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个人简介

主要成果与荣誉: 浙江省高校优秀共产党员(2016); 浙江省万人好党员(2016); 科技部中青年科技创新领军人才(2015); 台州市500精英人才(2015); 浙江省“新世纪”151第一层次人才; 2008年获得国家科技发明二等奖1项(3/5); 2007年获得浙江省科学技术一等奖1项(3/11)、中国石化协会技术发明一等奖1项 (3/5); 2006年获得浙江省高校成果一等奖1项(1/5)、二等奖1项(3/5); 2004年被评为浙江工业大学首批青年学术骨干; 授权专利有: 1.顺丁烯二酸酯化合物在制备油菜菌核病菌抑菌剂中的应用, ZL201010122276.9,1/5 2.顺丁烯二酸酯类化合物对油菜菌核病菌的抑制,ZL201010122683.X, 1/5 3.顺丁烯二酸酐类化合物在抗灰霉病方面的应用,ZL201010122309.X, 1/5 4.一种提高变构霉素发酵产量的制备方法,ZL201010199312.1,1/5 5.一种变构酸的制备方法,ZL201010178819.8,1/5 6.一种顺丁烯二酰亚胺类化合物及其制备与应用,ZL201110249201.1, 1/5 7.N-(3,5-二氯苯基)-3,4-二氯-顺丁烯二酰亚胺在抗真菌感染中的应 用,ZL201310462766.7,1/5 8.G6PDH基因在提高黑根霉对甾体C11α-羟基化能力中的应用及菌株, ZL201310505530.7,1/5 9.一种3,4-二氯顺丁烯二酰亚胺化合物及其制备与应用, ZL201310047509.7,2/5 主持的项目有: 1.国家自然科学基金项目“基因组学法研究马来酰亚胺类化合物抗 Sclerotiniasclerotiorum机制及作用靶标酶” 2.浙江省科学厅重大专项(2012C12003-1)“产糖基转移酶基因工程菌株的构建及其在生物 催化法生产井冈霉素A中的应用” 3.国家自然科学基金项目(21172198)"基于变构霉素含顺丁烯二酸酐片段的化合物衍生、优 化及其抗菌核病菌活性研究" 4.浙江省科学厅重大专项(2007C12088)“顺丁烯二酸酐结构先导物生物合成及农药活性化 合物创制” 5.浙江自然科学基金项目(编号M303049)“腺苷蛋氨酸合成酶的基因克隆及其酶学特性研究” 主持企业横向项目20余项。

