个人简介
主要成果与荣誉:
浙江省高校优秀共产党员(2016);
浙江省万人好党员(2016);
科技部中青年科技创新领军人才(2015);
台州市500精英人才(2015);
浙江省“新世纪”151第一层次人才;
2008年获得国家科技发明二等奖1项(3/5);
2007年获得浙江省科学技术一等奖1项(3/11)、中国石化协会技术发明一等奖1项
(3/5);
2006年获得浙江省高校成果一等奖1项(1/5)、二等奖1项(3/5);
2004年被评为浙江工业大学首批青年学术骨干;
授权专利有:
1.顺丁烯二酸酯化合物在制备油菜菌核病菌抑菌剂中的应用,
ZL201010122276.9,1/5
2.顺丁烯二酸酯类化合物对油菜菌核病菌的抑制,ZL201010122683.X,
1/5
3.顺丁烯二酸酐类化合物在抗灰霉病方面的应用,ZL201010122309.X,
1/5
4.一种提高变构霉素发酵产量的制备方法,ZL201010199312.1,1/5
5.一种变构酸的制备方法,ZL201010178819.8,1/5
6.一种顺丁烯二酰亚胺类化合物及其制备与应用,ZL201110249201.1,
1/5
7.N-(3,5-二氯苯基)-3,4-二氯-顺丁烯二酰亚胺在抗真菌感染中的应
用,ZL201310462766.7,1/5
8.G6PDH基因在提高黑根霉对甾体C11α-羟基化能力中的应用及菌株,
ZL201310505530.7,1/5
9.一种3,4-二氯顺丁烯二酰亚胺化合物及其制备与应用,
ZL201310047509.7,2/5
主持的项目有:
1.国家自然科学基金项目“基因组学法研究马来酰亚胺类化合物抗
Sclerotiniasclerotiorum机制及作用靶标酶”
2.浙江省科学厅重大专项(2012C12003-1)“产糖基转移酶基因工程菌株的构建及其在生物
催化法生产井冈霉素A中的应用”
3.国家自然科学基金项目(21172198)"基于变构霉素含顺丁烯二酸酐片段的化合物衍生、优
化及其抗菌核病菌活性研究"
4.浙江省科学厅重大专项(2007C12088)“顺丁烯二酸酐结构先导物生物合成及农药活性化
合物创制”
5.浙江自然科学基金项目(编号M303049)“腺苷蛋氨酸合成酶的基因克隆及其酶学特性研究”
主持企业横向项目20余项。
研究领域
主要研究方向:抗生素的结构修饰、生物催化与生物转化、生物分离工程
近期论文
查看导师新发文章
(温馨提示:请注意重名现象,建议点开原文通过作者单位确认)
主要代表性论文论著:
1.LuYuele,ChenXiaolong*.StereoselectiveBehavioroftheChiralHerbicidesDiclofop-Methyl
andDiclofopDuringtheSoySauceBrewingProcess.Chirality,2016,28:78-84;
2.LuYuele,ChenXiaolong*.StereoselectiveBehaviorofFungicideBenalaxylduringGrapeGrowthandWine-makingProcess.Chirality,2016,28:394-398.
3.Xiao-LongChen*,Li-JunZhang,Fu-GeLi,Yong-XianFan,Wei-PingWang,Bao-JuLiandYin-ChuShen.Synthesisandantifungalevaluation
ofaseriesofmaleimides.PestManagementScience,2015,71:433
440.
4.ChenXiaolong*;LuoXinrong;CaoFeifei;ZhuTingheng.Molecularcloning,expressionofCPRgenefromRhizopusoryzaeintoRhizopusnigericansanditsapplicationinthe11alphahydroxylationof16alpha,17-epoxy-progesteroneEnzymeandMicrobialTechnology,2014,66:28-34.
5.ZhenzhongShen,YongxianFan,FugeLi,XiaolongChen*,YinchuShen.SynthesisofaseriesofN-substituteddimethylmaleimidesandtheirantifungalactivitiesagainstSclerotiniasclerotiorum.JournalofPestScience,2013,86,363-360.
6.YongxianFan,YangYu,XiaoqingJia,XiaolongChen*,YinchuShen.Cloning,expressionandmediumoptimizationofvalidamycinglycosyltransferasefromStreptomyceshygroscopicusvar.jinggangensisforthebiotransformationofvalidoxylamineAtoproducevalidamycinAusingfreerestingcells.BioresourceTechnology,2013,131:13-20.
7.RuiGuo,YongxianFan,XiaolongChen*,YinchuShen.Chiralresolutionofracemicp-methylsulfonylphenylserineethylesterwithlipases:Themechanismofsidereactionanditssuppression.JournalofAgriculturalandFoodChemistry,2013,61:152-166.
