Skrynnikov, Nikolai R. - Purdue University

个人简介

B.Sc., 1989, M.Sc., 1991 Leningrad State University; Ph.D. 1996 McGill University; postdoctoral fellow, 1997-98, Swiss Federal Institute of Technology; postdoctoral fellow, 1999-2002, University of Toronto.

近期论文

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Y. Xue, T. Yuwen, F. Zhu, N. R. Skrynnikov, Role of Electrostatic Interactions in Binding of Peptides and Intrinsically Disordered Proteins to Their Folded Targets. 1. NMR and MD Characterization of the Complex between the c- Crk N -SH3 Domain and the Peptide Sos. Biochemistry 2014, 53, 6473-6495. T. Yuwen, N. R. Skrynnikov, CP-HISQC: a better version of HSQC experiment for intrinsically disordered proteins under physiological conditions. J. Biomol. NMR 2014, 58, 175-192. Y. Xue, N. R. Skrynnikov, Ensemble MD simulations restrained via crystallographic data: accurate structure leads to accurate dynamics. Prot. Sci. 2014, 23, 488-507. T. Yuwen, N. R. Skrynnikov, Proton-decoupled CPMG: A better experiment for measuring 15N R2 relaxation in disordered proteins. J. Magn. Reson. 2014, 241, 155-169. J. M. Ward, N. R. Skrynnikov, Very large residual dipolar couplings from deuterated ubiquitin. J. Biomol. NMR 2012, 54, 53-67. Y. Xue, J. M. Ward, T. Yuwen, I. S. Podkorytov, N. R. Skrynnikov, Microsecond time-scale conformational exchange in proteins: using long Molecular Dynamics trajectory to simulate NMR relaxation dispersion data. J. Am. Chem. Soc. 2012, 134, 2555-2562. Y. Xue, N. R. Skrynnikov, Motion of a disordered polypeptide chain as studied by paramagnetic relaxation enhancements, 15N relaxation, and Molecular Dynamics simulations: How fast is segmental diffusion in denatured ubiquitin? J. Am. Chem. Soc. 2011, 133, 14614-14628. Supplemental: movie I movie II movie III T. Yuwen, C. B. Post, N. R. Skrynnikov, Domain cooperativity in multidomain proteins: what can we learn from molecular alignment in anisotropic media? J. Biomol. NMR 2011, 51, 131-150. V. Chevelkov, Y. Xue, R. Linser, N. R. Skrynnikov, B. Reif, Comparison of solid-state dipolar couplings and solution relaxation data provides insight into protein backbone dynamics. J. Am. Chem. Soc. 2010, 132, 5015-5017. V. Chevelkov, Y. Xue, D. Krishna Rao, J. D. Forman-Kay, N. R. Skrynnikov, 15NH/D-SOLEXSY experiment for accurate measurement of amide solvent exchange rates: application to denatured drkN SH3. J. Biomol. NMR 2010, 46, 227-244. J. Xu, Y. Xue, N. R. Skrynnikov, Detection of nanosecond time scale side-chain jumps in a protein dissoloved in water/glycerol solvent. J. Biomol. NMR 2009, 45, 57-72. Y. Xue, I. S. Podkorytov, D. Krishna Rao, N. Benjamin, H. Sun, N. R. Skrynnikov, Paramagnetic relaxation enhancements in unfolded proteins: theory and application to drkN SH3 domain. Prot. Sci. 2009, 18, 1401-1424. Supplemental: movie I movie II V. Agarwal, Y. Xue, B. Reif, N. R. Skrynnikov, Protein side-chain dynamics as observed by solution- and solid-state NMR spectroscopy: a similarity revealed. J. Am. Chem. Soc. 2008, 130, 16611-16621. N. R. Skrynnikov, Asymmetric doublets in MAS NMR: coherent and incoherent mechanisms. Magn. Reson. Chem., 2007, 45, S161-S173. V. Chevelkov; A. Zhuravleva; Y. Xue; B. Reif; N. R. Skrynnikov, Combined analysis of 15N relaxation data from solid- and solution-state NMR. J. Am. Chem. Soc., 2007, 129, 12594-12595 Y. E. Ryabov; C. White; Y. Xue; N. R. Skrynnikov, Introducing color into stacking gels makes sample loading easy. Anal. Biochemistry 2007, 366, 111-112. Y. Xue; M. S. Pavlova; Y. E. Ryabov; B. Reif; N. R. Skrynnikov, Methyl rotation barriers in proteins from 2H relaxation data. Implications for protein structure. J. Am. Chem. Soc. 2007, 129, 6827-6838. I. S. Podkorytov; N. R. Skrynnikov, Transient NOE-exchange-relay experiment. Application to ligand-protein binding under slow exchange conditions. J. Magn. Reson. 2007, 187, 44-51. C. Eichmüller; N. R. Skrynnikov, Observation of ms time-scale protein dynamics in the presence of Ln3+ ions: application to the N-terminal domain of cardiac troponin C. J. Biomol. NMR 2007, 37, 79-95. V. Agarwal; A. Diehl; N. R. Skrynnikov; B. Reif, High resolution proton detected proton-carbon correlation spectra of a protein in MAS solid state NMR spectroscopy. J. Am. Chem. Soc. 2006, 128, 12620-12621.