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Chen, Y., Lin, Y.C., Kuo, T.Z., Knight, Z.A., Sensory detection of food rapidly modulates arcuate feeding circuits, Cell. 2015, February 26; 160(5) Earlier work Ekstrand, M.I., Nectow, A.R., Knight, Z.A., Latcha, K.N., Pomeranz, L.E. and Friedman, J.M., Molecular profiling of neurons based on connectivity, Cell. 2014, May 22; 157(5) Tan K., Knight, Z.A.,, Friedman J.M., Ablation of AgRP neurons impairs adaptation to restricted feeding, Molecular Metabolism. 2014, July 10; 3(7):694-704 Knight, Z.A.,, Schmidt, S., Birsoy, K., Tan, K., Friedman J.M., A critical role for mTORC1 in erythropoiesis and anemia., Elife. 2014, September 8;3:e01913 Knight, Z.A., Tan, K., Birsoy, K., Schmidt, S., Garrison, J.L., Wysocki, R.W., Ekstrand, M.I., Friedman, J.M., Molecular profiling of activated neurons by phosphorylated ribosome capture, Cell. 2012, November 21; 151(5) Knight, Z.A., For a PDK1 inhibitor, the substrate matters, Biochemical Journal. 2011, January 15; 433(2):1-2. Knight, Z.A., Hannan, K.S., Greenberg, M., and Friedman, J.M., Hyperleptinemia is required for the development of leptin resistance, PLoS One. 2010, June; 5(6):1-8. Knight, Z.A., Small molecule inhibitors of the PI3-kinase family, Phosphoinositide 3-kinase in Health and Disease: Current Topics in Microbiology and Immunology. 2010, May 7; 346:. Williams, O., Houseman, B.T., Kunkel, E.J., Aizenstein, B., Hoffman, R., Knight, Z.A., and Shokat K.M., Discovery of dual inhibitors of the immune cell PI3-Ks p110delta and p110gamma inhibitors: a prototype for new anti-inflammatory drugs, Chemistry & Biology. 2010, February 26; 17(2):123-134. Knight, Z.A., Lin, H., Shokat, K.M., Targeting the cancer kinome through polypharmacology, Nature Reviews Cancer. 2010, February; 10(2):130-137. Niedermeier, M., Hennessy, B.T., Knight, Z.A., Henneberg, M., Hu, J., Kurtova, A.V., Wierda, W.G., Keating, M.J., Shokat, K..M., and Burger, J.A. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach, Blood. 2009, May 28; 113(22):5549-57. Fan, Q.W., Cheng, C., Knight, Z.A., Haas-Kogan, D., Stokoe, D., James, C.D., McCormick, F., Shokat, K.M., and Weiss, W.A. EGFR signals to mTOR through PKC and independently of Akt in glioma, Science Signaling. 2009, January 27; 2(55):1-9. Feldman, M.E., Apsel, B.A., Uotila, A., Loewith, R., Knight, Z.A., Ruggero D., Shokat, K.M., Active site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2, PLoS Biology. 2009, February; 7(2):e38.