8.WeiLi,YongxianFan,ZhenzhongShen,XiaolongChen*,YinchuShen.AntifungalactivityofsimplecompoundswithmaleicanhydrideordimethylmaleimidestructureagainstBotrytiscinerea.JournalofPesticideScience,2012,37:1-5.
9.XiaolongChen,XiaohuiZhu,YichengDing,YinchuShen.Antifungal
activityoftautomycinandrelatedcompoundsagainstSclerotiniasclerotiorum.TheJournalofAntibiotics,2011,64:563569.
10.Xiao-LongChen,Yu-HuaXu,Yu-GuoZheng,andYin-ChuShen.2010.ImprovementoftautomycinproductionwithStreptomycesspiroverticillatusbyfeedingglucoseandmaleicanhydride.BiotechnologyandBioprocessEngineering,15:969-974.
11.XiaolongChen,YuguoZheng,YinchuShen.BioassaymethodforthequantitativedeterminationoftautomycininthefermentationbrothwithSclerotiniasclerotiorum.JournalofRapidMethodsandAutomationinMicrobiology,2008,16:199-209.
12.XiaolongChen,YuguoZheng,YinchuShen.NaturalProductswith
MaleicAnhydrideStructure:Nonadrides,Tautomycin,ChaetomellicAnhydrideandOtherCompounds.ChemicalReviews2007,107:1777-1830.
13.XiaolongChen,YuguoZheng,YinchuShen.Voglibose(Basen(R)AO128),oneofthemostimportantalpha-glucosidaseinhibitors.CurrentMedicinalChemistry2006,13:109-116.
14.XiaolongChen,YongxianFan,YuguoZhengandYinchu
Shen.Propertiesandproductionofvalienamineanditsrelatedanalogues.ChemicalReviews,2003,103:1955-1977.
15.XiaolongChen,YuguoZhengandYinchuShen.Anewmethodforthe
productionofvalienaminewithmicrobialdegradationofacarbose.BiotechnologyProgress,2005,21:1002-1003.
16.XiaolongChen,YuguoZhengandYinchuShen.Quantitativeanalysis
ofvalienamineinthemicrobialdegradationofvalidamycinAafterderivationwithp-nitrofluorobenzenebyreversed-phasehighperformanceliquidchromatography.JournalofChromatographyB,2005824:341-347.
17.YuguoZheng,XiaolongChenandZhaoWang.Microbialbiomass
productionfromricestrawhydrolysateinairlift
bioreactors.JournalofBiotechnology,2005,118:413-420.
18.YuguoZheng,XiaolongChen,ZhaoWangandYinchuShen.Production
ofvalidamycinsfromcrudesubstratesbyStreptomyceshygroscopicusinanexternal-loopairliftbioreactorwithlowerheight-to-diameterratio.ChineseJournalofChemicalEngineering,2004,12:102-107.
19.YuguoZheng,ZhaoWangandXiaolongChen.Productionof
extracellularproteasefromcrudesubstrateswithdregsinanexternal-loopairliftbioreactorwithlowerratioofheight-to
diameter.BiotechnologyProgress,2001,17:273-277.
20.YuguoZheng,ZhaoWangandXiaolongChen.α-Amylaseproductionby
Bacillussubtiliswithdregsinanexternal-loopairliftbioreactor.BiochemicalEngineeringJournal,2000,5:115-121.
21.YuguoZheng,XiaolongChenandZhaoWang.Productionofsingle
cellproteinfromhydrolysateofricehullinexternal-loopairliftbioreactors.EnvironmentalScience,2000,21:85-88.
22.YuguoZheng,ZhaoWangandXiaolongChen.Citricacidproduction
fromthemashofdregsbyAspergillusnigerinanexternal-loop
airliftbioreactor.ProcessBiochemistry,1999,35:237-242.
23.方夏,李琳,韩君芳,吴芳,毛雪萍,陈小龙.Botrytiscinerea蛋白磷酸酶的分离纯
化及酶学性质.农药,2011,50,795-798.(工大A类)
24.江琴琴,陈小龙,沈寅初.产灰霉病菌物质的微生物筛选和鉴定.农药,2010,49:
257-259.(工大A类)
25.陈小龙,方夏,沈寅初.纹枯病菌对井冈霉素的作用机制、抗药性及安全性.农药,
2010,49:481-483.(工大A类)
26.黄振,陈小龙.抗真菌剂两性霉素B的结构修饰.中国抗生素杂志,2010,35:571-575.
(中文核心期刊)
国内外著名杂志上发表论文100多篇。
出版专著有:
陈小龙,陆跃乐,范永仙,沈寅初.Validamycinanditsderivatives-
Discovery,chemicalsynthesis,andbiologicalactivity.Elsevier,2017.4.
学术兼职
学校及社会兼职:浙江工业大学发酵工程研究所所长,浙江省重中之重生物工程重点学科发酵工程团队负责人,浙江工业大学天台研究院院长