杨红 - 辽宁师范大学 - 生命科学学院

个人简介

杨红，教授，博士生导师。教育部“新世纪优秀人才支持计划”项目获得者，辽宁省特聘教授。主要研究领域为水盐代谢与消化系统疾病机制和药物高通量筛选研究。一、学习经历 2009.11-2010.5德国慕尼黑大学（LMU）药理学与化学系，高级访问学者 2002.4-2003.5美国加州大学旧金山医学院（UCSF）医学系，访问学者 2001.8－2003.10吉林大学基础医学院，博士后 1998.9-2001.7东北师范大学细胞与遗传学研究所，博士生，获理学博士学位 1992.9-1995.7吉林大学研究生院生物化学专业，硕士生，获理学硕士学位 1987.9-1992.7吉林大学分子生物学系生物化学专业，本科生，获理学学士学位二、工作经历 2006.8-至今辽宁师范大学生命科学学院，博士生导师 2004.8-至今辽宁师范大学生命科学学院，教授 2001.12-2004.7东北师范大学遗传与细胞研究所，副教授 1995.7－2001.12东北师范大学遗传与细胞研究所，助教、讲师研究成果（一）近年来主持的主要科研项目科技部重大新药创制“高端制剂、新型辅料品种及共性关键技术研发”课题“中药雾化吸入制剂吸入给药的关键技术研究”（2017ZX09201-002-007）分课题负责人，50.02万元，2017.1—2020.12 国家自然科学基金面上项目“CFTR选择性抑制剂的发现及其在上皮液体分泌研究中的应用”(No.81473265)，65万元，2015.1—2018.12 辽宁省特聘教授计划项目，100万元，2015.12-2018.12 国家自然科学基金面上项目“CFTR氯离子通道在慢性胰腺炎发病机理及治疗中的作用”(No.30973577)，32万元，2010.1－2012.12 科技部国家重点基础研究发展计划项目（973项目）“脑血管疾病发生和防治的基础研究”课题“新的天然活性化合物在脑卒中研究与防治中的应用”（2009CB521908）课题骨干，60万元，2009-2013 美国囊性纤维化基金会药物发现专项（项目号MA08XX0），“DiscoveryofNaturalcompoundsF508-CFTRmisprocessingcorrectorsfromChinesemedicinalherbs”,CysticFibrosisFoundation,USA.co-PI，28万美元，2008-2010 教育部“新世纪优秀人才支持计划”项目“cAMP激活的氯离子通道在遗传性多囊肾病发病机理中的作用”（NCET-07-0406），50万元，2007－2009 国家自然科学基金面上项目“CFTR氯离子通道在常染色体显性多囊肾病发病机理中的作用”(No.30570864)，26万元，2006.1－2008.12 国家自然科学基金面上项目“CLC-7氯离子通道小分子调节剂的高通量筛选及应用”(No.30470405)，21万元，2005.1－2007.12 高等学校博士学科点专项科研基金项目（博导类）“特异性CFTR氯离子通道抑制剂的发现及其作用机制研究”（20112136110002），12万元，2012.1—2014.12 辽宁省“高等学校优秀人才支持计划”项目“氯离子通道蛋白CFTR在ADPKD中的作用”（2006R33），10万元，2007.1-2009.12 发明专利 “嘧啶（硫）酮类化合物在制药中的应用”。发明人：麻彤辉，杨红。专利号ZL200510017135.X。授权时间：2009年2月15日。基因工程新药——“重组人粒细胞集落刺激因子”，2000年通过国家药品监督管理局审评鉴定，获得国家新药证书（国药证字(2002)S-38号），主要完成人。 “重组人粒细胞集落刺激因子”，2002年通过教育部鉴定，第三完成人。 “纤溶酶原的结构与功能”，2004年通过吉林省科技厅鉴定，第二完成人。 “基因工程新药——重组人粒细胞集落刺激因子的研制”项目，获2002年度吉林省科技进步二等奖，第三完成人。荣誉教育部“新世纪优秀人才支持计划”项目获得者辽宁省特聘教授辽宁省“百千万人才工程”百人层次人选辽宁省“高等学校优秀人才支持计划”项目获得者辽宁省优秀青年骨干教师

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YuB,JiangY,ZhangB,YangH*,MaT*.Resveratroldimertrans-ε-viniferinpreventsrotaviraldiarrheainmicebyinhibitionoftheintestinalcalcium-activatedchloridechannel.PharmacolRes.2018Mar;129:453-461. YangH,MaT*.LuminallyActingAgentsforConstipationTreatment:AReviewBasedonLiteraturesandPatents.FrontPharmacol.2017Jun30;8:418. JiangY,ZhangG,YanD,YangH*,YeZ*,MaT.Bioactivity-GuidedFractionationoftheTraditionalChineseMedicineResinaDraconisRevealsLoureirinBasaPAI-1Inhibitor.EvidBasedComplementAlternatMed.Volume2017