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个人简介

教育经历 1987.10-1991.01 英国牛津大学,无机化学系,博士 1985.09-1987.09 武汉大学,化学系,研究生 1980.09-1985.07 中国科学技术大学,应用化学系,本科 工作经历 2018.10-现在 中国计量大学,研究员 2004.07-2018.09 中国科学院生态环境研究中心,研究员 1991.01-1995.06 美国Rochester大学,化学系,博士后 国家杰出青年基金获得者,国家重大科学研究计划首席科学家,中国科学院“百人计划”入选者,英国皇家化学会Fellow。主要从事环境毒理学和环境分析化学的研究。在环境毒理学方向,研究多溴联苯醚、全氟有机物、大气颗粒物、环境纳米材料等新型和典型区域污染物与激素受体、代谢酶、转运蛋白等具有重要功能的生物大分子之间的相互作用,这些作用对细胞和活体正常生理功能的干扰,以及作用产生的毒性效应和健康危害。在环境分析化学方向,主要研究快速、高灵敏度、高通量的生物检测方法,实现对持久性有机污染物的定量检测;研究基于机制的毒性传感技术,实现对致癌物、内分泌干扰物等有毒化合物的快速毒性筛查。作为通讯作者在Environmental Health Perspectives, Achieves of Toxicology, Nanotoxicology, Environmental Science & Technology, Nano Letters, ACS Catalysis, Analytical Chemistry等国际知名期刊上发表SCI论文100余篇,共同主编专著《环境纳米科学与技术》,撰写中英文专业书籍章节10个。指导研究生39名。任《环境化学》主编,英国皇家化学会期刊Environmental Science: Processes and Impacts副主编,《分析化学》编委,《生态毒理学》编委,大气环境化学与健康联合实验室主任,中国毒理学会分析毒理专业委员会常务委员,中国化学会环境化学专业委员会委员,中国化学会分析质谱专业委员会委员,中国环境科学学会环境医学与健康分会委员,中国仪器仪表学会分析仪器分会电化学分析专业委员会委员。荣获中国科学院杰出科技成就奖、中国分析测试协会科学技术奖二等奖、国家百千万人才工程“有突出贡献中青年专家”称号。享受国务院政府特殊津贴。

