy. Chemical Communications 2014, 50(75), 10945-10948. IF: 6.319