Shokat, Kevan - University of California, San Francisco - Department of Chemistry and Chemical Biology

个人简介

Education 1986 B.A. Chemistry - Reed College, Portland, OR 1991 Ph.D. Chemistry - University of California, Berkeley, CA Professional Experience: 2010 - Chair, Department of Cellular and Molecular Pharmacology, UCSF 2005 - Investigator, Howard Hughes Medical Institute 2004 - Vice-Chair, Department of Cellular and Molecular Pharmacology, UCSF 2001 - Professor of Cellular and Molecular Pharmacology, UCSF 2001 - Professor of Chemistry, UC Berkeley 1999 - Associate Professor of Cellular and Molecular Pharmacology, UCSF 1999 - Associate Professor of Chemistry, University of California, Berkeley 1998-99 - Associate Professor of Chemistry and Molecular Biology, Princeton University 1994-98 - Assistant Professor of Chemistry and Molecular Biology, Princeton University 1992-94 - Advisor: Prof. Christopher C. Goodnow, Stanford University Investigation of mechanisms of immune self-tolerance in transgenic mice. 1986-91 - Advisor: Prof. Peter G. Schultz, UC Berkeley Design and synthesis of haptens for the generation of catalytic antibodies. Thesis Title: New Routes to Catalytic Antibodies. Awards 2010 - Elected, National Academy of Sciences 2010 - Society for Biomolecular Sciences Accomplishment Award 2006 - UCSF 2nd Annual PSA-sponsored Outstanding Mentor Award 2003 - Thomas Edison Patent Award 2002 - Eli Lilly Award in Biological Chemistry 2001 - Protein Society Young Investigator 1999-2001 - Alfred P. Sloan Research Fellow 1997-98 - Glaxo-Wellcome Scholar in Organic Chemistry 1997-00 - Cottrell Scholar 1997-00 - Searle Scholar 1996-00 - Pew Scholar in the Biomedical Sciences 1995-97 - NSF Early Career Development Award 1992-94 - Life Sciences Research Foundation Post-Doctoral Fellow 1989-90 - UC Berkeley University Fellowship 1986-87 - UC Berkeley Regents Fellowship 1986 - Phi Beta Kappa - Reed College

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Davies JM, Robinson AE, Cowdrey C, Mummaneni PV, Ducker GS, Shokat KM, Bollen A, Hann B, Phillips JJ. (2014) Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. J Neurosurg. Feb;120(2):331-6. doi: 10.3171/2013.10.JNS13598. Epub 2013 Nov 29. PMID: 24286145 Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A. (2014) Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling., Nat Immunol. Feb;15(2):186-94. doi: 10.1038/ni.2772. Epub 2013 Dec 8. PMID: 24317039 Kliegman JI, Fiedler D, Ryan CJ, Xu YF, Su XY, Thomas D, Caccese MC, Cheng A, Shales M, Rabinowitz JD, Krogan NJ, Shokat KM. (2013) Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae. Cell Rep. Dec 26;5(6):1725-36. doi: 10.1016/j.celrep.2013.11.040. Epub 2013 Dec 19. PMID: 24360963 Lopez MS, Choy JW, Peters U, Sos ML, Morgan DO, Shokat KM. (2013) Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. J Am Chem Soc. Dec 4;135(48):18153-9. doi: 10.1021/ja408704u. Epub 2013 Nov 20. PMID: 24171479 Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. (2013) K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. Nov 28;503(7477):548-51. doi: 10.1038/nature12796. Epub 2013 Nov 20. PMID: 24256730 Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA. (2013) EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. Oct 14;24(4):438-49. doi:10.1016/j.ccr.2013.09.004. PMID: 24135280 Hertz NT, Berthet A, Sos ML, Thorn KS, Burlingame AL, Nakamura K, Shokat KM. (2013) A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell. Aug 15;154(4):737-47. doi: 10.1016/j.cell.2013.07.030. PMID: 23953109 Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM. (2013) Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. ACS Chem Biol. Sep 20;8(9):1931-8. doi: 10.1021/cb400376p. Epub 2013 Jul 23. PMID: 23841803 Pourdehnad M, Truitt ML, Siddiqi IN, Ducker GS, Shokat KM, Ruggero D. (2013) Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A. Jul 16;110(29):11988-93. doi: 10.1073/pnas.1310230110. Epub 2013 Jun 26. Erratum in: Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):1760. PMID: 23803853 Atreya CE, Sangale Z, Xu N, Matli MR, Tikishvili E, Welbourn W, Stone S, Shokat KM, Warren RS. (2013) PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival. Cancer Med. Aug;2(4):496-506. doi: 10.1002/cam4.97. Epub 2013 Jun 10. PMID: 24156022 Schachter MM, Merrick KA, Larochelle S, Hirschi A, Zhang C, Shokat KM, Rubin SM, Fisher RP. (2013) A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression. Mol Cell. Apr 25;50(2):250-60. doi: 10.1016/j.molcel.2013.04.003. PMID: 23622515 Lourido S, Zhang C, Lopez MS, Tang K, Barks J, Wang Q, Wildman SA, Shokat KM, Sibley LD. (2013) Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. J Med Chem. Apr 11;56(7):3068-77. doi: 10.1021/jm4001314. Epub 2013 Mar 26. PMID: 23470217 Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptáček LJ, Fu YH. (2013) Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab. Feb 5;17(2):291-302. doi: 10.1016/j.cmet.2012.12.017. PMID: 23395175 Statsuk AV, Shokat KM. (2012) Covalent cross-linking of kinases with their corresponding peptide substrates. Methods Mol Biol. 795:179-90. Atreya CE, Ducker GS, Feldman ME, Bergsland EK, Warren RS, Shokat KM. (2012) Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer. Invest New Drugs. Dec;30(6):2219-25. doi: 10.1007/s10637-012-9793-y. Epub 2012 Jan 24. PMID: 22270257 Soskis MJ, Ho HY, Bloodgood BL, Robichaux MA, Malik AN, Ataman B, Rubin AA, Zieg J, Zhang C, Shokat KM, Sharma N, Cowan CW, Greenberg ME. (2012) A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nat Neurosci. Dec 15(12):1645-54. doi: 10.1038/nn.3249. Epub Nov 11. PMID: 23143520 Larochelle S, Amat R, Glover-Cutter K, Sansó M, Zhang C, Allen JJ, Shokat KM, Bentley DL, Fisher RP. (2012) Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II. Nat Struct Mol Biol. Nov 19(11):1108-15. doi: 10.1038/nsmb.2399. Epub 2012 Oct 14. PMID: 23064645