个人简介
刘国东,男,1972年出生,博士,现任美国北达科他州立大学(NorthDakotaStateUniversity)化学与生物化学系副教授,福建农林大学闽江学者讲座教授。在JournaloftheAmericanChemistrySociety、AnalyticalChemistry、BiosensorsandBioelectronics、ChemicalCommunications等分析化学领域顶级期刊上发表了SCI论文70余篇,这些论文被SCI期刊他人正面引用1000余次。
受教育经历:
2004/10-2006/09美国PacificNorthWestNationalLaboratory生物分析化学博士后
2002/01-2004/09美国NewMexicoStateUniversity生物分析化学博士后
2001/06湖南大学生物分析化学博士学位
1998/07湖南大学分析化学硕士学位
1995/07湖南师范大学分析化学学士学位
研究工作经历:
2013-至今美国NorthDakotaStateUniversity副教授
2007-2013美国NorthDakotaStateUniversity助理教授
2006-2007美国PacificNorthwestNationalLaboratory研究员
硕士生导师招生学科介绍:
1.食品科学
2.农业推广(食品加工与安全领域)
科研项目:
1.“DevelopmentofHand-HeldCancerBiomarkerMonitor”(NIH,R21,5R21CA137703-02),项目负责人,2010/09/01-2014/04/30.
2.“DevelopmentofLateralFlowNucleicAcidBiosensorsfortheDetectionofHPV”(DakotaBioCorp,IndustryResearchFunds,FAR0020201),项目负责人,2012/08/01-2015/02/28.
3.“ConjugatesofQuantumDotsandNaturalIronComplexesforDetectingGram-negativePathogensandProbingMembraneTransportMechanisms”(CenterofProteaseResearchNDSU,COBREPilotProject,FAR0020201),项目负责人,2013/03/01-2014/06/30.
4.“ArrayedLateralFlowBiosensorforRapidMolecularIdentificationofUTI-Related”(LynntechInc,SBIRsubcontract,1R43AI102357-01),项目负责人,2012/09/01-2013/05/31.
5.“APOCFieldTestfortheRapidDeterminationofFolateInsufficiency(SBIR,PhaseI)”(LynntechInc,SBIRsubcontract,200-2012-M-52272),项目负责人,2012/09/01-2013/05/31.
6.“RapidandCost-EffectiveDiagnosticSystemforSexuallyTransmittedInfections”(LynntechInc,NIHSBIRsubcontract),项目负责人,2011/12/01-2012/05/31.
7.“AnIntegratedOpticalDNADetectorforPortablePCR”(LynntechInc,NIHSBIRsubcontract),项目负责人,2010/01/01-2010/05/31.
8.“InnovativeBiomonitoringDeviceforRapidDiagnosisofExposuretoNerveAgents”(PacificNorthwestNationalLaboratory,NIHU01subcontract),项目负责人,2007/01/11-2010/05/30.
9.“NorthDakotaStateUniversityNewFacultyStartup”(NorthDakotaStateUniversity,Start-upfunds),项目负责人,2007/08/01-2009/07/31.
10.“DevelopmentofPoint-of-CareNucleicacidBiosensorsforClinicalDiagnosis”(NIHINBRELynntechInc,Seedgrant),项目负责人,2008/09/01-2009/04/30.
11.“IntegratedNucleicacidandProteinBiosensorsforCancerEarlyDiagnosis”(CenterofProteasesResearchNDSU,CPRSeedgrant),项目负责人,2009/01/01-2009/05/30.
12.“PortableAnalyzerforon-siteMonitoringofworkerExposuretoToxicMetal”(PacificNorthwestNationalLaboratory,NIHR21Sub-contract),项目负责人,2008/01-2008/07.
研究领域
研究领域主要为构建基于纳米材料的生物传感器、生物分析方法和现场检测装置,应用于生物医药中核酸、蛋白质超灵敏检测,食品安全检测,临床即时检测以及环境监测等。
近期论文
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1.Qiu,W.;Xu,H.;Takalkar,S.;Gurung,A.S.;Liu,B.;Zheng,Y.;Guo,Z.;Baloda,M.;Baryeh,K.;Liu,G.*“Carbonnanotube-basedlateralflowbiosensorforsensitiveandrapiddetectionofDNAsequence.”BiosensorsandBioelectronics2015,64,367-372.
