李厚金 - 中山大学 - 化学工程与技术学院（珠海）

研究领域

主要开展天然产物研究与开发。具体研究方向有：（1）海洋微生物，包括细菌、真菌、放线菌等产生的新结构化合物的发现和药物应用；（2）南海海洋生物的代谢产物及其应用研究；（3）陆源植物、特色中草药的药用成分研究与开发；（4）微生物生物转化的研究与应用。

近期论文

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Zeng Xu, Lei Huang, Xiao-Hong Chen, Xiao-Feng Zhu, Xiao-Jun Qian , Gong-Kan Feng, Wen-Jian Lan, Hou-Jin Li*. Cytotoxic Prenylated Xanthones from the Pericarps of Garcinia mangostana. Molecules, 2014, 19(2), 1820-1827. Hou-Jin Li*, Wen-Han Jiang, Wan-Ling Liang, Jia-Xin Huang, Yu-Fei Mo, Yan-Qing Ding, Chi-Keung Lam, Xiao-Jun Qian, Xiao-Feng Zhu, Wen-Jian Lan. Induced Marine Fungus Chondrostereum sp. as a Means of Producing New Sesquiterpenoids Chondrosterins I and J by Using Glycerol as the Carbon Source, Marine Drugs, 2014, 12(1), 167-175. Hou-Jin Li, Ting Chen, Ying-Lu Xie, Wen-Dan Chen, Xiao-Feng Zhu, Wen-Jian Lan. Isolation and Structure Elucidation of Chondrosterins F–H from the Marine Fungus Chondrostereum sp.. Marine Drugs, 2013, 11, 551-558. Zhong-Liang Xie, Hou-Jin Li*, Lai-You Wang, Wan-Ling Liang, Wei Liu, and Wen-Jian Lan. Trichodermaerin, a Novel Diterpenoid Lactone from the Marine Fungus Trichoderma erinaceum Associated with Seastar Acanthaster planci. Natural Product Communications, 2013, 8(1), 67-68. Yang Zhao, Shu-Qing Li, Hou-Jin Li*, Wen-Jian Lan. Lanostane Triterpeoids from the Fungus Ceriporia lacerate Associated with Acanthaster planci. Chemistry of Natural Compounds, 2013, 49(4), 653-656. Fen Yang, Wen-Dan Chen, Rong Deng, Hui Zhang, Jun Tang, Ke-Wei Wu, Dan-Dan Li, Gong-Kan Feng, Wen-Jian Lan, Hou-Jin Li*, Xiao-Feng Zhu. Hirsutanol A, a novel sesquiterpene compound from fungus Chondrostereum sp., induces apoptosis and inhibits tumor growth through mitochondrial-independent ROS production: Hirsutanol A inhibits tumor growth through ROS production. Journal of Translational Medicine, 2013, 11: 32. Wen-Jian Lan, Yang Zhao, Zhong-Liang Xie, Li-Zhen Liang, Wei-Yan Shao, Long-Ping Zhu, De-Po Yang, Xiao-Feng Zhu, Hou-Jin Li*. Novel Sorbicillin Analogues from the Marine Fungus Trichoderma sp. Associated with the Seastar Acanthaster planci. Natural Product Communications, 2012, 7(10), 1337-1340. Hou-Jin Li, Da-Lang Zhou, Ting-Juan Xu, Chi-Keung Lam and Wen-Jian Lan. 5,6,7,5’-Tetramethoxy-3’,4’-methylenedioxyflavone Monohydrate. Acta Cryst. (2012). E68, o1390 Fen Yang, Wen-Dan Chen, Deng Rong, Dan-Dan Li, Ke-Wei Wu, Gong-Kan Feng, Hou-Jin Li*, Xiao-Feng Zhu. Hirsutanol A induces apoptosis and autophagy via reactive oxygen species accumulation in breast cancer MCF-7 cells. Journal of Pharmacological Sciences, 2012, 119(3), 214-220. Hou-jin Li, Ying-lu Xie, Zhong-liang Xie, Ying Chen, Chi-Keung Lam, Wen-jian Lan. Chondrosterins A–E, Triquinane-Type Sesquiterpenoids from Soft Coral- Associated Fungus Chondrostereum sp., Marine Drugs, 2012, 10(3), 627-638. Hou-Jin Li, Wen-Jian Lan*, Chi-keung Lam, Fen Yang, Xiao-Feng Zhu. Hirsutane Sesquiterpenoids from the Marine-Derived Fungus Chondrostereum sp., Chemistry ＆ Biodiversity, 2011, 8(2), 317-324. Wen-Jian Lan, Shou-Liang Wang, Hou-Jin Li*. Additional New Tetracyclic Tetraterpenoid, Methyl Tortuoate D from Soft Coral Sarcophyton tortuosum. Natural Product Communications, 2009, 4(9), 1193-1196. Wen-Jian Lan, Hong-Ping Wan, Guo-Xi Li, Hou-Jin Li*, Yun-Yun Chen, Cheng-Zhu Liao, Ji-Wen Cai. New Sesquiterpene Formamides from the Marine Sponge Axinyssa sp.. Helvetica Chimica Acta, 2008, 91(3), 426-434. Guo-Xi Li, Ren-Sen Zeng, Hou-Jin Li, Zhong-Yi Yang, Guo-Rong Xin, Jian-Gang Yuan, Yi Luo. Allelopathic effects of decaying Italian ryegrass (Lolium mutiflorum Lam.) residues on rice. Allelopathy Journal, 2008, 22(1), 15-23. Wen-Jian Lan, Lin-Feng Mo, Chuang-Hua Cai, Yi-Pin Zhou, Jun-Hua Yao, Hou-Jin Li*. Studies on culture condition of new marine bacterium Zooshikella sp. SY01. Frontiers of Chemical Engineering in China, 2008, 2(4), 443-446. Wen-Jian Lan, Hou-Jin Li *. New Sesterterpenoids from the Sponge Phyllospongia papyracea. Helvetica Chimica Acta, 2007, 90(6), 1218-1222. Wen-Jian Lan, Hou-Jin Li, Su-Jun Yan, Jing-Yu Su, Long-Mei Zeng. New tetraterpenoids from the soft coral Sarcophyton tortuosum. Journal of Asian Natural Products Research, 2007, 9(3), 267-271. Hou-Jin Li, Taro Amagata, Karen Tenney, Phillip Crews. Additional scalarane sesterterpenes from the sponge Phyllospongia papyracea. Journal of Natural Products, 2007, 70(5), 802-807. Hou-Jin Li*, Wen-Jian Lan, Chuang-Hua Cai, Yi-Pin Zhou, Yong-Cheng Lin. The bioactive pigments from marine bacteria Pseudomonas sp.. NATURAL PRODUCTS-Essential Resources for Human Survival, World Scientific Publishing Company, Feburary, 2007, p188-194. Hou-Jin Li*, Wen-Jian Lan, Chuang-Hua Cai, Yi-Pin Zhou, Yong-Cheng Lin. Biotransformation of limonene by marine bacteria. Chinese Journal of Analytical Chemistry, 2006, 34(7), 946-950.