毛宗万 - 中山大学

个人简介

教育经历 1982年：获四川大学学士学位 1991年：获南京大学硕士学位（导师：唐雯霞教授） 1994年：获南京大学博士学位（导师：唐雯霞教授） 1995-1996年：中山大学博士后研究（合作导师：计亮年院士） 1997-1998年：德国埃尔兰根-纽伦堡大学洪堡访问学者（合作导师：Rudi van Eldik教授）工作经历先后在绵阳师范学院和四川师范学院工作，现为中山大学化学学院教授。

研究领域

生物无机化学，金属化学生物学，药物化学生物学，核酸化学，分子诊疗，分子探针，生物成像

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

K. Peng, Y. Zheng, W. Xia*, Z.W. Mao*, Organometallic Anti-tumor Agents: Targeting from Biomolecules to Dynamic Bioprocesses. Chem. Soc. Rev., 2023, 52, 2790–2832. DOI: 10.1039/d2cs00757f X. Su, B. Liu, W. J. Wang, K. Peng, B.B. Liang, Y. Zheng, Q. Cao*, Z.W. Mao*, Disruption of Zinc Homeostasis by a Novel Platinum(IV)-Terthiophene Complex for Antitumor Immunity. Angew. Chem. Int. Ed., 2023, 62, e202216917. DOI: 10.1002/anie.202216917 L.Y. Liu, T.Z. Ma, Y.L. Zeng, W. Liu*, Z.W. Mao*, Structural Basis of Pyridostatin and Its Derivatives Specifically Binding to G-Quadruplexes. J. Am. Chem. Soc., 2022, 144, 11878-11887. DOI: 10.1021/jacs.2c04775 Z. Zhao, X. Tao, Y. Xie, Q. Lai, Y. Zheng, W. Lin, K. Lu, J. Wang, W. Xia*, Z.W. Mao*, In Situ Prodrug Activation by an Affibody-ruthenium Catalyst Hybrid for HER2-targeted Chemotherapy. Angew. Chem. Int. Ed., 2022, 61, e202202855. DOI: 10.1002/anie.202202855 W.J. Wang, Y.Y. Ling, Y.M. Zhong, Z.Y. Li, C.P. Tan*, Z.W. Mao*, Ferroptosis-enhanced Cancer Immunity by a Ferrocene-appended Iridium(III) Diphosphine Complex. Angew. Chem. Int. Ed., 2022, e202115247. DOI: 10.1002/anie.202115247 X. Su, W.J. Wang, Q. Cao*, H. Zhang, B. Liu, Y. Ling, X. Zhou, Z.W. Mao*, A Carbonic Anhydrase IX(CAIX)-Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti-tumor Immunity. Angew. Chem. Int. Ed., 2022, 61, e202115800. DOI: 10.1002/anie.202115800 Y.Y. Ling, X.Y. Xia, L. Hao, W.J. Wang, H. Zhang, L.Y. Liu, W. Liu, Z.Y. Li, C.P. Tan*, Z.W. Mao*, Simultaneous Photoactivation of cGAS‐STING Pathway and Pyroptosis by Pt(II)-triphenylamine Complexes for Cancer Immunotherapy. Angew. Chem. Int. Ed., 2022, e202210988. DOI: 10.1002/anie.202210988 K.N. Wang, L.Y. Liu, D. Mao, M.X. Hou, C.P. Tan, Z.W. Mao*, B. Liu*, A Nuclear-Targeted AIE Photosensitizer for Enzyme Inhibition and Photosensitization in Cancer Cell Ablation. Angew. Chem. Int. Ed., 2022, 61, e202114600. DOI: 10.1002/anie.202114600 B.C. Zhu, J. He, X.Y. Xia, J. Jiang, W. Liu, L.Y. Liu, B.B. Liang, H.G. Yao, Z. Ke*, W. Xia*, Z.W. Mao*, Solution Structure of a Thrombin Binding Aptamer Complex with a Non-planar Platinum(II) Compound. Chem. Sci., 2022, 13, 8371-8379. DOI: 10.1039/D2SC01196D G.G. Yang, X.X. Su, B.B. Liang, Z.Y. Pan, Q. Cao*. Z.W. Mao*, Platinum-Ruthenium Hybrid Prodrug with Multi-enzymatic Activities for Chemo-catalytic Therapy of Hypoxic Tumors. Chem. Sci., 2022, 13, 11360-11367. DOI: 10.1039/D2SC03375E W. Liu, B.C. Zhu, L.Y. Liu, X.Y. Xia, Z.W. Mao*, G-quadruplex Structural Transition Driven By a Platinum Compound. Nucleic Acids Res., 2022, 50, 7816–7828. DOI: 10.1093/nar/gkac572 L. Hao, Y.Y. Ling, Z.X. Huang, Z.Y. Pan, C.P. Tan*, Z.W. Mao*, Real-time Tracking of ER Turnover during ERLAD by a Rhenium Complex via Lifetime Imaging. Natl. Sci. Rev., 2022, 9, nwab194. DOI: 10.1093/nsr/nwab194/6413567. W.J. Wang, X. Mu, C.P. Tan*, Y.J. Wang, Y. Zhang*, G. Li*, Z.W. Mao*, Induction and Monitoring of DNA Phase Separation in Living Cells by a Light-Switching Ruthenium Complex. J. Am. Chem. Soc., 2021, 143, 11370-11381. DOI: 10.1021/jacs.1c01424 