2.Xu,H.;Chen,J.;Birrenkott,J.;Zhao,J.X.;Takalkar,S.;Baryeh,K.;Liu,G.*“Gold-nanoparticle-decoratedsilicananorodsforsensitivevisualdetectionofproteins.“AnalyticalChemistry2014,86,7351-7359.
3.Gao,X.;Xu,H.;Baloda,M.;Gurung,A.S.;Xu,L.;Wang,T.;Zhang,X.;Liu,G.*“VisualDetectionofmicroRNAwithLateralFlowNucleicAcidBiosensor.”BiosensorandBioelectronics2014,54,578-584.
4.Shen,G.;Xu,H.;Gurung,A.S.;Yang,Y.;Liu,G.*“LateralFlowImmunoassaywiththeSignalEnhancedbyGoldNanoparticleAggregatesBasedonPolyamidoamineDendrimer.”AnalyticalSciences,2013,29,799-804.
5.Xu,L.;Wang,S.;Dong,H.;Liu,G.;Wen,Y.;WangS.;Zhang,X.“Fractalgoldmodifiedelectrodeforultrasensitivethrombindetection.”Nanoscale20124,3786-3790.
6.He,Y.;Zhang,X.;Zhang,S.;Kris,K.L.;Man,F.C.;Kawde,A.;Liu,G.*“Visualdetectionofsingle-basemismatchesinDNAusinghairpinoligonucleotidewithdouble-targetDNAbindingsequencesandgoldnanoparticles.”BiosensorandBioelectronics2012,34,37-43.
7.He,Y.;Zeng,K.;ZhangS.;Gurung,A.S.;Baloda,M.;Zhang,X.;Liu,G.*“Visualdetectionofgenemutationsbasedonisothermalstrand-displacementpolymerasereactionandlateralflowstrip.”BiosensorandBioelectronics2012,31(1),310-315.
8.He,Y.;Zhang,X.;Zeng,K.;Zhang,X.;Baloda,M.;Gurung,A.S.;LiuG.*“VisualdetectionofHg²⁺inqueousolutionusinggoldnanoparticlesandthymine-richhairpinDNAprobes.”BiosensorandBioelectronics2011,26(11),4464-4470.
9.He,Y.;Zhang,S.;Zhang,X.;Baloda,M.;Gurung,A.S.;Xu,H.;Zhang,X.;Liu,G.*“Ultrasensitivenucleicacidbiosensorbasedonenzyme-goldnanoparticleduallabelandlateralflowstripbiosensor.”BiosensorsandBioelectronics2011,26(5),2018-2024.
10.Fang,Z.;Huang,J.;Lie,P.;Xiao,Z.;Ouyang,C.;Wu,Q.;Wu,Y.;Liu,G.*;Zeng,L.“LateralflownucleicacidbiosensorforCu2+detectioninaqueoussolutionwithhighsensitivityandselectivity.”ChemicalCommunications2010,46(47),9043-9045.
11.He,Y.;Zeng,K.;Gurung,A.;Baloda,M.;Xu,H.;Zhang,X.;Liu,G.*“Visualdetectionofsingle-nucleotidepolymorphismwithhairpinoligonucleotide-functionalizedgoldnanoparticles.”AnalyticalChemistry2010,82(17),7169-7177.
12.He,Y.;Zeng,K.;Zhang,X.;Gurung,A.;Baloda,M.;Xu,H.;Liu,G.*“Ultrasensitiveelectrochemicaldetectionofnucleicacidbasedontheisothermalstrand-displacementpolymerasereactionandenzymedualamplification.”ElectrochemistryCommunications,2010,12,985-988.
13.Zhao,L.;He,Y.;Mao,X.;Sun,Y.;Zhang,X.;Li,C.;Liu,G.*“Electrochemicalassayofactiveprostate-specificantigen(PSA)usingferrocene-functionalizedpeptideprobes.”ElectrochemistryCommunications2010,12(3),471-474.
学术兼职
现为Nano-Bio-Analysis杂志编委,美国化学学会、科学发展协会和电分析化学协会会员并应邀担任“FrontierinBioscience”,“AnalyticalChemistry”,“JournalofAmericanChemistrySociety”,“ElectrochemistryCommunication”、“ChemicalCommunications”、“Electroanalysis”、“AnalyticalChimicaActa”、“JournalofNanoscienceandNanotechnology”、“Analyst”等杂志审稿人。