,ArticleID9425963. YuB,ZhangG,JinL,ZhangB,YanD,YangH*,YeZ*,MaT.InhibitionofPAI-1ActivitybyToddalolactoneasaMechanismforPromotingBloodCirculationandRemovingStasisbyChineseHerbZanthoxylumnitidumvar.tomentosum.FrontPharmacol.2017Jul21;8:489. YuB,JiangY,JinL,MaT*,YangH*.RoleofQuercetininModulatingChlorideTransportintheIntestine.FrontPhysiol.2016Nov23;7:549. JiangY,YuB,YangH*,MaT*.ShikoninInhibitsIntestinalCalcium-ActivatedChlorideChannelsandPreventsRotaviralDiarrhea.FrontPharmacol.2016Aug23;7:270. JiangY,YuB,FangF,CaoH,MaT,YangH*.Modulationofchloridechannelfunctionsbytheplantlignancompoundskobusinandeudesmin.FrontPlantSci.2015Nov25;6:1041. YuB,JiangY,LiuY,MaT*,YangH*.ChloridechannelinhibitionbyethanolextractfromBistortaerhizomapreventssecretorydiarrhea.BangladeshJPharmacol2015;10:00-00. YangH*,MaT.F508del-cysticfibrosistransmembraneregulatorcorrectorsfortreatmentofcysticfibrosis:apatentreview.ExpertOpinTherPat.2015Sep;25(9):991-1002. ChenL,YuB,ZhangY,GaoX,ZhuL,MaT,YangH*.Bioactivity-guidedFractionationofanAntidiarrhealChineseHerbRhodiolakirilowii(Regel)MaximReveals(-)–epicatechin-3-gallateand(-)–epigallocatechin-3-gallateasInhibitorsofCysticFibrosisTransmembraneConductanceRegulator.PLoSOne.2015Mar6;10(3):e0119122. LuanJ,ZhangY,YangS,WangX,YuB,YangH*.Oridonin:Asmallmoleculeinhibitorofcysticfibrosistransmembraneconductanceregulator(CFTR)isolatedfromtraditionalChinesemedicine.Fitoterapia.2015Jan;100:88-94. JiangY,YuB,WangX,SuiY,ZhangY,YangS,YangH*,MaT.StimulationeffectofwidetypeCFTRchloridechannelbythenaturallyoccurringflavonoidtangeretin.Fitoterapia.2014Dec;99:284-291. ZhangY,YuB,SuiY,GaoX,YangH*,MaT*.Identificationofresveratrololigomersasinhibitorsofcysticfibrosistransmembraneconductanceregulatorbyhigh-throughputscreeningofnaturalproductsfromchinesemedicinalplants.PLoSOne.2014Apr8;9(4):e94302. YuB,ZhangY,SuiY,YangS,LuanJ,WangX,MaT,YangH*.PotentiationofmutantCFTRCl-channelcurrentsbythenaturallyoccurringstilbenecompoundresveratrol.Pharmazie.2013Nov;68(11):877-881. YangS,YuB,SuiY,ZhangY,LuanJ,WangX,HwangT,MaT,YangH*.CFTRchloridechannelisamoleculartargetofthenaturalcancerpreventiveagentresveratrol.PHARMAZIE,2013,68(9):772–776. WangX,ZhangY,YuB,YangS,LuanJ,YangH*.Dehydrocostuslactone,asesquiterpenelactoneactivateswild-typeandF508mutantCFTRchloridechannel.JAsianNatProdRes.2013Aug;15(8):855-866. ZhouY,BiY,YangC,YangJ,JiangY,MengF,YuB,KhanM,MaT,YangH*.MagnololInducesApoptosisinMCF-7HumanBreastCancerCellsthroughG2/MPhaseArrestandCaspase-independentPathway.PHARMAZIE,2013,68(9):755–762. MengF,YangJ,YangC,JiangY,ZhouY,YuB,KhanM,YangH*.VitexicarpinInducesApoptosisinHumanProstateCarcinomaPC-3CellsthroughG2/MPhaseArrest.AsianPacJCancerPrev.2012,13(12),6369-6374. JiangY,YangJ,YangC,MengF,ZhouY,YuB,KhanM,YangH*.VitaminK4InduceTumorCytotoxicityinHumanProstateCarcinomaPC-3CellsviatheMitochondria-relatedApoptoticPathway.PHARMAZIE,2013,68:442–448. MengX,WangY,ZhengX,LiuC,SuB,NieH,ZhaoB,ZhaoX,YangH*.shRNA-mediatedknockdownofBmi-1inhibitlungadenocarcinomacellmigrationandmetastasis.LungCancer.2012,77(1):24-30. RasulA,YuB,YangLF,AliM,KhanM,MaT,YangH*.InductionofMitochondria-mediatedApoptosisinHumanGastricAdenocarcinomaSGC-7901CellsbyKuraridinandNor-kurarinoneIsolatedfromSophoraFlavescens.AsianPacJCancerPrev.2011,12(10):2499-2504. RasulA,KhanM,YuB,MaT,YangH*.Xanthoxyletin,acoumarininducesSphasearrestandapoptosisinhumangastricadenocarcinomaSGC-7901cells.AsianPacJCancerPrev.2011,12(5):1219-1223. LiK,DiaoY,ZhangH,WangS,ZhangZ,YuB,HuangS,YangH*.TanninextractsfromimmaturefruitsofTerminaliachebulaFructusRetz.promotecutaneouswoundhealinginrats.BMCComplementAlternMed.2011,11(1):86. YangH*,XuL,SuiY,LiuX,HeC,FangR,LiuJ,HaoF,MaT.StimulationofairwayandintestinalmucosalsecretionbynaturalcoumarinCFTRactivators.FrontPharmacol.2011;2:52. YangH*,XuLN,HeCY,LiuX,FangRY,MaTH.CFTRchloridechannelasamoleculartargetofanthraquinonecompoundsinherballaxatives.ActaPharmacolSin.2011,32(6):834-839. JinL,LiuX,SunY,LinS,ZhouN,XuL,YuB,HouS,YangH*.ActivationofCFTR-mediateCl-transportbyMagnolin.Chem.Res.ChineseU.2008,24(2):187-191. LiuX,GuanL,HeC,ZhangX,XuL,ShangD,MaT,YangH*.NaturalCompoundCurcumin—aChannelPotentiatorRatherThanaCorrectoroftheDefectiveIntracellularProcessingofF508MutantCysticFibrosisTransmembraneConductanceRegulator.Chem.Res.ChineseU.2008,24(2):200-203. HaoL,LiuX,XuL,ZhuN,LinS,HouS,ZhouN,ShiD,ShangD,MaT,YangH*.NaturalCompoundCurcuminCorrectstheGatingDefectofG551DMutantCysticFibrosisTransmembraneConductanceRegulator.Chem.Res.ChineseU.2008,24(1):92-95. LiuJ,LiuL,WangS,XuL,YuB,Lin,S,HouS,ZhouN,JinL,YangH*.DictaminestimulatescysticfibrosistransmembraneconductanceregulatorCl-transport.Chem.Res.ChineseU.2007,23(5):554-557. JinS,LiuY,XuL,JiangY,WangY,YangB,YangH*,MaT.Cloningandcharacterizationofaporcineaquaporin1waterchannelexpressedextensivelyingastrointestinalsystem.WorldJGastroenterol.2006,12(7):1092-1097. ShiL,XuL,HouS,LinS,YangH*andMaT.ActivationeffectofcartharticnaturalcompoundrheintoCFTRchloridechannel.Chem.Res.ChineseU.2006,22(3):312-314. WangY,ZhaoL,HeC,XuL,YangH*.ActivationofG551D-CFTRbyBicyclooctaneCompoundsIscAMP-dependentandExhibitsLowSensitivitytoThiazolidinoneCFTRInhibitorCFTRinh-172.Chem.Res.ChineseU.2005,21(2):183-186. HeC,ZhaoL,LiuY,XuL,ShangD,YangH*.AClassofHigh-affinityBicyclooctaneG551D-CFTRActivatorsIdentifiedbyHighThroughputScreening.Chem.Res.ChineseU.2004,20(6):738-742. ZhaoL,HeC,ZhouH,ZhouJ,YangH*.Ahigh-affinitybicyclooctaneactivatorofG551D-CFTRcloridechannelidentifiedbyhighthroughputscreening.Chem.Res.ChineseU.2004,20(6):743-746. HeC,ZhangH,SuZ,ZhouJ,YangH*,MaT.SynthesisandcharacterizationofasmallmoleculethiazolidinoneCFTRchloridechannelinhibitor.Chem.Res.ChineseU.2004,20(3):334-337. YangH,ShelatAA,GuyRK,GopinathVS,MaT,DuK,LukacsGL,TaddeiA,FolliC,PedemonteN,GaliettaLJ,VerkmanAS.NanomolarAffinitySmallMoleculeCorrectorsofDefective{Delta}F508-CFTRChlorideChannelGating.JBiolChem.2003,278(37):35079-35085. ZhengX,WangY,LiuB,LiuC,LiuD,ZhuJ,YangC,YanJ,LiaoX,MengX*,YangH.Bmi-1-shRNAInhibitstheProliferationofLungAdenocarcinomaCellsbyBlockingtheG1/SPhaseThroughDecreasingCyclinD1andIncreasingp21/p27Levels.NucleicAcidTher.2014Jun;24(3):210-216. MaT,GaoH,FangX,YangH.Waterchannelproteinsintheperipheralnervoussysteminhealthanddisease.MolAspectsMed.2012,33(5-6):605-611. RasulA,YuB,ZhongL,KhanM,YangH,MaT.CytotoxiceffectofevodiamineinSGC-7901humangastricadenocarcinomacellsviasimultaneousinductionofapoptosisandautophagy.OncolRep.2012,27(5):1481-1487. KhanM,YuB,RasulA,AlShawiA,YiF,YangH,MaT.JaceosidinInducesApoptosisinU87GlioblastomaCellsthroughG2/MPhaseArrest.EvidBasedComplementAlternatMed.2012;2012:703034. RasulA,YuB,KhanM,ZhangK,IqbalF,MaT,YangH.Magnolol,anaturalcompound,inducesapoptosisofSGC-7901humangastricadenocarcinomacellsviathemitochondrialandPI3K/Aktsignalingpathways.IntJOncol.2011,40(4):1153-1161. ZhuN,FengX,HeC,GaoH,YangL,MaQ,GuoL,QiaoY,YangH,MaT.Defectivemacrophagefunctioninaquaporin-3deficiency.FASEBJ.2011,25(12):4233-4239. MaT,GaoH,FangX,YangH.Expressionandfunctionofaquaporinsinperipheralnervoussystem.ActaPharmacolSin.2011,32(6):711-715. HaoF,YiF,ZhangD,NingY,SuiY,SuW,FengX,YangH,MaT*.IdentificationofherbalcompoundImperatorinwithadverseeffectsonANO1andCFTRchloridechannels.Chem.Res.ChineseU.2011,27(3):461-463. JiangY,SuB,MengX*,LiuC,LiuB,LiuD,FanY,YangH.EffectofsiRNA-mediatedsilencingofBmi-1geneexpressiononHeLacells.CancerSci.2010,101(2):379-386. LiuX,GeH,ZhaoX,HouT,SunJ,YangJ,HeC*,YangH.DirectActivationofCFTRChlorideChannelbyNaturalCompoundTheophylline.Chem.Res.ChineseU.2009,25(6):887-890. GaoH,HeC,FangX,HouX,FengX,YangH,ZhaoX,andMaT*.Localizationofaquaporin-1waterchannelinglialcellsofthehumanperipheralnervoussystem.Glia.2006,53(7):783-787. WangF,FengX,LiY,YangH,MaT*.Aquaporinsaspotentialdrugtargets.ActaPharmacologicaSinica.2006,27(4):395-401. ZhaoX,HouT,GeH,SunJ,YangH,MaT*.ActivationofCFTR-mediatedCl–TransportbyCapsaicinoidsinCellCultureModel.Chem.Res.ChineseU.2009,25(2):220-223. LiuY,WangY,JiangY,ZhuN,LiangH,XuL,FengX,YangH,MaT*.MildProcessingDefectofPorcineF508-CFTRSuggeststhatF508PigsMayNotDevelopCysticFibrosisDisease.Biochem.Biophys.Res.Commun.2008,15(373):113-118. XuL,NaW,LiuX,HouS,LinS,YangH,MaT*.IdentificationOfNaturalcoumarincompoundsthatrescuedefectiveF508-CFTRchloridechannelgating.ClinicalandExperimentalPharmacologyandPhysiology,2008,35(8):878-883. LiY,FengX,YangH,MaT*.Expressionofaquaporin-1inSMMC-7221livercarcinomacellspromotescellmigration.ChineseScienceBulletin.2006,51(20):2466-2471. LiM,JiangY,WangS,LiY,WangF,HouX,YangH,MaT*.cDNACloning,ProkaryoticandEukaryoticExpressionandCharacterizationofPorcineLeukemiaInhibitoryFactor.Chem.Res.ChineseU.2006,22(2):145-149. SpringsteelMF,GaliettaLJ,MaT,ByK,BergerGO,YangH,DicusCW,ChoungW,QuanC,ShelatAA,GuyRK,VerkmanAS,KurthMJ,NantzMH.Benzoflavoneactivatorsofthecysticfibrosistransmembraneconductanceregulator:towardsapharmacophoremodelforthenucleotide-bindingdomain.BioorgMedChem.2003,11(18):4113-4120. MaT,ThiagarajahJR,YangH,SonawaneND,FolliC,GaliettaLJ,VerkmanAS*.ThiazolidinoneCFTRinhibitoridentifiedbyhigh-throughputscreeningblockscholeratoxin-inducedintestinalfluidsecretion.JClinInvest.2002,110(11):1651-1658. MaT,VetrivelL,YangH,PedemonteN,Zegarra-MoranO,GaliettaLJ,VerkmanAS*.High-affinityactivatorsofcysticfibrosistransmembraneconductanceregulator(CFTR)chlorideconductanceidentifiedbyhigh-throughputscreening.JBiolChem.2002,277(40):37235-37241.