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个人简介

学士(1988-1992):湘潭师范学院(现湖南科技大学)化学系 硕士(1994-1997):南开大学化学学院 博士(1997-2000):中山大学化学与化学工程学院 访问学者 (2000-2003):香港科技大学化学系 博士后(2004-2005):美国Texas A&M大学化学系 讲师(2000-2002):中山大学化学与化学工程学院 副教授(2002-2007):中山大学化学与化学工程学院 教授(2007-2016):中山大学化学与化学工程学院 教授(2016-至今):中山大学化学学院 2002年6月:被遴选为中山大学无机化学专业、化学生物学专业硕士生导师 2006年11月:被遴选为中山大学无机化学专业博士生导师 2008年10月:被批准为中山大学化学生物学专业博士生导师 2005年-至今:生物无机与合成化学教育部重点实验室PI

研究领域

DNA/RNA生物大分子结构识别及其生物功能调控 金属多吡啶配合物为基元的光电分子器件研究 金属抗肿瘤、抗菌药物 生物荧光成像试剂

近期论文

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Xueze Zhao,† Jiangping Liu† (†equal contributors), Jiangli Fan*, Hui Chao,* Xiaojun Peng, “Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application”, Chem. Soc. Rev., 50 (2021) 4185-4219. Leli Zeng, Pranav Gupta, Yanglu Chen, Enju Wang, Liangnian Ji, Hui Chao*, Zhe-Sheng Chen*, "The development of anticancer ruthenium(II) complexes: from single molecule compounds to nanomaterials", Chem. Soc. Rev., 46 (2017) 5771-5804. (Inside front cover) Jinchao Shen, Thomas W Rees, Liangnian Ji, Hui Chao*, “Recent advances in ruthenium(II) and iridium(III) complexes containing nanosystems for cancer treatment and bioimaging”, Coord. Chem. Rev., 443 (2021) 214016. Fangmian Wei†, Thomas W. Rees† (†equal contributors), Xinxing Liao, Liangnian Ji, Hui Chao*, “Oxygen self-sufficient photodynamic therapy”, Coord. Chem. Rev., 432 (2021) 213714. Kangqiang Qiu, Hongyi Zhu, Thomas W. Rees, Liangnian Ji, Qianling Zhang*, Hui Chao*, “Recent advances in lysosome-targeting luminescent transition metal complexes”, Coord. Chem. Rev., 398 (2019) 113010. Kangqiang Qiu, Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Organelle-targeting metal complexes: From molecular design to bio-applications”, Coord. Chem. Rev., 378 (2019) 66-86. Jiangping Liu, Chen Zhang, Thomas W. Rees, Libing Ke, Liangnian Ji, Hui Chao*, “Harnessing ruthenium(II) as photodynamic agents: encouraging advances in cancer therapy”, Coord. Chem. Rev., 363 (2018) 17–28. Yu Chen†, Ruilin Guan† (†equal contributors), Chen Zhang, Juanjuan Huang, Liangnian Ji, Hui Chao∗, “Two-photon luminescent metal complexes for bioimaging and cancer phototherapy”, Coord. Chem. Rev., 310 (2016) 16-40. Yu Chen, Thomas W. Rees, Liangnian Ji, Hui Chao*, “Mitochondrial dynamics tracking with iridium(III) complexes”, Curr. Opin. Chem. Biol., 43 (2018) 51-57. Huaiyi Huang†, Samya Banerjee† (†equal contributors), Kangqiang Qiu, Pingyu Zhang, Olivier Blacque, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Michael Staniforth, Vasilios G. Stavros, Gilles Gasser*, Hui Chao*, Peter J. Sadler*, “Targeted photoredox catalysis in cancer cells”, Nat. Chem., 11 (2019) 1041-1048. Johannes Karges, Shi Kuang, Federica Maschietto, Olivier Blacque, Ilaria Ciofini, Hui Chao*, Gilles