研究领域

环境毒理学环境分析化学化学物质对细胞和模式动物功能的影响及其生物学机制生物传感检测方法、技术与器件研究

近期论文

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1.Xuejing Cui, Bin Wan,* Yu Yang, Yan Xin, Yi-Chun Xie, Liang-Hong Guo*, and Lin L. Mantell, "Carbon Nanomaterials Stimulate HMGB1 Release From Macrophages and Induce Cell Migration and Invasion" Toxicological Sciences, 2019, 172(2), 398–410. 2.Oluniyi O. Fadare, Bin Wan,* Liang-Hong Guo,* Yan Xin, Weiping Qin, Yu Yang, "Humic acid alleviates the toxicity of polystyrene nanoplastic particles to Daphnia magna" Environ. Sci.: Nano, 2019, 6, 1466-1477. 3.Lin-ying Cao, Xiao-min Ren, Liang-Hong Guo*, "Estrogen-related receptor g is a novel target for Lower-Chlorinated Polychlorinated Biphenyls and their hydroxylated and sulfated metabolites" Environmental Pollution, 2019, 254, 113088. 4.Yan Xin, Xiao-min Ren, Bin Wan, Liang-Hong Guo* "Comparative in Vitro and in Vivo Evaluation of the Estrogenic Effect of Hexafluoropropylene Oxide Homologues" Environmental Science & Technology, 2019, 53, 8371-8380. 5.Chuanhai Li, Xiao-min Ren, Liang-Hong Guo* "Adipogenic Activity of Oligomeric Hexafluoropropylene Oxide (Perfluorooctanoic Acid Alternative) through Peroxisome Proliferator-Activated Receptor γ Pathway" Environmental Science & Technology, 2019, 53, 3287-3295. 6.Xiao-min Ren, Chuanhai Li, Jian-Qing Zhang, Liang-Hong Guo* "Binding and activity of sulfated metabolites of lower-chlorinated polychlorinated biphenyls towards thyroid hormone receptor alpha" Ecotoxicology and Environmental Safety, 2019, 180, 686–692. 7. Wei-Ping Qin, Chuan-Hai Li, Liang-Hong Guo,* Xiao-Min Ren,* Jian-Qing Zhang "Binding and activity of polybrominated diphenyl ether sulfates to thyroid hormone transport proteins and nuclear receptors" Environ. Sci.: Processes Impacts, 2019, 21, 950–956. 8.Fengjie Chen, Wanchao Yu, Yu Qie, Lixia Zhao*, Hui Zhang, Liang-Hong Guo "Enhanced photocatalytic removal of hexavalent chromium through localized electrons in polydopamine-modified TiO2 under visible irradiation" Chemical Engineering Journal, 2019, 373, 58–67. 9. Hai-Yan Ma, Lixia Zhao*, Liang-Hong Guo, Hui Zhang, Feng-Jie Chen, Wan-Chao Yu "Roles of reactive oxygen species (ROS) in the photocatalytic degradation of pentachlorophenol and its main toxic intermediates by TiO2/UV" Journal of Hazardous Materials, 2019, 369, 719–726. 10.Wanchao Yu, Lixia Zhao,* Fengjie Chen, Hui Zhang, Liang-Hong Guo "Surface Bridge Hydroxyl-Mediated Promotion of Reactive Oxygen Species in Different Particle Size TiO2 Suspensions" J. Phys. Chem. Lett. 2019, 10, 3024-3028. 11. Dabin Wang, Lixia Zhao,* Dean Song, Jun Qiu, Fanyu Kong*, Liang-Hong Guo "A formation model of superoxide radicals photogenerated in nano-TiO2 suspensions" RSC Adv., 2019, 9, 29429–29432. 12.Hui Zhang, Weimin Wang, Huanxin Zhao, Lixia Zhao, Li-Yong Gan, Liang-Hong Guo* "Facet-Dependent Interfacial Charge Transfer in Fe(III)-Grafted TiO2 Nanostructures Activated by Visible Light" ACS Catalysis, 2018, 8, 9399-9407. 13. Yan Xin, Bin Wan*, Yu Yang, Xue?Jing Cui, Yi?Chun Xie, Liang-Hong Guo* "Perfluoroalkyl acid exposure induces protective mitochondrial and endoplasmic reticulum autophagy in lung cells" Archives of Toxicology, 2018, 92, 3131-3147. 14.Yan Xin, Xiao-Min Ren, Ting Ruan, Chuan-Hai Li, Liang-Hong Guo*, Guibin Jiang "Chlorinated Polyfluoroalkylether Sulfonates Exhibit Similar Binding Potency and Activity to Thyroid Hormone Transport Proteins and Nuclear Receptors as Perfluorooctane sulfonate" Environ. Sci. Technol. 2018, 52, 52, 9412-9418. 15. Dabin Wang, Lixia Zhao*, Dan Wang, Li Yan, Chuanyong Jing, Hui Zhang, Liang-Hong Guo*, Ning Tang "Direct evidence for surface long-lived superoxide radicals photo-generated in TiO2 and other metal oxide suspensions" Phys. Chem. Chem. Phys., 2018, 20, 18978-18985. 