张振伟 - 广西中医药大学

个人简介

张振伟，男，博士，副教授，硕士研究生导师，广西中医药大学硕士学位授权点学科药物化学二级学科秘书，广西中医药大学第一批“岐黄工程”高层次人才团队培育项目成员，广西高校高水平创新团队成员。2011年6月中山大学药学院药物化学专业博士研究生毕业，2017年7月起在广西中医药大学药学院药物化学教研室从事本科生及硕士研究生的《药物化学》、《药学专业英语》、《制药工程导论》和《药物化学专论》等课程的教学工作。现主持广西自然科学基金2项、广西科技基地和人才专项1项；参与国家自然科学基金2项、广西科技重大专项1项、广西自然科学基金2项、广西科技基地和人才专项1项。　

研究领域

药物分子的设计合成与活性评价研究；新型有机小分子催化剂的设计合成与应用研究；中药化学成分及其结构修饰、活性评价研究

近期论文

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Ning Lin*, Qiu-Xiang Wei, Li-Hua Jiang, Yan-Qiu Deng, Zhen-Wei Zhang*, Qing Chen. Asymmetric Michael addition of malononitrile with chalcones via rosin-derived bifunctional squaramide. Catalysts, 2020, 10, 14; doi:10.3390/catal10010014.　 Wen-Run Zhu (#), Zhen-Wei Zhang (#), Wei-Hua Huang, Ning Lin*, Qing Chen*, Kai-Bin Chen, Bi-Chuan Wang, Jiang Weng, Gui Lu*. Asymmetric synthesis of vicinally bis(trifluoromethyl)-substituted 3,3’-pyrrolidinyl spirooxindoles via organocatalytic 1,3-dipolar cycloaddition reactions. Synthesis, 2019, 51, 1969-1979.　 Wang Xia, Zhen-Wei Zhang, Yongsu Li, Xiaoding Jiang, Hao Liang, Yaqi Zhang, Rihui Cao, Liqin Qiu*. Enantioselective synthesis of chiral heterocyclic biaryls via asymmetric Suzuki-Miyaura cross-coupling of 3-bromopyridine derivatives. Org. Biomol. Chem., 2019, 9, 2351-2355.　　 Wen-Run Zhu, Qing Chen, Ning Lin*, Kai-Bin Chen, Zhen-Wei Zhang, Gang Fang, Jiang Weng, Gui Lu*. Organocatalytic Michael/cyclization cascade reactions of 3-isothiocyanato oxindoles with 3-trifluoroethylidene oxindoles: approach for the synthesis of 3′-trifluoromethyl substituted 3,2′-pyrrolidinyl-bispirooxindoles. Org. Chem. Front., 2018, 5, 1375-1380. 　　 Hui-Xuan Chen, Yaqi Zhang, Yuyang Zhang, Xuefeng He, Zhen-Wei Zhang, Hao Liang, Wenhuan He, Xiaoding Jiang, Xiangmeng Chen, Liqin Qiu*. Synthesis of six-membered spirooxindoles via a chiral Brønsted acid-catalyzed asymmetric intramolecular Friedel–Crafts reaction. RSC Adv., 2018, 8, 37035-37039.　 Lichun Zhao, Xue Wang, Junxiu Li, Xiaoming Tan, Lanlan Fan, Zhenwei Zhang, Jing Leng*. Effect of cyclocarya paliurus on hypoglycemic effect in Type 2 diabetic mice. Med. Sci. Monit., 2019, 25, 2976-2983.　 Xin Zhao (#*), Zhen-Wei Zhang (#), Wei Cui, Shengwei Chen, Yang Zhou, Jianghong Dong, Yanling Jie, Junting Wan, Yong Xu*, Wenhui Hu*. Identification of camphor derivatives as novel M2 ion channel inhibitors of influenza A virus. Med. Chem. Comm., 2015, 6, 727-731. (现已更名为：RSC Medicinal Chemistry)　 Ning Lin, Yan-Qiu Deng, Zhen-Wei Zhang, Qian Wang, Gui Lu*. Asymmetric synthesis of chiral β-hydroxy-α-amino acid derivatives by organocatalytic Aldol reaction of isocyanoesters with β,γ-unsaturated α-ketoesters. Tetrahedron: Asymmetry, 2014, 25, 650-657.　　 Yan-Qiu Deng, Zhen-Wei Zhang, Ya-Hui Feng, Albert S. C. Chan, Gui Lu*. Enantioselective Michael reaction of nitroalkanes onto nitroalkenes catalyzed by cinchona alkaloid derivatives. Tetrahedron: Asymmetry, 2012, 23, 1647-1652.　 Zhen-Wei Zhang, Gui Lu*, Miao-Miao Chen, Ning Lin, Yong-Bo Li, Tamio Hayashi, Albert S. C. Chan*. Organocatalytic asymmetric mannich-type reaction of N-Sulfonylimines with isocyanoesters leading to optically active 2-imidazolines. Tetrahedron: Asymmetry, 2010, 21, 1715-1721.　