Gasser*, “Rationally Designed Ruthenium Complexes for 1- and 2-Photon Photodynamic Therapy”, Nat. Commun., 11 (2020) 3262. Zhixuan Zhou†, Jiangping Liu† (†equal contributors), Juanjuan Huang, Thomas W. Rees, Heng Wang, Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A self-assembled Ru-Pt metallacage as a lysosome-targeting photosensitizer for two-photon photodynamic therapy”, Proc. Natl, Acad. Sci. USA, 116 (2019) 20296-20302. Zhixuan Zhou†, Jiangping Liu† (†equal contributors), Thomas W. Rees, Heng Wang, Xiaopeng Li, Hui Chao*, Peter J. Stang*, “A Heterometallic Ru-Pt Metallacycle for Two-Photon Photodynamic Therapy”, Proc. Natl, Acad. Sci. USA, 115 (2018) 5664-5669. Chengzhi Jin, Guanying Li, Xia Wu, Jiangpin Liu, Weijun Wu, Toshio Sasaki, Hui Chao*, Ye Zhang*, “Robust Packing of a Self-Assembling Iridium Complex via Endocytic Trafficking for Long-Term Lysosome Tracking”, Angew. Chem. Int. Ed., 60 (2021) 7597-7601. Lili Wang, Ruilin Guan, Lina Xie, Xinxing Liao, Kai Xiong, Thomas W. Rees, Yu Chen, Liangnian Ji, Hui Chao*, “An ER-Targeting Iridium(III) Complex which Induces Immunogenic Cell Death in Non-Small Cell Lung Cancer”, Angew. Chem. Int. Ed., 60 (2021) 4657-4665. (VIP Article) Cheng Ouyang, Yongguang Li, Thomas W. Rees, Xinxing Liao, Jianhua Jia, Yu Chen*, Xiting Zhang*, Liangnian Ji, Hui Chao*, “Supramolecular Assembly of An Organoplatinum(II) Complex with Ratiometric Dual Emission for Two-Photon Bioimaging”, Angew. Chem. Int. Ed., 60 (2021) 4150-4157. Shi Kuang†, Lingli Sun† (†equal contributors), Xianrui Zhang, XinXing Liao, Thomas W. Rees, Leli Zeng, Yu Chen*, Xiting Zhang*, Liangnian Ji, Hui Chao*, “A Mitochondrion-Localized Two-Photon Photosensitizer Generating Carbon Radicals against Hypoxic Tumors”, Angew. Chem. Int. Ed., 59 (2020) 20697-20703. Kai Xiong, Chen Qian, Yixian Yuan, Lin Wei, Xinxing Liao, Liting He, Thomas W. Rees, Yu Chen*, Jian Wan*, Liangnian Ji, Hui Chao*, “Necroptosis Induced by Ruthenium(II) Complexes as Dual Catalytic Inhibitors of Topoisomerase I/II”, Angew. Chem. Int. Ed., 59 (2020) 16631-16637. (Hot Paper) Chengzhi Jin†, Fengyin Liang† (†equal contributors), Jinquan Wang, Lili Wang, Jiangping Liu, Xinxing Liao, Thomas W. Rees, Bo Yuan, Hui Wang, Yong Shen*, Zhong Pei*, Liangnian Ji, Hui Chao*, “Rational Design of Cyclometalated Iridium(III) Complexes for Three-Photon Phosphorescence Bioimaging”, Angew. Chem. Int. Ed., 59 (2020) 15987-15991. (Hot Paper) Shi Kuang, Xinxing Liao, Xianrui Zhang, Thomas W. Rees, Ruilin Guan, Kai Xiong, Yu Chen*, Liangnian Ji, Hui Chao*, “FerriIridium: A Lysosome-Targeting Iridium(III) Prodrug for Iron(III)-Activated Chemotherapy in Gastric Cancer Cells”, Angew. Chem. Int. Ed., 59 (2020) 3315-3321. (VIP Article)

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