16. Lin-Ying Cao, Xiao-Min Ren*, Yu Yang, Bin Wan, Liang-Hong Guo*, De Chen, Yong Fan "Hydroxylated Polybrominated Diphenyl Ethers Exert Estrogenic Effects via Non-Genomic G Protein–Coupled Estrogen Receptor Mediated Pathways" Environmental Health Perspectives, 2018, 126, doi: 10.1289/EHP2387. 17.G. Qin, J. Xia, Y. Zhang, L. Guo, R. Chen, N. Sang* "Ambient fine particulate matter exposure induces reversible cardiac dysfunction and fibrosis in juvenile and older female mice" Particle and Fibre Toxicology, 2018, 15-27. 18. Yin-Feng Zhang, Xiao-Min Ren, Yuan-Yuan Li, Xiao-Fang Yao, Chuan-Hai Li, Zhan-Fen Qin*, Liang-Hong Guo "Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo" Environmental Pollution, 2018, 237, 1072-1079. 19. Chuan-Hai Li, Xiao-Min Ren,* Ting Ruan, Lin-Ying Cao, Yan Xin, Liang-Hong Guo,* Guibin Jiang "Chlorinated Polyfluorinated Ether Sulfonates Exhibit Higher Activity toward Peroxisome Proliferator-Activated Receptors Signaling Pathways than Perfluorooctanesulfonate" Environ. Sci. Technol. 2018, 52, 3232-3239 20.Hai-Yan Ma, Lixia Zhao,* Da-Bin Wang, Hui Zhang, Liang-Hong Guo* "Dynamic Tracking of Highly Toxic Intermediates in Photocatalytic Degradation of Pentachlorophenol by Continuous Flow Chemiluminescence" Environ. Sci. Technol. 2018, 52, 2870-2877 21.Lin-Ying Cao, Xiao-Min Ren,* Chuan-Hai Li, Liang-Hong Guo* "Organophosphate Esters Bind to and Inhibit Estrogen-Related Receptor γ in Cells" Environ. Sci. Technol. Lett. 2018, 5, 68-73 22.Yuxin Gu, Yu Yang,* Bin Wana, Minjie Li, Liang-Hong Guo* "Inhibition of O-linked N-acetylglucosamine transferase activity in PC12 cells–A molecular mechanism of organophosphate flame retardants developmental neurotoxicity" Biochem. Pharmacol., 2018, 152, 21–33 23.王丹,赵利霞*,张辉,郭良宏 "二氧化钛光催化产生超氧自由基的形态分布研究" 《分析化学》, 2017, 45, 1882-1887 24.Tianyi Dong, Yanping Peng, Ning Zhong, Fengyan Liu, Hanyu Zhang, Mengchen Xu, Rutao Liu, Mingyong Han, Xingsong Tian, Jihui Jia, Lap Kam Chang, Liang-Hong Guo,* Shili Liu* "Perfluorodecanoic acid (PFDA) promotes gastric cell proliferation via sPLA2-IIA" Oncotarget, 2017, 8, 50911-50920 25.Dan Wang, Lixia Zhao,* Haiyan Ma, Hui Zhang, Liang-Hong Guo* "Quantitative Analysis of Reactive Oxygen Species Photogenerated on Metal Oxide Nanoparticles and Their Bacteria Toxicity: The Role of Superoxide Radicals" Environ. Sci. Technol. 2017, 51, 10137-10145 26.Lin-Ying Cao, Xiao-Min Ren,* Chuan-Hai Li, Jing Zhang, Wei-Ping Qin, Yu Yang, Bin Wan, Liang-Hong Guo* "Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway" Environ. Sci. Technol. 2017, 51, 11423-11430. 27.Rui Feng, Gang Liang, Liang-Hong Guo*, Yi-Ping Wu "A chemical toxicity sensor based on the electrochemiluminescence quantification of apurinic/apyrimidinic sites in double-stranded DNA monolayer" Sensors and Actuators B, 2017, 248, 512–518. 28.Yu Yang*, Yuxin Gu, Bin Wan, Xiaomin Ren, Liang-Hong Guo* "Label-free electrochemical biosensing of small-molecule inhibition on OGlcNAc glycosylation" Biosensors and Bioelectronics, 2017, 95, 94–99. 29.Xuejing Cui, Bin Wan*, Yu Yang, Xiaomin Ren, Liang-Hong Guo* "Length effects on the dynamic process of cellular uptake and exocytosis of single-walled carbon nanotubes in murine macrophage cells" Scientific Reports, 2017, 7, 1518 (DOI:10.1038/s41598-017-01746-9) 30.Yu Yang, Qi-Yan Lv, Liang-Hong Guo*, Bin Wan, Xiao-Min Ren, Ya-Li Shi, Ya-Qi Cai "Identification of protein tyrosine phosphatase SHP-2 as a new target of perfluoroalkyl acids in HepG2 cells" Arch. Toxicol., 2017, 91, 1697–1707.

学术兼职

任《环境化学》主编,英国皇家化学会期刊EnvironmentalScience:ProcessesandImpacts副主编,《分析化学》编委,《生态毒理学》编委,大气环境化学与健康联合实验室主任,中国毒理学会分析毒理专业委员会常务委员,中国化学会环境化学专业委员会委员,中国化学会分析质谱专业委员会委员,中国环境科学学会环境医学与健康分会委员,中国仪器仪表学会分析仪器分会电化学分析专业委员会委员。

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