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Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA. Cell. 2015 Jan 15;160(1-2):339-50. Specific Gene Repression by CRISPRi System Transferred through Bacterial Conjugation Ji W, Lee D, Wong E, Dadlani P, Dinh D, Huang V, Kearns K, Teng S, Chen S, Haliburton J, Heimberg G, Heineike B, Ramasubramanian A, Stevens T, Helmke KJ, Zepeda V, Qi LS, Lim WA. ACS Synth Biol. 2014 Dec 19;3(12):929-31. Abstract. PDF. Supplemental Data. Sending mixed messages for cell population control. Hyun Youk and Wendell A. Lim Cell (Preview) 158 : 973-975 (2014) Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Jason S. Park, Benjamin Rhau, Aynur Hermann, Krista A. McNally, Carmen Zhou, Delquin Gong, Orion D. Weiner, Bruce R. Conklin, James Onuffer, and Wendell A. Lim Proceedings of the National Academy of Sciences (April 2014) Abstract. PDF. Supplemental Data. Supplemental Movie 1. Supplemental Movie 2. Supplemental Movie 3. Supplemental Movie 4. Supplemental Movie 5 Supplemental Movie 6. Secreting and sensing the same molecule allows cells to achieve versatile social behaviors. Hyun Youk and Wendell A. Lim Science 343 (6171): 1242782 (2014) Abstract. PDF. Supplemental Data. Perspective in Science by Anna J. Lee and Linchong You (PDF) Using optogenetics to interrogate the dynamic control of signal transmission by the ras/erk module. Jared E. Toettcher, Orion D. Weiner, and Wendell A. Lim. Cell 155(6):1422-34 (2013) Abstract. PDF. Supplemental Data. Supplemental Movie 1. Supplemental Movie 2. RPPA data. Counting molecules in single organelles with superresolution microscopy allows tracking of the endosome maturation trajectory. Elias M. Puchner, Jessica M. Walter, Robert Kasper, Bo Huang, and Wendell A. Lim. Proceedings of the National Academy of Sciences 110(40):16015-16020 (2013) Abstract. PDF. Supplemental Data. Exploitation of Latent Allostery Enables the Evolution of New Modes of MAP Kinase Regulation. Scott M. Coyle, Jonathan Flores, and Wendell A. Lim Cell 154, 875-887 (2013) Abstract. PDF. Supplemental Data. CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes. Luke A. Gilbert, Matthew H. Larson, Leonardo Morsut, Zairan Liu, Gloria A. Brar, Sandra E. Torres, Noam Stern-Ginossar, Onn Brandman, Evan H. Whitehead, Jennifer A. Doudna, Wendell A. Lim, Jonathan S. Weissman, Lei S. Qi Cell (Resource) 154, 1-10 (2013) Cell-based therapeutics: the next pillar of medicine. Michael A. Fischbach, Jeffrey A. Bluestone, Wendell A. Lim Science Translational Medicine 5(179) (2013) Cell biology 2.0. Wendell A. Lim, Rebecca Alvania, Wallace F. Marshall Trends Cell Biol. 22(12):611-2 (2013) Design principles of regulatory networks: searching for the molecular algorithms of the cell. Wendell A. Lim, Connie M. Lee, Chao Tang Mol. Cell 49(2):202-12 (2013)