Renslo, Adam - University of California, San Francisco - Department of Chemistry and Chemical Biology

研究领域

Our lab synthesizes small molecules that can be used to better understand the biology of disease and ultimately to produce more effective therapeutics.

近期论文

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Chimenti MS, Bulfer SL, Neitz RJ, Renslo AR, Jacobson MP, James TL, Arkin MR, Kelly MJ. A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP.5 J Biomol Screen. 2015 Feb 17. pii: 1087057115570550. [Epub ahead of print] Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R Jr, Nunneley JW, Barnard D, Pöhlmann S, McKerrow JH, Renslo AR, Simmons G. Protease inhibitors targeting coronavirus and filovirus entry.6 Antiviral Res. 2015 Feb 7;116C:76-84. doi: 10.1016/j.antiviral.2015.01.011. [Epub ahead of print] Fontaine SD, Spangler B, Gut J, Lauterwasser EM, Rosenthal PJ, Renslo AR. Drug delivery to the malaria parasite using an arterolane-like scaffold.7 ChemMedChem. 2015 Jan;10(1):47-51. doi: 10.1002/cmdc.201402362. Epub 2014 Oct 14. Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. Lead identification to clinical candidate selection: drugs for Chagas disease.8 J Biomol Screen. 2015 Jan;20(1):101-11. doi: 10.1177/1087057114553103. Epub 2014 Oct 3. Turner DM, Tom CT, Renslo AR. Simple Plate-Based, Parallel Synthesis of Disulfide Fragments using the CuAAC Click Reaction. ACS Comb Sci. 2014 Oct 29. View in: PubMed9 10 Fontaine SD, DiPasquale AG, Renslo AR. Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery. Org Lett. 2014 Nov 7; 16(21):5776-9. View in: PubMed11 12 Fontaine SD, Spangler B, Gut J, Lauterwasser EM, Rosenthal PJ, Renslo AR. Drug Delivery to the Malaria Parasite Using an Arterolane-Like Scaffold. ChemMedChem. 2014 Oct 14. View in: PubMed7 13 Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. Lead Identification to Clinical Candidate Selection: Drugs for Chagas Disease. J Biomol Screen. 2014 Oct 3. View in: PubMed8 10 Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry. 2014 Jul 22; 53(28):4648-60. View in: PubMed14 10 Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrob Agents Chemother. 2014 Jul; 58(7):4138-44. View in: PubMed15 Arkin MR, Ang KK, Chen S, Davies J, Merron C, Tang Y, Wilson CG, Renslo AR. UCSF Small Molecule Discovery Center: Innovation, Collaboration and Chemical Biology in the Bay Area16. Comb Chem High Throughput Screen. 2014 May; 17(4):333-42. Nichols DA, Renslo AR, Chen Y. Fragment-based inhibitor discovery against ß-lactamase17. Future Med Chem. 2014 Mar; 6(4):413-27. Silber BM, Gever JR, Rao S, Li Z, Renslo AR, Widjaja K, Wong C, Giles K, Freyman Y, Elepano M, Irwin JJ, Jacobson MP, Prusiner SB. Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells18. Bioorg Med Chem. 2014 Mar 15; 22(6):1960-72.