B.C. Zhu, J. He, W. Liu*, X.Y. Xia, L.Y. Liu, B.B. Liang, H.G. Yao, B. Liu, L.N. Ji, Z.W. Mao*, Selectivity and Targeting of G-quadruplex Binders Activated by Adaptive Binding and Controlled by Chemical Kinetics. Angew. Chem. Int. Ed., 2021, 60, 15340-15343. DOI: 10.1002/anie.202104624 L.Y. Liu, K.N. Wang, W. Liu*, Y.L. Zeng, M.X. Hou, J. Yang, Z.W. Mao*, Spatial Matching Selectivity and Solution Structure of Organic-Metal Hybrid to Quadruplex-Duplex Hybrid. Angew. Chem. Int. Ed., 2021, 60, 20833-20839. DOI: 10.1002/anie.202106256 K. Peng, B.B. Liang, W. Liu, Z.W. Mao*, What Blocks More Anticancer Platinum Complexes From Experiment to Clinic: Major Problems and Potential Strategies from Drug Design Perspectives. Coord. Chem. Rev., 2021, 449, 214210. DOI: 10.1016/j.ccr.2021.214210 X. Tao, L. Zhang, L. Du, R. Liao, H. Cai, K. Lu, Z. Zhao, Y. Xie, P.H. Wang, J.A. Pan, Y. Zhang, G. Li, J. Dai, Z.W. Mao*, W. Xia*, Allosteric Inhibition of SARS-CoV-2 3CL Protease by Colloidal Bismuth Subcitrate. Chem. Sci., 2021, 12, 14098-14102. DOI: 10.1039/D1SC03526F C.P. Tan*, Y.M. Zhong, L.N. Ji, Z.W. Mao*, Phosphorescent metal complexes as theranostic anticancer agents: combining imaging and therapy in a single molecule. Chem. Sci., 2021, 12, 2357-2367. DOI: 10.1039/d0sc06885c K.N. Wang, X. Shao, Z. Tian, L.Y. Liu, C. Zhang, C.P. Tan, J. Zhang, P. Ling, F. Liu, Q. Chen, J. Diao*, Z.W. Mao*, A Continuous Add-on Probe Reveals the Nonlinear Enlargement of Mitochondria in Light-Activated Oncosis. Adv. Sci., 2021, 8, 2004566. DOI: 10.1002/advs.202004566. Y. Zheng, Y. Ling, D.Y. Zhang, C.P. Tan*, H. Zhang, G.G. Yang, H. Wang, L.N. Ji, Z.W. Mao, Regulating Tumor N6-methyladenosine Methylation Landscape Using Hypoxia-Modulating OsSx Nanoparticles. Small, 2021, 17(1), 2005086. DOI: 10.1002/smll.202005086. F.X. Wang, J.W. Liu, X.Q. Hong, C.P. Tan, L. Zhang*, W.H. Chen*, P. Sadler*, Z.W. Mao*, Anion-responsive Manganese Porphyrin Facilitates Chloride Transport and Induces Immunogenic Cell Death. CCS Chem., 2021, 3, 2527-2537. DOI:10.31635/ccschem. 021.202101212. Q. Cao, D.J. Zhou, Z.Y. Pan, G.G. Yang, H. Zhang, L.N. Ji, Z.W. Mao*, CAIXplatins: Highly Potent Platinum(IV) Prodrugs Selective Against Carbonic Anhydrase IX for the Treatment of Hypoxic Tumors, Angew. Chem. Int. Ed., 2020, 59, 18556−18562. DOI: 10.1002/anie.202005362 L.Y. Liu, H. Fang, Q. Chen, M.H. Chan, M. Ng, K.N. Wang, W. Liu, Z. Tian, J. Diao*, Z.W. Mao*, V.W. Yam*, Multiple-color Platinum Complex with Super-large Stokes Shift for Super-resolution Imaging of Autolysosome Escape, Angew. Chem. Int. Ed., 2020, 59, 19229−19236. DOI: 10.1002/anie.202007878 L.Y. Liu, W. Liu, K.N. Wang, B.C. Zhu, X.Y. Xia, L.N. Ji, Z.W. Mao*, Quantitative Detection of G-Quadruplex DNA in Live Cells Based on Photon Counts and Complex Structure Discrimination, Angew. Chem. Int. Ed., 2020, 59, 9719−9726. DOI: 10.1002/anie.202002422 Z.Y. Pan, C.P. Tan*, L.S. Rao, H. Z., Y. Zheng, L. Hao, L.N. Ji, Z.W. Mao, Recoding the Cancer Epigenome by Intervening in Metabolism and Iron Homeostasis with Mitochondria-Targeted Rhenium(I) Complexes, Angew. Chem. Int. Ed., 2020, 59, 2−10. DOI: 10.1002/anie.202008624 J.H. Liang, Y. Zheng, X.W. Wu, C.P. Tan*, L.N. Ji, Z.W. Mao*, A Tailored Multifunctional Anticancer Nanodelivery System for Ruthenium-based Photosensitizers: Tumor Microenvironment Adaption and Remodeling. Adv. Sci., 2020, 7, 1901992. DOI: 10.1002/advs.201901992.