研究领域

主要研究方向:抗生素的结构修饰、生物催化与生物转化、生物分离工程

近期论文

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主要代表性论文论著: 1.LuYuele,ChenXiaolong*.StereoselectiveBehavioroftheChiralHerbicidesDiclofop-Methyl andDiclofopDuringtheSoySauceBrewingProcess.Chirality,2016,28:78-84; 2.LuYuele,ChenXiaolong*.StereoselectiveBehaviorofFungicideBenalaxylduringGrapeGrowthandWine-makingProcess.Chirality,2016,28:394-398. 3.Xiao-LongChen*,Li-JunZhang,Fu-GeLi,Yong-XianFan,Wei-PingWang,Bao-JuLiandYin-ChuShen.Synthesisandantifungalevaluation ofaseriesofmaleimides.PestManagementScience,2015,71:433 440. 4.ChenXiaolong*;LuoXinrong;CaoFeifei;ZhuTingheng.Molecularcloning,expressionofCPRgenefromRhizopusoryzaeintoRhizopusnigericansanditsapplicationinthe11alphahydroxylationof16alpha,17-epoxy-progesteroneEnzymeandMicrobialTechnology,2014,66:28-34. 5.ZhenzhongShen,YongxianFan,FugeLi,XiaolongChen*,YinchuShen.SynthesisofaseriesofN-substituteddimethylmaleimidesandtheirantifungalactivitiesagainstSclerotiniasclerotiorum.JournalofPestScience,2013,86,363-360. 6.YongxianFan,YangYu,XiaoqingJia,XiaolongChen*,YinchuShen.Cloning,expressionandmediumoptimizationofvalidamycinglycosyltransferasefromStreptomyceshygroscopicusvar.jinggangensisforthebiotransformationofvalidoxylamineAtoproducevalidamycinAusingfreerestingcells.BioresourceTechnology,2013,131:13-20. 7.RuiGuo,YongxianFan,XiaolongChen*,YinchuShen.Chiralresolutionofracemicp-methylsulfonylphenylserineethylesterwithlipases:Themechanismofsidereactionanditssuppression.JournalofAgriculturalandFoodChemistry,2013,61:152-166. 8.WeiLi,YongxianFan,ZhenzhongShen,XiaolongChen*,YinchuShen.AntifungalactivityofsimplecompoundswithmaleicanhydrideordimethylmaleimidestructureagainstBotrytiscinerea.JournalofPesticideScience,2012,37:1-5. 9.XiaolongChen,XiaohuiZhu,YichengDing,YinchuShen.Antifungal activityoftautomycinandrelatedcompoundsagainstSclerotiniasclerotiorum.TheJournalofAntibiotics,2011,64:563569. 10.Xiao-LongChen,Yu-HuaXu,Yu-GuoZheng,andYin-ChuShen.2010.ImprovementoftautomycinproductionwithStreptomycesspiroverticillatusbyfeedingglucoseandmaleicanhydride.BiotechnologyandBioprocessEngineering,15:969-974. 11.XiaolongChen,YuguoZheng,YinchuShen.BioassaymethodforthequantitativedeterminationoftautomycininthefermentationbrothwithSclerotiniasclerotiorum.JournalofRapidMethodsandAutomationinMicrobiology,2008,16:199-209. 12.XiaolongChen,YuguoZheng,YinchuShen.NaturalProductswith MaleicAnhydrideStructure:Nonadrides,Tautomycin,ChaetomellicAnhydrideandOtherCompounds.ChemicalReviews2007,107:1777-1830. 13.XiaolongChen,YuguoZheng,YinchuShen.Voglibose(Basen(R)AO128),oneofthemostimportantalpha-glucosidaseinhibitors.CurrentMedicinalChemistry2006,13:109-116. 14.XiaolongChen,YongxianFan,YuguoZhengandYinchu Shen.Propertiesandproductionofvalienamineanditsrelatedanalogues.ChemicalReviews,2003,103:1955-1977. 15.XiaolongChen,YuguoZhengandYinchuShen.Anewmethodforthe productionofvalienaminewithmicrobialdegradationofacarbose.BiotechnologyProgress,2005,21:1002-1003. 16.XiaolongChen,YuguoZhengandYinchuShen.Quantitativeanalysis ofvalienamineinthemicrobialdegradationofvalidamycinAafterderivationwithp-nitrofluorobenzenebyreversed-phasehighperformanceliquidchromatography.JournalofChromatographyB,2005824:341-347. 17.YuguoZheng,XiaolongChenandZhaoWang.Microbialbiomass productionfromricestrawhydrolysateinairlift bioreactors.JournalofBiotechnology,2005,118:413-420. 18.YuguoZheng,XiaolongChen,ZhaoWangandYinchuShen.Production ofvalidamycinsfromcrudesubstratesbyStreptomyceshygroscopicusinanexternal-loopairliftbioreactorwithlowerheight-to-diameterratio.ChineseJournalofChemicalEngineering,2004,12:102-107. 19.YuguoZheng,ZhaoWangandXiaolongChen.Productionof extracellularproteasefromcrudesubstrateswithdregsinanexternal-loopairliftbioreactorwithlowerratioofheight-to diameter.BiotechnologyProgress,2001,17:273-277. 20.YuguoZheng,ZhaoWangandXiaolongChen.α-Amylaseproductionby Bacillussubtiliswithdregsinanexternal-loopairliftbioreactor.BiochemicalEngineeringJournal,2000,5:115-121. 21.YuguoZheng,XiaolongChenandZhaoWang.Productionofsingle cellproteinfromhydrolysateofricehullinexternal-loopairliftbioreactors.EnvironmentalScience,2000,21:85-88. 22.YuguoZheng,ZhaoWangandXiaolongChen.Citricacidproduction fromthemashofdregsbyAspergillusnigerinanexternal-loop airliftbioreactor.ProcessBiochemistry,1999,35:237-242. 23.方夏,李琳,韩君芳,吴芳,毛雪萍,陈小龙.Botrytiscinerea蛋白磷酸酶的分离纯 化及酶学性质.农药,2011,50,795-798.(工大A类) 24.江琴琴,陈小龙,沈寅初.产灰霉病菌物质的微生物筛选和鉴定.农药,2010,49: 257-259.(工大A类) 25.陈小龙,方夏,沈寅初.纹枯病菌对井冈霉素的作用机制、抗药性及安全性.农药, 2010,49:481-483.(工大A类) 26.黄振,陈小龙.抗真菌剂两性霉素B的结构修饰.中国抗生素杂志,2010,35:571-575. (中文核心期刊) 国内外著名杂志上发表论文100多篇。 出版专著有: 陈小龙,陆跃乐,范永仙,沈寅初.Validamycinanditsderivatives- Discovery,chemicalsynthesis,andbiologicalactivity.Elsevier,2017.4.

学术兼职

学校及社会兼职:浙江工业大学发酵工程研究所所长,浙江省重中之重生物工程重点学科发酵工程团队负责人,浙江工业大学天台研究院院长

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