个人简介
教育经历 1978年2月-1982年1月,山东大学化学系有机化学专业,本科; 1993年9月-1996年7月,中山大学化学系有机化学专业,博士。 工作经历 1996年6月中山大学有机化学专业博士毕业留校任教至今,先后任讲师、副教授、教授。先后于1998和1999年赴美国Brigham Young University和2001—2002年赴台湾大学做博士后研究各一年。主讲过《有机化学》、《有机分析》、《有机化学实验》、《物理有机化学》等课程。公开发表研究论文60余篇。 1982年1月—1993年8月,郑州轻工业学院化工系任教; 1996年7月—1998年8月,中山大学化学系,副教授; 1998年9月—1999年8月,美国Brigham Young University,博士后; 1999年8月—2001年9月,中山大学化学院,副教授; 2001年9月—2002年8月,台湾大学化学系,博士后; 2002年8月—2004年3月,中山大学化学院,副教授; 2004年4月—2016年2月,中山大学化学院,教授,博士生导师。 2016年2月—至今,中山大学化学工程与技术学院,教授,博士生导师。
近期论文
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1. 1-(1-Arylethylidene)Thiosemicarbazide derivatives: A new class of tyrosinase inhibitors, Bioorganic and Medicinal Chemistry, 2008, 1096; 2. Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivatives, Bioorganic & Medicinal Chemistry Letters, 2008, 6558; 3. Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted β-carboline derivatives, European Journal Medicinal Chemistry,2008, 533; 4. Synthesis and biological evaluation of helicid analoguesas novel acetylcholinester as einhibitors, European Journal Medicinal Chemistry, 2008, 166; 5. The synthesis and preliminary optical study of 1-alkyl-2,4,5-triphenylimidazole derivatives, Dyes and Pigments, 2008, 17; 6. Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors, Bioorganic & Medicinal Chemistry Letters, 2008, 6490; 7. A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds, European Journal Medicinal Chemistry, 2009, 1773; 8. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives, European Journal Medicinal Chemistry, 2009, 1737; 9. Discovery of 4-functionalized phenyl-O-β-d-glycosides as a new class of mushroom tyrosinase inhibitors, Bioorganic & Medicinal Chemistry Letters, 2009, 6157; 10.Synthesis and biological evaluation of novel4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors, European Journal of Medicinal Chemistry, 2009, 1737; 11. Synthesis and evaluation of 5-benzylidene(thio)barbiturate-β-d-glycosides as mushroom tyrosinase inhibitors, Bioorganic & Medicinal Chemistry Letters, 2009, 4055; 12. Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities, European Journal of Medicinal Chemistry, 2009, 4235; 13. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives, European Journal of Medicinal Chemistry, 2009, 1737; 14. Synthesis and optical behaviors of 2-(9-phenanthrenyl)-, 2-(9-anthryl)-, and 2-(1-pyrenyl)-1-alkylimidazole homologues, Spectrochimica Acta Part A, 2009, 233; 15. Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants, Food Chemistry, 2009, 381; 16. Synthesis of 4-[(diethylamino)methyl]phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyryl cholinesterase, Bioorganic & Medicinal Chemistry Letters,2010, 3254; 17. Synthesis and cytotoxic evaluation of N-benzylatedquaternary b-carboline amino acid ester conjugates, European Journal of Medicinal Chemistry, 2010, 1515; 18. Synthesis and preliminary optical study of 1,3,4-oxadiazole derivatives containing imidazole units, Dyes and Pigments, 2010, 249; 19. Synthesis of novel β-carbolines with efficient DNA-binding capacity and potent cytotoxicity, Bioorganic & Medicinal Chemistry Letters, 2010, 3876; 20. Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents, European Journal of Medicinal Chemistry, 2010,2503;